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Radiation necrosis

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https://www.readbyqxmd.com/read/28447147/diffusion-kurtosis-as-an-in-vivo-imaging-marker-of-early-radiation-induced-changes-in-radiation-induced-temporal-lobe-necrosis-in-nasopharyngeal-carcinoma-patients
#1
Lu Liyan, Wang Si, Wang Qian, Shao Yuhui, Wei Xiaoer, Li Yuehua, Li Wenbin
PURPOSE: Diffusion kurtosis imaging (DKI), an extension of the popular diffusion tensor imaging (DTI) model, has been applied in clinical studies of brain tissue changes. We explored the value of DKI for the early detection of radiation-induced changes in temporal lobe necrosis (TLN) after radiotherapy (RT) for nasopharyngeal carcinoma (NPC). METHODS: A total of 400 patients with NPC were retrospectively enrolled; all participants underwent MRI scans 0-7 days before RT, at 4 weeks during RT, and 1 month after completing RT...
April 26, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28443515/indication-of-bevacizumab-for-cerebral-radiation-necrosis
#2
Hongqing Zhuang, Xiangkun Yuan, Zhiyong Yuan, Ping Wang
BACKGROUND: The effect of bevacizumab (BVZ) for cerebral radiation necrosis (CRN) was clear. However, the indications of BVZ had no reports. OBJECTIVE: The aim of the paper was to investigate the indications of BVZ for CRN. METHODS: Fourteen CRN patients (confirmed by imaging diagnosis)who underwent BVZ treatment between June 2011 and December 2014 were analyzed. BVZ was administered (5 mg/kg body weight) once every three to four weeks for at least three cycles...
April 25, 2017: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/28438965/radiation-induces-proinflammatory-dysbiosis-transmission-of-inflammatory-susceptibility-by-host-cytokine-induction
#3
Shiran Gerassy-Vainberg, Alexandra Blatt, Yael Danin-Poleg, Katya Gershovich, Edmond Sabo, Alex Nevelsky, Shahar Daniel, Aviva Dahan, Oren Ziv, Rishu Dheer, Maria T Abreu, Omry Koren, Yechezkel Kashi, Yehuda Chowers
OBJECTIVE: Radiation proctitis (RP) is a complication of pelvic radiotherapy which affects both the host and microbiota. Herein we assessed the radiation effect on microbiota and its relationship to tissue damage using a rectal radiation mouse model. DESIGN: We evaluated luminal and mucosa-associated dysbiosis in irradiated and control mice at two postradiation time points and correlated it with clinical and immunological parameters. Epithelial cytokine response was evaluated using bacterial-epithelial co-cultures...
April 24, 2017: Gut
https://www.readbyqxmd.com/read/28438396/the-versatile-use-of-revisited-de-epithelialization-concept-in-superficial-circumflex-iliac-and-anterolateral-thigh-perforator-free-flap-for-head-and-neck-reconstructions
#4
Jong Woo Choi, Young Chul Kim, Tae Suk Oh, Kyung S Koh, Woo Shik Jeong
BACKGROUND: Although the perforator free flap is now a standard choice for head and neck reconstruction, problems such as microvascular complications, insufficient volume support for the defect, and fistula formation occur. We revisited a de-epithelialized concept for superficial circumflex iliac artery and anterolateral thigh perforator free flap to overcome these problems. METHODS: We applied the de-epithelized perforator free flaps in 35 cases among 761 microsurgical head and neck reconstructions and investigated flap characteristics (length gain of pedicle, flap size, and volumetric analysis) and outcomes (flap failure, partial flap necrosis, hematoma, infection, and fistula)...
February 20, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28434110/the-risk-of-radiation-necrosis-following-stereotactic-radiosurgery-with-concurrent-systemic-therapies
#5
Joseph M Kim, Jacob A Miller, Rupesh Kotecha, Roy Xiao, Aditya Juloori, Matthew C Ward, Manmeet S Ahluwalia, Alireza M Mohammadi, David M Peereboom, Erin S Murphy, John H Suh, Gene H Barnett, Michael A Vogelbaum, Lilyana Angelov, Glen H Stevens, Samuel T Chao
To investigate late toxicity among patients with newly-diagnosed brain metastases undergoing stereotactic radiosurgery (SRS) with concurrent systemic therapies with or without whole-brain radiation therapy (WBRT). Patients with newly-diagnosed brain metastasis who underwent SRS at a single tertiary-care institution from 1997 to 2015 were eligible for inclusion. The class and timing of all systemic therapies were collected for each patient. The primary outcome was the cumulative incidence of radiographic radiation necrosis (RN)...
April 22, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28430714/ultrasound-molecular-imaging-of-inflammation-in-mouse-abdominal-aorta
#6
Shiying Wang, Sunil Unnikrishnan, Elizabeth B Herbst, Alexander L Klibanov, Frank William Mauldin, John A Hossack
OBJECTIVES: The aim of this study was to demonstrate a new clinically translatable ultrasound molecular imaging approach, modulated acoustic radiation force-based imaging, which is capable of rapid and reliable detection of inflammation as validated in mouse abdominal aorta. MATERIALS AND METHODS: Animal studies were approved by the Institutional Animal Care and Use Committee at the University of Virginia. C57BL/6 mice stimulated with tumor necrosis factor α, or fed with a high-fat diet, were used as inflammation (MInflammation) and diet-induced obesity (DIO) (MDIO) models, respectively...
April 20, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28425047/can-anti-vascular-endothelial-growth-factor-antibody-reverse-radiation-necrosis-a-preclinical-investigation
#7
Chong Duan, Carlos J Perez-Torres, Liya Yuan, John A Engelbach, Scott C Beeman, Christina I Tsien, Keith M Rich, Robert E Schmidt, Joseph J H Ackerman, Joel R Garbow
Anti-vascular endothelial growth factor (anti-VEGF) antibodies are a promising new treatment for late time-to-onset radiation-induced necrosis (RN). We sought to evaluate and validate the response to anti-VEGF antibody in a mouse model of RN. Mice were irradiated with the Leksell Gamma Knife Perfexion™ and then treated with anti-VEGF antibody, beginning at post-irradiation (PIR) week 8. RN progression was monitored via anatomic and diffusion MRI from weeks 4-12 PIR. Standard histology, using haematoxylin and eosin (H&E), and immunohistochemistry staining were used to validate the response to treatment...
April 19, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28419284/laser-thermal-ablation-for-metastases-failing-radiosurgery-a-multicentered-retrospective-study
#8
Tafadzwa L Chaunzwa, Di Deng, Eric C Leuthardt, Stephen B Tatter, Alireda M Mohammadi, Gene H Barnett, Veronica L Chiang
BACKGROUND: Radiosurgical failure following stereotactic radiosurgery for brain metastases can be attributed to tumor regrowth or radiation necrosis. MRI-guided laser thermal ablation (LTA) therapy has emerged as an option for treatment; however, previous literature demonstrates variable results across centers. OBJECTIVE: To assess the outcomes of LTA in the treatment of metastases failing radiosurgery across multiple centers and to determine if any treatment factors are predictive of outcome...
April 13, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28405509/improved-time-to-disease-progression-in-the-brain-in-patients-with-melanoma-brain-metastases-treated-with-concurrent-delivery-of-radiosurgery-and-ipilimumab
#9
Tijana Skrepnik, Srinath Sundararajan, Haiyan Cui, Baldassarre Stea
Background: To identify the optimal sequencing and timing of immunotherapy (IT) and stereotactic radiosurgery (SRS) for melanoma brain metastases (MBMs). Methods: The elapsed days between IT and SRS were correlated with local control (LC), regional brain control (RBC), time to CNS progression (TTPCNS), overall survival (OS), and radiation necrosis (RN). Logistic regression and Cox proportional models were used for statistical analysis. Results: Twenty-five patients with 58 MBMs underwent SRS and IT. Median follow-up was 22...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28398880/cerebrovascular-remodeling-and-neuroinflammation-is-a-late-effect-of-radiation-induced-brain-injury-in-non-human-primates
#10
Rachel N Andrews, Linda J Metheny-Barlow, Ann M Peiffer, David B Hanbury, Janet A Tooze, J Daniel Bourland, Robert E Hampson, Samuel A Deadwyler, J Mark Cline
Fractionated whole-brain irradiation (fWBI) is a mainstay of treatment for patients with intracranial neoplasia; however late-delayed radiation-induced normal tissue injury remains a major adverse consequence of treatment, with deleterious effects on quality of life for affected patients. We hypothesize that cerebrovascular injury and remodeling after fWBI results in ischemic injury to dependent white matter, which contributes to the observed cognitive dysfunction. To evaluate molecular effectors of radiation-induced brain injury (RIBI), real-time quantitative polymerase chain reaction (RT-qPCR) was performed on the dorsolateral prefrontal cortex (DLPFC, Brodmann area 46), hippocampus and temporal white matter of 4 male Rhesus macaques (age 6-10 years), which had received 40 Gray (Gy) fWBI (8 fractions of 5 Gy each, twice per week), and 3 control comparators...
March 6, 2017: Radiation Research
https://www.readbyqxmd.com/read/28398275/natural-killer-t-cell-lymphomas-in-pediatric-and-adolescent-patients
#11
REVIEW
Amanda M Termuhlen
Natural killer/T-cell (NK/T-cell) lymphomas are rare in children and adolescents and consist predominantly of nasal-type extranodal NK/T-cell lymphomas. More than half of pediatric/adolescent patients with NK/T-cell lymphomas present with localized nasal/sinus involvement, but the disease may involve many organs. NK/T-cell lymphoma cells are cytotoxic and associated with necrosis and angioinvasion; they express CD56, CD2, cytoplasmic CD3 epsilon, and to a variable degree CD30. The cells contain Epstein-Barr virus (EBV)-encoded RNA...
March 2017: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/28393926/a-strategy-for-precise-treatment-of-cardiac-malignant-neoplasms
#12
Wenshuo Wang, Jinqiang Shen, Hongyue Tao, Yun Zhao, Hui Nian, Lai Wei, Xiaoyuan Ling, Ye Yang, Limin Xia
The prevalence of cardiac malignant neoplasms in the general population has been shown to be significant higher than what was previously estimated, yet their treatment has remained difficult and effective therapies are lacking. In the current study, we developed a novel thermotherapy in which PEG-functionalized carbon nanotubes were injected into the tumor regions to assist in the targeted delivery of infrared radiation energy with minimal hyperthermic damage to the surrounding normal tissues. In a mouse model of cardiac malignant neoplasms, the injected carbon nanotubes could rapidly induce coagulative necrosis of tumor tissues when exposed to infrared irradiation...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28369015/nipple-areola-complex-malposition-in-nipple-sparing-mastectomy-a-review-of-risk-factors-and-corrective-techniques-from-greater-than-1000-reconstructions
#13
Mihye Choi, Jordan D Frey, Ara A Salabian, Nolan S Karp
BACKGROUND: Nipple-areola complex (NAC) malposition after nipple-sparing mastectomy (NSM) can be a challenging issue to correct. The current literature is largely limited to smaller series and implant-based reconstructions. METHODS: A retrospective review of all NSMs from 2006 to 2016 at a single institution was performed. Incidence, risk factors and corrective techniques of NAC malposition were analyzed. RESULTS: 1037 cases of NSM were identified, of which 77 (7...
March 31, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28368903/the-incidence-of-radiation-necrosis-following-stereotactic-radiotherapy-for-melanoma-brain-metastases-the-potential-impact-of-immunotherapy
#14
Orit Kaidar-Person, Timothy M Zagar, Allison Deal, Stergios J Moschos, Matthew G Ewend, Deanna Sasaki-Adams, Carrie B Lee, Frances A Collichio, David Fried, Lawrence B Marks, Bhishamjit S Chera
Stereotactic radiotherapy (SRT) is the standard treatment for patients with limited number of brain metastases. In the past few years, newer immunotherapies (immune checkpoint inhibitors) have been proven to prolong survival in patients with metastatic melanoma. The safety of the combination of SRT and immunotherapy for brain metastases is unknown. We retrospectively identified patients with melanoma brain metastases treated with SRT between 2007 and 2015. Patients who did not have at least 3 months of follow-up with imaging after SRT were excluded from the analysis...
March 31, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28358936/association-of-radiotherapy-boost-for-ductal-carcinoma-in-situ-with-local-control-after-whole-breast-radiotherapy
#15
Meena S Moran, Yinjun Zhao, Shuangge Ma, Youlia Kirova, Alain Fourquet, Peter Chen, Karen Hoffman, Kelly Hunt, Julia Wong, Lia M Halasz, Gary Freedman, Robert Prosnitz, Michael Yassa, David H A Nguyen, Tarek Hijal, Bruce G Haffty, Elaine S Wai, Pauline T Truong
Importance: The use of a radiotherapy (RT) boost to the tumor bed after whole-breast RT (WBRT) for ductal carcinoma in situ (DCIS) is largely extrapolated from invasive cancer data, but robust evidence specific to DCIS is lacking. Objective: To compare ipsilateral breast tumor recurrence (IBTR) in women with DCIS treated with vs without the RT boost after breast-conserving surgery and WBRT. Design, Setting, and Participants: This retrospective analysis pooled deidentified patient-level data from 10 academic institutions in the United States, Canada, and France from January 1, 1980, through December 31, 2010...
March 30, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28355119/high-intensity-focused-ultrasound-for-the-treatment-of-prostate-cancer-a-review
#16
Christian G Chaussy, Stefan Thüroff
Over the past 25 years, the average life expectancy for men has increased almost 4 years, and the age of prostate cancer detection has decreased an average of 10 years with diagnosis increasingly made at early-stage disease where curative therapy is possible. These changing trends in the age and extent of malignancy at diagnosis have revealed limitations in conventional curative therapies for prostate cancer, including a significant risk of aggressive cancer recurrence, and the risk of long-term genitourinary morbidity and its detrimental impact on patient's quality of life (QOL)...
April 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28351585/proposal-for-a-new-risk-classification-system-for-nasopharyngeal-carcinoma-patients-with-post-radiation-nasopharyngeal-necrosis
#17
Qi Yang, Xiong Zou, Rui You, You-Ping Liu, Yuan Han, Yi-Nuan Zhang, Ling Guo, Hai-Qiang Mai, Chuan-Miao Xie, Li Li, Ming-Huang Hong, Ming-Yuan Chen
PURPOSE: To analyze the clinical outcomes of nasopharyngeal carcinoma (NPC) patients with post-radiation nasopharyngeal necrosis (PRNN) and construct a new risk classification system for predicting survival of PRNN. METHODS: A total of 276 patients with PRNN were consecutively enrolled. Complete magnetic resonance (MR) images of the nasopharynx and neck were available for all patients and were used to assess nasopharyngeal necrosis status. After 2010, patients with PRNN were initially treated by radical endoscopic necrectomy followed by reconstruction with nasal flap (ENNF)...
April 2017: Oral Oncology
https://www.readbyqxmd.com/read/28351000/targeted-superparamagnetic-nanoparticles-coated-with-2-deoxy-d-gloucose-and-doxorubicin-more-sensitize-breast-cancer-cells-to-ionizing-radiation
#18
Jalil Pirayesh Islamian, Milad Hatamian, Negar Abbasi Aval, Mohammad Reza Rashidi, Asghar Mesbahi, Mohammad Mohammadzadeh, Mohammad Asghari Jafarabadi
INTRODUCTION: Nanoparticles are promising as a new approach to enhance chemo- radiotherapy efficiency in breast cancer mainly via targeted therapy. MATERIALS & METHODS: SKBR3 and T47D breast cancer cells were treated with superparamagnetic mesoporous hydroxyapatite nanocomposites (SPmHANs)conjugated with 1 μM doxorubicin and 0.5 mM 2-Deoxy-d-Glucose and irradiated with 1 and 2 Gy gamma rays in vitro. The treatment toxicity and also the apoptosis/necrosis ratio were measured by MTT assay and also ELISA cell death detection PLUS, respectively...
March 25, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28348952/radiation-induced-abnormal-cortical-thickness-in-patients-with-nasopharyngeal-carcinoma-after-radiotherapy
#19
Jiabao Lin, Xiaofei Lv, Meiqi Niu, Lizhi Liu, Jun Chen, Fei Xie, Miao Zhong, Shijun Qiu, Li Li, Ruiwang Huang
Conventional MRI studies showed that radiation-induced brain necrosis in patients with nasopharyngeal carcinoma (NPC) in years after radiotherapy (RT) could involve brain gray matter (GM) and impair brain function. However, it is still unclear the radiation-induced brain morphological changes in NPC patients with normal-appearing GM in the early period after RT. In this study, we acquired high-resolution brain structural MRI data from three groups of patients, 22 before radiotherapy (pre-RT) NPC patients with newly diagnosed but not yet medically treated, 22 NPC patients in the early-delayed stage after radiotherapy (post-RT-ED), and 20 NPC patients in the late-delayed stage after radiotherapy (post-RT-LD), and then analyzed the radiation-induced cortical thickness alteration in NPC patients after RT...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28348613/histopathological-changes-in-dental-pulp-of-rats-following-radiotherapy
#20
Zahra Sadat Madani, Soheil Azarakhsh, Pouyan Amini Shakib, Masoomeh Karimi
BACKGROUND: Radiotherapy is one of the oral and pharyngeal cancer treatment methods that can cause damage to the tissues in the radiation area; the purpose of this study is to evaluate the effects of radiotherapy on dental pulp tissue in rats. MATERIALS AND METHODS: In this interventional, experimental double-blind study, 30 rats were studied in three groups (n = 10 each). The first group received 12 gray (Gy), the second group received 18 Gy in one session, and the third group was not exposed to radiation (control group)...
January 2017: Dental Research Journal
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