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https://www.readbyqxmd.com/read/28535120/differentiation-of-recurrent-glioblastoma-from-delayed-radiation-necrosis-by-using-voxel-based-multiparametric-analysis-of-mr-imaging-data
#1
Ra Gyoung Yoon, Ho Sung Kim, Myeong Ju Koh, Woo Hyun Shim, Seung Chai Jung, Sang Joon Kim, Jeong Hoon Kim
Purpose To assess a volume-weighted voxel-based multiparametric (MP) clustering method as an imaging biomarker to differentiate recurrent glioblastoma from delayed radiation necrosis. Materials and Methods The institutional review board approved this retrospective study and waived the informed consent requirement. Seventy-five patients with pathologic analysis-confirmed recurrent glioblastoma (n = 42) or radiation necrosis (n = 33) who presented with enlarged contrast material-enhanced lesions at magnetic resonance (MR) imaging after they completed concurrent chemotherapy and radiation therapy were enrolled...
May 23, 2017: Radiology
https://www.readbyqxmd.com/read/28531942/target-signalling-pathways-of-natural-plant-derived-radioprotective-agents-from-treatment-to-potential-candidates-a-reverse-thought-on-anti-tumour-drugs
#2
REVIEW
Ke-Li Yun, Zhen Yu Wang
Radiation damage can occur in nuclear power plant workers when physical protections fail, which results in nuclear leakage through the protective layers. Alternatively, workers may be unable to use physical protection in time (in the case of a sudden nuclear weapons attack). In addition, patients who receive local radiotherapy and are not allowed to adopt local physical protection may experience radiation damage. Thus, protection against chemical radiation has become indispensable. In view of the side effects caused by synthetic radioprotective agents (such as amisfostine), searching for radioprotective agents from plant sources is an alternative strategy...
May 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28529513/ionizing-radiation-induced-immune-and-inflammatory-reactions-in-the-brain
#3
REVIEW
Katalin Lumniczky, Tünde Szatmári, Géza Sáfrány
Radiation-induced late brain injury consisting of vascular abnormalities, demyelination, white matter necrosis, and cognitive impairment has been described in patients subjected to cranial radiotherapy for brain tumors. Accumulating evidence suggests that various degrees of cognitive deficit can develop after much lower doses of ionizing radiation, as well. The pathophysiological mechanisms underlying these alterations are not elucidated so far. A permanent deficit in neurogenesis, chronic microvascular alterations, and blood-brain barrier dysfunctionality are considered among the main causative factors...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28514842/gender-difference-in-radiotherapy-induced-carotid-stenosis
#4
Y Yang, W Yang, T J Wang
Radiotherapy (RT) is often the first choice of treatment for cancer of the larynx. Studies have shown that the incidence of carotid stenosis (CS) after radiotherapy of laryngeal cancer is increasing, and that gender difference in radiotherapy-induced side effects exist. Thus, we examined the gender difference in the incidence of CS and the impact of microinflammatory factors after radiotherapy. We reported this study on patients who received radiotherapy as part of the treatment for laryngeal cancer in the Jilin Province in China...
June 30, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28505006/myopericytomatosis-clinicopathologic-analysis-of-11-cases-with-molecular-identification-of-recurrent-pdgfrb-alterations-in-myopericytomatosis-and-myopericytoma
#5
Yin P Hung, Christopher D M Fletcher
Myopericytoma is a benign tumor of concentrically distributed perivascular myoid cells. Its molecular basis and relationship with myofibroma/myofibromatosis and other pericytic tumors are not fully understood. In our consultation/surgical files of over 1000 myopericytic lesions, we identified 11 cases with diffuse dermal/subcutaneous involvement by microscopic myopericytomatous nodules, a phenomenon we have termed myopericytomatosis. Myopericytomatosis affected mostly adults (female:male=8:3; median age, 37 y; range, 9 to 63 y) in the lower extremities (foot/ankle, 5; calf, 3; knee, 1; thigh, 1; neck, 1) over months to 25 years, ranging from 1...
May 12, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28503719/radiation-and-depression-associated-with-complications-of-tissue-expander-reconstruction
#6
Paul J Chuba, William A Stefani, Carrie Dul, Susan Szpunar, Jeffrey Falk, Rachael Wagner, Elango Edhayan, Anna Rabbani, Cynthia H Browne, Amr Aref
PURPOSE: Rates of implant failure, wound healing delay, and infection are higher in patients having radiation therapy (RT) after tissue expander (TE) and permanent implant reconstruction. We investigated pretreatment risk factors for TE implant complications. PATIENTS AND METHODS: 127 breast cancer patients had TE reconstruction and radiation. For 85 cases of bilateral TE reconstruction, the non-irradiated breast provided an internal control. Comparison of differences in means for continuous variables used analysis of variance, then multiple pairwise comparisons with Bonferroni correction of p value...
May 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28501692/trans-chalcone-added-in-topical-formulation-inhibits-skin-inflammation-and-oxidative-stress-in-a-model-of-ultraviolet-b-radiation-skin-damage-in-hairless-mice
#7
Renata M Martinez, Felipe A Pinho-Ribeiro, David L Vale, Vinicius S Steffen, Fabiana T M C Vicentini, Josiane A Vignoli, Marcela M Baracat, Sandra R Georgetti, Waldiceu A Verri, Rubia Casagrande
Trans-chalcone (TC) is a common precursor of flavonoids. However, the pharmacological properties of TC remain to be fully understood. The present study investigated whether topical formulation containing TC (TFcTC) presents therapeutic effect in UVB radiation-induced skin damage using disease, enzyme activity, antioxidant activity, protein and mRNA parameters. Control topical formulation (CTF) and TFcTC were applied in hairless mice before and after exposure to UVB radiation. Dorsal skin samples were collected after UVB exposure to evaluate: i) skin edema (weight) was measured by punch biopsy; ii) spectrophotometric assays were used to measure myeloperoxidase (MPO) and catalase activities, ferric (FRAP) and ABTS cation reducing antioxidant power, superoxide anion production and levels of reduced glutathione (GSH); iii) enzymography was used to measure matrix metalloproteinase-9 (MMP-9) activity; iv) chemiluminescence was used to measure the lipid peroxidation (LPO); v) enzyme-linked immunosorbent assay (ELISA) was used to measure tumor necrosis factor alpha (TNF-α) levels; vi) reverse transcription quantitative PCR (RT-qPCR) was used to measure cyclooxygenase-2 (COX-2), gp91(phox) (NADPH oxidase sub-unity), glutathione peroxidase-1 (Gpx1), glutathione reductase (Gr), nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase-1 (HO-1) mRNA expression...
May 2, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28500560/radiation-necrosis-with-stereotactic-radiosurgery-combined-with-ctla-4-blockade-and-pd-1-inhibition-for-treatment-of-intracranial-disease-in-metastatic-melanoma
#8
Penny Fang, Wen Jiang, Pamela Allen, Isabella Glitza, Nandita Guha, Patrick Hwu, Amol Ghia, Jack Phan, Anita Mahajan, Hussein Tawbi, Jing Li
Immune checkpoint inhibitors have demonstrated remarkable benefits in cancer patients. However, concern regarding toxicity in the setting of stereotactic radiosurgery (SRS) is often raised. In this study, we characterize radiation necrosis (RN) following immunotherapy and SRS. Melanoma patients treated with SRS and anti-CTLA-4 and/or anti-PD-1 at our institution from January 2006 to December 2015 were retrospectively reviewed. Overall survival (OS) and time to RN were assessed using Kaplan-Meier analysis. Logistic regression and Cox proportional hazards analyses were performed to identify predictors of radiation necrosis-free survival (RNFS) and RN risk...
May 12, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28480786/ultraviolet-a1-irradiation-therapy-for-systemic-lupus-erythematosus
#9
H McGrath
Systemic lupus erythematosus (lupus, SLE) is a chronic autoimmune disease characterized by the production of autoantibodies, which bind to antigens and are deposited within tissues to fix complement, resulting in widespread systemic inflammation. The studies presented herein are consistent with hyperpolarized, adenosine triphosphate (ATP)-deficient mitochondria being central to the disease process. These hyperpolarized mitochondria resist the depolarization required for activation-induced apoptosis. The mitochondrial ATP deficits add to this resistance to apoptosis and also reduce the macrophage energy that is needed to clear apoptotic bodies...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28479437/modified-mouse-models-of-chronic-secondary-lymphedema-tail-and-hind-limb-models
#10
Heungman Jun, Ji Yoon Lee, Ji Hun Kim, Minsu Noh, Tae-Won Kwon, Yong-Pil Cho, Young-Sup Yoon
BACKGROUND: Post-surgical secondary lymphedema is usually a progressive and lifelong condition lacking any curative treatment. The aim of this study was to develop new, simple surgical mouse models of chronic lymphedema, better simulating chronic nature of human post-surgical lymphedema. METHODS: Two experimental mouse models of secondary lymphedema were created surgically without radiation by modifications of the previously described methods: the tail model and the hind limb model...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28472527/biopsy-of-enlarging-lesions-after-stereotactic-radiosurgery-for-brain-metastases-frequently-reveals-radiation-necrosis
#11
Jessica L Narloch, S Harrison Farber, Sarah Sammons, Frances McSherry, James E Herndon, Jenny K Hoang, Fang-Fang Yin, John H Sampson, Peter E Fecci, Kimberly L Blackwell, John P Kirkpatrick, Grace J Kim
Background: Stereotactic radiosurgery (SRS) offers excellent local control for brain metastases (BM) with low rates of toxicity. Radiation necrosis (RN) may occur after treatment and is challenging to distinguish from local recurrence (LR). We evaluated enlarging brain lesions following SRS that were subsequently biopsied to differentiate RN versus LR. Methods: This study reviewed patients receiving SRS for BM between 2008-2012 who underwent a biopsy for suspicion of RN versus LR on MRI imaging...
May 3, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28463157/histologic-appearance-after-preoperative-radiation-therapy-for-soft-tissue-sarcoma-assessment-of-the-european-organization-for-research-and-treatment-of-cancer-soft-tissue-and-bone-sarcoma-group-response-score
#12
Inga-Marie Schaefer, Jason L Hornick, Constance M Barysauskas, Chandrajit P Raut, Sagar A Patel, Trevor J Royce, Christopher D M Fletcher, Elizabeth H Baldini
PURPOSE: To critically assess the prognostic value of the European Organization for Research and Treatment of Cancer-Soft Tissue and Bone Sarcoma Group (EORTC-STBSG) response score and define histologic appearance after preoperative radiation therapy (RT) for soft tissue sarcoma (STS). METHODS AND MATERIALS: For a cohort of 100 patients with STS of the extremity/trunk treated at our institution with preoperative RT followed by resection, 2 expert sarcoma pathologists evaluated the resected specimens for percent residual viable cells, necrosis, hyalinization/fibrosis, and infarction...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28463155/correlation-of-acute-and-late-brainstem-toxicities-with-dose-volume-data-for-pediatric-patients-with-posterior-fossa-malignancies
#13
Ronica H Nanda, Rohit G Ganju, Edward Schreibmann, Zhengjia Chen, Chao Zhang, Naresh Jegadeesh, Richard Cassidy, Claudia Deng, Bree R Eaton, Natia Esiashvili
PURPOSE: Radiation-induced brainstem toxicity after treatment of pediatric posterior fossa malignancies is incompletely understood, especially in the era of intensity modulated radiation therapy (IMRT). The rates of, and predictive factors for, brainstem toxicity after photon RT for posterior fossa tumors were examined. METHODS AND MATERIALS: After institutional review board approval, 60 pediatric patients treated at our institution for nonmetastatic infratentorial ependymoma and medulloblastoma with IMRT were included in the present analysis...
June 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28458967/improved-head-and-neck-free-flap-outcome-effects-of-a-treatment-protocol-adjustment-from-pre-to-postoperative-radiotherapy
#14
Martin Halle, Bjorn O Eriksson, Ann-Charlott Docherty Skogh, Pehr Sommar, Lalle Hammarstedt, Caroline Gahm
BACKGROUND: The impact of preoperative radiotherapy on microvascular reconstructive surgery outcome has been a subject of debate. However, data are conflicting and often dependent on local treatment protocols. We have studied the effects of radiotherapy in a unique, single-center setting where a treatment protocol change was undertaken from pre- to postoperative radiotherapy administration for microsurgical head and neck reconstructions. METHODS: A cohort study was conducted for 200 consecutive head and neck free flap cases, where 100 were operated on before and 100 after the treatment protocol adjustment in 2006...
March 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28450235/repeat-stereotactic-radiosurgery-for-locally-recurrent-brain-metastases
#15
Paul Koffer, Jason Chan, Paul Rava, Daniel Gorovets, Daniel Ebner, Guy Savir, Timothy Kinsella, Deus Cielo, Jaroslaw T Hepel
PURPOSE: /Objective(s): The outcomes of repeat stereotactic radiosurgery (SRS) after failure of previous SRS are not well established. We report our overall experience using SRS for the retreatment of locally recurrent brain metastases. METHODS: Patients with brain metastases diagnosed between 2003-2015 who underwent repeat SRS for local tumor progression following prior SRS were identified. Rates of local control, radiation necrosis, and overall survival were analyzed...
April 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28447147/diffusion-kurtosis-as-an-in-vivo-imaging-marker-of-early-radiation-induced-changes-in-radiation-induced-temporal-lobe-necrosis-in-nasopharyngeal-carcinoma-patients
#16
Lu Liyan, Wang Si, Wang Qian, Shao Yuhui, Wei Xiaoer, Li Yuehua, Li Wenbin
PURPOSE: Diffusion kurtosis imaging (DKI), an extension of the popular diffusion tensor imaging (DTI) model, has been applied in clinical studies of brain tissue changes. We explored the value of DKI for the early detection of radiation-induced changes in temporal lobe necrosis (TLN) after radiotherapy (RT) for nasopharyngeal carcinoma (NPC). METHODS: A total of 400 patients with NPC were retrospectively enrolled; all participants underwent MRI scans 0-7 days before RT, at 4 weeks during RT, and 1 month after completing RT...
April 26, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28443515/indication-of-bevacizumab-for-cerebral-radiation-necrosis
#17
Hongqing Zhuang, Xiangkun Yuan, Zhiyong Yuan, Ping Wang
BACKGROUND: The effect of bevacizumab (BVZ) for cerebral radiation necrosis (CRN) was clear. However, the indications of BVZ had no reports. OBJECTIVE: The aim of the paper was to investigate the indications of BVZ for CRN. METHODS: Fourteen CRN patients (confirmed by imaging diagnosis)who underwent BVZ treatment between June 2011 and December 2014 were analyzed. BVZ was administered (5 mg/kg body weight) once every three to four weeks for at least three cycles...
April 25, 2017: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/28438965/radiation-induces-proinflammatory-dysbiosis-transmission-of-inflammatory-susceptibility-by-host-cytokine-induction
#18
Shiran Gerassy-Vainberg, Alexandra Blatt, Yael Danin-Poleg, Katya Gershovich, Edmond Sabo, Alex Nevelsky, Shahar Daniel, Aviva Dahan, Oren Ziv, Rishu Dheer, Maria T Abreu, Omry Koren, Yechezkel Kashi, Yehuda Chowers
OBJECTIVE: Radiation proctitis (RP) is a complication of pelvic radiotherapy which affects both the host and microbiota. Herein we assessed the radiation effect on microbiota and its relationship to tissue damage using a rectal radiation mouse model. DESIGN: We evaluated luminal and mucosa-associated dysbiosis in irradiated and control mice at two postradiation time points and correlated it with clinical and immunological parameters. Epithelial cytokine response was evaluated using bacterial-epithelial co-cultures...
April 24, 2017: Gut
https://www.readbyqxmd.com/read/28438396/the-versatile-use-of-revisited-de-epithelialization-concept-in-superficial-circumflex-iliac-and-anterolateral-thigh-perforator-free-flap-for-head-and-neck-reconstructions
#19
Jong Woo Choi, Young Chul Kim, Tae Suk Oh, Kyung S Koh, Woo Shik Jeong
BACKGROUND: Although the perforator free flap is now a standard choice for head and neck reconstruction, problems such as microvascular complications, insufficient volume support for the defect, and fistula formation occur. We revisited a de-epithelialized concept for superficial circumflex iliac artery and anterolateral thigh perforator free flap to overcome these problems. METHODS: We applied the de-epithelized perforator free flaps in 35 cases among 761 microsurgical head and neck reconstructions and investigated flap characteristics (length gain of pedicle, flap size, and volumetric analysis) and outcomes (flap failure, partial flap necrosis, hematoma, infection, and fistula)...
February 20, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28434110/the-risk-of-radiation-necrosis-following-stereotactic-radiosurgery-with-concurrent-systemic-therapies
#20
Joseph M Kim, Jacob A Miller, Rupesh Kotecha, Roy Xiao, Aditya Juloori, Matthew C Ward, Manmeet S Ahluwalia, Alireza M Mohammadi, David M Peereboom, Erin S Murphy, John H Suh, Gene H Barnett, Michael A Vogelbaum, Lilyana Angelov, Glen H Stevens, Samuel T Chao
To investigate late toxicity among patients with newly-diagnosed brain metastases undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or without whole-brain radiation therapy (WBRT). Patients with newly-diagnosed brain metastasis who underwent SRS at a single tertiary-care institution from 1997 to 2015 were eligible for inclusion. The class and timing of all systemic therapies were collected for each patient. The primary outcome was the cumulative incidence of radiographic radiation necrosis (RN)...
April 22, 2017: Journal of Neuro-oncology
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