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Radiation necrosis

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https://www.readbyqxmd.com/read/27900811/exuberant-squamous-metaplasia-with-calcification-following-intraoperative-radiotherapy-for-breast-carcinoma-report-of-an-unusual-case-and-retrospective-review-of-cases-from-a-single-institution
#1
Paula S Ginter, John Ng, Rebecca Zhuo, Alexander J Swistel, Timothy M D'Alfonso
Intraoperative radiotherapy (IORT) is a novel and increasingly utilized radiation technique in the treatment of breast carcinoma. There are few reports on the histologic changes seen in breast tissue from patients who have undergone IORT. We sought to evaluate the histologic changes observed in specimens received following IORT, as well as report an unusual case which prompted our study. A retrospective review of patients who received IORT and subsequently had breast tissue histologically evaluated at our institution was performed...
November 30, 2016: Breast Journal
https://www.readbyqxmd.com/read/27893337/inflammatory-cytokines-and-comorbidity-development-in-breast-cancer-survivors-versus-noncancer-controls-evidence-for-accelerated-aging
#2
Catherine M Alfano, Juan Peng, Rebecca R Andridge, Monica E Lindgren, Stephen P Povoski, Adele M Lipari, Doreen M Agnese, William B Farrar, Lisa D Yee, William E Carson, Janice K Kiecolt-Glaser
Purpose The sequelae of cancer treatment may increase systemic inflammation and create a phenotype at increased risk of functional decline and comorbidities, leading to premature mortality. Little is known about how this trajectory compares with natural aging among peers of the same age without cancer. This longitudinal study investigated proinflammatory cytokines and comorbidity development over time among breast cancer survivors and a noncancer control group. Methods Women (N = 315; 209 with breast cancer and 106 in the control group) were recruited at the time of their work-up for breast cancer; they completed the baseline questionnaire, interview, and blood draw (lipopolysaccharide-stimulated production of interleukin [IL] -6, tumor necrosis factor-α, and IL-1β)...
November 28, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27889300/tofacitinib-versus-biologic-treatments-in-patients-with-active-rheumatoid-arthritis-who-have-had-an-inadequate-response-to-tumor-necrosis-factor-inhibitors-results-from-a-network-meta-analysis
#3
Maria-Cecilia Vieira, Samuel H Zwillich, Jeroen P Jansen, Brielan Smiechowski, Dean Spurden, Gene V Wallenstein
PURPOSE: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). This analysis compared the efficacy and safety of tofacitinib with biologic disease-modifying antirheumatic drugs in patients with RA and a prior inadequate response (IR) to tumor necrosis factor inhibitors (TNFi). METHODS: A systematic literature review identified 5 randomized placebo-controlled trials that evaluated tofacitinib or biologic disease-modifying antirheumatic drugs (bDMARDs) against placebo in patient populations with RA with a prior IR to TNFi...
November 23, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27885954/novel-biomarker-identification-using-metabolomic-profiling-to-differentiate-radiation-necrosis-and-recurrent-tumor-following-gamma-knife-radiosurgery
#4
Alex Y Lu, Jack L Turban, Eyiyemisi C Damisah, Jie Li, Ahmed K Alomari, Tore Eid, Alexander O Vortmeyer, Veronica L Chiang
OBJECTIVE Following an initial response of brain metastases to Gamma Knife radiosurgery, regrowth of the enhancing lesion as detected on MRI may represent either radiation necrosis (a treatment-related inflammatory change) or recurrent tumor. Differentiation of radiation necrosis from tumor is vital for management decision making but remains difficult by imaging alone. In this study, gas chromatography with time-of-flight mass spectrometry (GC-TOF) was used to identify differential metabolite profiles of the 2 tissue types obtained by surgical biopsy to find potential targets for noninvasive imaging...
November 25, 2016: Journal of Neurosurgery
https://www.readbyqxmd.com/read/27879026/ionizing-radiation-promotes-ccl27-secretion-from-keratinocytes-through-the-cross-talk-between-tnf-%C3%AE-and-ros
#5
Qian Zhang, Linlin Zhu, Gang Wang, Ye Zhao, Na Xiong, Hegang Bao, Wensen Jin
The skin-associated chemokine CCL27 and its receptor CCR10 mediate the immune response of skin-homing T cells. The CCL27 secreted from keratinocytes was reportedly involved in inflammatory skin diseases such as atopic dermatitis, contact dermatitis, and psoriasis. However, whether ionizing radiation increases the levels of CCL27 secretion still remains unclear. In HaCaT cells, a human keratinocyte cell line, CCL27 secretion was markedly increased after X-ray irradiation. We further found that irradiation boosted the generation of reactive oxygen species (ROS), which was concomitant with the release of tumor necrosis factor-alpha (TNF-α)...
November 23, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27872946/implementation-of-image-guided-intensity-modulated-accelerated-partial-breast-irradiation-three-year-results-of-a%C3%A2-phase%C3%A2-ii-clinical-study
#6
Norbert Mészáros, Tibor Major, Gábor Stelczer, Zoltán Zaka, Emőke Mózsa, Dávid Pukancsik, Zoltán Takácsi-Nagy, János Fodor, Csaba Polgár
PURPOSE: To report 3‑year results of accelerated partial breast irradiation (APBI) using image-guided intensity-modulated radiotherapy (IG-IMRT) following breast conserving surgery (BCS) for low-risk early invasive breast cancer. PATIENTS AND METHODS: Between July 2011 and March 2014, 60 patients with low-risk early invasive breast cancer underwent BCS and were enrolled in this phase II prospective study. The total dose was 36.9 Gy (9 fractions of 4.1 Gy, two fractions/day)...
November 21, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27872484/co-occurrence-of-local-anisotropic-gradient-orientations-collage-a-new-radiomics-descriptor
#7
Prateek Prasanna, Pallavi Tiwari, Anant Madabhushi
In this paper, we introduce a new radiomic descriptor, Co-occurrence of Local Anisotropic Gradient Orientations (CoLlAGe) for capturing subtle differences between benign and pathologic phenotypes which may be visually indistinguishable on routine anatomic imaging. CoLlAGe seeks to capture and exploit local anisotropic differences in voxel-level gradient orientations to distinguish similar appearing phenotypes. CoLlAGe involves assigning every image voxel an entropy value associated with the co-occurrence matrix of gradient orientations computed around every voxel...
November 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27867922/palliative-resection-of-metastatic-brain-tumors-previously-treated-by-stereotactic-radiosurgery
#8
Yoo Sung Jeon, Young-Cho Koh, Sang Woo Song, Joon Cho, So Dug Lim
BACKGROUND: Therapeutic approaches to brain metastases include surgery, whole-brain radiotherapy, stereotactic radiosurgery (SRS), and combination therapy. Recently, postoperative or preoperative SRS draws more attention to reduce postoperative recurrence in brain metastases. The goal of this study is to review surgical outcome of patients who had been treated by SRS, and to discuss the effectiveness of preoperative SRS. METHODS: From 2009 to 2015, 174 patients were treated by SRS for brain metastases, and among these 50 patients underwent surgery...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27863947/the-effects-of-low-dose-radiotherapy-on-fresh-osteochondral-allografts-an-experimental-study-in-rabbits
#9
Uğur Gönç, Mehmet Çetinkaya, Mesut Atabek
OBJECTIVE: The aim of this study was to investigate the effects of low-dose fractionated radiotherapy on cartilage degeneration after distal femoral fresh massive osteochondral allograft transplantation. METHODS: Twenty-four New Zealand White rabbits were divided into three groups of 8 rabbits each. All rabbits underwent distal femoral medial condyle fresh massive osteochondral allograft transplantation from California rabbits. The group 1 underwent transplantation without any preliminary process...
November 15, 2016: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/27861326/long-term-follow-up-of-25-cases-of-biopsy-proven-radiation-necrosis-or-post-radiation-treatment-effect-treated-with-magnetic-resonance-guided-laser-interstitial-thermal-therapy
#10
Cody J Smith, Charlotte S Myers, Kristina M Chapple, Kris A Smith
BACKGROUND: Magnetic resonance-guided laser-induced thermal therapy (MRgLITT) is a minimally invasive surgical treatment for progressive neoplasms and post-radiation treatment effect (PRTE). OBJECTIVE: To evaluate the radiographic response and efficacy of MRgLITT for biopsy-confirmed PRTE and the quality-of-life outcomes of patients following MRgLITT. METHODS: We conducted a single-center retrospective study of radiographic responses and clinical outcomes of 25 patients with previously treated primary or secondary brain neoplasms (World Health Organization grades 4 [n = 8], 3 [n = 5], 2 [n = 5]) and metastatic brain tumors (n = 7)...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27861325/the-role-of-mrglitt-in-overcoming-the-challenges-in-managing-infield-recurrence-after-radiation-for-brain-metastasis
#11
Purvee D Patel, Nitesh V Patel, Christian Davidson, Shabbar F Danish
: Radiation necrosis and tumor recurrence are common sequelae after radiation therapy for brain metastasis. The differentiation of radiation necrosis and recurrent brain metastases continues to remain a difficult task despite a number of diagnostic methods. Techniques including magnetic resonance imaging, diffusion-weighted imaging, nuclear studies, and the gold standard of biopsy have all been studied for their effectiveness in accurately diagnosing the postradiation condition. Various specific treatment options of the distinct pathologies are available with the general theory that recurrences require more immediate treatment whereas radiation necrosis can be observed until symptomatic before intervention...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27861323/stereotactic-laser-interstitial-thermal-therapy-for-recurrent-high-grade-gliomas
#12
Ian Lee, Steven Kalkanis, Constantinos G Hadjipanayis
BACKGROUND: The value of maximal safe cytoreductive surgery in recurrent high-grade gliomas (HGGs) is gaining wider acceptance. However, patients may harbor recurrent tumors that may be difficult to access with open surgery. Laser interstitial thermal therapy (LITT) is emerging as a technique for treating a variety of brain pathologies, including primary and metastatic tumors, radiation necrosis, and epilepsy. OBJECTIVE: To review the role of LITT in the treatment of recurrent HGGs, for which current treatments have limited efficacy, and to discuss the possible role of LITT in the disruption of the blood-brain barrier to increase delivery of chemotherapy locoregionally...
December 2016: Neurosurgery
https://www.readbyqxmd.com/read/27856365/use-of-intestinal-ultrasound-to-monitor-crohn-s-disease-activity
#13
Torsten Kucharzik, Bianca M Wittig, Ulf Helwig, Norbert Börner, Alexander Rössler, Stefan Rath, Christian Maaser
BACKGROUND & AIMS: We performed a multicenter study to determine whether transabdominal bowel wall ultrasonography, a non-invasive procedure that does not require radiation, can be used to monitor progression of Crohn's disease (CD). METHODS: We performed a 12-month prospective, non-interventional study at 47 sites in Germany, from December 2010 through September 2014. Our study included 234 adult patients with CD who experienced a flare, defined as Harvey-Bradshaw index score of ≥7...
November 14, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27851877/understanding-the-continuum-of-radionecrosis-and-vascular-disorders-in-the-brain-following-gamma-knife-irradiation-an-mri-study
#14
Julie Constanzo, Laurence Masson-Côté, Luc Tremblay, Jérémie P Fouquet, Philippe Sarret, Sameh Geha, Kevin Whittingstall, Benoit Paquette, Martin Lepage
PURPOSE: The radiation dose delivered to brain tumors is limited by the possibility to induce vascular damage and necrosis in surrounding healthy tissue. In the present study, we assessed the ability of MRI to monitor the cascade of events occurring in the healthy rat brain after stereotactic radiosurgery, which could be used to optimize the radiation treatment planning. METHODS: The primary somatosensory forelimb area (S1FL) and the primary motor cortex in the right hemisphere of Fischer rats (n = 6) were irradiated with a single dose of Gamma Knife radiation (Leksell Perfexion, Elekta AG, Stockholm, Sweden)...
November 10, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27833757/a-prospective-multicentre-single-arm-clinical-trial-of-bevacizumab-for-patients-with-surgically-untreatable-symptomatic-brain-radiation-necrosis-%C3%A2
#15
Motomasa Furuse, Naosuke Nonoguchi, Toshihiko Kuroiwa, Susumu Miyamoto, Yoshiki Arakawa, Jun Shinoda, Kazuhiro Miwa, Toshihiko Iuchi, Koji Tsuboi, Kiyohiro Houkin, Shunsuke Terasaka, Yusuke Tabei, Hideo Nakamura, Motoo Nagane, Kazuhiko Sugiyama, Mizuhiko Terasaki, Tatsuya Abe, Yoshitaka Narita, Nobuhito Saito, Akitake Mukasa, Kuniaki Ogasawara, Takaaki Beppu, Toshihiro Kumabe, Tadashi Nariai, Naohiro Tsuyuguchi, Eiji Nakatani, Shoko Kurisu, Yoko Nakagawa, Shin-Ichi Miyatake
BACKGROUND: Brain radiation necrosis (BRN) can be a complication of radiotherapy for primary and secondary brain tumors, as well as head and neck tumors. Since vascular endothelial growth factor (VEGF) is also a vascular permeability factor in the brain, bevacizumab, a humanized antibody that inhibits VEGF, would be expected to reduce perilesional edema that often accompanies BRN. METHODS: Patients with surgically untreatable, symptomatic BRN refractory to conventional medical treatments (eg, corticosteroid, anticoagulants, or hyperbaric oxygen therapy) were enrolled...
December 2016: Neuro-oncology Practice
https://www.readbyqxmd.com/read/27826659/fractionated-stereotactic-radiotherapy-for-metastatic-brain-tumors-that-recurred-after-gamma-knife-radiosurgery-results-in-acceptable-toxicity-and-favorable-local-control
#16
Akifumi Miyakawa, Yuta Shibamoto, Shinya Takemoto, Toru Serizawa, Shinya Otsuka, Tatsuo Hirai
BACKGROUND: To treat local recurrence of brain metastases after gamma knife radiosurgery (GKS), we have used fractionated stereotactic radiotherapy (SRT). The purpose of this study was to evaluate the efficacy and toxicity of SRT in these patients. METHODS: Fifty locally recurrent metastatic brain tumors in 47 patients were treated with SRT. The median prescribed dose of GKS was 20 Gy at the periphery. The median interval between the GKS (the last session in cases in which multiple GKS procedures were performed) and recurrence was 7...
November 8, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27818949/the-necrosis-avid-small-molecule-hq4-dtpa-as-a-multimodal-imaging-agent-for-monitoring-radiation-therapy-induced-tumor-cell-death
#17
Marieke A Stammes, Azusa Maeda, Jiachuan Bu, Deborah A Scollard, Iris Kulbatski, Philip J Medeiros, Riccardo Sinisi, Elena A Dubikovskaya, Thomas J A Snoeks, Ermond R van Beek, Alan B Chan, Clemens W G M Löwik, Ralph S DaCosta
PURPOSE: Most effective antitumor therapies induce tumor cell death. Non-invasive, rapid and accurate quantitative imaging of cell death is essential for monitoring early response to antitumor therapies. To facilitate this, we previously developed a biocompatible necrosis-avid near-infrared fluorescence (NIRF) imaging probe, HQ4, which was radiolabeled with (111)Indium-chloride ((111)In-Cl3) via the chelate diethylene triamine pentaacetic acid (DTPA), to enable clinical translation. The aim of the present study was to evaluate the application of HQ4-DTPA for monitoring tumor cell death induced by radiation therapy...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27816997/gamma-knife-radiosurgery-for-neurofibromatosis-type-2-associated-meningiomas-a-22-year-patient-series
#18
Brandon Birckhead, Terence T Sio, Bruce E Pollock, Michael J Link, Nadia N Laack
Neurofibromatosis type 2 (NF2) is a debilitating genetic condition with potential development of multiple meningiomas. We report our experience treating a series of NF2-associated intracranial meningiomas with Gamma Knife radiosurgery (GKRS). Between 1992 and 2013, 15 consecutive patients (age 20-54 years) with 62 intracranial meningiomas were treated with single-fraction GKRS. Fifty-five percent of tumors involved the convexity or parasagittal/falx. The median prescription dose was 16 Gy (range 13-20 Gy)...
November 5, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27816875/differentiation-of-recurrent-spinal-ependymoma-from-postradiation-treatment-necrosis-through-multiparametric-pet-mr-and-perfusion-mri
#19
Mojgan Hojjati, Vasant Garg, Chaitra A Badve, Salim E Abboud, Andrew E Sloan, Leo J Wolansky
A 67-year-old male presented with papilledema and back pain localized to the T10 level. Initial workup revealed multifocal spinal ependymoma which was resected and treated with external beam radiotherapy. Nine years after treatment, the patient had a relapse of back pain, and MRI was inconclusive in distinguishing posttreatment radiation necrosis from recurrent tumor. We present the first described report with the utilization of multiparametric positron emission tomography-magnetic resonance imaging and perfusion MRI to distinguish recurrent spinal ependymoma from radiation necrosis...
September 13, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27816646/hesperidin-ameliorates-uv-radiation-induced-skin-damage-by-abrogation-of-oxidative-stress-and-inflammatory-in-hacat-cells
#20
Min Li, Xiang-Fei Lin, Jie Lu, Bing-Rong Zhou, Dan Luo
Ultraviolet A (UVA) radiation contributes to skin photoaging. Hesperidin which is a flavanone glycoside found in citrus fruit peels, have been intensively studied for their UVA-protective activity, but its effects and mechanisms on UVA irradiation-induced inflammation and oxidative stress have never been described. Thus, the purpose of this study was to evaluate the effects of hesperidin in skin oxidative stress and inflammation induced by UVA irradiation. In this study, we firstly examined whether hesperidin may exert direct protective effects on the UVA-induced in human keratinocytes (HaCaT) cell injury in vitro...
November 1, 2016: Journal of Photochemistry and Photobiology. B, Biology
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