We have located links that may give you full text access.
Antibacterial mechanism of artemisinin / beta-cyclodextrins against methicillin-resistant Staphylococcus aureus (MRSA).
Microbial Pathogenesis 2018 May
A new inhibitor to overcome the multi-drug resistance of MRSA was developed in this study. Artemisinin (ART) was encapsulated in beta-cyclodextrin (β-CD) in order to enhance the solubility of ART. The molecular encapsulation of ART was confirmed by using Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC), X-Ray Diffraction (XRD), and nuclear magnetic resonance (1 H NMR) methods. The phase solubility study showed the relationship between ART solubility and β-CD concentration. The antibacterial activity of ART/β-CDs inclusion complexes (ART/β-CDs-IC) (20 mg/mL) against MRSA was distinguished, with the inhibition rate of 99.94% after 4 days. The antibacterial mechanism research indicated the membrane permeability of MRSA can be increased by the complexes. Besides, the respiratory metabolism of MRSA was inhibited via Embden-Meyerhof-Parnas (EMP) pathway. The conclusion was further confirmed by measuring the contents of three enzymes in the irreversible reaction in EMP pathway. The obtained results enable the potential use of ART/β-CDs-IC in the field of antimicrobial.
Full text links
Related Resources
Trending Papers
Review article: Recent advances in ascites and acute kidney injury management in cirrhosis.Alimentary Pharmacology & Therapeutics 2024 March 26
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app