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Current Vascular Pharmacology

Kazuhiko Kotani, Michiaki Miyamoto, Hitoshi Ando
Rheumatoid arthritis (RA) is a chronic inflammatory disease with a potential cardiovascular (CV) risk. Flow-mediated vasodilation (FMD) is an ultrasonic method to evaluate endothelial function. RA is a contributor to endothelial dysfunction, a CV risk. Relevant insights on the improvement of the CV outcomes in RA patients may be obtained by a systematic review of trials that investigated the effects of RA treatment on FMD in RA patients. This review found that treatments with antirheumatic drugs and some non-antirheumatic drugs could improve the FMD in RA patients...
October 13, 2016: Current Vascular Pharmacology
Vasilios Tsimihodimos, Theodosios D Filippatos, Sebastian Fillippas-Ntekouan, Moses S Elisaf
Sodium-glucose co-transporter 2 inhibitors (SGLT-2) inhibitors) represent a new class of antidiabetic drugs that act through the inhibition of glucose and sodium reabsorption at proximal tubules. It has been shown that tThese substances may exhibit renonephroprotective properties, since they expressed clinically as a prevention of the deterioration of the glomerular filtration rate and a reductionreduce in the degree of albuminuria in patients with established diabetes-associated kidney disease. In this review we present in detail the pathophysiologic mechanisms that have been recently implicated in the rennephroprotective properties of SGLT-2 inhibitors...
October 7, 2016: Current Vascular Pharmacology
Domenico Maurizio Toraldo, Michele De Benedetto, Luana Conte, Francesco De Nuccio
Obstructive sleep apnea (OSA) is characterized by repetitive interruptions of breathing, causing a Chronic Intermittent Hypoxia (CIH) that can be a key step in the development and progression of cardiovascular diseases. Nowadays, in fact, there is scientific evidence showing the close relationship between OSA and atherosclerosis, even in those patients who do not show co-morbidities such as hypertension, diabetes, high levels of low-density lipoprotein (LDL), cigarette smoking and obesity, which normally are able to activate the endothelium...
October 7, 2016: Current Vascular Pharmacology
Esma R Isenovic, Zoran Gluvic, Bozidarka Zaric, Ivana Resanovic, Milan Obradovic, Aleksandar Mitrovic, Djordje Radak
Metabolic syndrome (MetS) is a leading public health and clinical challenge worldwide. MetS represents a group of interelated risk factors that predict cardiovascular diseases (CVD) and diabetes mellitus (DM). Its prevalence ranges between 10 and 84%, depending of the geographic region, urban or rural environment, individual demographic characteristics of the population studied (sex, age, racial and ethnic origin), as well as the criteria used to define MetS. Persons with MetS have higher mortality rate when compared with people without MetS, primarily caused by progressive atherosclerosis, accelerated by pro-inflammatory and pro-coagulation components of MetS...
October 7, 2016: Current Vascular Pharmacology
Konstantinos Imprialos, M Doumas, Maria Tokamani, Raphael Sandaltzopoulos, Vasilios G Athyros
No abstract text is available yet for this article.
October 3, 2016: Current Vascular Pharmacology
Magdalena Rysz-Górzyńska, Anna Gluba-Brzózka, Maciej Banach
BACKGROUND: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD). CKD is accompanied by high cardiovascular mortality due to many factors, but atherosclerosis is thought to be a major cause at every CKD stage. It has been suggested that measuring and estimating changes in high density lipoprotein (HDL) and low density lipoprotein (LDL) subfractions may be important for predicting CVD in CKD patients. OBJECTIVE: The aim of this study was to determine and compare levels of HDL and LDL subfractions in patients with different CKD stages...
October 2, 2016: Current Vascular Pharmacology
Coskun U Oruc, Yunus E Akpinar, Shirkhan Amikishiyev, Ayse Kubat Uzum, Artur Salmaslioglu, Figen Gurdol, Beyhan Omer
OBJECTIVES: Recent research has shown that hypovitaminosis D may increase the risk of hypertension, vascular disease, diabetes mellitus, obesity and metabolic syndrome (MetS). Endothelial dysfunction (ED) is one of the key components of MetS which is associated with an imbalance between vasoactive substances such as nitric oxide (NO) and endothelins (ET). In this study, we assessed the association of 25(OH) D3 level with endothelial dysfunction and subclinical atherosclerosis in MetS patients...
October 2, 2016: Current Vascular Pharmacology
Konstantinos Spanos, Christos Karathanos, Athanasios Athanasoulas, Vasileios Saleptsis, Ioannis Vasilopoulos, Sokol Xhepa, Miltiadis Matsagkas, Athanasios D Giannoukas
BACKGROUND: Endovascular (EVAR) or open surgical (OSR) repair are current treatment options for abdominal aortic aneurysm (AAA). OBJECTIVE: To produce a systematic review comparing the impact of these 2 treatment options on renal function during mid- and long term follow up. METHODS: The MEDLINE, EMBASE and Cochrane databases and key references were searched. RESULTS: Six studies were included from 2000 to 2016, (4 retrospective and 2 RCT studies) reporting on 2,102 patients (54%; 1096 EVAR, 46%; 1006 OSR)...
October 2, 2016: Current Vascular Pharmacology
Ibrahim Al-Zakwani, Abdullah Shehab, Ali T Al-Hinai, Wael Al Mahmeed, Mohamed Arafah, Omer Al Tamimi, Mahmoud Al Awadhi, Faisal Al Anazi, Haitham Amin, Khalid Al Nemer, Shorook Al Herz, Othman Metwally, Akram Alkhadra, Mohammed Fakhry, Hossam Elghetany, Abdel Razak Medani, Afzal Hussein Yusufali, Obaid Al Jassim, Omar Al Hallaq, Fahad Omar, Ahmed S Baslaib, Khalid Al Waili, Khamis Al Hashmi, Vasilios Athyros, Khalid Al Rasadi
BACKGROUND: Few studies assessed gender disparity in lipid goal attainment in the Arabian Gulf. Hence, we estimated gender gaps in lipid target achievements among patients at high and very high atherosclerotic cardiovascular disease (ASCVD) risk in the Centralized Pan-Middle East Survey on the undertreatment of hypercholesterolemia (CEPHEUS). METHODS: The study (conducted between November 22, 2009 and July 7, 2010) included 4,384 patients (≥18 years) on lipid lowering drugs at high and very ASCVD risk status from outpatient clinics of 177 specialists and primary care physicians in 6 Arabian Gulf countries...
October 2, 2016: Current Vascular Pharmacology
Tanja Celic, Valérie Metzinger-Le Meuth, Isabelle Six Ziad A Massy, Laurent Metzinger
The discovery of small RNAs has shed new light on microRNA (mRNA) regulation and a range of biological processes. The recognition that miRNAs-221 and -222 are sensitive regulators in the endothelium may enable the identification of novel biomarkers and therapeutic targets. Given that endothelial dysfunction precedes the development of atherosclerosis and contributes to the development of cardiovascular damage, circulating miRNAs produced by endothelial cells (ECs) are putative biomarkers for a wide range of cardiovascular diseases...
September 14, 2016: Current Vascular Pharmacology
Ci He, Peng Wang, Fei-Zhou Du, Jian-Wen Gu, Zhi-Gang Yang
OBJECTIVE: To evaluate the epidemiological and morphological characteristics of coronary plaque in diabetic patients with symptomatic coronary heart disease (CHD) by dual-source computed tomography (DSCT). MATERIALS AND METHODS: From June 2013 to December 2014, 267 consecutive patients with type 2 diabetes mellitus were examined by DSCT. Plaque type, distribution, as well as extent and obstructive characteristics were determined for each segment. RESULTS: A total of 225 patients were included in the final study...
September 14, 2016: Current Vascular Pharmacology
Evaggelia Papadopoulou, Maria Meidani, Maria Boutsikou, Pinelopi Papaspiropoulou, Theodosia Kelaiditou, Afedia Koukouzli, Anastasia Tapola, Ioanna Voudoufianaki, Sophie Mavrogeni, Niki Katsiki, Genovefa Kolovou, Ioannis Lekakis
AIMS: Specialized nurses estimated the HeartScore in an urban Greek population by recognizing cardiovascular disease (CVD) risk factors in the setting of the Onassis Cardiovascular Prevention Program (OCPP). They also provided nursing consultation and assessed the clinical and biochemical characteristics of the studied population. METHODS AND RESULTS: Individuals were recruited through TV announcements and via the website of the Onassis Cardiac Surgery Centre. All participants visited the Onassis Cardiac Centre from 20 September to 30 October 2011...
September 14, 2016: Current Vascular Pharmacology
Zoe Jayne, Anjly Jain, Devaki R Nair
No abstract text is available yet for this article.
September 9, 2016: Current Vascular Pharmacology
Kosmas I Paraskevas, J David Spence
No abstract text is available yet for this article.
September 9, 2016: Current Vascular Pharmacology
Vasilios G Athyros, Niki Katsiki, Asterios Karagiannis
No abstract text is available yet for this article.
September 9, 2016: Current Vascular Pharmacology
P Vas, P Panagopoulos, N Papanas
No abstract text is available yet for this article.
September 9, 2016: Current Vascular Pharmacology
Antonio Siniscalchi, Roman Sztajzel, Giovanni Malferrari, Giovambattista De Sarro, Andrea Saletti, Luca Gallelli
No abstract text is available yet for this article.
September 9, 2016: Current Vascular Pharmacology
Marija Macesic, Nebojsa M Lalic, Vladimir S Kostic, Aleksandra Jotic, Katarina Lalic, Elka Stefanova, Tanja Milicic, Ljiljana Lukic, Jelena Stanarcic Gajovic, Nina Krako
OBJECTIVE: We analysed: (a) insulin sensitivity, (b) insulin secretion capacity, (c) plasma insulin, (d) adiponectin levels, and, (e) lipid parameters in normoglycaemic, nonobese patients with Alzheimer's disease (AD) (group A, n=62), mild cognitive impairment (MCI) (group B, n=41), and healthy controls (group C, n=25). METHOD: Insulin sensitivity was determined both by euglycemic hyperinsulinaemic clamp (M value) and homeostasis model assessment (HOMA-IR), insulin secretion capacity by acute insulin response and first-phase insulin response (FPIR), plasma insulin by RIA and adiponectin by ELISA methods, total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and triglycerides by enzymatic method...
September 5, 2016: Current Vascular Pharmacology
Anna E Körei, Miklós Kempler, Ildikó Istenes, Orsolya E Vági, Zsuzsanna Putz, Viktor J Horváth, Katalin Keresztes, Csaba Lengyel, Ádám Gy Tabák, Vincenza Spallone, Péter Kempler
OBJECTIVE: Historically, a set of 5 cardiovascular autonomic reflex tests (CARTs) was considered to be the gold standard in the assessment of cardiovascular autonomic neuropathy (CAN). However, measuring diastolic blood pressure (BP) response to sustained handgrip is omitted in recent guidelines. We aimed to assess the association between the handgrip and the other 4 tests as well as to identify determinants of the handgrip test results in diabetic patients. PATIENTS AND METHODS: 353 patients with diabetes (DM) were recruited (age: 60...
August 22, 2016: Current Vascular Pharmacology
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