keyword
MENU ▼
Read by QxMD icon Read
search

Cartilage regeneration

keyword
https://www.readbyqxmd.com/read/29782701/tgf-%C3%AE-1-modified-hyaluronic-acid-poly-glycidol-hydrogels-for-chondrogenic-differentiation-of-human-mesenchymal-stromal-cells
#1
Thomas Böck, Verena Schill, Martin Krähnke, Andre F Steinert, Jörg Tessmar, Torsten Blunk, Jürgen Groll
In cartilage regeneration, the biomimetic functionalization of hydrogels with growth factors is a promising approach to improve the in vivo performance and furthermore the clinical potential of these materials. In order to achieve this without compromising network properties, multifunctional linear poly(glycidol) acrylate (PG-Acr) is synthesized and utilized as crosslinker for hydrogel formation with thiol-functionalized hyaluronic acid via Michael-type addition. As proof-of-principle for a bioactivation, transforming growth factor-beta 1 (TGF-β1) is covalently bound to PG-Acr via Traut's reagent which does not compromise the hydrogel gelation and swelling behavior...
May 21, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29773398/sulfated-polysaccharide-mediated-tgf-%C3%AE-1-presentation-in-pre-formed-injectable-scaffolds-for-cartilage-tissue-engineering
#2
Neha Ashok Waghmare, Aditya Arora, Arijit Bhattacharjee, Dhirendra S Katti
In this work, a plant-derived polysaccharide carboxymethylcellulose (CMC) was chemically modified to incorporate sulfate groups to facilitate binding of cationic growth factors. The sulfated CMC (heparin mimic) was then used with CMC (glycosaminoglycan mimic) and gelatin (collagen mimic) to fabricate injectable pre-formed, macroporous scaffolds for cartilage tissue engineering. These scaffolds demonstrated high resilience and shape memory, thereby making them injectable through a 14G needle for up to 4-6 aspiration and injection cycles...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29772932/recent-advances-in-kartogenin-for-cartilage-regeneration
#3
Gaorui Cai, Wei Liu, Yong He, Jianghong Huang, Li Duan, Jianyi Xiong, Lijun Liu, Daping Wang
Either osteoarthritisor sports-related injuries can lead to cartilage defects,whereas both chondrocyte self-renewal and conventional treatments face limitations. In cartilage regenerative medicine, growth factors are commonly used to induce chondrogenic differentiation of stem cells. However, application of growth factors is confined by some drawbacks. Emerging small molecules are regarded as an alternative for cartilage regeneration. A recently discovered small-molecule compound, kartogenin (KGN), has been proven to be a chondrogenic and chondroprotective agent and is more effective in inducing cartilage regeneration when compared with growth factors...
May 18, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29772583/-correction-debridement-in-focal-cartilage-damage-of-the-knee-systematical-review-of-the-literature-and-recommendations-of-the-working-group-clinical-tissue-regeneration-of-the-german-society-of-orthopaedics-and-trauma-dgou
#4
Kolja Gelse, Peter Angele, Peter Behrens, Peter U Bruckner, Jakob Fay, Daniel Günther, Peter Kreuz, Jörg Lützner, Henning Madry, Peter E Müller, Philipp Niemeyer, Geert Pagenstert, Thomas Tischer, Markus Walther, Wolfgang Zinser, Gunter Spahn
No abstract text is available yet for this article.
May 17, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29772345/autologous-liquid-platelet-rich-fibrin-a-novel-drug-delivery-system
#5
REVIEW
Richard J Miron, Yufeng Zhang
There is currently widespread interest within the biomaterial field to locally deliver biomolecules for bone and cartilage regeneration. Substantial work to date has focused on the potential role of these biomolecules during the healing process, and the carrier system utilized is a key factor in their effectiveness. Platelet rich fibrin (PRF) is a naturally derived fibrin scaffold that is easily obtained from peripheral blood following centrifugation. Slower centrifugation speeds have led to the commercialization of a liquid formulation (liquid-PRF) resulting in an upper plasma layer composed of liquid fibrinogen/thrombin prior to clot formation that remains in its liquid phase for approximately 15 minutes until injected into bodily tissues...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29772338/hyaluronic-acid-an-efficient-biomacromolecule-for-treatment-of-inflammatory-skin-and-joint-diseases-a-review-of-recent-developments-and-critical-appraisal-of-preclinical-and-clinical-investigations
#6
REVIEW
Li Hui Chen, Jian Feng Xue, Zhi Yong Zheng, Muhammad Shuhaidi, Hnin Ei Thu, Zahid Hussain
Hyaluronic acid (HA) plays multifaceted role in regulating various biological processes and maintaining homeostasis into the body. Numerous researches evidenced the biomedical implications of HA in skin repairmen, cancer prognosis, wound healing, tissue regeneration, anti-inflammatory, immunomodulation. The present review was aimed to summarize and critically appraise the recent developments and efficacy of HA for treatment of inflammatory skin and joint diseases. A thorough analysis of the literature revealed that HA based formulations (i...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29770595/repair-potential-of-non-surgically-delivered-induced-pluripotent-stem-cell-derived-chondrocytes-in-a-rat-osteochondral-defect-model
#7
Yeri Alice Rim, Yoojun Nam, Narae Park, Jennifer Lee, Sung-Hwan Park, Ji Hyeon Ju
Human induced pluripotent stem cells (hiPSCs) are thought to be an alternative cell source for future regenerative medicine. hiPSCs may allow unlimited production of cell types that have low turnover rates and are difficult to obtain such as autologous chondrocytes. In this study, we generated hiPSC-derived chondrogenic pellets and chondrocytes were isolated. To confirm the curative effects, chondrogenic pellets and isolated chondrocytes were transplanted into rat joints with osteochondral defects. Isolated hiPSC-derived chondrocytes were delivered in the defect by a single intra-articular injection...
May 16, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29766656/microencapsulated-rabbit-adipose-stem-cells-initiate-tissue-regeneration-in-a-rabbit-ear-defect-model
#8
Shirae K Leslie, David J Cohen, Sharon L Hyzy, Christopher R Dosier, Anthony Nicolini, Janina Sedlaczek, Zvi Schwartz, Barbara D Boyan
Cell-based tissue engineering can promote cartilage tissue regeneration, but cell retention in the implant site post-delivery is problematic. Alginate microbeads containing adipose stem cells (ASCs) pretreated with chondrogenic media (CM) have been used successfully to regenerate hyaline cartilage in critical size defects in rat xiphoid suggesting that they may be used to treat defects in elastic cartilages like the ear. To test this, we used microbeads made with low viscosity, high mannuronate medical grade alginate using a high electrostatic potential and a calcium cross linking solution containing glucose...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29765426/current-therapeutic-strategies-for-stem-cell-based-cartilage-regeneration
#9
REVIEW
Yoojun Nam, Yeri Alice Rim, Jennifer Lee, Ji Hyeon Ju
The process of cartilage destruction in the diarthrodial joint is progressive and irreversible. This destruction is extremely difficult to manage and frustrates researchers, clinicians, and patients. Patients often take medication to control their pain. Surgery is usually performed when pain becomes uncontrollable or joint function completely fails. There is an unmet clinical need for a regenerative strategy to treat cartilage defect without surgery due to the lack of a suitable regenerative strategy. Clinicians and scientists have tried to address this using stem cells, which have a regenerative potential in various tissues...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765425/production-of-adult-human-synovial-fluid-derived-mesenchymal-stem-cells-in-stirred-suspension-culture
#10
Kristen D Jorgenson, David A Hart, Roman Krawetz, Arindom Sen
The chondrogenic potential of synovial fluid-derived mesenchymal stem cells (SF-MSCs) supports their use in cartilage regeneration strategies. However, their paucity in synovial fluid necessitates their proliferation in culture to generate clinically relevant quantities. Here it was determined that 125 mL stirred suspension bioreactors utilizing Cytodex-3 microcarrier beads represent a viable platform for the proliferation of these cells. During the inoculation phase, a bead loading of 2 g/L, an inoculation ratio of 4...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765416/combating-osteoarthritis-through-stem-cell-therapies-by-rejuvenating-cartilage-a-review
#11
REVIEW
Navneet Kumar Dubey, Viraj Krishna Mishra, Rajni Dubey, Shabbir Syed-Abdul, Joseph R Wang, Peter D Wang, Win-Ping Deng
Knee osteoarthritis (OA) is a chronic degenerative disorder which could be distinguished by erosion of articular cartilage, pain, stiffness, and crepitus. Not only aging-associated alterations but also the metabolic factors such as hyperglycemia, dyslipidemia, and obesity affect articular tissues and may initiate or exacerbate the OA. The poor self-healing ability of articular cartilage due to limited regeneration in chondrocytes further adversely affects the osteoarthritic microenvironment. Traditional and current surgical treatment procedures for OA are limited and incapable to reverse the damage of articular cartilage...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765413/human-urine-derived-stem-cells-potential-for-cell-based-therapy-of-cartilage-defects
#12
Long Chen, Lang Li, Fei Xing, Jing Peng, Kun Peng, Yuanzheng Wang, Zhou Xiang
Stem cell therapy is considered an optimistic approach to replace current treatments for cartilage defects. Recently, human urine-derived stem cells (hUSCs), which are isolated from the urine, are studied as a promising candidate for many tissue engineering therapies due to their multipotency and sufficient proliferation activities. However, it has not yet been reported whether hUSCs can be employed in cartilage defects. In this study, we revealed that induced hUSCs expressed chondrogenic-related proteins, including aggrecan and collagen II, and their gene expression levels were upregulated in vitro ...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29765410/comparison-of-regenerative-tissue-quality-following-matrix-associated-cell-implantation-using-amplified-chondrocytes-compared-to-synovium-derived-stem-cells-in-a-rabbit-model-for-cartilage-lesions
#13
Hagen Schmal, Justyna M Kowal, Moustapha Kassem, Michael Seidenstuecker, Anke Bernstein, Katharina Böttiger, Tanshiyue Xiong, Norbert P Südkamp, Eva J Kubosch
Known problems of the autologous chondrocyte implantation motivate the search for cellular alternatives. The aim of the study was to test the potential of synovium-derived stem cells (SMSC) to regenerate cartilage using a matrix-associated implantation. In an osteochondral defect model of the medial femoral condyle in a rabbit, a collagen membrane was seeded with either culture-expanded allogenic chondrocytes or SMSC and then transplanted into the lesion. A tailored piece synovium served as a control. Rabbit SMSC formed typical cartilage in vitro...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29760735/stem-cells-for-cartilage-regeneration-a-roadmap-to-the-clinic
#14
EDITORIAL
Celeste Scotti, Alberto Gobbi, Norimasa Nakamura, Giuseppe M Peretti
No abstract text is available yet for this article.
2018: Stem Cells International
https://www.readbyqxmd.com/read/29756586/the-review-of-nanomaterials-inducing-the-differentiation-of-stem-cells-into-chondrocyte-phenotypes-in-cartilage-tissue-engineering
#15
Xueping Xie, Qi Zhang, Tengfei Zhou, Quanquan Ma, Liao JinFeng
Cartilage, as a nanostructured tissue, because of its awfully poor capacity for inherent regeneration and complete hierarchical structure, is severely difficult to regenerate after damages. Tissue engineering methods have provided great contribution for cartilage repair. Nanomaterials have special superiority in regulating stem cell behaviors due to their special mechanical and biological properties and biomimetic characteristics, therefore, they have been given great attention in tissue regeneration. Nanomaterials are divided into organic and inorganic nanomaterials...
May 11, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29756585/animal-models-used-for-testing-hydrogels-in-cartilage-regeneration
#16
Chuntie Zhu, Qiong Wu, Xu Zhang, Fubo Chen, Xiyang Liu, Qixiang Yang, Lei Zhu
Focal cartilage or osteochondral lesions can be painful and detrimental. Besides pain and limited function of joints, cartilage defect is considered as one of the leading extrinsic risk factors for osteoarthritis (OA). Thus, clinicians and scientists have paid great attention to regenerative therapeutic methods for the early treatment of cartilaginous defects. Regenerative medicine, showing great hope for regenerating cartilage tissue, rely on the combination of biodegradable scaffolds and specific biological cues, such as growth factors, adhesive factors and genetic materials...
May 14, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29746554/effects-of-collagen-matrix-and-bioreactor-cultivation-on-cartilage-regeneration-of-a-full-thickness-critical-size-knee-joint-cartilage-defects-with-subchondral-bone-damage-in-a-rabbit-model
#17
Kuo-Hwa Wang, Richard Wan, Li-Hsuan Chiu, Yu-Hui Tsai, Chia-Lang Fang, John F Bowley, Kuan-Chou Chen, Hsin-Nung Shih, Wen-Fu Thomas Lai
Cartilage has limited self-repair ability. The purpose of this study was to investigate the effects of different species of collagen-engineered neocartilage for the treatment of critical-size defects in the articular joint in a rabbit model. Type II and I collagen obtained from rabbits and rats was mixed to form a scaffold. The type II/I collagen scaffold was then mixed with rabbit chondrocytes to biofabricate neocartilage constructs using a rotating cell culture system [three-dimensional (3D)-bioreactor]. The rabbit chondrocytes were mixed with rabbit collagen scaffold and rat collagen scaffold to form neoRBT (neo-rabbit cartilage) and neoRAT (neo-rat cartilage) constructs, respectively...
2018: PloS One
https://www.readbyqxmd.com/read/29743810/auricular-cartilage-regeneration-with-adipose-derived-stem-cells-in-rabbits
#18
Se-Joon Oh, Hee-Young Park, Kyung-Un Choi, Sung-Won Choi, Sung-Dong Kim, Soo-Keun Kong, Kyu-Sup Cho
Tissue engineering cell-based therapy using induced pluripotent stem cells and adipose-derived stem cells (ASCs) may be promising tools for therapeutic applications in tissue engineering because of their abundance, relatively easy harvesting, and high proliferation potential. The purpose of this study was to investigate whether ASCs can promote the auricular cartilage regeneration in the rabbit. In order to assess their differentiation ability, ASCs were injected into the midportion of a surgically created auricular cartilage defect in the rabbit...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29739472/repair-of-articular-cartilage-defects-with-intra-articular-injection-of-autologous-rabbit-synovial-fluid-derived-mesenchymal-stem-cells
#19
Zhaofeng Jia, Qisong Liu, Yujie Liang, Xingfu Li, Xiao Xu, Kan Ouyang, Jianyi Xiong, Daping Wang, Li Duan
BACKGROUND: The role of rabbit synovial fluid-derived mesenchymal stem cells (rbSF-MSCs) in cartilage defect repair remains undefined. This work evaluates the in vivo effects of rbSF-MSCs to repair knee articular cartilage defects in a rabbit model. METHODS: Cartilage defects were made in the patellar grooves of New Zealand white rabbits. The rbSF-MSCs were generated from the knee cavity by arthrocentesis. Passage 5 rbSF-MSCs were assayed by flow cytometry. The multipotency of rbSF-MSCs was confirmed after 3 weeks induction in vitro and the autologous rbSF-MSCs and predifferentiated rbSF-MSCs were injected into the synovial cavity...
May 9, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29737330/therapy-for-cartilage-defects-functional-ectopic-cartilage-constructed-by-cartilage-simulating-collagen-chondroitin-sulfate-and-hyaluronic-acid-cch-hybrid-hydrogel-with-allogeneic-chondrocytes
#20
Xianfang Jiang, Junting Liu, Qin Liu, Zhenhui Lu, Li Zheng, Jinmin Zhao, Xingdong Zhang
OBJECTIVE: To regenerate functional cartilage-mimicking ectopic cartilage as a source for the restoration of cartilage defects, we used a previously synthesized three-phase collagen, chondroitin sulfate and hyaluronic acid (CCH) hydrogel for the encapsulation of allogeneic chondrocytes with a diffusion chamber system that was buried subcutaneously in the host for 4 weeks and then implanted into a cartilage defect. METHODS: The CCH hydrogel was prepared and seeded with allogeneic chondrocytes from new-born rabbits, prior to being enveloped in a diffusion chamber that prevents cell ingrowth and vascular invasion of the host, as described previously...
May 8, 2018: Biomaterials Science
keyword
keyword
17430
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"