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Radiation necrosis

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https://www.readbyqxmd.com/read/29336987/the-in-vitro-radiosensitizer-potential-of-resveratrol-on-mcf-7-breast-cancer-cells
#1
Isabel Cristina da Costa Araldi, Fernando Primitivo Romero Bordin, Francine Carla Cadoná, Fernanda Barbisan, Verônica Farina Azzolin, Cibele Ferreira Teixeira, Tadeu Baumhardt, Ivana Beatrice Mânica da Cruz, Marta Maria Medeiros Frescura Duarte, Liliane de Freitas Bauermann
Radiation therapy is commonly applied in breast cancer (BC) patients. However, radioresistance and side effects are limiting factors of this practice. Therefore, studying substances that can enhance the radiation effect and, at the same time, protect normal cells is very relevant. Thus, the aim of this work was to assess the radiosensitizer effect of resveratrol (RV) on BC cells (MCF-7). A high cytotoxic and antiproliferative effect was observed in the treatment with 10 μM of RV + 3 Gy ionizing radiation (IR)...
January 11, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29327059/immunotherapy-and-symptomatic-radiation-necrosis-in-patients-with-brain-metastases-treated-with-stereotactic-radiation
#2
Allison M Martin, Daniel N Cagney, Paul J Catalano, Brian M Alexander, Amanda J Redig, Jon D Schoenfeld, Ayal A Aizer
No abstract text is available yet for this article.
January 11, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/29324473/chondromyxoid-fibroma-arising-in-craniofacial-sites-a-clinicopathologic-analysis-of-25-cases
#3
David M Meredith, Christopher D M Fletcher, Vickie Y Jo
Chondromyxoid fibroma (CMF) is a rare benign tumor, usually arising in the metaphysis of long bones in young adults. Occurrence in craniofacial bones presents a particular diagnostic challenge given its unusual location and resemblance to malignant mimics. We describe the clinicopathologic features of 25 cases of craniofacial CMF identified between 1999 and 2017. Patients were 14 men and 11 women, with median age of 44 years (range, 5 to 83 y). Sites of involvement were sphenoid (7), ethmoid (5), maxilla (3), occipital (2), nasal septum (2), palatine (2), temporal (2), orbit (1), and undisclosed skull (1)...
January 10, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29315235/response-of-fibroblasts-mrc-5-to-flufenamic-acid-grafted-mcm-41-nanoparticles
#4
Giovanna Gomes Lara, Marcelo Fernandes Cipreste, Gracielle Ferreira Andrade, Wellington Marcos da Silva, Edésia Martins Barros de Sousa
Recently, flufenamic acid (FFA) was discovered among fenamates as a free radical scavenger and gap junction blocker; however, its effects have only been studied in cancer cells. Normal cells in the surroundings of a tumor also respond to radiation, although they are not hit by it directly. This phenomenon is known as the bystander effect, where response molecules pass from tumor cells to normal ones, through communication channels called gap junctions. The use of the enhanced permeability and retention effect, through which drug-loaded nanoparticles smaller than 200 nm may accumulate around a tumor, can prevent the local side effect upon controlled release of the drug...
January 9, 2018: Bioengineering
https://www.readbyqxmd.com/read/29303446/combination-ipilimumab-and-radiosurgery-for-brain-metastases-tumor-edema-and-adverse-radiation-effects
#5
Kevin Diao, Shelly X Bian, David M Routman, Cheng Yu, Paul E Kim, Naveed A Wagle, Michael K Wong, Gabriel Zada, Eric L Chang
OBJECTIVE Tumor and edema volume changes of brain metastases after stereotactic radiosurgery (SRS) and ipilimumab are not well described, and there is concern regarding the safety of combination treatment. The authors evaluated tumor, edema, and adverse radiation-induced changes after SRS with and without ipilimumab and identified associated risk factors. METHODS This single-institution retrospective study included 72 patients with melanoma brain metastases treated consecutively with upfront SRS from 2006 to 2015...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29299366/bridging-therapy-effectiveness-in-the-treatment-of-hepatocellular-carcinoma-prior-to-orthotopic-liver-transplantation
#6
Maria M Rubinstein, Andreas Kaubisch, Milan Kinkhabwala, John Reinus, Qiang Liu, Jennifer W Chuy
Background: Orthotopic liver transplantation (OLT) is the most effective treatment for hepatocellular carcinoma (HCC) in patients with underlying cirrhosis and portal hypertension. Availability of OLT is limited by donor-organ shortages, which increase patient waiting time until OLT. A variety of bridging therapies (BT) have been used to halt tumor progression in patients on the OLT waiting list. Despite complete radiologic responses following BT, viable tumor is often present in explants...
December 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29299105/the-radiologic-and-pathologic-diagnosis-of-biphasic-pulmonary-blastoma
#7
Fadi Nemeh, Anderson H Kuo, Jenny Ross, Carlos S Restrepo
Pulmonary blastomas are rare malignancies, representing 0.25% to 0.5% of all primary lung neoplasms with often aggressive progression and poor prognosis. Clinical management of pulmonary blastomas depends on histologic subtype, staging, and presentation, and may consist of surgery, chemotherapy, and radiation. Biphasic pulmonary blastoma is a subtype of pulmonary blastoma that exhibits biphasic histology, with both epithelial and mesenchymal malignant elements. We report a case of biphasic pulmonary blastoma in a 33-year-old female with 1 pack per day history of smoking for approximately 16 years, who presented with left-sided pleuritic chest pain on deep inspiration without otherwise significant pat medical history...
September 2017: Journal of Radiology Case Reports
https://www.readbyqxmd.com/read/29298730/cytokine-release-syndrome-after-radiation-therapy-case-report-and-review-of-the-literature
#8
Christopher A Barker, Samuel K Kim, Sadna Budhu, Konstantina Matsoukas, Anthony F Daniyan, Sandra P D'Angelo
BACKGROUND: Cytokine release syndrome (CRS) has been reported after immunologic manipulations, most often through therapeutic monoclonal antibodies. To our knowledge, CRS after radiation therapy (RT) for cancer has not been reported before. The development of unusual clinical signs and symptoms after RT led us to investigate the possibility of CRS after RT and review the medical literature on this topic. CASE PRESENTATION: A 65 year-old man with untreated chronic lymphocytic leukemia and recurrent, metastatic Merkel cell carcinoma undergoing anti-programmed death 1 (PD1) immunotherapy was referred for palliative RT to sites of progressing metastases...
January 3, 2018: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29297951/study-of-the-utility-and-problems-of-common-iliac-artery-balloon-occlusion-for-placenta-previa-with-accreta
#9
Yoshihisa Ono, Yoshihiko Murayama, Sumiko Era, Shigetaka Matsunaga, Tomonori Nagai, Hisato Osada, Yasushi Takai, Kazunori Baba, Satoru Takeda, Hiroyuki Seki
AIMS: We investigated whether common iliac artery balloon occlusion (CIABO) was effective for decreasing blood loss during cesarean hysterectomy (CH) in patients with placenta previa with accreta and was safe for mothers and fetuses. METHODS: Of the 67 patients who underwent CH for placenta previa with accreta at our facility from 1985 to 2014, 57 patients were eligible for the study. The amount of intraoperative bleeding during CH was compared between three groups: surgery without blood flow occlusion (13 patients), internal iliac artery ligation (15 patients) and CIABO (29 patients)...
January 3, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29296907/tlr2-agonism-reverses-chemotherapy-induced-neutropenia-in-macaca-fascicularis
#10
Nicholas J Laping, Michael P DeMartino, Joshua E Cottom, Jeffrey M Axten, John G Emery, Jeffrey H Guss, Miriam Burman, James J Foley, Mui Cheung, Allen Oliff, Sanjay Kumar
Neutropenia is a common consequence of radiation and chemotherapy in cancer patients. The resulting immunocompromised patients become highly susceptible to potentially life-threatening infections. Granulocyte colony-stimulating factor (G-CSF) is known to stimulate neutrophil production and is widely used as a treatment of chemotherapy-induced neutropenia. A small-molecule G-CSF secretagogue without a requirement for refrigerated supply chain would offer a more convenient and cost-effective treatment of chemotherapy-induced neutropenia...
December 12, 2017: Blood Advances
https://www.readbyqxmd.com/read/29290464/complex-upper-arm-reconstruction-using-an-antero-lateral-thigh-free-flap-after-an-extravasation-of-yttrium-90-ibritumomab-tiuxetan-a-case-report-and-literature-review
#11
A Baus, C Keilani, C-S Bich, F Entine, M Brachet, P Duhamel, J-C Amabile, J V Malfuson, E Bey
Yttrium-90-Ibritumomab Tiuxetan (Zevalin®) is used in the treatment of non- Hodgkin's lymphoma. Extravasation is an iatrogenic complication that is fortunately rare. However, the treatment of this complication is often complex due to the risk of extensive skin necrosis and unpredictable evolution of localized irradiation. This vesicant drug requires emergency management when extravasation occured. Radiations burns have specificities. Therefore, wound coverage involves specific plastic surgical techniques. Here, we report the case of a man presenting a chronic and extensive skin necrosis of upper arm treated with an antero-lateral thigh free flap...
December 28, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29288110/cerebral-radiation-necrosis-an-analysis-of-clinical-and-quantitative-imaging-and-volumetric-features
#12
Rui Feng, Joshua Loewenstern, Amit Aggarwal, Puneet Pawha, Ahmed Gilani, Alfred Marc Iloreta, Richard Bakst, Brett Miles, Joshua Bederson, Anthony Costa, Vishal Gupta, Raj Shrivastava
BACKGROUND: Radiation therapy (RT) is an effective treatment for primary brain tumors and intracranial metastases, but can occasionally precede new enhancing lesions on imaging studies that are difficult to discern between a tumor recurrence (TR) or radiation necrosis (RN). There is a need to identify clinical presentation and imaging patterns that may obviate the need for invasive definitive biopsy. OBJECTIVE: To describe clinical and imaging characteristics of RN lesions compared to those from a TR...
December 26, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29280856/bovine-acellular-dermal-matrix-in-immediate-breast-reconstruction-a-retrospective-observational-study-with-surgimend
#13
Michael Scheflan, Helena Grinberg-Rashi, Keren Hod
BACKGROUND: Acellular dermal matrices can be combined with implant-based breast reconstruction to help optimize outcomes. SurgiMend PRS is a fetal bovine dermis-derived acellular dermal matrix composed of type I collagen and approximately 30 percent type III collagen, sharing many of the properties of human cadaveric acellular dermal matrix. METHODS: This was a retrospective, single-center analysis of 111 adult patients (147 breasts) undergoing one-stage (83.7 percent) or two-stage (16...
January 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29280457/reirradiation-for-recurrent-pediatric-central-nervous-system-malignancies-a-multi-institutional-review
#14
Avani D Rao, Arif S Rashid, Qinyu Chen, Rosangela C Villar, Daria Kobyzeva, Kristina Nilsson, Karin Dieckmann, Alexey Nechesnyuk, Ralph Ermoian, Sara Alcorn, Shannon M MacDonald, Matthew M Ladra, Eric C Ford, Brian A Winey, Maria Luisa S Figueiredo, Michael J Chen, Stephanie A Terezakis
PURPOSE: Reirradiation has been proposed as an effective modality for recurrent central nervous system (CNS) malignancies in adults. We evaluated the toxicity and outcomes of CNS reirradiation in pediatric patients. METHODS AND MATERIALS: The data from pediatric patients <21 years of age at the initial diagnosis who developed a recurrent CNS malignancy that received repeat radiation therapy (RT) across 5 facilities in an international pediatric research consortium were retrospectively reviewed...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29280066/diagnostic-accuracy-of-11c-methionine-pet-in-detecting-neuropathologically-confirmed-recurrent-brain-tumor-after-radiation-therapy
#15
Annika Kits, Heather Martin, Alejandro Sanchez-Crespo, Anna F Delgado
OBJECTIVE: This study aims to determine the diagnostic test accuracy (DTA) of 11C-methionine (MET) PET in the discrimination between recurrent tumor and radiation-induced injury in neuropathologically confirmed cases. METHODS: A retrospective cohort of 30 patients with previously irradiated intracranial tumors (23 gliomas, 6 metastases, and 1 meningioma) was included. All patients underwent a preoperative MET PET and postoperative neuropathological analysis. Maximum and mean standardized uptake values (SUV) were obtained in the lesion, in the contralateral mirror region, and in the contralateral frontal cortex...
December 26, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/29279811/radiation-necrosis-following-proton-beam-therapy-in-the-pediatric-population-a-case-series
#16
Justin Davanzo, Robert J Greiner, Mustafa Barbour, Elias Rizk
Radiation necrosis after proton beam radiotherapy in the pediatric population is a finding that should be evaluated. We present two cases of radiation necrosis in pediatric patients who underwent proton beam radiation therapy following gross total resection of tumors. As seen in both our cases, patients often present with radiographic changes found on surveillance imaging. While the progression of disease should certainly be considered in any patient with radiographic changes, understanding the radiographic findings and the clinical course of radiation necrosis is paramount in order to prevent unnecessary surgical intervention...
October 19, 2017: Curēus
https://www.readbyqxmd.com/read/29273189/soft-tissue-sarcoma-response-to-two-cycles-of-neoadjuvant-chemotherapy-a-multireader-analysis-of-mri-findings-and-agreement-with-recist-criteria-and-change-in-suvmax
#17
Jennifer L Favinger, Daniel S Hippe, Darin J Davidson, Saeed Elojeimy, Eira S Roth, Antoinette W Lindberg, Alice S Ha
RATIONALE AND OBJECTIVES: When soft tissue sarcomas are treated with neoadjuvant chemotherapy, the number of cycles of chemotherapy is usually dependent on the tumor's initial response. Popular methods to assess tumor response include Response Evaluation Criteria in Solid Tumors (RECIST) criteria, which rely solely on tumor size, and maximum standardized uptake value (SUVmax) reduction in positron emission tomography (PET), which requires an expensive and high radiation test. We hypothesized that contrast-enhanced magnetic resonance imaging (MRI) may offer a good alternative by providing additional information beyond tumor size...
December 19, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29243740/will-oncotype-dx-dcis-testing-guide-therapy-a-single-institution-correlation-of-oncotype-dx-dcis-results-with-histopathologic-findings-and-clinical-management-decisions
#18
Chieh-Yu Lin, Kelly Mooney, Winward Choy, Soo-Ryum Yang, Keegan Barry-Holson, Kathleen Horst, Irene Wapnir, Kimberly Allison
Given the increased detection rates of ductal carcinoma in situ (DCIS) and the limited overall survival benefit from adjuvant breast irradiation after breast-conserving surgery, there is interest in identifying subsets of patients who have low rates of ipsilateral breast tumor recurrence such that they might safely forgo radiation. The Oncotype DCIS score is a reverse transcription-PCR (RT-PCR)-based assay that was validated to predict which DCIS cases are most likely to recur. Clinically, these results may be used to assist in selecting which patients with DCIS might safely forgo radiation therapy after breast-conserving surgery; however, little is currently published on how this test is being used in practice...
December 15, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29242740/near-infrared-irradiation-increases-length-of-axial-pattern-flap-survival-in-rats
#19
Yoshichika Yasunaga, Kiyoshi Matsuo, Yohei Tanaka, Shunsuke Yuzuriha
Objective: We previously reported that near-infrared irradiation nonthermally induces long-lasting vasodilation of the subdermal plexus by causing apoptosis of vascular smooth muscle cells. To clarify the possible application of near-infrared irradiation to prevent skin flap necrosis, we evaluated the length of axial pattern flap survival in rats by near-infrared irradiation. Methods: A bilaterally symmetric island skin flap was elevated under the panniculus carnosus on the rat dorsum. Half of the flap was subjected to near-infrared irradiation just before flap elevation with a device that simulates solar radiation, which has a specialized contact cooling apparatus to avoid thermal effects...
2017: Eplasty
https://www.readbyqxmd.com/read/29242363/diagnostic-accuracy-of-amino-acid-and-fdg-pet-in-differentiating-brain-metastasis-recurrence-from-radionecrosis-after-radiotherapy-a-systematic-review-and-meta-analysis
#20
H Li, L Deng, H X Bai, J Sun, Y Cao, Y Tao, L J States, M D Farwell, P Zhang, B Xiao, L Yang
BACKGROUND: Current studies that analyze the usefulness of amino acid and FDG-PET in distinguishing brain metastasis recurrence and radionecrosis after radiation therapy are limited by small cohort size. PURPOSE: Our aim was to assess the diagnostic accuracy of amino acid and FDG-PET in differentiating brain metastasis recurrence from radionecrosis after radiation therapy. DATA SOURCES: Studies were retrieved from PubMed, Embase, and the Cochrane Library...
December 14, 2017: AJNR. American Journal of Neuroradiology
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