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Radiation necrosis

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https://www.readbyqxmd.com/read/28070162/contrast-enhanced-ultrasonography-in-evaluation-of-the-therapeutic-effect-of-chemotherapy-for-patients-with-liver-metastases
#1
Naoyuki Ueda, Haruki Nagira, Naoko Sannomiya, Saeko Ikunishi, Yuiko Hattori, Akira Kamida, Yuki Koyanagi, Kenta Shimabayashi, Kengo Sato, Hiroaki Saito, Yasuaki Hirooka
BACKGROUND: The therapeutic effect of chemotherapy for liver metastases is currently determined by changes in tumor diameter depicted on computed tomography (CT) and magnetic resonance imaging, but it cannot accurately determine if there is central necrosis. Furthermore, due to the risk of radiation exposure and high cost, frequent examination using these methods places a heavy burden on patients. Meanwhile, real-time observation of blood flow and vessel morphology within tumors has become possible by contrast-enhanced ultrasonography (CEUS)...
December 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/28060696/acute-pancreatitis-and-posterior-reversible-encephalopathy-syndrome-a-case-report
#2
Vítor Magno Pereira, Luís Marote Correia, Tiago Rodrigues, Gorete Serrão Faria
The posterior reversible encephalopathy syndrome is a neurological syndrome characterized by headache, confusion, visual disturbances and seizures associated with identifiable areas of cerebral edema on imaging studies. The authors report the case of a man, 33 years-old, leukodermic with a history of chronic alcohol and tobacco consumption, who is admitted to the emergency department for epigastric pain radiating to the back and vomiting with about six hours of evolution and an intense holocranial headache for two hours...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28049509/hyperbaric-oxygen-therapy-for-a-refractory-skin-ulcer-after-radical-mastectomy-and-radiation-therapy-a-case-report
#3
Mitsuhiro Enomoto, Kazuyoshi Yagishita, Kae Okuma, Takuya Oyaizu, Yasushi Kojima, Atsushi Okubo, Takuma Maeda, Satoko Miyamoto, Atsushi Okawa
BACKGROUND: Radiation therapy is performed as an adjuvant therapy when indicated following surgical resection of malignant tumors. However, radiation exposure induces acute or chronic dermatitis, depending on the radiation dose, interval, tissue volume, or irradiated area of the body. Radiation-induced skin ulcers and osteomyelitis of the underlying bone are intractable late-stage complications of radiation therapy, and often require reconstructive surgery to cover exposed tissue. Hyperbaric oxygen therapy has been suggested as a treatment for delayed radiation injury with soft tissue and bony necrosis...
January 4, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28048017/tu-d-207b-01-a-prediction-model-for-distinguishing-radiation-necrosis-from-tumor-progression-after-gamma-knife-radiosurgery-based-on-radiomics-features-from-mr-images
#4
Z Zhang, A Ho, X Wang, P Brown, N Guha-Thakurta, S Ferguson, X Fave, L Zhang, D Mackin, L Court, J Li, J Yang
PURPOSE: To develop and validate a prediction model using radiomics features extracted from MR images to distinguish radiation necrosis from tumor progression for brain metastases treated with Gamma knife radiosurgery. METHODS: The images used to develop the model were T1 post-contrast MR scans from 71 patients who had had pathologic confirmation of necrosis or progression; 1 lesion was identified per patient (17 necrosis and 54 progression). Radiomics features were extracted from 2 images at 2 time points per patient, both obtained prior to resection...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047600/we-fg-202-11-longitudinal-diffusion-mri-for-treatment-assessment-of-sarcoma-patients-with-pre-operative-radiation-therapy
#5
Y Yang, M Cao, M Kamrava, D Low, K Sheng, J Lamb, N Agazaryan, D Thomas, P Hu
PURPOSE: Diffusion weighted MRI (DWI) is a promising imaging technique for early prediction of tumor response to radiation therapy. A recently proposed longitudinal DWI strategy using a Co-60 MRI guided RT system (MRIgRT) may bring functional MRI guided adaptive radiation therapy closer to clinical utility. We report our preliminary results of using this longitudinal DWI approach performed on the MRIgRT system for predicting the response of sarcoma patient to preop RT. METHODS: Three sarcoma patients who underwent fractionated IMRT were recruited in this study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047547/su-f-t-647-linac-based-stereotactic-radiosurgery-srs-in-the-treatment-of-trigeminal-neuralgia-detailed-description-of-srs-procedural-technique-and-reported-clinical-outcomes
#6
D Pokhrel, S Sood, R Badkul, H Jiang, T Stepp, P Camarata, F Wang
PURPOSE: SRS is an effective non-invasive alternative treatment modality with minimal-toxicity used to treat patients with medically/surgically refractory trigeminal neuralgia root(TNR) or those who may not tolerate surgical intervention. We present our linac-based SRS procedure for TNR treatment and simultaneously report our clinical outcomes. METHODS: Twenty-eight TNR-patients treated with frame-based SRS at our institution (2009-2015) with a single-fraction point-dose of 60-80Gy to TNR were included in this IRB-approved study...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046583/su-f-t-323-a-post-mastectomy-radiation-therapy-dose-distribution-study-using-nanodots-and-films
#7
X Qian, K Vaidya, L Puckett, S Souri, Y Chen, Y Cao, A Jamshidi, L Lee, E Klein, F Diaz
PURPOSE: In post-mastectomy radiation therapy (RT), skin dose must be accurately estimated to assess skin reactions such as erythema, desquamation and necrosis. Planning systems cannot always provide accurate dosimetry for target volumes distal to skin. Therefore, in-vivo dosimetry is necessary. A female anthropomorphic phantom was used with optically stimulated luminescence dosimeters (nanoDots) to measure dose to chest wall skin. In addition, EBT2 films was employed to measure dose to left lung and heart in post-mastectomy RT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046320/we-fg-206-06-dual-input-tracer-kinetic-modeling-and-its-analog-implementation-for-dynamic-contrast-enhanced-dce-mri-of-malignant-mesothelioma-mpm
#8
S Lee, A Rimner, S Hayes, M Hunt, J Deasy, M Zauderer, V Rusch, N Tyagi
PURPOSE: To use dual-input tracer kinetic modeling of the lung for mapping spatial heterogeneity of various kinetic parameters in malignant MPM METHODS: Six MPM patients received DCE-MRI as part of their radiation therapy simulation scan. 5 patients had the epitheloid subtype of MPM, while one was biphasic. A 3D fast-field echo sequence with TR/TE/Flip angle of 3.62ms/1.69ms/15° was used for DCE-MRI acquisition. The scan was collected for 5 minutes with a temporal resolution of 5ߝ9 seconds depending on the spatial extent of the tumor...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046259/su-g-tep3-12-retrospective-assessment-of-r2star-using-ultra-high-field-mri-in-a-rodent-model-of-radiation-necrosis
#9
J Belliveau, R Menon
PURPOSE: To establish a quantitative MRI method that would be capable of predicting radiation necrosis without using a contrast agent. METHODS: Healthy male Fischer 344 rats were irradiated using an animal irradiator capable of delivering 2.3 Gy/min with a kVp of 225 V. A dose of 40 Gy was given to half the brain in a single session. Rats were scanned using a 9.4 T animal MRI before irradiation and every two weeks following radiation until either necrosis developed or they were sacrificed for health reasons...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046212/su-f-t-677-synergistic-effect-s-of-clotrimazole-on-radiation-cell-survival-of-a549-lung-cancer-cells-in-glucose-vs-galactose-media
#10
G Boss, M Tambasco, M Garakani
PURPOSE: In order to determine the synergistic effect of clotrimazole on radiosensitivity of A549 lung cancer cells, and the effect of oxidative pathways on modulating radiosensitivity, we studied how these cells survived under varying amounts of radiation and clotrimazole as well ass when glucose was switched for galactose media. METHODS: The glucose media was used to determine the presence of any synergistic effect of clotrimazole on radiation using values of radiation and clotrimazole concentrations, varying from 0 - 8 Gy and 0 - 20 µM, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045034/premature-senescence-of-endothelial-cells-upon-chronic-exposure-to-tnf%C3%AE-can-be-prevented-by-n-acetyl-cysteine-and-plumericin
#11
Shafaat Y Khan, Ezzat M Awad, Andre Oszwald, Manuel Mayr, Xiaoke Yin, Birgit Waltenberger, Hermann Stuppner, Markus Lipovac, Pavel Uhrin, Johannes M Breuss
Cellular senescence is characterized by a permanent cell-cycle arrest and a pro-inflammatory secretory phenotype, and can be induced by a variety of stimuli, including ionizing radiation, oxidative stress, and inflammation. In endothelial cells, this phenomenon might contribute to vascular disease. Plasma levels of the inflammatory cytokine tumor necrosis factor alpha (TNFα) are increased in age-related and chronic conditions such as atherosclerosis, rheumatoid arthritis, psoriasis, and Crohn's disease. Although TNFα is a known activator of the central inflammatory mediator NF-κB, and can induce the intracellular generation of reactive oxygen species (ROS), the question whether TNFα can induce senescence has not been answered conclusively...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28040452/delay-techniques-for-nipple-sparing-mastectomy-a-systematic-review
#12
REVIEW
Laurel S Karian, Paul J Therattil, Philip D Wey, Kevin T Nini
BACKGROUND: Rare but serious complications of nipple-sparing mastectomy (NSM) include necrosis of the nipple-areolar complex (NAC) and mastectomy skin flaps. NAC and mastectomy flap delay procedures are novel techniques designed to avoid these complications and may be combined with retroareolar biopsy as a first-stage procedure. We performed a systematic review of the literature to evaluate various techniques for NAC and mastectomy flap delay. METHODS: PubMed and Cochrane databases were searched from January 1975 through April 15, 2016...
November 29, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28039268/therapeutic-small-molecules-target-inhibitor-of-apoptosis-proteins-in-cancers-with-deregulation-of-extrinsic-and-intrinsic-cell-death-pathways
#13
Adeeb Derakhshan, Zhong Chen, Carter Van Waes
The Cancer Genome Atlas (TCGA) has unveiled genomic deregulation of various components of the extrinsic and intrinsic apoptotic pathways in different types of cancers. Such alterations are particularly common in head and neck squamous cell carcinomas (HNSCC), which frequently display amplification and overexpression of the Fas-associated via death domain (FADD) and inhibitor of apoptosis proteins (IAPs), that complex with members of the tumor necrosis factor (TNF) receptor family. SMAC mimetics, modeled after the endogenous IAP antagonist second mitochondria-derived activator of caspases (SMAC), and IAP inhibitors, represent important classes of novel small-molecules currently in phase I/II clinical trials...
December 30, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28031515/percutaneous-radiofrequency-ablation-for-osteoid-osteoma-under-guidance-of-threedimensional-fluoroscopy
#14
Yavuz Arıkan, Umut Yavuz, Osman Lapcin, Sami Sökücü, Bilge Özkan, Yavuz Kabukçuoğlu
PURPOSE: To evaluate the outcome of percutaneous radiofrequency ablation under guidance of 3-dimensional fluoroscopy in 17 patients with osteoid osteoma. METHODS: Records of 11 male and 6 female consecutive patients aged 4 to 28 (mean, 13.8) years who underwent radiofrequency ablation under guidance of 3-dimensional fluoroscopy for osteoid osteoma and were followed up for a mean of 15.8 (range, 12-28) months were reviewed. All patients had been treated with analgesics but failed to achieve lasting pain relief...
December 2016: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28003769/chronic-radiation-induced-dermatitis-challenges-and-solutions
#15
REVIEW
Mateusz Spałek
Chronic radiation dermatitis is a late side effect of skin irradiation, which may deteriorate patients' quality of life. There is a lack of precise data about its incidence; however, several risk factors may predispose to the development of this condition. It includes radiotherapy dose, fractionation, technique, concurrent systemic therapy, comorbidities, and personal and genetic factors. Chronic radiation dermatitis is mostly caused by the imbalance of proinflammatory and profibrotic cytokines. Clinical manifestation includes changes in skin appearance, wounds, ulcerations, necrosis, fibrosis, and secondary cancers...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28001907/ionizing-radiation-induces-innate-immune-responses-in-macrophages-by-generation-of-mitochondrial-reactive-oxygen-species
#16
Sup Kim, Jin Ho Choe, Gippeum Joy Lee, Yi Sak Kim, Soo Yeon Kim, Hye-Mi Lee, Hyo Sun Jin, Tae Sung Kim, Jin-Man Kim, Moon-June Cho, Eui-Cheol Shin, Eun-Kyeong Jo, Jun-Sang Kim
During radiotherapy for tumors, the innate immune system also responds to ionizing radiation and induces immune modulation. However, little is known about the molecular mechanisms by which radiation modulates innate immune responses. In this study, we observed that radiation triggered the generation of mitochondrial reactive oxygen species (mROS), leading to innate immune responses in murine bone marrow-derived macrophages (BMDM). Radiation-induced mROS was essential for robust induction of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-12p40 mRNA and protein in BMDM...
December 21, 2016: Radiation Research
https://www.readbyqxmd.com/read/28000105/comparing-pre-operative-stereotactic-radiosurgery-srs-to-post-operative-whole-brain-radiation-therapy-wbrt-for-resectable-brain-metastases-a-multi-institutional-analysis
#17
Kirtesh R Patel, Stuart H Burri, Danielle Boselli, James T Symanowski, Anthony L Asher, Ashley Sumrall, Robert W Fraser, Robert H Press, Jim Zhong, Richard J Cassidy, Jeffrey J Olson, Walter J Curran, Hui-Kuo G Shu, Ian R Crocker, Roshan S Prabhu
Pre-operative stereotactic radiosurgery (pre-SRS) has been shown as a viable treatment option for resectable brain metastases (BM). The aim of this study is to compare oncologic outcomes and toxicities for pre-SRS and post-operative WBRT (post-WBRT) for resectable BM. We reviewed records of consecutive patients who underwent resection of BM and either pre-SRS or post-WBRT between 2005 and 2013 at two institutions. Overall survival (OS) was calculated using the Kaplan-Meier method. Cumulative incidence was used for intracranial outcomes...
December 20, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27998887/first-in-human-study-testing-a-new-radioenhancer-using-nanoparticles-nbtxr3-activated-by-radiation-therapy-in-patients-with-locally-advanced-soft-tissue-sarcomas
#18
Sylvie Bonvalot, Cécile Le Pechoux, Thierry De Baere, Guy Kantor, Xavier Buy, Eberhard Stoeckle, Philippe Terrier, Paul Sargos, Jean Michel Coindre, Nathalie Lassau, Rafik Ait Sarkouh, Mikaela Dimitriu, Elsa Borghi, Laurent Levy, Eric Deutsch, Jean-Charles Soria
PURPOSE: This phase I study aimed to determine the recommended dose (RD), safety profile, and feasibility of a procedure combining intratumoral injection of hafnium oxide nanoparticles (NBTXR3; a radioenhancer) and external beam radiotherapy (EBRT) for preoperative treatment of adults with locally advanced soft tissue sarcoma (STS). EXPERIMENTAL DESIGN: Patients had a preoperative indication of EBRT for STS of the extremity or trunk. Baseline tumor volume (TV) was calculated by MRI...
October 6, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27995546/preliminary-experience-of-the-concurrent-use-of-radiosurgery-and-t-dm1-for-brain-metastases-in-her2-positive-metastatic-breast-cancer
#19
Arthur Geraud, Hao Ping Xu, Philippe Beuzeboc, Youlia M Kirova
This is preliminary study assessing the efficacy and safety of concurrent use of radiation therapy (RT) and T-DM1 for the treatment of brain metastases (BM) in patients with HER2-positive metastatic breast cancer (BC). We retrospectively studied 12 patients treated for BM at the Institut Curie in 2014-2015 with T-DM1 and concurrent (4) or sequential (8) radiosurgery with or without whole brain irradiation. The following variables were studied: local control, clinical and radiological response as well as early and late side effects...
December 19, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27995119/fibular-flap-for-mandible-reconstruction-in-osteoradionecrosis-of-the-jaw-selection-criteria-of-fibula-flap
#20
Ji-Wan Kim, Jong-Hyun Hwang, Kang-Min Ahn
BACKGROUND: Osteoradionecrosis is the most dreadful complication after head and neck irradiation. Orocutaneous fistula makes patients difficult to eat food. Fibular free flap is the choice of the flap for mandibular reconstruction. Osteocutaneous flap can reconstruct both hard and soft tissues simultaneously. This study was to investigate the success rate and results of the free fibular flap for osteoradionecrosis of the mandible and which side of the flap should be harvested for better reconstruction...
December 2016: Maxillofacial Plastic and Reconstructive Surgery
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