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American Journal of Translational Research

Xiang Wang, Rui Jiang, Enhai Cui, Wenming Feng, Huihui Guo, Donghua Gu, Chengwu Tang, Tao Xue, Ying Bao
[This corrects the article on p. 3921 in vol. 8, PMID: 27725871.].
2018: American Journal of Translational Research
Zehua Zhang, Feifan Chen, Jianhua Li, Fei Luo, Tianyong Hou, Jianzhong Xu, Dong Sun
1,25(OH)2 D3 is an immune modulation hormone with beneficial effects on T cell- mediated autoimmune diseases. The purpose of the present study is to investigate the direct effects of vitamin D on Bacillus Calmette Guerin (BCG)-infected CD4+ T cells in both VDR-deficient (VDR-/-) mice and wild type (WT) mice. Specifically, we aimed to investigate the effect of vitamin D on Th1 cells and elucidate the underlying molecular mechanism. Naïve CD4 T cells were purified from VDR-/- mice and WT mice to induce Th1 cells and were activated by BCG...
2018: American Journal of Translational Research
Hong Xie, Bojun Wei, Hong Shen, Ying Gao, Lingling Wang, Hui Liu
The aim of the present research was to investigate the association between the BRAF mutation and papillary thyroid carcinoma (PTC), and further explore the relationship between the systemic inflammation response index (SIRI) and BRAF mutation in patients with PTC. The clinicopathological data were extracted from the patients' medical records from June 2012 to June 2014 in our hospital. We enrolled 95 patients with PTC that have received the total or near-total thyroidectomy and pretracheal and paratracheal lymph node dissection...
2018: American Journal of Translational Research
Mary C Shields, Borna Mehrad, Ellen C Keeley
Circulating fibrocytes are a population of bone marrow-derived progenitor cells that have been implicated in neovascularization. The recruitment of coronary artery collaterals, a form of neovascularization, is associated with improved outcomes in coronary artery disease. In this study, we tested the hypothesis that, in subjects with stable chronic coronary artery disease, the blood concentration of fibrocytes is associated with the presence of angiographic coronary collaterals. A total of 58 subjects with at least one epicardial coronary artery with ≥ 90% luminal stenosis were enrolled, among whom 26 (45%) had angiographic evidence of coronary collaterals...
2018: American Journal of Translational Research
Jérôme Varvat, Magali Epinat, Aurélie Montmartin, Sandrine Accassat, Claire Boutet, Arnauld Garcin, Guorong Li, Fabrice Malergue, Céline Chapelle, Silvy Laporte, Pierre Garnier, Claude Lambert, Nora Mallouk, Patrick Mismetti
BACKGROUND AND PURPOSE: Low biological response to Clopidogrel prescribed after non cardioembolic ischemic stroke or transient ischemic attack (TIA) is a major clinical problem and could explain the recurrence of vascular events. Platelet α2-adrenoreceptors are involved in the high residual platelet reactivity in stable coronary artery disease patients on dual antiplatelet therapy. In the present study we investigated the impact of platelet α2-adrenoreceptors on ADP-induced platelet aggregation and on ADP-induced platelet membrane CD62P (P-selectin) expression, a marker of platelet activation on blood samples from patients hospitalized at the acute phase of a non cardioembolic ischemic stroke or TIA...
2018: American Journal of Translational Research
Fengyun Zhong, Meili Zhu, Kaijian Gao, Ping Xu, Huan Yang, Duanmin Hu, Dawei Cui, Min Wang, Xiaofang Xie, Yan Wei, Haifang Zhang, Hong Du
AIM: The contribution of long non-coding RNAs (lncRNAs) to gastric cancer associated with Helicobacter pylori ( H. pylori ) infection remains largely unknown. Therefore, the present study aimed to investigate the expression of a lncRNA NR_026827 in gastric epithelial cells infected with H. pylori , and demonstrate its expression characteristic in gastric cancer. MATERIALS AND METHODS: Gastric epithelial cell line cells, GES-1, were cultured and infected with H. pylori ...
2018: American Journal of Translational Research
Min Hu, Juan Li, Yuehui Zhang, Xin Li, Mats Brännström, Linus R Shao, Håkan Billig
CONTEXT: Polycystic ovary syndrome (PCOS) affects approximately 4%-18% of all reproductive-aged women and is often accompanied by endometrial progesterone (P4) resistance. Endometrial cells from PCOS patients display increased progesterone receptor (PGR) expression; however, in vivo knockout studies and in vitro experiments indicate the two PGR isoforms are not functionally equivalent. OBJECTIVE: We aimed to compare endometrial PGR isoform expression between non-PCOS and PCOS patients during the proliferative phase...
2018: American Journal of Translational Research
Baoxian Liu, Mengchao Wei, Furong Liu, Shuling Chen, Zhenwei Peng, Bin Li, Qian Zhou, Haibo Wang, Sui Peng, Ming Kuang
In the real-world, it is unclear that after the radiofrequency ablation (RFA), whether it is a cost-effective strategy to administer nucleotide analogue (NA) for patients with hepatitis B virus (HBV)-related HCC patients. The aim of this study was to estimate the cost-effectiveness of the RFA plus NA versus RFA alone in patients with HBV-related HCC within the Milan criteria in China and the USA. A Markov model was developed to simulate a cohort of patients with HCC within the Milan criteria and Child-Pugh A/B cirrhosis and underwent RFA with or without NA therapy over their remaining life expectancy...
2018: American Journal of Translational Research
Hai-Sheng Wang, Fu-Hua Yang, Yuan Li, Fei Pei, Ashok B Kulkarni, Zhi Chen, Lu Zhang
Periapical lesions are the distinct result of chronic root canal infection and could generate severe bone resorption surrounding apical regions. Despite the local cytokine and cell-mediated immune responses, periapical lesions are also characterized by its auto-restrict inflammation. However, the detailed mechanism related to its auto-restriction of immune response is still unclear. Co-inhibitory immune checkpoints are important molecules which could negatively modulate immune response especially in T cell function...
2018: American Journal of Translational Research
Jun-An Li, Bai-Chun Liu, Ying Song, Xin Chen
Colon cancer is one of the most fatal cancers in the United States, and is characterized by the presence of chromosomal instability (CIN), causes of which are largely unclear. Emerging evidence indicates that abnormal spindle geometry and supernumerary centrosomes lead to CIN in cells. However, if and how spindle geometry defects and centrosomes amplification occur in colon cancer remains unknown. Here we show that decrease in the cell cycle regulatory protein, cyclin A2, induces spindle geometry defects in colon cancer cells...
2018: American Journal of Translational Research
Xiaowei Chen, Jingjing Jiang, Nanxi Shen, Lingyun Zhao, Jiaxuan Zhang, Yuanyuan Qin, Shun Zhang, Li Li, Wenzhen Zhu
PURPOSE: To assess the feasibility of using diffusion-weighted imaging (DWI) with the stretched-exponential model (SEM) for glioma grading and determining the correlations among parameters and proliferating cell nuclear antigen and Ki-67 expression. MATERIALS AND METHODS: Mono-exponential model-DWI (MEM-DWI) and SEM-DWI were performed in 104 patients with pathologically proven gliomas. The patients were divided into the training set (n = 72) and test set (n = 32)...
2018: American Journal of Translational Research
Baogang Zhang, Changfeng Li, Zhixia Sun
Pancreatic cancer (PC) is a devastating human disease with aggressive course and extremely poor prognosis. Long non-coding RNAs (lncRNAs) have been studied to serve as a critical role in pancreatic development and progression. However, little is known about its expression pattern, biological function in PC. In our study, we measured the expression levels of six lncRNAs (LINC00346, LINC00578, LINC00673, LINC00671, LINC00261, and SNHG9) in PC tissues and serums. The results showed that LINC00346, LINC00578, and LINC00673 were highly expressed, whereas LINC00671, LINC00261, and SNHG9 were lowly expressed in PC tissues and serums, and their expression levels were correlated with clinical stages...
2018: American Journal of Translational Research
Rui Zhang, Peng Lin, Xia Yang, Rong-Quan He, Hua-Yu Wu, Yi-Wu Dang, Yong-Yao Gu, Zhi-Gang Peng, Zhen-Bo Feng, Gang Chen
Growing evidence has revealed that the initiation of various malignancies is closely associated with alternative splicing (AS) events in certain key oncogenes. However, in diffuse large B-cell lymphoma (DLBCL), there is still a great deal to learn about AS variants. In this study, 33,724 AS variant profiles were obtained from 16,278 genes in 48 DLBCL cases. A total of 10 AS variants were identified as overall survival (OS)- related events via multivariate Cox regression analysis. Notably, alternative donor (AD) sites in AS events in the low-risk group showed a significantly better outcome in DLBCL patients than in the high-risk group (P=0...
2018: American Journal of Translational Research
Chung-Ming Chen, Hsiu-Chu Chou
Hyperoxia induces activation of the renin-angiotensin system (RAS) in newborn rat lungs. This study investigated the therapeutic effects of human mesenchymal stem cells (MSCs) on lung development and RAS expression in neonatal rats exposed to hyperoxia. Sprague-Dawley rat pups were exposed to either room air (RA) or oxygen-enriched atmosphere (O2 ) treatment from postnatal days 1 to 14. Human MSCs (1 × 105 cells) in 0.03 mL of normal saline (NS) were administered intratracheally on postnatal day 5, and four study groups were obtained: RA + NS, RA + MSCs, O2 + NS, and O2 + MSCs...
2018: American Journal of Translational Research
Xinyuan Hu, Nitin Tandra, Zhijian Zhang, Aihua Gong, Jingyan Chen, Yang Li, Qian Chen, Wenrong Xu, Hui Qian
Pterygium is an invasive hyperplasia, resulting from the hyper-proliferation of epithelial cells in cornea. The aim of our present study is to identify stem cells derived from pterygiums and detect differentiation strategy of the pterygium stem cells in vitro. Fundamental properties of the cultured pterygium stem cells were mainly studied using immunofluorescence staining. While clone formation and MTT assay were utilized to evaluate the cell viability. Pterygium stem cells could be cultivated easily, expanded efficiently, but expressed multilineage stem cell markers, which could be differentiated into neuron, osteocytes and adipocytes in vitro...
2018: American Journal of Translational Research
Ruosi Yao, Xiaoyang Sun, Yu Xie, Linlin Liu, Danyang Han, Yao Yao, Hujun Li, Zhenyu Li, Kailin Xu
Multiple myeloma (MM) is an extremely malignant plasma cell disease, which is still incurable due to its drug resistance. Lithium chloride (LiCl) functions in many pathological processes, including bipolar disorder, acute brain injuries, and chronic neurodegenerative diseases, but its antagonistic role in MM progression has not been reported thus far. In this study, we found that LiCl inhibited MM cell proliferation and induced MM cell cycle G2/M phase arrest in a dose-dependent manner. Moreover, LiCl overcomes bortezomib (BTZ)-mediated resistance in MM cells and induces apoptosis in BTZ-resistant cells...
2018: American Journal of Translational Research
Cheng Wei Zhou, Wei Jun Zhao, Yong Gang Zhu, Xiao Dong Zhao
MicroRNA-185 (miR-185) is down-regulated in various tumor types. However, the cytological mechanism for inhibiting and restraining tumor growth of non-small-cell carcinoma (NSCLC) remains to be elucidated. In this study, it was revealed that miR-185 is significantly down-regulated in both NSCLC tumor tissues and cell lines, and over-expression of miR-185 inhibited cell growth, migration and invasion. To investigate the cellular machinery involved in miR-185's regulation of tumor growth, it was found that miR-185 directly targets SRY-Box 13 (SOX13)...
2018: American Journal of Translational Research
Lina Yang, Yi Fan, Xiuli Zhang, Lili Gao, Jianfei Ma
OBJECTIVE: To explore the effects of miRNA-21/phosphatase and tensin homolog (PTEN) on the high glucose-stimulated epithelial-to-mesenchymal transition (EMT) in human peritoneal mesothelial cells (HPMCs). METHODS: HPMCs were cultured under control conditions, or with high glucose (HG), HG with miRNA-21 mimic or a miRNA-21 inhibitor. Expression of miRNA-21, α-smooth muscle actin, >fibronectin, E-cadherin and PTEN were measured by real time PCR, Western blotting and immunofluorescence staining...
2018: American Journal of Translational Research
Han Liu, Dongdong Li, Hua Fang, Junnan Ning
Colorectal cancer (CRC) is highly invasive, and an increasing number of studies report that microRNAs (miRNAs) are involved in CRC cell invasion and metastasis. However, these studies focus on miRNAs with clear functional targets, often overlooking obscure miRNAs. Using TCGA data analysis, we compared differentially expressed miRNAs in colon and rectal adenocarcinoma (stages N0 and N1/N2) to identify miRNAs involved in invasion and metastasis; one identified candidate miRNA was miR-7702. Bioinformatics analysis identified TADA1 as a possible target gene of miR-7702...
2018: American Journal of Translational Research
Jianping Mao, Shan Li, Huihui Zhao, Yu Zhu, Ming Hong, Han Zhu, Sixuan Qian, Jianyong Li
Chidamide, a novel histone deacetylase inhibitor (HDACI), shows anticancer ability against leukemia and solid tumors. Decitabine (5-Aza-2'-deoxycytidine, DAC), an anti-leukemic drug, is effective in treating acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). In our study, we investigated the anti-leukemic ability of chidamide, as well as its combination with decitabine in leukemia cells (HL60 and NB4). The results showed that the inhibitive effect of chidamide was dose- and time-dependent at concentration of 0...
2018: American Journal of Translational Research
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