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Peng-Fei Xia, Guo-Chang Zhang, Berkley Walker, Seung-Oh Seo, Suryang Kwak, Jingjing Liu, Heejin Kim, Donald Ort, Shu-Guang Wang, Yong-Su Jin
Global climate change caused by the emission of anthropogenic greenhouse gasses (GHGs) is a grand challenge to humanity. To alleviate the trend, the consumption of fossil fuels needs to be largely reduced and alternative energy technologies capable of controlling GHG emissions are anticipated. In this study, we introduced a synthetic reductive pentose phosphate pathway (rPPP) into a xylose-fermenting Saccharomyces cerevisiae strain SR8 to achieve simultaneous lignocellulosic bioethanol production and carbon dioxide recycling...
October 17, 2016: ACS Synthetic Biology
Paula Regina Elias, Gleicekelly Silva Coelho, Viviane Flores Xavier, Policarpo Ademar Sales Junior, Alvaro José Romanha, Silvane Maria Fonseca Murta, Claudia Martins Carneiro, Nilton Soares Camilo, Flaviane Francisco Hilário, Jason Guy Taylor
A series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-triazole derivatives of xylitan. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected cell lineages. Benznidazole was used as positive control against T. cruzi and cytotoxicity was determined in mammalian L929 cells...
October 10, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Bettina K Wölnerhanssen, Anne Christin Meyer Gerspach, Christoph Beglinger
No abstract text is available yet for this article.
October 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
Su Hyun Seok, Seung-Yeob Kang, Jeong-Woong Seo, Su-Hyeon Kim, Kyu-Mok Hwang, Eun-Seok Park
The aims of this study were to improve in vitro dissolution property of poorly water-soluble everolimus (EVR) for enhanced bioavailability without using organic solvents and characterize the effects of microfluidization and freeze-drying on physicochemical properties of EVR nanosuspension and nanoparticle, respectively. EVR nanosuspension was prepared using microfluidization with various types and concentrations of stabilizers. After that, it was solidified into nanoparticle using freeze-drying with various concentrations of xylitol, a cryoprotectant...
2016: Chemical & Pharmaceutical Bulletin
Rodrigo S Raposo, M Catarina M D de Almeida, M da Conceição M A de Oliveira, M Manuela da Fonseca, M Teresa Cesário
Efficient production of poly-3-hydroxybutyrate (P(3HB)) based on glucose-xylose mixtures simulating different types of lignocellulosic hydrolysate (LCH) was addressed using Burkholderia sacchari, a wild strain capable of metabolizing both sugars and producing P(3HB). Carbon catabolite repression was avoided by maintaining glucose concentration below 10g/L. Xylose concentrations above 30g/L were inhibitory for growth and production. In fed-batch cultivations, pulse size and feed addition rate were controlled in order to reach high productivities and efficient sugar consumptions...
October 5, 2016: New Biotechnology
Rachel Fickes, Dennis R Voelker, Karin Zemski Berry, Robert C Murphy
RATIONALE: Structural analogs of the bioactive lipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, were synthesized with a xylitol polar headgroup and both diacyl and diether radyl groups. Mass spectral characterization of xylitol phospholipids (PX) was carried out using collisional activation and high resolution mass measurements of positive molecular ion species and compared with the phosphatidylglycerol (PG) analogs. METHODS: Xylitol phospholipids were synthesized using a transphosphatidylation reaction catalyzed by phospholipase D and purified by HPLC...
September 30, 2016: Rapid Communications in Mass Spectrometry: RCM
Letícia M F Sena, Camila G Morais, Mariana R Lopes, Renata O Santos, Ana P T Uetanabaro, Paula B Morais, Marcos J S Vital, Marcos A de Morais, Marc-André Lachance, Carlos A Rosa
Sixteen yeast isolates identified as belonging to the genus Sugiyamaella were studied in relation to D-xylose fermentation, xylitol production, and xylanase activities. The yeasts were recovered from rotting wood and sugarcane bagasse samples in different Brazilian regions. Sequence analyses of the internal transcribed spacer (ITS) region and the D1/D2 domains of large subunit rRNA gene showed that these isolates belong to seven new species. The species are described here as Sugiyamaella ayubii f.a., sp. nov...
September 29, 2016: Antonie Van Leeuwenhoek
Mona F Arafa, Sanaa A El-Gizawy, Mohamed A Osman, Gamal M El Maghraby
Dissolution enhancement is a promising strategy for improving drug bioavailability. Co-crystallization of drugs with inert material can help in this direction. The benefit will become even greater if the inert material can form co-crystal while maintaining its main function as excipient. Accordingly, the objective of the current study was to investigate xylitol as a potential co-crystal co-former for felodipine with the goal of preparing felodipine sublingual tablets. Co-crystallization was achieved by wet co-grinding of the crystals deposited from methanolic solutions containing felodipine with increasing molar ratios of xylitol (1:1, 1:2 and 1:3)...
September 28, 2016: Pharmaceutical Development and Technology
Xingguang Zhang, Karen Wilson, Adam F Lee
Biomass has been long exploited as an anthropogenic energy source; however, the 21st century challenges of energy security and climate change are driving resurgence in its utilization both as a renewable alternative to fossil fuels and as a sustainable carbon feedstock for chemicals production. Deconstruction of cellulose and hemicellulose carbohydrate polymers into their constituent C5 and C6 sugars, and subsequent heterogeneously catalyzed transformations, offer the promise of unlocking diverse oxygenates such as furfural, 5-hydroxymethylfurfural, xylitol, sorbitol, mannitol, and gluconic acid as biorefinery platform chemicals...
October 12, 2016: Chemical Reviews
Bruno Mello de Matos, Fernanda Lourenção Brighenti, Thuy Do, David Beighton, Cristiane Yumi Koga-Ito
OBJECTIVE: The aim of this study was to evaluate the acidogenicity of dual-species biofilms of bifidobacteria and Streptococcus mutans. MATERIALS AND METHODS: The following strains were tested: Bifidobacterium dentium DSM20436, Parascardovia denticolens DSM10105, and Scardovia inopinata DSM10107. Streptococcus mutans UA159 and Lactobacillus acidophilus ATCC4356 were used as control. Bifidobacteria were studied planktonically as they were not able to form monospecies biofilm, they were grown in biofilms associated with S...
September 23, 2016: Clinical Oral Investigations
Gil Y Yerushalmi, Lidiya Misyura, Andrew Donini, Heath A MacMillan
Chill susceptible insects like Drosophila lose the ability to regulate water and ion homeostasis at low temperatures. This loss of hemolymph ion and water balance drives a hyperkalemic state that depolarizes cells, causing cellular injury and death. The ability to maintain ion homeostasis at low temperatures and/or recover ion homeostasis upon rewarming is closely related to insect cold tolerance. We thus hypothesized that changes to organismal ion balance, which can be achieved in Drosophila through dietary salt loading, could alter whole animal cold tolerance phenotypes...
September 15, 2016: Journal of Insect Physiology
Peter de Cock, Kauko Mäkinen, Eino Honkala, Mare Saag, Elke Kennepohl, Alex Eapen
Objective. To provide a comprehensive overview of published evidence on the impact of erythritol, a noncaloric polyol bulk sweetener, on oral health. Methods. A literature review was conducted regarding the potential effects of erythritol on dental plaque (biofilm), dental caries, and periodontal therapy. The efficacy of erythritol on oral health was compared with xylitol and sorbitol. Results. Erythritol effectively decreased weight of dental plaque and adherence of common streptococcal oral bacteria to tooth surfaces, inhibited growth and activity of associated bacteria like S...
2016: International Journal of Dentistry
Cátia V T Mendes, Jorge M S Rocha, Fabrícia F Menezes, Maria Graça V S Carvalho
Primary sludge from a Portuguese pulp and paper mill, containing 60% of carbohydrates, and unbleached pulp (as reference material), with 93% of carbohydrates, were used to produce ethanol by simultaneous saccharification and fermentation (SSF). SSF was performed in batch or fed-batch conditions without the need of a pretreatment. Cellic(®) CTec2 was the cellulolytic enzymatic complex used and Saccharomyces cerevisiae (baker's yeast or ATCC 26602 strain) or the thermotolerant yeast Kluyveromyces marxianus NCYC 1426 were employed...
September 9, 2016: Environmental Technology
J Sharon Mano Pappu, Sathyanarayana N Gummadi
This study examines the use of unstructured kinetic model and artificial neural networks as predictive tools for xylitol production by Debaryomyces nepalensis NCYC 3413 in bioreactor. An unstructured kinetic model was proposed in order to assess the influence of pH (4, 5 and 6), temperature (25°C, 30°C and 35°C) and volumetric oxygen transfer coefficient kLa (0.14h(-1), 0.28h(-1) and 0.56h(-1)) on growth and xylitol production. A feed-forward back-propagation artificial neural network (ANN) has been developed to investigate the effect of process condition on xylitol production...
November 2016: Bioresource Technology
Christopher A Browne, Thomas P Forbes, Edward Sisco
The rapid and sensitive detection of sugar alcohol sweeteners was demonstrated using ion mobility spectrometry (IMS). IMS provides a valuable alternative in sensitivity, cost, and analysis speed between the lengthy gold-standard liquid chromatography-mass spectrometry (LC-MS) technique and rapid point-of-measurement disposable colorimetric sensors, for the Food and Nutrition industry's quality control and other "foodomics" area needs. The IMS response, characteristic signatures, and limits of detection for erythritol, pentaerythritol, xylitol, inositol, sorbitol, mannitol, and maltitol were evaluated using precise inkjet printed samples...
July 28, 2016: Analytical Methods: Advancing Methods and Applications
Takfarinas Kentache, Eliane Milohanic, Thanh Nguyen Cao, Abdelhamid Mokhtari, Francine Moussan Aké, Que Mai Ma Pham, Philippe Joyet, Josef Deutscher
Transposon insertion into Listeria monocytogenes lmo2665, which encodes an EIIC of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS), was found to prevent D-arabitol utilization. We confirm this result with a deletion mutant and show that Lmo2665 is also required for D-xylitol utilization. We therefore called this protein EIICAxl. Both pentitols are probably catabolized via the pentose phosphate pathway (PPP) because lmo2665 belongs to an operon, which encodes the three PTSAxl components, two sugar-P dehydrogenases, and most PPP enzymes...
August 24, 2016: Journal of Molecular Microbiology and Biotechnology
Prawphan Yuvadetkun, Noppol Leksawasdi, Mallika Boonmee
Candida shehatae ATCC 22984, a xylose-fermenting yeast, showed an ability to produce ethanol in both glucose and xylose medium. Maximum ethanol produced by the yeast was 48.8 g/L in xylose and 52.6 g/L in glucose medium with ethanol yields varied between 0.3-0.4 g/g depended on initial sugar concentrations. Xylitol was a co-product of ethanol production using xylose as substrate and glycerol was detected in both glucose and xylose media. Kinetic model equations indicated that growth, substrate consumption and products formation of C...
August 23, 2016: Preparative Biochemistry & Biotechnology
Aline Guadalupe Coelho, Dosil Pereira deJesus
In this work, a novel and simple analytical method using capillary electrophoresis (CE) with capacitively coupled contactless conductivity detection (C(4) D) is proposed for the determination of the polyols erythritol, maltitol, xylitol, and sorbitol in sugar free chocolate. CE separation of the polyols was achieved in less than 6 minutes, and it was mediated by the interaction between the polyols and the borate ions in the background electrolyte, forming negatively charged borate esters. The extraction of the polyols from the samples was simply obtained using ultra-pure water and ultrasonic energy...
August 13, 2016: Electrophoresis
Wiphat Sukpipat, Hidenobu Komeda, Poonsuk Prasertsan, Yasuhisa Asano
Meyerozyma caribbica strain 5XY2, which was isolated from an alcohol fermentation starter in Thailand, was found to catabolize l-arabinose as well as d-glucose and d-xylose. The highest production amounts of ethanol from d-glucose, xylitol from d-xylose, and l-arabitol from l-arabinose were 0.45 g/g d-glucose, 0.60 g/g d-xylose, and 0.61 g/g l-arabinose with 21.7 g/L ethanol, 20.2 g/L xylitol, and 30.3 g/l l-arabitol, respectively. The enzyme with l-arabitol dehydrogenase (LAD) activity was purified from the strain and found to exhibit broad specificity to polyols, such as xylitol, d-sorbitol, ribitol, and l-arabitol...
August 6, 2016: Journal of Bioscience and Bioengineering
Xiaoling Wang, Chuoyue Cheng, Chunling Ge, Bing Wang, Ye-Hua Gan
PURPOSE: To assess the acidogenic potential of eight different types of baked nuts or seeds eaten alone and after a sucrose challenge using in-dwelling electrode telemetry. METHODS: Six participants wearing a mandibular partial prosthesis incorporated with a miniature glass pH electrode were enrolled. The plaque pH was measured after 5 or 6 days of plaque accumulation. To establish a control, the subjects were instructed to rinse with sucrose, without any subsequent treatment, at the first visit...
June 2016: American Journal of Dentistry
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