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Current Vascular Pharmacology

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https://www.readbyqxmd.com/read/28056759/should-we-be-concerned-about-the-inflammatory-response-to-endovascular-procedures
#1
Djordje Radak, Nenad Djukic, Slobodan Tanaskovic, Milan Obradovic, Desanka Cenic-Milosevic, Esma R Isenovic
Endovascular surgery represents a minimally invasive procedure for the treatment of occlusive and aneurysmal arterial disease. However, it is followed by inflammatory response, with a rise in specific inflammatory biomarkers, such as C-reactive protein, serum amyloid A and fibrinogen. Shear stress during balloon inflation and vascular injury represents triggering events for the inflammatory process, stimulating the production of proinflammatory molecules and activation of circulating monocytes. The current literature indicates that stent implantation induces more prominent inflammatory reaction...
January 5, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28056758/thrombotic-management-of-antiphospholipid-syndrome-towards-novel-targeted-therapies
#2
Md Asiful Islam, Fahmida Alam, Kah Keng Wong, Mohammad Amjad Kamal, Siew Hua Gan
Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombosis and/or pregnancy morbidity with persistent levels of antiphospholipid antibodies (aPLs). The development of thrombosis in APS is mediated by aPLs and contributes to the high mortality rate in APS patients. However, although APS has been reported for more than 30 years, there has been no optimal regimen for its prevention or for the management of thrombosis, mainly because the mainstay treatment strategies for managing APS are not targeted towards aPL-mediated thrombotic pathophysiology...
5, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28056757/phytochemical-therapies-in-vascular-functioning-a-molecular-approach
#3
Hasan Gencoglu, Cemal Orhan, Kazim Sahin
There has been an increasing interest in the usage of natural products for the prevention and treatment of chronic diseases such as cardiovascular disease (CVD). Regular consumption of fruits, vegetables and whole grains has been shown to be negatively correlated with the risk of CVDs. These foods provide a diversity of nutrients and different bioactive compounds including phytochemicals, vitamins, minerals and fibers which play critical roles in the sustainability of optimal cardiovascular health. Plant-based foods or a nutritional cure are gradually being integrated into medical practice for CVD management partly due to the supporting experimental studies, clinical trials and epidemiological studies...
January 5, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28056756/vascular-endothelial-growth-factor-vegf-signaling-in-tumour-vascularization-potential-and-challenges
#4
Kodappully Sivaraman Siveen, Kirti Prabhu, Roopesh Krishnankutty, Shilpa Kuttikrishnan, Magdalini Tsakou, Feras Q Alali, Said Dermime, Ramzi M Mohammad, Shahab Uddin
Angiogenesis is defined as the physiological process by which new blood vessels develop from pre-existing vessels; either by sprouting or intussusception. Inhibition of angiogenesis is one of the most encouraging strategies to manage the growth and metastasis of cancers. The functional and proliferative status of blood vessels is regulated by the balance between various key molecules that either stimulate or inhibit angiogenesis. During quiescence, the "angiogenic switch" is "off". However, during tumour development pro-angiogenic factors such as vascular endothelial growth factor (VEGF), basic and acidic fibroblast growth factor, tumour necrosis factor-α and interleukin-1 are pathologically enhanced...
January 5, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28056755/common-therapeutic-modalities-against-diabetes-and-associated-cardiovascular-disease
#5
Nasimudeen R Jabir, Chelapram Kandy Firoz, Ghulam Md Ashraf, Syed Kashif Zaidi, Shazi Shakil, Mohammad Amjad Kamal, Shams Tabrez
Despite recent advances in medical research, the incidence of diabetes and cardiovascular disease (CVD)-induced fatal events is increasing. The literature point towards several co-occurring pathways that could lead to terminal complications related with these diseases. Different pathophysiological alterations such as hyperglycaemia, hyperinsulinaemia, insulin resistance, obesity, endothelial dysfunction and oxidative stress lead to the initiation and progression of atherosclerotic plaques. In view of the continuous rise in fatal events and overlapping pathological conditions associated with CVD and diabetes, there is a critical need to develop a common treatments against these diseases...
January 5, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28056754/gut-microbiota-in-vascular-disease-therapeutic-target
#6
A N Anbazhagan, S Priyamvada, M Priyadarshini
Gut microbiota is increasingly recognized as a powerful regulator of host physiology. Most of effects are mediated through metabolites acting as energy sources, signaling molecules, receptor ligands and substrates for host enzymes. Owing to the meta-stability and high amenability of the gut microbiota to modification by diet and environment, predicting specific gut microbes or its metabolites responsible for different host metabolic states is often confounded. However, through animal models and human studies a direct role of gut microbes in cardiovascular disorders (CVD) has emerged...
January 4, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28034366/pregnancy-associated-plasma-protein-a-and-its-role-in-cardiovascular-disease-biology-experimental-clinical-evidences-and-potential-therapeutic-approaches
#7
Francesca Ziviello, Stefano Conte, Giovanni Cimmino, Ferdinando Carlo Sasso, Bruno Trimarco, Plinio Cirillo
Pregnancy-Associated Plasma Protein-A (PAPP-A) is a zinc-binding metalloproteinase protein produced by placental syncytio-trophoblasts and secreted into the maternal circulation where its concentration progressively increases until term. In recent years, PAPP-A has been studied for its potential involvement in cardiovascular (CV) disease. However, all those studies did not provide a clear view to identify the pathophysiological links between PAPP-A plasma levels and the occurrence of CV events. In this review, starting from a complete description of PAPP-A structure and biology, we present an updated overview of experimental as well as clinical evidence on the role of this metalloproteinase in CV disease...
December 30, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28003008/glucagon-like-peptide-1-glp-1-receptor-agonists-in-the-treatment-of-obese-women-with-polycystic-ovary-syndrome
#8
Themistoklis Tzotzas, Spyridon N Karras, Niki Katsiki
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females and is often associated with a number of cardiometabolic disorders such as central obesity, dyslipidaemia, hypertension, insulin resistance, hyperinsulinaemia, glucose intolerance and type 2 diabetes mellitus (T2DM). Glucagon-like peptide-1 (GLP-1), a gut hormone secreted after a meal, enhances glucose-stimulated insulin secretion and additionally suppresses appetite and gastric motility. Most studies found impaired GLP-1 kinetics in obese individuals, whereas small studies in PCOS reported reduced, normal or even elevated GLP-1 levels...
December 21, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27928947/oral-glucose-lowering-drugs-and-cardiovascular-outcomes-from-the-negative-record-and-accord-to-neutral-tecos-and-promising-empa-reg
#9
C Tsioufis, E Andrikou, C Thomopoulos, N Papanas, D Tousoulis
Cardiovascular (CV) morbidity and mortality are higher among patients with diabetes mellitus type 2 (T2DM), particularly those with concomitant CV diseases, compared with other populations. In patients with T2DM, intensive glucose lowering reduces microvascular disease, but has a smaller and debated effect on CV events or mortality. In this setting, the US Food and Drug Administration (FDA) required in 2008 that all new agents for the treatment of T2DM should be evaluated in terms of CV safety. Metformin has long been established as first-line pharmacological therapy in patients with T2DM, due to its proven beneficial CV effects...
December 8, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27823556/apoptosis-and-acute-brain-ischemia-in-ischemic-stroke
#10
Djordje Radak, Niki Katsiki, Ivana Resanovic, Aleksandra Jovanovic, Emina Sudar-Milovanovic, Sonja Zafirovic, Shaker A Mousa, Esma R Isenovic
Apoptosis may contribute to a significant proportion of neuron death following acute brain ischemia (ABI), but the underlying mechanisms are still not fully understood. Brain ischemia may lead to stroke, which is one of the main causes of long-term morbidity and mortality in both developed and developing countries. Therefore, stroke prevention and treatment is clinically important. There are two important separate areas of the brain during ABI: the ischemic core and the ischemic penumbra. The ischemic core of the brain experiences a sudden reduction of blood flow, just minutes after ischemic attack with irreversible injury and subsequent cell death...
November 3, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27809757/editorial-thematic-issue-sex-environment-physical-activity-diet-and-obesity-in-cardiovascular-disease-risk
#11
EDITORIAL
Debabrata Mukherjee, Thomas F Whayne
No abstract text is available yet for this article.
November 1, 2016: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28029087/preface
#12
Dimitri P Mikhailidis
No abstract text is available yet for this article.
2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27781938/editorial-limited-utility-of-the-handgrip-test-for-the-diagnosis-of-diabetic-cardiovascular-autonomic-neuropathy-there-s-time-enough-but-none-to-spare
#13
EDITORIAL
K Pafili, E Maltezos, Nikolaos Papanas
No abstract text is available yet for this article.
2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27748200/statins-may-prevent-atherosclerotic-disease-in-osa-patients-without-co-morbidities
#14
Domenico Maurizio Toraldo, Michele De Benedetto, Luana Conte, Francesco De Nuccio
Obstructive sleep apnoea (OSA) is characterized by repetitive interruptions of breathing, causing Chronic Intermittent Hypoxia (CIH) that can be involved in the development and progression of cardiovascular diseases. There is evidence showing a close relationship between OSA and atherosclerosis, even in patients who do not show co-morbidities such as hypertension, diabetes, high levels of lowdensity lipoprotein cholesterol (LDL-C), cigarette smoking and obesity, which can activate the endothelium. This endothelium activation due to CIH and specific to OSA seems to be dependent on a different pathway...
2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27748199/link-between-metabolic-syndrome-and-insulin-resistance
#15
Zoran Gluvic, Bozidarka Zaric, Ivana Resanovic, Milan Obradovic, Aleksandar Mitrovic, Djordje Radak, Esma R Isenovic
Metabolic syndrome (MetS) is a leading public health and clinical challenge worldwide. MetS represents a group of interrelated risk factors that predict cardiovascular diseases (CVD) and diabetes mellitus (DM). Its prevalence ranges between 10 and 84%, depending on the geographic region, urban or rural environment, individual demographic characteristics of the population studied (sex, age, racial and ethnic origin), as well as the criteria used to define MetS. Persons with MetS have higher mortality rate when compared with people without MetS, primarily caused by progressive atherosclerosis, accelerated by pro-inflammatory and pro-coagulation components of MetS...
2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27739363/the-effect-of-treatments-for-rheumatoid-arthritis-on-endothelial-dysfunction-evaluated-by-flow-mediated-vasodilation-in-patients-with-rheumatoid-arthritis
#16
Kazuhiko Kotani, Michiaki Miyamoto, Hitoshi Ando
Rheumatoid Arthritis (RA) is a chronic inflammatory disease with a potential cardiovascular (CV) risk. Flow-Mediated Vasodilation (FMD) is an ultrasonic method to evaluate endothelial function. RA is a contributor to endothelial dysfunction, a CV risk. Relevant insights on the improvement of the CV outcomes in RA patients may be obtained by a systematic review of trials that investigated the effects of RA treatment on FMD in RA patients. This review found that treatments with antirheumatic drugs and some non-antirheumatic drugs could improve the FMD in RA patients...
2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27697065/gender-disparity-in-lipid-target-achievements-in-high-and-very-high-atherosclerotic-cardiovascular-disease-risk-patients-in-the-arabian-gulf
#17
Ibrahim Al-Zakwani, Abdullah Shehab, Ali T Al-Hinai, Wael Al Mahmeed, Mohamed Arafah, Omer Al Tamimi, Mahmoud Al Awadhi, Faisal Al Anazi, Haitham Amin, Khalid Al Nemer, Shorook Al Herz, Othman Metwally, Akram Alkhadra, Mohammed Fakhry, Hossam Elghetany, Abdel Razak Medani, Afzal Hussein Yusufali, Obaid Al Jassim, Omar Al Hallaq, Fahad Omar, Ahmed S Baslaib, Khalid Al Waili, Khamis Al Hashmi, Vasilios G Athyros, Khalid Al Rasadi
BACKGROUND: Few studies assessed gender disparity in lipid goal attainment in the Arabian Gulf. Hence, we estimated gender gaps in lipid target achievements among patients at high and very high atherosclerotic cardiovascular disease (ASCVD) risk in the Centralized Pan-Middle East Survey on the undertreatment of hypercholesterolemia (CEPHEUS). METHODS: The study (conducted between November 22, 2009 and July 7, 2010) included 4,384 patients (≥18 years) on lipid lowering drugs at high and very ASCVD risk status from outpatient clinics of 177 specialists and primary care physicians in 6 Arabian Gulf countries...
2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27697021/editorial-the-microrna-221-222-cluster-inaugurating-a-new-era-in-cardiovascular-disease-and-cancer
#18
EDITORIAL
Konstantinos Imprialos, M Doumas, Maria Tokamani, Raphael Sandaltzopoulos, Vasilios G Athyros
No abstract text is available yet for this article.
2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27633456/the-mir-221-222-cluster-is-a-key-player-in-vascular-biology-via-the-fine-tuning-of-endothelial-cell-physiology
#19
Tanja Celic, Valérie Metzinger-Le Meuth, Isabelle Six, Ziad A Massy, Laurent Metzinger
The discovery of small RNAs has shed new light on microRNA (mRNA) regulation and a range of biological processes. The recognition that miRNAs-221 and -222 are sensitive regulators in the endothelium may enable the identification of novel biomarkers and therapeutic targets. Given that endothelial dysfunction precedes the development of atherosclerosis and contributes to the development of cardiovascular damage, circulating miRNAs produced by Endothelial Cells (ECs) are putative biomarkers for a wide range of cardiovascular diseases...
2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/27633455/application-of-dual-source-ct-coronary-angiography-in-type-2-diabetic-patients-with-symptomatic-coronary-heart-disease
#20
Ci He, Peng Wang, Fei-Zhou Du, Zhi-Gang Yang
OBJECTIVE: To evaluate the epidemiological and morphological characteristics of coronary plaque in diabetic patients with symptomatic coronary heart disease (CHD) by dual-source computed tomography (DSCT). MATERIALS AND METHODS: From June 2013 to December 2014, 267 consecutive patients with type 2 diabetes mellitus were examined by DSCT. Plaque type, distribution, as well as extent and obstructive characteristics were determined for each segment. RESULTS: A total of 225 patients were included in the final study...
2017: Current Vascular Pharmacology
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