We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Fenoterol treatment and desensitization of beta-adrenoceptors in rabbit foetal lung.
The foetal lung responds to beta-receptor agonists with a release of surfactant from alveolar cells. The aim of the present study was to investigate whether the administration of the betamimetic fenoterol could influence the desensitization - associated decrease of beta-adrenoreceptors in the rabbit foetal lung. With experiments on pregnant rabbits, this hypothesis was put to the test and found to be true. At a gestational age of 27-28 days, does were infused 7.5-10.0 mg of fenoterol or given Ringer's solution. The does and foetuses were sacrificed at 12 hours from the start of the infusion, and the number and affinity of beta-adrenergic receptors in lung tissues were determined by a direct binding technique using 3H-dihydroprenolol. These studies show that fenoterol can induce desensitization of beta-receptors in the foetal lung but not in the doe. Thus, it is concluded that desensitization of foetal pulmonary adrenoreceptors may result in diminished lung function after long-term treatment with beta-2 sympathicomimetics.
Full text links
Related Resources
Trending Papers
Obesity pharmacotherapy in older adults: a narrative review of evidence.International Journal of Obesity 2024 May 7
Haemodynamic monitoring during noncardiac surgery: past, present, and future.Journal of Clinical Monitoring and Computing 2024 April 31
SGLT2 Inhibitors in Kidney Diseases-A Narrative Review.International Journal of Molecular Sciences 2024 May 2
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app