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English Abstract
Journal Article
[Application of CD19-CAR T Cells in Refractory Relapsed Acute B Lymphocyte Leukemia].
Zhongguo Shi Yan Xue Ye Xue za Zhi 2018 December
OBJECTIVE: To investigate the efficacy of CD19-targeted chimeric antigen receptor T-cell (CD19-CAR T) in the treatment of patients with refractory relapsed B cell acute lymphocyte leukemia(B-ALL).
METHODS: The efficacy and safety of CD19-CAR T cells in treatment of patients with refractory relapsed B-ALL from January 2015 to July 2017 in the Department of Hematology of Peking University Third Hospital were analyzed retrospectively.
RESULTS: A total of 10 patients were included in this analysis, all of which were consistent with the diagnosis of refractory relapsed B-ALL, and the immunophenotype of leukemia cells was CD19 positive. After treatment with CD19-CAR T cells, the overall response rate(ORR) on day 28 was 70%. Among them, 6 cases reached complete remission(CR), 1 case reached partial remission(PR). The rate of CR on day 90 was 30%.
CONCLUSION: CD19-CAR T cells are effective in the treatment of refractory relapsed B-ALL, and the adverse reactions are controllable.
METHODS: The efficacy and safety of CD19-CAR T cells in treatment of patients with refractory relapsed B-ALL from January 2015 to July 2017 in the Department of Hematology of Peking University Third Hospital were analyzed retrospectively.
RESULTS: A total of 10 patients were included in this analysis, all of which were consistent with the diagnosis of refractory relapsed B-ALL, and the immunophenotype of leukemia cells was CD19 positive. After treatment with CD19-CAR T cells, the overall response rate(ORR) on day 28 was 70%. Among them, 6 cases reached complete remission(CR), 1 case reached partial remission(PR). The rate of CR on day 90 was 30%.
CONCLUSION: CD19-CAR T cells are effective in the treatment of refractory relapsed B-ALL, and the adverse reactions are controllable.
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