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Current Vascular Pharmacology

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https://www.readbyqxmd.com/read/27823556/apoptosis-and-acute-brain-ischemia-in-ischemic-stroke
#1
Djordje Radak, Niki Katsiki, Ivana Resanovic, Aleksandra Jovanovic, Emina Sudar-Milovanovic, Sonja Zafirovic, Shaker A Mousa, Esma R Isenovic
Apoptosis may contribute to a significant proportion of neuron death following acute brain ischemia (ABI), but the underlying mechanisms are still not fully understood. Brain ischemia may lead to stroke, which is one of the main causes of long-term morbidity and mortality in both developed and developing countries. Therefore, stroke prevention and treatment is clinically important. There are two important separate areas of the brain during ABI: the ischemic core and the ischemic penumbra. The ischemic core of the brain experiences a sudden reduction of blood flow, just minutes after ischemic attack with irreversible injury and subsequent cell death...
November 3, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27809757/editorial-thematic-issue-sex-environment-physical-activity-diet-and-obesity-in-cardiovascular-disease-risk
#2
EDITORIAL
Debabrata Mukherjee, Thomas F Whayne
No abstract text is available yet for this article.
November 1, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27781957/valsartan-protects-against-contrast-induced-acute-kidney-injury-in-rats-by-inhibiting-endoplasmic-reticulum-stress-induced-apoptosis
#3
Yan Sun, Ping-An Peng, Yue Ma, Xiaoli Liu, Yi Yu, Shuo Jia, Xiaohan Xu, Sijing Wu, Yujie Zhou
Contrast-induced acute kidney injury (CI-AKI) is a serious complication of the administration of iodinated contrast media (CM) for diagnostic and interventional cardiovascular procedures and is associated with substantial morbidity and mortality. While the preventative measures can mitigate the risk of CI-AKI, there remains a need for novel and effective therapeutic approaches. The pathogenesis of CI-AKI is complex and not completely understood. CM-induced renal tubular cell apoptosis caused by the activation of endoplasmic reticulum (ER) stress is involved in CI-AKI...
October 25, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27781956/influence-of-a-high-fat-diet-on-cardiac-inos-in-female-rats
#4
Esma R Isenovic, Aleksandra Jovanovic, Emina Sudar Milovanovic, Sudar Milovanovic, Samantha J Pitt, Alan J Stewart, Sonja Zafirovic, Julijana Stanimirovic, Djordje Radak
Overexpression of inducible nitric oxide synthase (iNOS) is a key link between high-fat (HF) diet induced obesity and cardiovascular disease. Oestradiol has cardioprotective effects that may be mediated through reduction of iNOS activity/expression. In the present study, female Wistar rats were fed a standard diet or a HF diet (42% fat) for 10 weeks. iNOS gene and protein expressions were measured in heart tissue. HF-fed rats exhibited a significant increase in cardiac iNOS mRNA by 695% (p<0.05), iNOS protein level by 248% (p<0...
October 25, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27781959/relationships-between-alcohol-consumption-smoking-status-and-food-habits-in-greek-adolescents-vascular-implications-for-the-future
#5
Maria N Hassapidou, Anna I Fachantidou, Sousana K Papadopoulou, Niki Katsiki, Panagiotis Fachantidis, Efstratia Daskalou, Asterios P Deligiannis
We assessed the prevalence of alcohol consumption and smoking in Greek adolescents and evaluated their association with food habits. Adolescents (495 boys and 508 girls) aged 15 ± 1 years old and 15 ± 2 years old respectively, completed questionnaires regarding smoking, alcohol and food habits. Tobacco use and alcohol consumption were reported by 9.2% and 48.1% of them, respectively. Of those that drank alcohol, 13.9% were also smokers. Older adolescents were more likely to consume foods high in fat and sugar, low in vitamins and minerals as well as foods, considered by them to be less healthy and prepared in a less healthy way...
October 24, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27781958/metalloproteinases-activity-in-epicardial-adipose-tissue-of-patients-with-coronary-artery-disease
#6
Gabriela Berg, Verónica Miksztowicz, Celina Morales, Magalí Barchuk, Graciela López, Ricardo Póveda, Ricardo Gelpi, Laura Schreier, Miguel Rubio
BACKGROUND: Epicardial adipose tissue (EAT) is a visceral adipose tissue (AT) surrounding and infiltrating myocardium and coronary arteries. Increased EAT may represent a chronic inflammatory injury and represent a link with coronary artery disease (CAD). Metalloproteinases (MMPs) are involved in expansion of AT. OBJECTIVE: to evaluate MMP-2 and -9 behavior in EAT from coronary artery disease patients. METHODS: In EAT and subcutaneous AT (SAT) from patients undergoing coronary artery bypass graft (CABG, n=30) or valve replacement (No CABG, n=18), MMP-2 and -9 activity and localization, inflammatory cells and vascular endothelial growth factor (VEGF) levels were determined...
October 24, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27774887/lipoprotein-subfractions-uric-acid-and-cardiovascular-risk-in-end-stage-renal-disease-esrd-patients
#7
Anna Gluba-Brzózka, Beata Franczyk, Piotr Bartnicki, Magdalena Rysz-Górzyńska, Jacek Rysz
BACKGROUND: Chronic kidney disease (CKD) poses a worldwide public health problem. CKD is an independent risk factor for cardiovascular disease (CVD). OBJECTIVE: The aim of this study was to assess the cardiovascular risk in ESRD patients and to evaluate the relationship between serum uric acid and lipoprotein subfractions. METHODS: The study group consisted of 66 patients on dialysis and control group of 25 healthy volunteers. Concentration of HDL and LDL subfractions were analysed with Lipoprint™...
October 21, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27781939/editorial-full-blood-count-and-peripheral-arterial-disease-severity-and-prognosis
#8
Konstantinos Spanos, Miltiadis Matsagkas, Athanasios Giannoukas
No abstract text is available yet for this article.
October 19, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27781938/editorial-limited-utility-of-the-handgrip-test-for-the-diagnosis-of-diabetic-cardiovascular-autonomic-neuropathy-there-s-time-enough-but-none-to-spare
#9
K Pafili, E Maltezos, N Papanas
No abstract text is available yet for this article.
October 19, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27739363/the-effect-of-treatments-for-rheumatoid-arthritis-on-endothelial-dysfunction-evaluated-by-flow-mediated-vasodilation-in-patients-with-rheumatoid-arthritis
#10
Kazuhiko Kotani, Michiaki Miyamoto, Hitoshi Ando
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a potential cardiovascular (CV) risk. Flow-mediated vasodilation (FMD) is an ultrasonic method to evaluate endothelial function. RA is a contributor to endothelial dysfunction, a CV risk. Relevant insights on the improvement of the CV outcomes in RA patients may be obtained by a systematic review of trials that investigated the effects of RA treatment on FMD in RA patients. This review found that treatments with antirheumatic drugs and some non-antirheumatic drugs could improve the FMD in RA patients...
October 13, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27748201/renoprotective-effects-of-sglt2-inhibitors-beyond-glucose-reabsorption-inhibition
#11
Vasilios Tsimihodimos, Theodosios D Filippatos, Sebastian Fillippas-Ntekouan, Moses S Elisaf
Sodium-glucose co-transporter 2 inhibitors (SGLT-2) inhibitors) represent a new class of antidiabetic drugs that act through the inhibition of glucose and sodium reabsorption at proximal tubules. It has been shown that tThese substances may exhibit renonephroprotective properties, since they expressed clinically as a prevention of the deterioration of the glomerular filtration rate and a reductionreduce in the degree of albuminuria in patients with established diabetes-associated kidney disease. In this review we present in detail the pathophysiologic mechanisms that have been recently implicated in the rennephroprotective properties of SGLT-2 inhibitors...
October 7, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27748200/statins-may-prevent-atherosclerotic-disease-in-osa-patients-without-co-morbidities
#12
Domenico Maurizio Toraldo, Michele De Benedetto, Luana Conte, Francesco De Nuccio
Obstructive sleep apnea (OSA) is characterized by repetitive interruptions of breathing, causing a Chronic Intermittent Hypoxia (CIH) that can be a key step in the development and progression of cardiovascular diseases. Nowadays, in fact, there is scientific evidence showing the close relationship between OSA and atherosclerosis, even in those patients who do not show co-morbidities such as hypertension, diabetes, high levels of low-density lipoprotein (LDL), cigarette smoking and obesity, which normally are able to activate the endothelium...
October 7, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27748199/link-between-metabolic-syndrome-and-insulin-resistance
#13
Zoran Gluvic, Bozidarka Zaric, Ivana Resanovic, Milan Obradovic, Aleksandar Mitrovic, Djordje Radak, Esma R Isenovic
Metabolic syndrome (MetS) is a leading public health and clinical challenge worldwide. MetS represents a group of interelated risk factors that predict cardiovascular diseases (CVD) and diabetes mellitus (DM). Its prevalence ranges between 10 and 84%, depending of the geographic region, urban or rural environment, individual demographic characteristics of the population studied (sex, age, racial and ethnic origin), as well as the criteria used to define MetS. Persons with MetS have higher mortality rate when compared with people without MetS, primarily caused by progressive atherosclerosis, accelerated by pro-inflammatory and pro-coagulation components of MetS...
October 7, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27697021/editorial-the-microrna-221-222-cluster-inaugurating-a-new-era-in-cardiovascular-disease-and-cancer
#14
Konstantinos Imprialos, M Doumas, Maria Tokamani, Raphael Sandaltzopoulos, Vasilios G Athyros
No abstract text is available yet for this article.
October 3, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27697068/high-density-lipoprotein-and-low-density-lipoprotein-subfractions-in-patients-with-chronic-kidney-disease
#15
Magdalena Rysz-Górzyńska, Anna Gluba-Brzózka, Maciej Banach
BACKGROUND: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD). CKD is accompanied by high cardiovascular mortality due to many factors, but atherosclerosis is thought to be a major cause at every CKD stage. It has been suggested that measuring and estimating changes in high density lipoprotein (HDL) and low density lipoprotein (LDL) subfractions may be important for predicting CVD in CKD patients. OBJECTIVE: The aim of this study was to determine and compare levels of HDL and LDL subfractions in patients with different CKD stages...
October 2, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27697067/hypovitaminosis-d-is-associated-with-endothelial-dysfunction-in-patients-with-metabolic-syndrome
#16
Coskun U Oruc, Yunus E Akpinar, Shirkhan Amikishiyev, Ayse Kubat Uzum, Artur Salmaslioglu, Figen Gurdol, Beyhan Omer
OBJECTIVES: Recent research has shown that hypovitaminosis D may increase the risk of hypertension, vascular disease, diabetes mellitus, obesity and metabolic syndrome (MetS). Endothelial dysfunction (ED) is one of the key components of MetS which is associated with an imbalance between vasoactive substances such as nitric oxide (NO) and endothelins (ET). In this study, we assessed the association of 25(OH) D3 level with endothelial dysfunction and subclinical atherosclerosis in MetS patients...
October 2, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27697066/renal-function-impairment-in-patients-undergoing-elective-evar-vs-elective-open-repair-during-follow-up-period-a-systematic-review-of-the-literature
#17
Konstantinos Spanos, Christos Karathanos, Athanasios Athanasoulas, Vasileios Saleptsis, Ioannis Vasilopoulos, Sokol Xhepa, Miltiadis Matsagkas, Athanasios D Giannoukas
BACKGROUND: Endovascular (EVAR) or open surgical (OSR) repair are current treatment options for abdominal aortic aneurysm (AAA). OBJECTIVE: To produce a systematic review comparing the impact of these 2 treatment options on renal function during mid- and long term follow up. METHODS: The MEDLINE, EMBASE and Cochrane databases and key references were searched. RESULTS: Six studies were included from 2000 to 2016, (4 retrospective and 2 RCT studies) reporting on 2,102 patients (54%; 1096 EVAR, 46%; 1006 OSR)...
October 2, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27697065/gender-disparity-in-lipid-target-achievements-in-high-and-very-high-atherosclerotic-cardiovascular-disease-risk-patients-in-the-arabian-gulf
#18
Ibrahim Al-Zakwani, Abdullah Shehab, Ali T Al-Hinai, Wael Al Mahmeed, Mohamed Arafah, Omer Al Tamimi, Mahmoud Al Awadhi, Faisal Al Anazi, Haitham Amin, Khalid Al Nemer, Shorook Al Herz, Othman Metwally, Akram Alkhadra, Mohammed Fakhry, Hossam Elghetany, Abdel Razak Medani, Afzal Hussein Yusufali, Obaid Al Jassim, Omar Al Hallaq, Fahad Omar, Ahmed S Baslaib, Khalid Al Waili, Khamis Al Hashmi, Vasilios Athyros, Khalid Al Rasadi
BACKGROUND: Few studies assessed gender disparity in lipid goal attainment in the Arabian Gulf. Hence, we estimated gender gaps in lipid target achievements among patients at high and very high atherosclerotic cardiovascular disease (ASCVD) risk in the Centralized Pan-Middle East Survey on the undertreatment of hypercholesterolemia (CEPHEUS). METHODS: The study (conducted between November 22, 2009 and July 7, 2010) included 4,384 patients (≥18 years) on lipid lowering drugs at high and very ASCVD risk status from outpatient clinics of 177 specialists and primary care physicians in 6 Arabian Gulf countries...
October 2, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27633456/the-mir-221-222-cluster-is-a-key-player-in-vascular-biology-via-the-fine-tuning-of-endothelial-cell-physiology
#19
Tanja Celic, Valérie Metzinger-Le Meuth, Isabelle Six Ziad A Massy, Laurent Metzinger
The discovery of small RNAs has shed new light on microRNA (mRNA) regulation and a range of biological processes. The recognition that miRNAs-221 and -222 are sensitive regulators in the endothelium may enable the identification of novel biomarkers and therapeutic targets. Given that endothelial dysfunction precedes the development of atherosclerosis and contributes to the development of cardiovascular damage, circulating miRNAs produced by endothelial cells (ECs) are putative biomarkers for a wide range of cardiovascular diseases...
September 14, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27633455/application-of-dual-source-ct-coronary-angiography-in-type-2-diabetic-patients-with-symptomatic-coronary-heart-disease
#20
Ci He, Peng Wang, Fei-Zhou Du, Jian-Wen Gu, Zhi-Gang Yang
OBJECTIVE: To evaluate the epidemiological and morphological characteristics of coronary plaque in diabetic patients with symptomatic coronary heart disease (CHD) by dual-source computed tomography (DSCT). MATERIALS AND METHODS: From June 2013 to December 2014, 267 consecutive patients with type 2 diabetes mellitus were examined by DSCT. Plaque type, distribution, as well as extent and obstructive characteristics were determined for each segment. RESULTS: A total of 225 patients were included in the final study...
September 14, 2016: Current Vascular Pharmacology
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