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Biomedical informatics

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https://www.readbyqxmd.com/read/29304188/drug-knowledge-bases-and-their-applications-in-biomedical-informatics-research
#1
Yongjun Zhu, Olivier Elemento, Jyotishman Pathak, Fei Wang
Recent advances in biomedical research have generated a large volume of drug-related data. To effectively handle this flood of data, many initiatives have been taken to help researchers make good use of them. As the results of these initiatives, many drug knowledge bases have been constructed. They range from simple ones with specific focuses to comprehensive ones that contain information on almost every aspect of a drug. These curated drug knowledge bases have made significant contributions to the development of efficient and effective health information technologies for better health-care service delivery...
January 3, 2018: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29302090/an-approach-for-some-in-advanced-pharmacy-informatics-education
#2
Allen Flynn, Brent I Fox, Kevin A Clauson, Terry L Seaton, Elizabeth Breeden
Computerization is transforming health care while the quantity and complexity of biomedical knowledge rapidly grows. Today, all clinicians use health information technology (HIT), but only some pharmacists need to be cross-trained in "all" that advanced informatics entails so they can devise new and better information systems to support the pharmacy practice of the future. We propose a dual approach to informatics education in pharmacy: incorporate fundamental informatics education into pharmacy curricula for all students; and train some students interested in becoming informatics experts to design, develop, implement, and evaluate novel HIT for pharmacy...
November 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29284909/evaluation-of-founding-members-of-the-international-academy-of-health-sciences-informatics-iahsi-based-on-google-scholar-and-scopus-parameters
#3
Izet Masic
Introduction: The International Academy of Health Sciences Informatics (IAHSI) is established by International Medical Informatics Association (IMIA) which is the world body for health and biomedical informatics. The Academy will serve as an honor society that recognizes expertise in biomedical and health informatics internationally. Academy membership will be one of the highest honors in the international field of biomedical and health informatics. Aim: To present scientometric analysis of founding members of the International Academy of Health Sciences Informatics, to evaluate members and their scientific rating...
December 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29234465/ten-quick-tips-for-machine-learning-in-computational-biology
#4
REVIEW
Davide Chicco
Machine learning has become a pivotal tool for many projects in computational biology, bioinformatics, and health informatics. Nevertheless, beginners and biomedical researchers often do not have enough experience to run a data mining project effectively, and therefore can follow incorrect practices, that may lead to common mistakes or over-optimistic results. With this review, we present ten quick tips to take advantage of machine learning in any computational biology context, by avoiding some common errors that we observed hundreds of times in multiple bioinformatics projects...
2017: BioData Mining
https://www.readbyqxmd.com/read/29218919/the-diversity-and-disparity-in-biomedical-informatics-ddbi-workshop
#5
William M Southerland, S Joshua Swamidass, Philip R O Payne, Laura Wiley, ClarLynda Williams-DeVane
The Diversity and Disparity in Biomedical Informatics (DDBI) workshop will be focused on complementary and critical issues concerned with enhancing diversity in the informatics workforce as well as diversity in patient cohorts. According to the National Institute of Minority Health and Health Disparities (NIMHD) at the NIH, diversity refers to the inclusion of the following traditionally underrepresented groups: African Americans/Blacks, Asians (>30 countries), American Indian or Alaska Native, Native Hawaiian or Other Pacific Islander, Latino or Hispanic (20 countries)...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218873/session-introduction-challenges-of-pattern-recognition-in-biomedical-data
#6
Shefali Setia Verma, Anurag Verma, Anna Okula Basile, Marta-Byrska Bishop, Christian Darabos
The analysis of large biomedical data often presents with various challenges related to not just the size of the data, but also to data quality issues such as heterogeneity, multidimensionality, noisiness, and incompleteness of the data. The data-intensive nature of computational genomics problems in biomedical informatics warrants the development and use of massive computer infrastructure and advanced software tools and platforms, including but not limited to the use of cloud computing. Our session aims to address these challenges in handling big data for designing a study, performing analysis, and interpreting outcomes of these analyses...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29193890/translational-biomedical-informatics-and-pharmacometrics-approaches-in-the-drug-interactions-research
#7
REVIEW
Pengyue Zhang, Heng-Yi Wu, Chien-Wei Chiang, Lei Wang, Samar Binkheder, Xueying Wang, Donglin Zeng, Sara K Quinney, Lang Li
No abstract text is available yet for this article.
November 28, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/29191560/msbis-a-multi-step-biomedical-informatics-screening-approach-for-identifying-medications-that-mitigate-the-risks-of-metoclopramide-induced-tardive-dyskinesia
#8
Dong Xu, Alexandrea G Ham, Rickey D Tivis, Matthew L Caylor, Aoxiang Tao, Steve T Flynn, Peter J Economen, Hung K Dang, Royal W Johnson, Vaughn L Culbertson
In 2009 the U.S. Food and Drug Administration (FDA) placed a black box warning on metoclopramide (MCP) due to the increased risks and prevalence of tardive dyskinesia (TD). In this study, we developed a multi-step biomedical informatics screening (MSBIS) approach leveraging publicly available bioactivity and drug safety data to identify concomitant drugs that mitigate the risks of MCP-induced TD. MSBIS includes (1) TargetSearch (http://dxulab.org/software) bioinformatics scoring for drug anticholinergic activity using CHEMBL bioactivity data; (2) unadjusted odds ratio (UOR) scoring for indications of TD-mitigating effects using the FDA Adverse Event Reporting System (FAERS); (3) adjusted odds ratio (AOR) re-scoring by removing the effect of cofounding factors (age, gender, reporting year); (4) logistic regression (LR) coefficient scoring for confirming the best TD-mitigating drug candidates...
November 22, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29181520/predictors-of-osteopathic-medical-students-readiness-to-use-health-information-technology
#9
Robin J Jacobs, Hassan Iqbal, Arif M Rana, Zaid Rana, Michael N Kane
Context: The advent of health information technology (HIT) tools can affect the practice of modern medicine in many ways, ideally by improving quality of care and efficiency and reducing medical errors. Future physicians will play a key role in the successful implementation of HIT. However, osteopathic medical students' willingness to learn, adopt, and use technology in a health care setting is not well understood. Objective: To understand osteopathic medical students' knowledge, attitudes, and behaviors regarding HIT and to identify factors that may be related to their readiness to use HIT...
December 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29171014/the-influence-of-big-clinical-data-and-genomics-on-precision-medicine-and-drug-development
#10
Joshua C Denny, Sara L Van Driest, Wei-Qi Wei, Dan M Roden
Drug development continues to be costly and slow, with medications failing due to lack of efficacy or presence of toxicity. The promise of pharmacogenomic discovery includes tailoring therapeutics based on an individual's genetic makeup, rational drug development, and repurposing medications. Rapid growth of large research cohorts, linked to electronic health record (EHR) data, fuels discovery of new genetic variants predicting drug action, supports Mendelian randomization experiments to show drug efficacy, and suggests new indications for existing medications...
November 24, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29118849/examining-the-need-potential-for-biomedical-engineering-to-strengthen-health-care-delivery-for-displaced-populations-victims-of-conflict
#11
Devika Nadkarni, Imad Elhajj, Zaher Dawy, Hala Ghattas, Muhammad H Zaman
Conflict and the subsequent displacement of populations creates unique challenges in the delivery of quality health care to the affected population. Equitable access to quality care demands a multi-pronged strategy with a growing need, and role, for technological innovation to address these challenges. While there have been significant contributions towards alleviating the burden of conflict via data informatics and analytics, communication technology, and geographic information systems, little has been done within biomedical engineering...
2017: Conflict and Health
https://www.readbyqxmd.com/read/29114113/managing-information-in-health-informatics
#12
REVIEW
Rodolfo A Fiorini, Izet Masic
Only once we agree upon our understanding of what words really mean can we debate whether a concept, represented by those words, is or not well represented significantly in specific application. Conceptual clarity and predicative/impredicative competence are the fundamental components for managing information more effectively in Health Informatics, Healthcare and Medicine applications, while promoting innovation and creativity. Medicine was always the art and science of healing. The science became more and more a mechanistic technology in Healthcare; the art was dropped altogether...
September 2017: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/29092930/developing-cancer-informatics-applications-and-tools-using-the-nci-genomic-data-commons-api
#13
Shane Wilson, Michael Fitzsimons, Martin Ferguson, Allison Heath, Mark Jensen, Josh Miller, Mark W Murphy, James Porter, Himanso Sahni, Louis Staudt, Yajing Tang, Zhining Wang, Christine Yu, Junjun Zhang, Vincent Ferretti, Robert L Grossman
The NCI Genomic Data Commons (GDC) was launched in 2016 and makes available over 4 petabytes (PB) of cancer genomic and associated clinical data to the research community. This dataset continues to grow and currently includes over 14,500 patients. The GDC is an example of a biomedical data commons, which collocates biomedical data with storage and computing infrastructure and commonly used web services, software applications, and tools to create a secure, interoperable, and extensible resource for researchers...
November 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/29084368/electronic-health-record-phenotypes-for-precision-medicine-perspectives-and-caveats-from-treatment-of-breast-cancer-at-a-single-institution
#14
Matthew K Breitenstein, Hongfang Liu, Kara N Maxwell, Jyotishman Pathak, Rui Zhang
Precision medicine is at the forefront of biomedical research. Cancer registries provide rich perspectives and electronic health record(EHR)s are commonly utilized to gather additional clinical data elements needed for translational research. However, manual annotation is resource-intense and not readily scalable. Informatics-based phenotyping presents an ideal solution, but perspectives obtained can be impacted by both data source and algorithm selection. We derived breast cancer(BC) receptor status phenotypes from structured and unstructured EHR data using rule-based algorithms, including natural language processing(NLP)...
October 30, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/29074071/data-acquisition-workflows-in-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry-based-metabolomics-where-do-we-stand
#15
REVIEW
François Fenaille, Pierre Barbier Saint-Hilaire, Kathleen Rousseau, Christophe Junot
Typical mass spectrometry (MS) based untargeted metabolomics protocols are tedious as well as time- and sample-consuming. In particular, they often rely on "full-scan-only" analyses using liquid chromatography (LC) coupled to high resolution mass spectrometry (HRMS) from which metabolites of interest are first highlighted, and then tentatively identified by using targeted MS/MS experiments. However, this situation is evolving with the emergence of integrated HRMS based-data acquisition protocols able to perform multi-event acquisitions...
December 1, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29063556/knowledge-representation-and-management-it-s-time-to-integrate
#16
F Dhombres, J Charlet
Objectives: To select, present, and summarize the best papers published in 2016 in the field of Knowledge Representation and Management (KRM). Methods: A comprehensive and standardized review of the medical informatics literature was performed based on a PubMed query. Results: Among the 1,421 retrieved papers, the review process resulted in the selection of four best papers focused on the integration of heterogeneous data via the development and the alignment of terminological resources. In the first article, the authors provide a curated and standardized version of the publicly available US FDA Adverse Event Reporting System...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063540/findings-from-the-2017-yearbook-section-on-health-information-management
#17
M Bloomrosen, E S Berner
Objectives: To summarize the recent literature and research and present a selection of the best papers published in 2016 in the field of Health Information Management (HIM). Methods: A systematic review of the literature for the IMIA Yearbook HIM section was performed by the two section editors with the help of a medical librarian. We searched bibliographic databases for HIM-related papers were searched using both MeSH headings and key words in titles and abstracts. A shortlist of candidate best papers was first selected by section editors before being peer-reviewed by independent external reviewers...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29063539/findings-from-the-2017-yearbook-section-on-health-information-management
#18
M Bloomrosen, E S Berner
Objectives: To summarize the recent literature and research and present a selection of the best papers published in 2016 in the field of Health Information Management (HIM). Methods: A systematic review of the literature for the IMIA Yearbook HIM section was performed by the two section editors with the help of a medical librarian. We searched bibliographic databases for HIM-related papers were searched using both MeSH headings and key words in titles and abstracts. A shortlist of candidate best papers was first selected by section editors before being peer-reviewed by independent external reviewers...
August 2017: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29060435/symptom-based-data-preprocessing-for-the-detection-of-disease-outbreak
#19
Khanita Duangchaemkarn, Varin Chaovatut, Phongtape Wiwatanadate, Ekkarat Boonchieng
Early warning systems for outbreak detection is a challenge topic for researchers in the epidemiology and biomedical informatics fields. We are proposing a new method for detecting disease epidemics using a symptom-based approach. The data was collected from developed mobile applications which include users' demographic information and a list of chief complaint symptoms. Deliberated outbreaks are differentiated from seasonal outbreak by specific symptoms that represent a sign of infection. These symptoms were grouped, classified, and then converted to a time-series digital signal using the consensus scoring approach...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29042394/effects-of-e-learning-in-a-continuing-education-context-on-nursing-care-a-review-of-systematic-qualitative-quantitative-and-mixed-studies-reviews-protocol
#20
Geneviève Rouleau, Marie-Pierre Gagnon, José Côté, Julie Payne-Gagnon, Emilie Hudson, Julien Bouix-Picasso, Carl-Ardy Dubois
INTRODUCTION: Continuing education (CE) is imperative to the future of professional nursing. The use of e-learning by registered nurses for CE is spreading. A review of systematic reviews will be conducted to develop a broad picture of the effects of e-learning in a CE context on nursing care. METHODS AND ANALYSIS: Systematic qualitative, quantitative and mixed studies reviews published in English, French or Spanish from 1 January 2006 will be included. The outcomes of interest will be extracted and analysed inductively and deductively from the Nursing Care Performance Framework; some themes include nursing resources, nurses' practice environment, processes, professional satisfaction, and nursing sensitive outcomes...
October 16, 2017: BMJ Open
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