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https://www.readbyqxmd.com/read/27889621/identifying-non-toxic-doses-of-manganese-for-manganese-enhanced-magnetic-resonance-imaging-to-map-brain-areas-activated-by-operant-behavior-in-trained-rats
#1
Rita Gálosi, Csaba Szalay, Mihály Aradi, Gábor Perlaki, József Pál, Roy Steier, László Lénárd, Zoltán Karádi
Manganese-enhanced magnetic resonance imaging (MEMRI) offers unique advantages such as studying brain activation in freely moving rats, but its usefulness has not been previously evaluated during operant behavior training. Manganese in a form of MnCl2, at a dose of 20mg/kg, was intraperitoneally infused. The administration was repeated and separated by 24h to reach the dose of 40mg/kg or 60mg/kg, respectively. Hepatotoxicity of the MnCl2 was evaluated by determining serum aspartate aminotransferase, alanine aminotransferase, total bilirubin, albumin and protein levels...
November 24, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27751944/hippocampal-to-basal-forebrain-transport-of-mn-2-is-impaired-by-deletion-of-klc1-a-subunit-of-the-conventional-kinesin-microtubule-based-motor
#2
Christopher S Medina, Octavian Biris, Tomas L Falzone, Xiaowei Zhang, Amber J Zimmerman, Elaine L Bearer
Microtubule-based motors carry cargo back and forth between the synaptic region and the cell body. Defects in axonal transport result in peripheral neuropathies, some of which are caused by mutations in KIF5A, a gene encoding one of the heavy chain isoforms of conventional kinesin-1. Some mutations in KIF5A also cause severe central nervous system defects in humans. While transport dynamics in the peripheral nervous system have been well characterized experimentally, transport in the central nervous system is less experimentally accessible and until now not well described...
October 14, 2016: NeuroImage
https://www.readbyqxmd.com/read/27729278/memri-detects-neuronal-activity-and-connectivity-in-hypothalamic-neural-circuit-responding-to-leptin
#3
Anna Ulyanova, Xuan Vinh To, A B M A Asad, Weiping Han, Kai-Hsiang Chuang
Hypothalamus plays the central role in regulating energy homeostasis. To understand the hypothalamic neurocircuit in responding to leptin, Manganese-Enhanced MRI (MEMRI) was applied. Highly elevated signal could be mapped in major nuclei of the leptin signaling pathway, including the arcuate nucleus (ARC), paraventricular nucleus (PVN), ventromedial hypothalamus (VMH) and dorsomedial hypothalamus (DMH) in fasted mice and the enhancement was reduced by leptin administration. However, whether changes in MEMRI signal reflect Ca(2+) channel activity, neuronal activation or connectivity in the leptin signaling pathway are not clear...
October 8, 2016: NeuroImage
https://www.readbyqxmd.com/read/27727394/melanopsin-phototransduction-contributes-to-light-evoked-choroidal-expansion-and-rod-l-type-calcium-channel-function-in-vivo
#4
Bruce A Berkowitz, Tiffany Schmidt, Robert H Podolsky, Robin Roberts
Purpose: In humans, rodents, and pigeons, the dark → light transition signals nonretinal brain tissue to increase choroidal thickness, a major control element of choroidal blood flow, and thus of photoreceptor and retinal pigment epithelium function. However, it is unclear which photopigments in the retina relay the light signal to the brain. Here, we test the hypothesis that melanopsin (Opn4)-regulated phototransduction modulates light-evoked choroidal thickness expansion in mice. Methods: Two-month-old C57Bl/6 wild-type (B6), 4- to 5-month-old C57Bl/6/129S6 wild-type (B6 + S6), and 2-month-old melanopsin knockout (Opn4-/-) on a B6 + S6 background were studied...
October 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27630707/dose-response-and-time-course-of-manganese-enhanced-magnetic-resonance-imaging-for-visual-pathway-tracing-in-vivo
#5
Wei-Ling Wang, Hui Xu, Ying Li, Zhi-Zhong Ma, Xiao-Dong Sun, Yun-Tao Hu
Axonal tracing is useful for detecting optic nerve injury and regeneration, but many commonly used methods cannot be used to observe axoplasmic flow and synaptic transmission in vivo. Manganese (Mn(2+))-enhanced magnetic resonance imaging (MEMRI) can be used for in vivo longitudinal tracing of the visual pathway. Here, we explored the dose response and time course of an intravitreal injection of MnCl2 for tracing the visual pathway in rabbits in vivo using MEMRI. We found that 2 mM MnCl2 enhanced images of the optic nerve but not the lateral geniculate body or superior colliculus, whereas at all other doses tested (5-40 mM), images of the visual pathway from the retina to the contralateral superior colliculus were significantly enhanced...
July 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27555555/eliminating-nox2-reactive-oxygen-species-production-protects-dystrophic-skeletal-muscle-from-pathological-calcium-influx-assessed-in-vivo-by-manganese-enhanced-magnetic-resonance-imaging
#6
James A Loehr, Gary R Stinnett, Mayra Hernández-Rivera, Wesley T Roten, Lon J Wilson, Robia G Pautler, George G Rodney
KEY POINTS: Inhibiting Nox2 reactive oxygen species (ROS) production reduced in vivo calcium influx in dystrophic muscle. The lack of Nox2 ROS production protected against decreased in vivo muscle function in dystrophic mice. Manganese-enhanced magnetic resonance imaging (MEMRI) was able to detect alterations in basal calcium levels in skeletal muscle and differentiate disease status. Administration of Mn(2+) did not affect muscle function or the health of the animal, and Mn(2+) was cleared from skeletal muscle rapidly...
November 1, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27542275/spatial-learning-and-memory-impairments-are-associated-with-increased-neuronal-activity-in-5xfad-mouse-as-measured-by-manganese-enhanced-magnetic-resonance-imaging
#7
Xiang Tang, Di Wu, Li-Hua Gu, Bin-Bin Nie, Xin-Yang Qi, Yan-Juan Wang, Fang-Fang Wu, Xiao-Li Li, Feng Bai, Xiao-Chun Chen, Lin Xu, Qing-Guo Ren, Zhi-Jun Zhang
Dysfunction of neuronal activity is a major and early contributor to cognitive impairment in Alzheimer's disease (AD). To investigate neuronal activity alterations at early stage of AD, we encompassed behavioral testing and in vivo manganese-enhanced magnetic resonance imaging (MEMRI) in 5XFAD mice at early ages (1-, 2-, 3- and 5-month). The 5XFAD model over-express human amyloid precursor protein (APP) and presenilin 1 (PS1) harboring five familial AD mutations, which have a high APP expression correlating with a high burden and an accelerated accumulation of the 42 amino acid species of amyloid-β...
August 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27477722/nano-theranostics-and-nitroxyl-radical-labeled-antitumor-agents-for-magnetic-resonance-imaging
#8
Ichio Aoki
The advent of functional contrast agents and nanoparticle drug delivery systems (nano-DDS) is opening new pathways to understanding pathophysiology using magnetic resonance imaging (MRI). Nitroxyl radical compounds are promising functional contrast agents for redox evaluation. We have developed a novel nitroxyl radical theranostic compound for noninvasive real-time imaging of blood-brain barrier-permeable antitumor drugs. Divalent manganese ions (Mn(2+)) can also be used as an intracellular functional MRI contrast agent...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27453232/ability-of-mn-2-to-permeate-the-eye-and-availability-of-manganese-enhanced-magnetic-resonance-imaging-for-visual-pathway-imaging-via-topical-administration
#9
Yao Chen, Chun-Yan Shi, Ying Li, Yun-Tao Hu, Hong-Bin Han, Xiao-Dong Sun, Satyajeet S Salvi, Zhi-Zhong Ma
BACKGROUND: Manganese-enhanced magnetic resonance imaging (MEMRI) for visual pathway imaging via topical administration requires further research. This study investigated the permeability of the corneal epithelium and corneal toxicity after topical administration of Mn2+ to understand the applicability of MEMRI. METHODS: Forty New Zealand rabbits were divided into 0.05 mol/L, 0.10 mol/L, and 0.20 mol/L groups as well as a control group (n = 10 in each group). Each group was further subdivided into epithelium-removed and epithelium-intact subgroups (n = 5 in each subgroup)...
August 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27329163/manganese-enhanced-magnetic-resonance-imaging-for-detection-of-vasoactive-intestinal-peptide-receptor-2-agonist-therapy-in-a-model-of-parkinson-s-disease
#10
REVIEW
Katherine E Olson, Aditya N Bade, Charles R Schutt, Jingdong Dong, Scott J Shandler, Michael D Boska, R Lee Mosley, Howard E Gendelman, Yutong Liu
Neuroprotective immunity is defined by transformation of T-cell polarity for therapeutic gain. For neurodegenerative disorders and specifically for Parkinson's disease (PD), granulocyte-macrophage colony stimulating factor or vasoactive intestinal peptide receptor 2 (VIPR2) agonists elicit robust anti-inflammatory microglial responses leading to neuronal sparing in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice. While neurotherapeutic potential was demonstrated for PD, there remain inherent limitations in translating these inventions from the laboratory to patients...
July 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27316350/combining-systemic-and-stereotactic-memri-to-detect-the-correlation-between-gliosis-and-neuronal-connective-pathway-at-the-chronic-stage-after-stroke
#11
Xiao-Zhu Hao, Le-Kang Yin, Xiao-Xue Zhang, Jia-Qi Tian, Chan-Chan Li, Xiao-Yuan Feng, Min Jiang, Yan-Mei Yang
BACKGROUND: The early dysfunction and subsequent recovery after stroke, characterized by the destruction and remodeling of connective pathways between cortex and subcortical regions, is associated with neuroinflammation. As major components of the inflammatory process, reactive astrocytes have double-edged effects on pathological progression. The temporal patterns of astrocyte and neuronal pathway activity can be revealed by systemic and stereotactic manganese-enhanced magnetic resonance imaging (MEMRI), respectively...
2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27241944/altered-brain-morphology-and-functional-connectivity-reflect-a-vulnerable-affective-state-after-cumulative-multigenerational-stress-in-rats
#12
J Keiko McCreary, L Sorina Truica, Becky Friesen, Youli Yao, David M Olson, Igor Kovalchuk, Albert R Cross, Gerlinde A S Metz
Prenatal stress is a risk factor for abnormal neuroanatomical, cognitive, behavioral and mental health outcomes with potentially transgenerational consequences. Females in general seem more resilient to the effects of prenatal stress than males. Here, we examined if repeated stress across generations may diminish stress resiliency and cumulatively enhance the susceptibility for adverse health outcomes in females. Pregnant female rats of three successive generations were exposed to stress from gestational days 12-18 to generate multigenerational prenatal stress (MPS) in the maternal lineage...
August 25, 2016: Neuroscience
https://www.readbyqxmd.com/read/27117361/-manganese-enhanced-magnetic-resonance-imaging-investigation-in-the-central-auditory-pathway-of-the-cat
#13
T Li, R Zeng, X X Wang, J F Xian
OBJECTIVE: To compare enhancement of the central auditory pathway in cats receiving auditory stimulation between manganese enhanced magnetic resonance imaging (MEMRI) with intraperitoneal manganese injection route and MEMRI with intratympanic manganese injection route, and investigate the optimal method for displaying enhancement of the central auditory pathway. METHODS: Twenty-seven normal hearing adult cats were randomly divided into three groups, receiving intraperitoneal manganese injection, left intratympanic manganese injection or left intratympanic gadolinium injection respectively...
April 19, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27078034/central-nervous-activity-upon-systemic-salicylate-application-in-animals-with-kanamycin-induced-hearing-loss-a-manganese-enhanced-mri-memri-study
#14
Moritz Gröschel, Romy Götze, Susanne Müller, Arne Ernst, Dietmar Basta
This study investigated the effect of systemic salicylate on central auditory and non-auditory structures in mice. Since cochlear hair cells are known to be one major target of salicylate, cochlear effects were reduced by using kanamycin to remove or impair hair cells. Neuronal brain activity was measured using the non-invasive manganese-enhanced magnetic resonance imaging technique. For all brain structures investigated, calcium-related neuronal activity was increased following systemic application of a sodium salicylate solution: probably due to neuronal hyperactivity...
2016: PloS One
https://www.readbyqxmd.com/read/27038036/alcohol-preference-and-consumption-are-controlled-by-the-caudal-linear-nucleus-in-alcohol-preferring-rats
#15
Mateusz Dudek, Petri Hyytiä
The neuroanatomical and neurochemical basis of alcohol drinking has been extensively studied, but the neural circuitry mediating alcohol reinforcement has not been fully delineated. In the present experiments, we used both neuroimaging and pharmacological tools for identifying neural systems associated with alcohol preference and high voluntary alcohol drinking in the alcohol-preferring AA (Alko Alcohol) rats. First, we compared the basal brain activity of AA rats with that of heterogeneous Wistar rats with manganese-enhanced magnetic resonance imaging (MEMRI)...
April 2, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27005046/neural-interfaces-with-electrically-controllable-delivery-of-manganese-ions-applied-for-memri-functionalized-deep-brain-stimulation
#16
Wei-Chen Huang, Yu-Chin Lo, You-Yin Chen, San-Yuan Chen
No abstract text is available yet for this article.
September 10, 2015: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/26943911/semiquantitative-assessment-of-optic-nerve-injury-using-manganese-enhanced-mri
#17
Jun Yang, Qinqing Li, Mary Wang, Xia Cao, Yingying Ding, Guanshun Wang, Chengde Liao
OBJECTIVE: To evaluate the capability of manganese (Mn(2+))-enhanced MRI (MEMRI) in a continuously semiquantitative assessment of rat optic nerve (ON) injury. METHODS: Forty rats were divided into three groups: (I) a control group that was submitted to MEMRI or to fluorescent labeling of retinal ganglion cells (RGCs) (n = 10); (II) an ON injury group that was submitted to MEMRI (n = 15); (III) an ON injury group that was submitted to fluorescent labeling of RGCs (n = 15)...
May 2016: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/26940602/ceftriaxone-prevents-the-neurodegeneration-and-decreased-neurogenesis-seen-in-a-parkinson-s-disease-rat-model-an-immunohistochemical-and-mri-study
#18
Jun-Cheng Weng, Maria A Tikhonova, Jian-Horng Chen, Mei-Shiuan Shen, Wan-Yun Meng, Yen-Ting Chang, Ke-Hsin Chen, Keng-Chen Liang, Ching-Sui Hung, Tamara G Amstislavskaya, Ying-Jui Ho
Manganese-enhanced magnetic resonance imaging (MEMRI) is a widely used technique for detecting neuronal activity in the brain of a living animal. Ceftriaxone (CEF) has been shown to have neuroprotective effects in neurodegenerative diseases. The present study was aimed at clarifying whether, in an 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease (PD) rat model, the known CEF-induced neuronal protection was accompanied by neurogenesis and decreased loss of neuronal activity. After MPTP lesioning (day 0), the rats were treated with CEF (100mg/kg/day, i...
May 15, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/26851200/modulation-of-nucleus-accumbens-connectivity-by-alcohol-drinking-and-naltrexone-in-alcohol-preferring-rats-a-manganese-enhanced-magnetic-resonance-imaging-study
#19
Mateusz Dudek, Santiago Canals, Wolfgang H Sommer, Petri Hyytiä
The nonselective opioid receptor antagonist naltrexone is now used for the treatment of alcoholism, yet naltrexone's central mechanism of action remains poorly understood. One line of evidence suggests that opioid antagonists regulate alcohol drinking through interaction with the mesolimbic dopamine system. Hence, our goal here was to examine the role of the nucleus accumbens connectivity in alcohol reinforcement and naltrexone's actions using manganese-enhanced magnetic resonance imaging (MEMRI). Following long-term free-choice drinking of alcohol and water, AA (Alko Alcohol) rats received injections of MnCl2 into the nucleus accumbens for activity-dependent tracing of accumbal connections...
March 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26846539/telmisartan-in-the-diabetic-murine-model-of-acute-myocardial-infarction-dual-contrast-manganese-enhanced-and-delayed-enhancement-mri-evaluation-of-the-peri-infarct-region
#20
Ildiko Toma, Paul J Kim, Rajesh Dash, Michael V McConnell, Dwight Nishimura, Phillip Harnish, Phillip C Yang
BACKGROUND: A novel MRI technique, employing dual contrast manganese-enhanced MRI (MEMRI) and delayed enhancement MRI (DEMRI), can evaluate the physiologically unstable peri-infarct region. Dual contrast MEMRI-DEMRI enables comprehensive evaluation of telmisartan to salvage the peri-infarct injury to elucidate the underlying mechanism of restoring the ischemic cardiomyopathy in the diabetic mouse model. METHODS AND RESULTS: Dual contrast MEMRI-DEMRI was performed on weeks 1, 2, and 4 following initiation of telmisartan treatment in 24 left anterior descendent artery ligated diabetic mice...
2016: Cardiovascular Diabetology
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