Cushing's Syndrome should be Cited as a Disease with High Cardiovascular Risk in Relevant Guidelines.

The intention of the paper is to give rationale and to suggest enlisting Cushing's syndrome (CS) amongst high cardiovascular (CV) risk conditions. A considerable amount of data refers to several-fold amplified mortality in CS. The causes are based on high occurrence of many CV risk factors in persons with CS (e.g., adiposity, arterial hypertension, dyslipidemia, as well as diabetes mellitus /DM/). Therefore, practically all individuals with CS have correspondingly the metabolic syndrome (MetSy), which is known as laden with high CV risk. Characteristically, in spite of the young average age, numerous of CS individuals dysplay a 'high' or a 'very high' CV risk, with the risk of a major CV event of over 20% in the following ten years. Although DM is listed as a condition with high cardiovascular risk CS is not, despite the fact that the greater part of CS population have either diabetes mellitus or diagnosed impaired glucose tolerance. CS is stated as a risk factor for aortic dissection in current guidelines, and it should be named as a disease with high CV risk (alike DM and chronic kidney disease) in the relevant guidelines, as well.