Risk factors of pregnancy failure in elderly infertility patients undergoing human assisted reproductive technology.

OBJECTIVE: To investigate the risk factors of pregnancy failure in elderly infertile patients undergoing human assisted reproductive technology (ART).

METHODS: A total of 565 infertile patients undergoing ART were selected and divided into failed pregnancy group (127 cases) and continued pregnancy group (438 cases). Their clinical data were collected, and the influencing factors of pregnancy failure were assessed and compared by univariate and multivariate analysis.

RESULTS: The success and failure rates of in vitro fertilization-embryo transfer (IVF-ET) in pregnant women were 79.44% and 20.56%, while those of intracytoplasmic sperm injection (ICSI) were 75.96% and 24.04%, respectively. There was no remarkable difference between them (all P>0.05). Women's age, numbers of embryos transferred and previous abortion history in the failed pregnancy group were higher than those in the continued pregnancy group, while the number of high-quality embryos, BMI and endometrial thickness (EMT) on human chorionic gonadotropin (hCG) day in the former were lower (all P<0.05).

CONCLUSION: The risk factors of ART pregnancy failure in elderly infertility patients are related to woman's age, numbers of embryos transferred, previous pregnancy abortion history, numbers of high-quality embryos and EMT on hCG day.