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https://www.readbyqxmd.com/read/28550778/construction-of-efficient-xylose-fermenting-saccharomyces-cerevisiae-through-a-synthetic-isozyme-system-of-xylose-reductase-from-scheffersomyces-stipitis
#1
Jung-Hyun Jo, Yong-Cheol Park, Yong-Su Jin, Jin-Ho Seo
Engineered Saccharomyces cerevisiae has been used for ethanol production from xylose, the abundant sugar in lignocellulosic hydrolyzates. Development of engineered S. cerevisiae able to utilize xylose effectively is crucial for economical and sustainable production of fuels. To this end, the xylose-metabolic genes (XYL1, XYL2 and XYL3) from Scheffersomyces stipitis have been introduced into S. cerevisiae. The resulting engineered S. cerevisiae strains, however, often exhibit undesirable phenotypes such as slow xylose assimilation and xylitol accumulation...
May 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28532266/soft-chewable-gelatin-based-pharmaceutical-oral-formulations-a-technical-approach
#2
Morten J Dille, Magnus N Hattrem, Kurt I Draget
OBJECTIVE: Hard tablets and capsules for oral drug delivery cause problems for people experiencing dysphagia. The present work describes the formulation and properties of a gelatin based, self-preserved and soft chewable tablet as an alternative and novel drug delivery format. MATERIALS AND METHODS: Gelatin (8.8-10% in 24.7-29% water) constituted the matrix of the soft, semi-solid tablets. Three different pharmaceuticals (Ibuprofen 10%, Acetaminophen 15%, Meloxicam 1...
May 22, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28529327/metabolite-profiling-of-obese-individuals-before-and-after-a-one-year-weight-loss-program
#3
N Geidenstam, M Al-Majdoub, M Ekman, P Spégel, M Ridderstråle
OBJECTIVE: We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate if baseline metabolite levels and weight loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits. METHODS: Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a one year non-surgical weight loss program...
May 22, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28527826/metabolic-pathway-analysis-of-the-xylose-metabolizing-yeast-protoplast-fusant-zlyrhz7
#4
Jingping Ge, Renpeng Du, Gang Song, Yuhuan Zhang, Wenxiang Ping
Xylose is the second major fermentable sugar present in hard woods and herbs (after d-glucose). Therefore, efficient conversion of xylose to ethanol is essential for the commercialization of lignocellulosic ethanol, which may provide an ideal alternative to fossil fuels in the future. ZLYRHZ7 is a fusant produced by protoplast fusion between two different yeast species, Saccharomyces cerevisiae W5 and Candida shehatae 20335, which is able to utilize xylose to produce ethanol. To improve ethanol production and to quantitatively analyze metabolic pathway in ZLYRHZ7, we used high performance liquid chromatography (HPLC) to assess the utilization rates of xylose, xylitol, and xylulose, and to measure ethanol yields using xylose, xylitol, and xylulose as sole carbon sources...
May 17, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28527765/lignocellulosic-sugar-management-for-xylitol-and-ethanol-fermentation-with-multiple-cell-recycling-by-kluyveromyces-marxianus-iipe453
#5
Diptarka Dasgupta, Debashish Ghosh, Sheetal Bandhu, Dilip K Adhikari
Optimum utilization of fermentable sugars from lignocellulosic biomass to deliver multiple products under biorefinery concept has been reported in this work. Alcohol fermentation has been carried out with multiple cell recycling of Kluyveromyces marxianus IIPE453. The yeast utilized xylose-rich fraction from acid and steam treated biomass for cell generation and xylitol production with an average yield of 0.315±0.01g/g while the entire glucose rich saccharified fraction had been fermented to ethanol with high productivity of 0...
July 2017: Microbiological Research
https://www.readbyqxmd.com/read/28494761/production-of-fuels-and-chemicals-from-xylose-by-engineered-saccharomyces-cerevisiae-a-review-and-perspective
#6
REVIEW
Suryang Kwak, Yong-Su Jin
Efficient xylose utilization is one of the most important pre-requisites for developing an economic microbial conversion process of terrestrial lignocellulosic biomass into biofuels and biochemicals. A robust ethanol producing yeast Saccharomyces cerevisiae has been engineered with heterologous xylose assimilation pathways. A two-step oxidoreductase pathway consisting of NAD(P)H-linked xylose reductase and NAD(+)-linked xylitol dehydrogenase, and one-step isomerase pathway using xylose isomerase have been employed to enable xylose assimilation in engineered S...
May 11, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28492501/urinary-metabolomics-in-pediatric-obesity-and-nafld-identifies-metabolic-pathways-metabolites-related-to-dietary-habits-and-gut-liver-axis-perturbations
#7
Jacopo Troisi, Luca Pierri, Annamaria Landolfi, Francesca Marciano, Antonella Bisogno, Federica Belmonte, Carmen Palladino, Salvatore Guercio Nuzio, Pietro Campiglia, Pietro Vajro
To get insight into still elusive pathomechanisms of pediatric obesity and non-alcoholic fatty liver disease (NAFLD) we explored the interplay among GC-MS studied urinary metabolomic signature, gut liver axis (GLA) abnormalities, and food preferences (Kid-Med). Intestinal permeability (IP), small intestinal bacterial overgrowth (SIBO), and homeostatic model assessment-insulin resistance were investigated in forty children (mean age 9.8 years) categorized as normal weight (NW) or obese (body mass index <85th or >95th percentile, respectively) ± ultrasonographic bright liver and hypertransaminasemia (NAFLD)...
May 11, 2017: Nutrients
https://www.readbyqxmd.com/read/28471330/characterization-and-gene-cloning-of-l-xylulose-reductase-involved-in-l-arabinose-catabolism-from-the-pentose-fermenting-fungus-rhizomucor-pusillus
#8
Shino Yamasaki-Yashiki, Hidenobu Komeda, Kazuhiro Hoshino, Yasuhisa Asano
l-Xylulose reductase (LXR) catalyzes the reduction of l-xylulose to xylitol in the fungal l-arabinose catabolic pathway. LXR (RpLXR) was purified from the pentose-fermenting zygomycetous fungus Rhizomucor pusillus NBRC 4578. The native RpLXR is a homotetramer composed of 29 kDa subunits and preferred NADPH as a coenzyme. The Km values were 8.71 mM for l-xylulose and 3.89 mM for dihydroxyacetone. The lxr3 (Rplxr3) gene encoding RpLXR consists of 792 bp and encodes a putative 263 amino acid protein (Mr = 28,341)...
May 4, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28469699/metabolomics-approach-reveals-annual-metabolic-variation-in-roots-of-cyathula-officinalis-kuan-based-on-gas-chromatography-mass-spectrum
#9
Kai Tong, Zhao-Ling Li, Xu Sun, Shen Yan, Mei-Jie Jiang, Meng-Sheng Deng, Ji Chen, Jing-Wei Li, Meng-Liang Tian
BACKGROUND: Herbal quality is strongly influenced by harvest time. It is therefore one of crucial factors that should be well respected by herbal producers when optimizing cultivation techniques, so that to obtain herbal products of high quality. In this work, we paid attention on one of common used Chinese herbals, Cyathula officinalis Kuan. According to previous studies, its quality may be related with growth years because of the variation of several main bioactive components in different growth years...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28465256/a-combination-of-the-probiotic-and-prebiotic-product-can-prevent-the-germination-of-clostridium-difficile-spores-and-infection
#10
M Rätsep, S Kõljalg, E Sepp, I Smidt, K Truusalu, E Songisepp, J Stsepetova, P Naaber, R H Mikelsaar, M Mikelsaar
Clostridium difficile infection (CDI) is one of the most prevalent healthcare associated infections in hospitals and nursing homes. Different approaches are used for prevention of CDI. Absence of intestinal lactobacilli and bifidobacteria has been associated with C. difficile colonization in hospitalized patients. Our aim was to test a) the susceptibility of C. difficile strains of different origin and the intestinal probiotic Lactobacillus plantarum Inducia (DSM 21379) to various antimicrobial preparations incl...
April 29, 2017: Anaerobe
https://www.readbyqxmd.com/read/28461883/comparison-of-antimicrobial-effects-of-titanium-tetrafluoride-chlorhexidine-xylitol-and-sodium-fluoride-on-streptococcus-mutans-an-in-vitro-study
#11
Tahereh Eskandarian, Mohammad Motamedifar, Peyman Arasteh, Seyed Sajad Eghbali, Ali Adib, Zahra Abdoli
INTRODUCTION: No studies have yet documented the bactericidal effects of TiF4, and its role in the treatment of dental caries, and no definite protocol has been introduced to regulate its use. The aim of this study was to determine the antimicrobial/bactericidal effects of TiF4 on Streptococcus Mutans (S. Mutans) and to compare it with chlorhexidine (Chx), sodium fluoride (NaF) and xylitol. METHODS: This study was conducted at the Shiraz University of Medical Sciences microbiology laboratory during March 2015 to September 2015...
March 2017: Electronic Physician
https://www.readbyqxmd.com/read/28452022/xylitol-production-from-non-detoxified-and-non-sterile-lignocellulosic-hydrolysate-using-low-cost-industrial-media-components
#12
Tatyaso Yewale, Shruti Panchwagh, Shaileshkumar Sawale, Rishi Jain, Pradip B Dhamole
Immobilized Candida tropicalis cells in freeze dried calcium alginate beads were used for production of xylitol from lignocellulosic waste like corn cob hydrolysate without any detoxification and sterilization of media. Media components for xylitol fermentation were screened by statistical methods. Urea, KH2PO4 and initial pH were identified as significant variables by Plackett-Burman (PB) design. Significant medium components were optimized by response surface methodology (RSM). Predicted xylitol yield by RSM model and experimental yield was 0...
May 2017: 3 Biotech
https://www.readbyqxmd.com/read/28448807/alternative-sweeteners-influence-the-biomass-of-oral-biofilm
#13
Fathilah Abdul Razak, Baizatul Amirah Baharuddin, Elisya Farha Mohd Akbar, Amira Hanim Norizan, Nur Fazilah Ibrahim, Md Yusoff Musa
OBJECTIVE: Compact-structured oral biofilm accumulates acids that upon prolonged exposure to tooth surface, causes demineralisation of enamel. This study aimed to assess the effect of alternative sweeteners Equal Stevia(®), Tropicana Slim(®), Pal Sweet(®) and xylitol on the matrix-forming activity of plaque biofilm at both the early and established stages of formation. METHODS: Saliva-coated glass beads (sGB) were used as substratum for the adhesion of a mixed-bacterial suspension of Streptococcus mutans, Streptococcus sanguinis and Streptococcus mitis...
April 20, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28433914/accumulation-of-sugar-from-pulp-and-xylitol-from-xylose-by-pyruvate-decarboxylase-negative-white-rot-fungus-phlebia-sp-mg-60
#14
Taku Tsuyama, Megumi Yamaguchi, Ichiro Kamei
Phlebia sp. MG-60 is a white-rot fungus that produces ethanol with high efficiency from lignocellulosic biomass without additional enzymes. Through engineering of this powerful metabolic pathway for fermentation in Phlebia sp. MG-60, chemical compounds other than ethanol could be produced. Here, we demonstrate sugar accumulation from unbleached hardwood kraft pulp and conversion of xylose to xylitol by pyruvate decarboxylase (pdc)-negative Phlebia sp. MG-60. We isolated Phlebia sp. strain MG-60-P2 from protoplasts to unify the protoplast phenotypes of the regenerated strains...
April 7, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28425351/metabolic-changes-in-methomyl-poisoned-rats-treated-by-vitamin-e
#15
J Weng, B Cai, J Chen, B Chen, H Wu, C Wen, F Sun, L Hu, C Chen, X Wang, Z Wang
In this study, we developed a serum and urine metabolomic method based on gas chromatography-mass spectrometry (GC-MS) combination with biomedical results to evaluate the effect of vitamin E treatment on methomyl poisoning rats. The rats were divided into three groups: the control group, methomyl poisoning group, and vitamin E treatment group. Partial least squares discriminate analysis (PLS-DA) showed that methomyl poisoning induced metabolic perturbations. Compared to the control group, based on the urinary metabolomics data, the level of ribitol, l-proline, xylitol, hydrocinnamic acid, 11-cis-octadecenoic acid, octadecanoic acid, and hexadecanoic acid of methomyl poisoning group increased, while the level of 2,3,4-trihydroxybutyric acid, ethanimidic acid, pantothenic acid, and retinoic acid decreased...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28403843/knowledge-about-preventive-dentistry-versus-self-reported-competence-in-providing-preventive-oral-healthcare-a-study-among-nepalese-dentists
#16
Madhu Wagle, Ganesh Acharya, Purusotam Basnet, Tordis A Trovik
BACKGROUND: Dentists' and dental healthcare providers' professional knowledge and attitude towards the prevention of oral diseases may have an impact on the oral health of the general population. The aim of this study was to describe Nepalese dentists' competency in giving preventive education and treatment to their patients, and to assess their level of knowledge about preventive dental health. METHODS: This was a cross-sectional study of 195 dentists (71 males and 124 females)...
April 12, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28390875/effect-of-non-nutritive-sugars-to-decrease-the-survivorship-of-spotted-wing-drosophila-drosophila-suzukii
#17
Man-Yeon Choi, Siew Bee Tang, Seung-Joon Ahn, Kaushalya G Amarasekare, Peter Shearer, Jana C Lee
In this study, we investigated the effects of non-nutritive sugars and sugar alcohols on the survivorship of spotted wing drosophila, Drosophila suzukii, and found erythritol and erythrose as potentially insecticidal to the fly. In a dose-dependent study, erythritol and erythrose significantly reduced fly longevity, with 100% mortality with 1, 0.5, 0.1 & 0.05M doses after feeding for 7days. When sucrose and erythritol solutions were provided separately to flies for 7days, there was no effect on survivorship regardless of erythritol concentrations...
April 5, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28390807/xylitol-nasal-irrigation-in-the-treatment-of-chronic-rhinosinusitis
#18
Lin Lin, Xinyue Tang, Jinjin Wei, Fei Dai, Guangbin Sun
OBJECTIVE: To evaluate the efficacy of xylitol nasal irrigation (XNI) treatment on chronic rhinosinusitis (CRS) and to investigate the effect of XNI on nasal nitric oxide (NO) and inducible nitric oxide synthase (iNOS) mRNA in maxillary sinus. MATERIALS AND METHODS: Patients with CRS were enrolled and symptoms were assessed by Visual Analog Scale (VAS) and Sino-Nasal Outcome Test 22 (SNOT-22). Nasal NO and iNOS mRNA in the right maxillary sinus were also examined...
April 4, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28390459/effectiveness-of-xylitol-in-reducing-dental-caries-in-children
#19
Abdullah A Marghalani, Emilie Guinto, Minhthu Phan, Vineet Dhar, Norman Tinanoff
PURPOSE: The purpose of this study was to evaluate the effectiveness of xylitol in reducing dental caries in children compared to no treatment, a placebo, or preventive strategies. METHODS: MEDLINE via PubMed, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched from January 1, 1995 through Sept. 26, 2016 for randomized and controlled trials on children consuming xylitol for at least 12 months. The primary endpoint was caries reduction measured by mean decayed, missing, and filled primary and permanent surfaces/ teeth (dmfs/t, DMFS/T, respectively)...
March 15, 2017: Pediatric Dentistry
https://www.readbyqxmd.com/read/28386802/description-of-hyphopichia-buzzinii-f-a-sp-nov-and-hyphopichia-homilentoma-comb-nov-the-teleomorph-of-candida-homilentoma
#20
Lucas R Ribeiro, Ana R O Santos, Marizeth Groenewald, Maudy Th H Smith, Carla A Lara, Aristóteles Góes-Neto, Noémie Jacques, Cécile Grondin, Serge Casaregola, Marc-André Lachance, Carlos A Rosa
During studies of the yeast diversity associated with rotting wood in Brazil and fruits, plants and insects in French Guiana, three strains of a new species were isolated. Analysis of the sequences of the internal transcribed spacer (ITS)-5.8S and D1/D2 domains of the large subunit of the rRNA gene showed that this species belongs to the genus Hyphopichia and its closest relative is Candida homilentoma. These species differ by 44 nucleotide substitutions in D1/D2 sequences. A new species Hyphopichia buzzinii f...
April 6, 2017: Antonie Van Leeuwenhoek
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