We have located links that may give you full text access.
Home continuous positive airway pressure therapy in infants: a single center experience.
Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine 2022 December 3
STUDY OBJECTIVES: There is limited data on indications and outcomes of home continuous positive airway pressure (CPAP) therapy in the first year of life. We aimed to analyze the clinical, demographic, and polysomnographic (PSG) characteristics of a cohort of children initiated on home CPAP for treatment of sleep disordered breathing (SDB) and as respiratory support in the first year of life.
METHODS: Children started on CPAP in the first year of life at the Queensland Children's Hospital were retrospectively evaluated for clinical & demographic parameters, underlying diagnoses, respiratory support, airway surgical intervention, PSG results at baseline and on CPAP.
RESULTS: Twenty-nine infants [median age (IQR) at CPAP initiation 182 days (126-265.5); 12F] were included. Underlying aetiology included Trisomy 21 (n=6), craniofacial syndromes (n=5), hypotonia (n=8; 5 with non-craniofacial syndrome), airway malacia (n=5), skeletal dysplasia (n=2), non-syndromic upper airway obstruction (n=2) and CNLD (n=1). The median (IQR) Obstructive Apnoea-Hypopnea Index was 14\hr (6.2-31) at CPAP initiation, which improved on CPAP to 3.4\hr (1.4-6.4). Median (IQR) TcCO2 max remained unchanged on CPAP [56.6 mmHg (49-66.5 mmHg) pre-CPAP vs. 54.9 mmHg (47-62mmHg) on CPAP]. 15 children needed surgical airway intervention (11 pre and 4 post CPAP). CPAP therapy could be successfully ceased in 9 children, 2 needed tracheostomy and 1 child died during follow-up period.
CONCLUSIONS: Home CPAP as respiratory support is an effective long-term therapy in infancy and can be weaned even if initiated early. Prospective studies with pre-defined criteria for CPAP initiation and cessation would help ascertain long term outcomes in this poorly researched group.
METHODS: Children started on CPAP in the first year of life at the Queensland Children's Hospital were retrospectively evaluated for clinical & demographic parameters, underlying diagnoses, respiratory support, airway surgical intervention, PSG results at baseline and on CPAP.
RESULTS: Twenty-nine infants [median age (IQR) at CPAP initiation 182 days (126-265.5); 12F] were included. Underlying aetiology included Trisomy 21 (n=6), craniofacial syndromes (n=5), hypotonia (n=8; 5 with non-craniofacial syndrome), airway malacia (n=5), skeletal dysplasia (n=2), non-syndromic upper airway obstruction (n=2) and CNLD (n=1). The median (IQR) Obstructive Apnoea-Hypopnea Index was 14\hr (6.2-31) at CPAP initiation, which improved on CPAP to 3.4\hr (1.4-6.4). Median (IQR) TcCO2 max remained unchanged on CPAP [56.6 mmHg (49-66.5 mmHg) pre-CPAP vs. 54.9 mmHg (47-62mmHg) on CPAP]. 15 children needed surgical airway intervention (11 pre and 4 post CPAP). CPAP therapy could be successfully ceased in 9 children, 2 needed tracheostomy and 1 child died during follow-up period.
CONCLUSIONS: Home CPAP as respiratory support is an effective long-term therapy in infancy and can be weaned even if initiated early. Prospective studies with pre-defined criteria for CPAP initiation and cessation would help ascertain long term outcomes in this poorly researched group.
Full text links
Related Resources
Trending Papers
Review article: Recent advances in ascites and acute kidney injury management in cirrhosis.Alimentary Pharmacology & Therapeutics 2024 March 26
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app