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Radiation necrosis

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https://www.readbyqxmd.com/read/28627990/systemic-metastases-from-central-nervous-system-ependymoma-case-report-and-review-of-the-literature
#1
Claudia Marsecano, Federico Bruno, Giulia Michelini, Marco Perri, Giuseppe Calvisi, Ernesto Di Cesare, Alessandra Splendiani
Ependymal tumours in adults are rare, accounting for less than 4% of primary tumours of the central nervous system, and exceptionally metastasise outside the nervous system. In this study, we present a case of anaplastic ependymoma, which developed metastases outside the nervous system less than a year after its clinical onset. A healthy 65-year-old woman suddenly presented with drowsiness of unknown origin, accompanied by ingravescent fatigue, inability to maintain the upright posture, headache, nausea and vomiting...
June 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28623401/biomarkers-in-the-assessment-of-oral-mucositis-in-head-and-neck-cancer-patients-a-systematic-review-and-meta-analysis
#2
REVIEW
Ana Gabriela Costa Normando, Camila Lopes Rocha, Isabela Porto de Toledo, Paulo Tadeu de Souza Figueiredo, Paula Elaine Diniz Dos Reis, Graziela De Luca Canto, Eliete Neves Silva Guerra
PURPOSE: The aim of this study was to evaluate the capability of biomarkers to predict the risk of oral mucositis in head and neck cancer patients, as well as to assess the correlation between these biomarkers and the severity of mucositis. METHODS: The search was performed at LILACS, PubMed, Science Direct, Scopus, and Web of Science. A search of the gray literature was performed on Google Scholar, OpenGrey, and ProQuest. The methodological quality of the included studies was assessed using the Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) tool, and the evidence quality was assessed by the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) system...
June 16, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28619837/differentiation-between-treatment-induced-necrosis-and-recurrent-tumors-in-patients-with-metastatic-brain-tumors-comparison-among-11-c-methionine-pet-fdg-pet-mr-permeability-imaging-and-mri-adc-preliminary-results
#3
N Tomura, M Kokubun, T Saginoya, Y Mizuno, Y Kikuchi
BACKGROUND AND PURPOSE: In patients with metastatic brain tumors after gamma knife radiosurgery, the superiority of PET using (11)C-methionine for differentiating radiation necrosis and recurrent tumors has been accepted. To evaluate the feasibility of MR permea- bility imaging, it was compared with PET using (11)C-methionine, FDG-PET, and DWI for differentiating radiation necrosis from recurrent tumors. MATERIALS AND METHODS: The study analyzed 18 lesions from 15 patients with metastatic brain tumors who underwent gamma knife radiosurgery...
June 15, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28619755/epidermal-growth-factor-receptor-egfr-targeted-photoimmunotherapy-pit-for-the-treatment-of-egfr-expressing-bladder-cancer
#4
Reema Railkar, L Spencer Krane, Q Quentin Li, Thomas Sanford, Mohammad Rashid Siddiqui, Diana Haines, Srinivas Vourganti, Sam J Brancato, Peter L Choyke, Hisataka Kobayashi, Piyush K Agarwal
The use of light as a means of therapy for bladder cancer (BC) has a long history but has been hampered by a lack of tumor specificity and therefore, damage to the normal bladder mucosa. Here, we describe a targeted form of photo-therapy called photoimmunotherapy (PIT) which targets EGFR-expressing BC. Anti-EGFR antibody panitumumab (pan) was labeled with the photo-absorber (PA), IRDye 700Dx (IR700), to create a pan IR700 antibody-PA conjugate which is activated by near-infrared radiation (NIR). BC tissue microarray (TMA) and BC cell lines were analyzed for expression of EGFR...
June 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28609551/chronic-exposure-to-tetracyclines-and-subsequent-diagnosis-for-non-melanoma-skin-cancer-in-a-large-midwestern-u-s-patient-population
#5
P P Vakharia, B Nardone, B J Schlosser, D Lee, L Serrano, D P West
Tetracyclines (TCNs) are commonly used in the management of several chronic dermatological disorders, partly due to their affinity for inflamed skin tissue, as they are known to suppress cytokines including tumor necrosis factor-alpha and interleukin-6 that are typically involved in inflammatory skin disorders.(1) TCNs are known to be photoreactive following ultraviolet (UV) radiation exposure, a known risk factor for the development of nonmelanoma skin cancer (NMSC), notably basal cell carcinoma (BCC) and squamous cell carcinoma (SCC)...
June 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28603525/modulating-both-tumor-cell-death-and-innate-immunity-is-essential-for-improving-radiation-therapy-effectiveness
#6
REVIEW
Qiuji Wu, Awatef Allouch, Isabelle Martins, Catherine Brenner, Nazanine Modjtahedi, Eric Deutsch, Jean-Luc Perfettini
Radiation therapy is one of the cornerstones of cancer treatment. In tumor cells, exposure to ionizing radiation (IR) provokes DNA damages that trigger various forms of cell death such as apoptosis, necrosis, autophagic cell death, and mitotic catastrophe. IR can also induce cellular senescence that could serve as an additional antitumor barrier in a context-dependent manner. Moreover, accumulating evidence has demonstrated that IR interacts profoundly with tumor-infiltrating immune cells, which cooperatively drive treatment outcomes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28599998/-pet-scan-and-nmr-spectroscopy-for-the-differential-diagnosis-between-brain-radiation-necrosis-and-tumour-recurrence-after-stereotactic-irradiation-of-brain-metastases-place-in-the-decision-tree
#7
I Menoux, G Noël, I Namer, D Antoni
PURPOSE: After stereotactic radiation therapy for brain metastases, one of the complications is radionecrosis. Differential diagnosis with tumour recurrence can be helped by different methods of imaging, although histology remains the gold standard. According to the treatment centres, practice diverges. The objective of this single-centre retrospective study was to define the power of MRI, PET scan and NMR spectroscopy to establish a decision tree. MATERIAL AND METHODS: This study included patients who underwent stereotactic radiation therapy for brain metastases, and required, during follow-up, both a PET scan and NMR spectroscopy in order to differentiate a radiation necrosis and tumour recurrence...
June 6, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28599843/psychiatric-care-of-the-radiation-oncology-patient
#8
REVIEW
Emily G Holmes, Jordan A Holmes, Eliza M Park
BACKGROUND: In recent decades, psychiatrists have become increasingly involved in the care of patients with cancer. Psychiatrists are often less familiar with the field of radiation oncology than with other medical specialties. OBJECTIVE: Therefore, it is beneficial for consulting psychiatrists to be familiar with the basic principles of radiation therapy (RT) and its potential neuropsychiatric sequelae. METHODS: We performed a PubMed search to identify articles describing neuropsychiatric symptoms resulting from RT, including anxiety, claustrophobia, posttraumatic stress disorder, and neurocognitive impairment...
April 15, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28595034/preclinical-and-clinical-studies-of-coriolus-versicolor-polysaccharopeptide-as-an-immunotherapeutic-in-china
#9
Yajing Chang, Meng Zhang, Yifei Jiang, Yong Liu, Heng Luo, Cui Hao, Pengjiao Zeng, Lijuan Zhang
Conventional cancer treatments include surgery, chemotherapy, and radiation therapy. In recent years, immunotherapy in cancer care has been gaining momentum. Interestingly, an immunotherapeutic regime that employs polysaccharopeptide (PSP), a unique peptide-containing polysaccharide isolated from Coriolus versicolor, has already become a routine clinical practice in Japan since 1977 and in China since 1987. Coriolus versicolor is one of the most well-known traditional food and medicinal mushrooms in China for thousands of years...
April 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28593488/optimizing-patient-selection-for-direct-to-implant-immediate-breast-reconstruction-using-wise-pattern-skin-reducing-mastectomy-in-large-and-ptotic-breasts
#10
Amir Inbal, Eyal Gur, Benjamin T Lemelman, Daphna Barsuk, Tehilla Menes, David Leshem, Yoav Barnea
BACKGROUND: Immediate breast reconstruction in large and ptotic breasts is challenging, often requiring skin-reducing procedures. The Wise-pattern skin-reducing mastectomy (WPSRM) technique provides reliable one-stage implant coverage using the pectoralis muscle and a de-epithelialized inferiorly based dermal flap. However, de-vascularization may result in mastectomy skin flap necrosis. We aimed to critically evaluate and isolate patients at high risk of complications using this procedure...
June 7, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28591062/extracranial-bone-metastases-from-recurrent-anaplastic-astrocytoma-on-fdg-pet-ct-a-case-report-a-care-compliant-article
#11
Zu-Gui Li, Hai-Yu Mu
OBJECTIVE: Extracranial bone metastases from astrocytoma are rare and frequently detected as part of multiorgan metastases. It is extremely rare for astrocytoma to have extracranial bone metastases alone. The importance of whole-body fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging in evaluating extracranial metastasis (ECMs) has not been described effectively due to the rarity of this event. The purpose of our case report is to emphasize the role of FDG PET/CT in the assessment of tumor recurrence and extracranial bone metastases from anaplastic astrocytoma...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28586960/preliminary-results-of-a-phase-1-dose-escalation-trial-for-early-stage-breast-cancer-using-5-fraction-stereotactic-body-radiation-therapy-for-partial-breast-irradiation
#12
Asal Rahimi, Kimberly Thomas, Ann Spangler, Roshni Rao, Marilyn Leitch, Rachel Wooldridge, Aeisha Rivers, Stephen Seiler, Kevin Albuquerque, Stella Stevenson, Sally Goudreau, Dan Garwood, Barbara Haley, David Euhus, John Heinzerling, Chuxiong Ding, Ang Gao, Chul Ahn, Robert Timmerman
PURPOSE: To evaluate the tolerability of a dose-escalated 5-fraction stereotactic body radiation therapy for partial-breast irradiation (S-PBI) in treating early-stage breast cancer after partial mastectomy; the primary objective was to escalate dose utilizing a robotic stereotactic radiation system treating the lumpectomy cavity without exceeding the maximum tolerated dose. METHODS AND MATERIALS: Eligible patients included those with ductal carcinoma in situ or invasive nonlobular epithelial histologies and stage 0, I, or II, with tumor size <3 cm...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28577030/stereotactic-radiosurgery-for-small-brain-metastases-and-implications-regarding-management-with-systemic-therapy-alone
#13
Daniel M Trifiletti, Colin Hill, Or Cohen-Inbar, Zhiyuan Xu, Jason P Sheehan
While stereotactic radiosurgery (SRS) has been shown effective in the management of brain metastases, small brain metastases (≤10 mm) can pose unique challenges. Our aim was to investigate the efficacy of SRS in the treatment of small brain metastases, as well as elucidate clinically relevant factors impacting local failure (LF). We utilized a large, single-institution cohort to perform a retrospective analysis of patients with brain metastases up to 1 cm in maximal dimension. Clinical and radiosurgical parameters were investigated for an association with LF and compared using a competing risk model to calculate cumulative incidence functions, with death and whole brain radiotherapy serving as competing risks...
June 2, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28567329/carcinosarcoma-of-the-tunica-vaginalis-following-radiation-therapy-for-localized-prostate-cancer
#14
Charles D Viers, Subodh M Lele, Tara Kirkpatrick, Chad A LaGrange
Spermatic cord tumors (SCTs) are rare neoplasms with 80% exhibiting benign pathology. Of the malignant SCTs, 90% are sarcomas. To date there has only been one documented case of primary CS of the spermatic cord which occurred in a 40 year old with no reported medical history. A 76-year-old male with a history of biopsy proven Gleason score 7 (3 + 4) prostatic adenocarcinoma underwent external beam radiation therapy (7920 cGy) in 44 fractions in 2004. He presented with a 3 year history of an asymptomatic right hydrocele...
July 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28560406/silencing-of-atm-expression-by-sirna-technique-contributes-to-glioma-stem-cell-radiosensitivity-in-vitro-and-in-vivo
#15
Yan Li, Luchun Li, Zhijuan Wu, Lulu Wang, Yongzhong Wu, Dairong Li, Uiwen Ma, Jianghe Shao, Huiqing Yu, Donglin Wang
Evidence has shown that both high expression of the ataxia-telangiectasia mutated (ATM) gene and glioma stem cells (GSCs) are responsible for radioresistance in glioma. Thus, we hypothesized that brain tumor radiosensitivity may be enhanced via silencing of the ATM gene in GSCs. In the present study we successfully induced GSCs from two cell lines and used CD133 and nestin to identify GSCs. A lentivirus was used to deliver siRNA-ATMPuro (A group) to GSCs prior to radiation, while siRNA-HKPuro (N group) and GSCs (C group) were used as negative and blank controls, respectively...
May 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28560022/combined-tram-flap-with-latissimus-dorsi-myocutaneous-flap-for-reconstruction-of-a-large-breast-post-radiation-induced-necrosis
#16
Ahmed Al Maksoud, Mohammed Moneer, Adel K Barsoum
Radiation therapy is a critical component of breast cancer management following breast-conserving surgery. Post-radiation sequelae are greater in women with larger breasts, given the need for higher doses and dosing heterogeneity. The goal of breast reconstruction post-mastectomy is to improve the quality of life and add no more health risk. The optimal reconstruction should make the patient feel as natural as possible. Reconstruction of a large-sized breast with aesthetically satisfactory outcome poses a challenge to the breast surgeon...
May 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28559202/inhibitory-effects-of-rosmarinic-acid-on-pterygium-epithelial-cells-through-redox-imbalance-and-induction-of-extrinsic-and-intrinsic-apoptosis
#17
Ya-Yu Chen, Chia-Fang Tsai, Ming-Chu Tsai, Yu-Wen Hsu, Fung-Jou Lu
Pterygium is a common tumor-like ocular disease, which may be related to exposure to chronic ultraviolet (UV) radiation. Although the standard treatment for pterygium is surgical intervention, the recurrence rate of pterygium is high when no effective inhibitory drug is used after surgery. Rosmarinic acid (RA) is a polyphenol antioxidant with many biological activities, including anti-UV and anti-tumor properties. This study aimed to examine the inhibitory effects of RA on pterygium epithelial cells (PECs)...
May 27, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28555423/improving-the-utility-of-1-h-mrs-for-the-differentiation-of-glioma-recurrence-from-radiation-necrosis
#18
Ian D Crain, Petra S Elias, Kristina Chapple, Adrienne C Scheck, John P Karis, Mark C Preul
Proton magnetic resonance spectroscopy ((1)H-MRS) has shown promise in distinguishing recurrent high-grade glioma from posttreatment radiation effect (PTRE). The purpose of this study was to establish objective (1)H-MRS criteria based on metabolite peak height ratios to distinguish recurrent tumor (RT) from PTRE. A retrospective analysis of magnetic resonance imaging and (1)H-MRS data was performed. Spectral metabolites analyzed included N-acetylaspartate, choline (Cho), creatine (Cr), lactate (Lac), and lipids (Lip)...
May 29, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28551851/the-ratio-of-hla-dr-and-vnn2-expression-on-cd14-myeloid-derived-suppressor-cells-can-distinguish-glioblastoma-from-radiation-necrosis-patients
#19
David C Soler, Andrew B Young, Kevin D Cooper, Amber Kerstetter-Fogle, Jill S Barnholtz-Sloan, Haley Gittleman, Thomas S McCormick, Andrew E Sloan
Glioblastoma (GBM) is the most aggressive and lethal type of brain cancer with a median survival of less than two years even following aggressive treatment (Stupp et al., N Engl J Med 352:987-996, 2005). Among the many challenges in treating patients with this devastating disease is the ability to differentiate Magnetic Resonance Imaging (MRI) images that appear following radiation therapy, often termed "radiation necrosis" from true GBM recurrence. Radiation necrosis (RN) and GBM are very difficult to distinguish and currently only a brain biopsy can conclusively differentiate these pathologies...
May 27, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28548957/involvement-of-p38-%C3%AE-trcp-tristetraprolin-tnf%C3%AE-axis-in-radiation-pneumonitis
#20
Pranathi Meda Krishnamurthy, Shirish Shukla, Paramita Ray, Rohit Mehra, Mukesh K Nyati, Theodore S Lawrence, Dipankar Ray
Early release of tumor necrosis factor-alpha (TNF-α) during radiotherapy of thoracic cancers plays an important role in radiation pneumonitis, whose inhibition may provide lung radioprotection. We previously reported radiation inactivates Tristetraprolin (TTP), a negative regulator of TNF-α synthesis, which correlated with increased TNF-α release. However, the molecular events involved in radiation-induced TTP inactivation remain unclear. To determine if eliminating Ttp in mice resulted in a phenotypic response to radiation, Ttp-null mice lungs were exposed to a single dose of 15 Gy, and TNF-α release and lung inflammation were analyzed at different time points post-irradiation...
May 10, 2017: Oncotarget
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