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https://www.readbyqxmd.com/read/30220027/prognostic-value-of-paravertebral-muscle-density-in-patients-with-spinal-metastases-from-gastrointestinal-cancer
#1
Sho Dohzono, Ryuichi Sasaoka, Kiyohito Takamatsu, Masatoshi Hoshino, Hiroaki Nakamura
PURPOSE: Morphometric analyses have shown that trunk muscle mass and density are associated with mortality in cancer patients. Because of the low incidence of spinal metastasis from gastrointestinal cancer and the limited life expectancy of these patients, few studies have been reported in this population. We evaluated the prognostic value of trunk muscle area and density in predicting overall survival. METHODS: The data from 78 patients with spinal metastases from gastrointestinal cancer, collected from February 2009 to July 2016, were evaluated...
September 15, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29999170/distribution-of-bile-acid-receptor-tgr5-in-the-gastrointestinal-tract-of-dogs
#2
Paula R Giaretta, Jan S Suchodolski, Anna K Blick, Joerg M Steiner, Jonathan A Lidbury, Raquel R Rech
Takeda-G-protein-receptor-5 (TGR5) is a receptor for bile acids and its expression has been described in a variety of tissues and species. Characterization of TGR5 distribution and function has been investigated in drug discovery for the treatment of metabolic diseases in humans. Because dogs are one of the species used in biomedical research and share some similarities with human gastrointestinal diseases, the objective of this study was to characterize the distribution of TGR5 receptor in the canine species...
July 12, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29994628/automatic-multi-organ-segmentation-on-abdominal-ct-with-dense-v-networks
#3
Eli Gibson, Francesco Giganti, Yipeng Hu, Ester Bonmati, Steve Bandula, Kurinchi Gurusamy, Brian Davidson, Stephen P Pereira, Matthew J Clarkson, Dean C Barratt
Automatic segmentation of abdominal anatomy on computed tomography (CT) images can support diagnosis, treatment planning, and treatment delivery workflows. Segmentation methods using statistical models and multi-atlas label fusion (MALF) require inter-subject image registrations, which are challenging for abdominal images, but alternative methods without registration have not yet achieved higher accuracy for most abdominal organs. We present a registration-free deep-learning-based segmentation algorithm for eight organs that are relevant for navigation in endoscopic pancreatic and biliary procedures, including the pancreas, the gastrointestinal tract (esophagus, stomach, and duodenum) and surrounding organs (liver, spleen, left kidney, and gallbladder)...
August 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29872347/lifetime-risks-loss-of-life-expectancy-and-health-care-expenditures-for-19-types-of-cancer-in-taiwan
#4
Tzu-Yi Wu, Chia-Hua Chung, Chia-Ni Lin, Jing-Shiang Hwang, Jung-Der Wang
Background: The mortality rates for different cancers are no longer an efficient tool for making national policy. The purpose of this study were to quantify the lifetime risks, life expectancies (LEs) after diagnosis, expected years of life lost (EYLL), and lifetime health care expenditures for 19 major cancers in Taiwan. Methods: A total of 831,314 patients with 19 pathologically proven cancers were abstracted from the Taiwan Cancer Registry from 1998 to 2012. They were linked to the National Mortality Registry (1998-2014) and National Health Insurance reimbursement database (1998-2013) for survival and health care costs...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29662231/processed-meat-and-risk-of-selected-digestive-tract-and-laryngeal-cancers
#5
Valentina Rosato, Daisuke Kawakita, Eva Negri, Diego Serraino, Werner Garavello, Maurizio Montella, Adriano Decarli, Carlo La Vecchia, Monica Ferraroni
BACKGROUND/OBJECTIVES: To assess the association between processed meat and the risk of selected digestive tract and laryngeal cancers. SUBJECTS/METHODS: We conducted a series of case-control studies between 1985 and 2007 in Italy. The studies included a total of 1475 cases of cancer of the oral cavity and pharynx, 1077 of the larynx, 716 of the esophagus, 999 of the stomach, 684 of the liver, 159 of the biliary tract, 688 of the pancreas, and a total of 9720 controls...
April 16, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29080344/bile-acids-and-cancer-direct-and-environmental-dependent-effects
#6
REVIEW
Agostino Di Ciaula, David Q-H Wang, Emilio Molina-Molina, Raquel Lunardi Baccetto, Giuseppe Calamita, Vincenzo O Palmieri, Piero Portincasa
Bile acids (BAs) regulate the absorption of fat-soluble vitamins, cholesterol and lipids but have also a key role as singalling molecules and in the modulation of epithelial cell proliferation, gene expression and metabolism. These homeostatic pathways, when disrupted, are able to promote local inflammation, systemic metabolic disorders and, ultimately, cancer. The effect of hydrophobic BAs, in particular, can be linked with cancer in several digestive (mainly oesophagus, stomach, liver, pancreas, biliary tract, colon) and extra-digestive organs (i...
November 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/27102013/cancer-incidence-in-urban-shanghai-1973-2010-an-updated-trend-and-age-period-cohort-effects
#7
Ping-Ping Bao, Ying Zheng, Chun-Xiao Wu, Zhe-Zhou Huang, Yu-Tang Gao, Fan Jin, Yong-Bing Xiang, Wei-Jian Zhong, Wei Lu, Fan Wu
BACKGROUND: To provide a comprehensive overview of temporal trends in cancer incidence during 1973-2010 in urban Shanghai. METHODS: The estimated annual percent changes (EAPCs) for the whole period and for the time segments in age-standardized incidence rates (ASR) were evaluated with Joinpoint analysis. Age-period-cohort (APC) models were modeled to examine the effects of age, period and birth cohort on cancer incidence. RESULTS: The overall ASR decreased slightly and significantly in males (EAPC of -0...
April 21, 2016: BMC Cancer
https://www.readbyqxmd.com/read/26951748/italian-cancer-figures-report-2015-the-burden-of-rare-cancers-in-italy
#8
MULTICENTER STUDY
Susanna Busco, Carlotta Buzzoni, Sandra Mallone, Annalisa Trama, Marine Castaing, Francesca Bella, Rosalba Amodio, Sabrina Bizzoco, Tiziana Cassetti, Claudia Cirilli, Rosanna Cusimano, Roberta De Angelis, Mario Fusco, Gemma Gatta, Valerio Gennaro, Adriano Giacomin, Paolo Giorgi Rossi, Lucia Mangone, Salvatore Mannino, Silvia Rossi, Daniela Pierannunzio, Andrea Tavilla, Sandro Tognazzo, Rosario Tumino, Massimo Vicentini, Maria Francesca Vitale, Emanuele Crocetti, Luigino Dal Maso
OBJECTIVES: This collaborative study, based on data collected by the network of Italian Cancer Registries (AIRTUM), describes the burden of rare cancers in Italy. Estimated number of new rare cancer cases yearly diagnosed (incidence), proportion of patients alive after diagnosis (survival), and estimated number of people still alive after a new cancer diagnosis (prevalence) are provided for about 200 different cancer entities. MATERIALS AND METHODS: Data herein presented were provided by AIRTUM population- based cancer registries (CRs), covering nowadays 52% of the Italian population...
January 2016: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/25228515/pancreatic-and-gastric-heterotopy-in-the-gastrointestinal-tract
#9
REVIEW
Jakub Wlaź, Agnieszka Mądro, Weronika Kaźmierak, Krzysztof Celiński, Maria Słomka
Heterotopic or ectopic tissue is a congenital anomaly defined as the presence of the tissue outside its normal location. This tissue is usually discovered incidentally and may be asymptomatic or may present with non-specific gastrointestinal (GI) symptoms. Two types of heterotopic tissues, pancreatic and gastric, predominantly occur in the GI tract. The frequency of ectopic pancreas found in autopsy studies is approximately 0.5%-13.7%. Heterotopic pancreatic tissue can be located anywhere along the GI tract; the most common sites are the stomach (27...
2014: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/24920034/fruit-vegetable-and-fiber-intake-in-relation-to-cancer-risk-findings-from-the-european-prospective-investigation-into-cancer-and-nutrition-epic
#10
REVIEW
Kathryn E Bradbury, Paul N Appleby, Timothy J Key
Fruit, vegetables, and certain components of plant foods, such as fiber, have long been thought to protect against cancer. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort that includes >500,000 participants from 10 European countries and has made a substantial contribution to knowledge in this research area. The purpose of this article is to summarize the findings published thus far from the EPIC study on the associations between fruit, vegetable, or fiber consumption and the risk of cancer at 14 different sites...
July 2014: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/24519874/the-magnitude-of-the-association-between-smoking-and-the-risk-of-developing-cancer-in-brazil-a-multicenter-study
#11
MULTICENTER STUDY
Marcione Aparecida de Souza Moura, Anke Bergmann, Suzana Sales de Aguiar, Luiz Claudio Santos Thuler
OBJECTIVES: To estimate the magnitude of association and identify the aetiological fraction (AF) attributable to smoking in the development of different types of cancers in Brazil. SETTING: We conducted a case-control study, including 231 102 patients registered in the Cancer Hospital Registries (CHR) in the period from 1998 to 2011. PARTICIPANTS: A total of 204 131 cancer cases relating to 30 topographies were compared with 26 971 cases of non-melanoma skin cancer...
2014: BMJ Open
https://www.readbyqxmd.com/read/24282903/metastatic-ovarian-tumors-a-clinicopathologic-study-of-150-cases
#12
Isabel Alvarado-Cabrero, Adriana Rodríguez-Gómez, Jorge Castelan-Pedraza, Raquel Valencia-Cedillo
OBJECTIVE: To determine the frequency of metastatic ovarian tumors and to identify their clinicopathologic features. STUDY DESIGN: A total of 150 patients with pathologically confirmed metastatic ovarian carcinoma who were treated between 1995 and 2011 at the Mexican Oncology Hospital were identified by retrospective review. Clinicopathologic data were analyzed. RESULTS: Metastatic ovarian carcinoma accounted for 15.7% of all ovarian malignancies...
October 2013: Analytical and Quantitative Cytopathology and Histopathology
https://www.readbyqxmd.com/read/24095786/increased-incidence-of-gastrointestinal-cancers-among-patients-with-pyogenic-liver-abscess-a-population-based-cohort-study
#13
Hsueh-Chou Lai, Che-Chen Lin, Ken-Sheng Cheng, Jung-Ta Kao, Jen-Wei Chou, Cheng-Yuan Peng, Shih-Wei Lai, Pei-Chun Chen, Fung-Chang Sung
BACKGROUND & AIMS: The relationship between pyogenic liver abscess (PLA) and gastrointestinal (GI) cancer was first reported more than 20 years ago, yet little is known about this connection. We evaluated this association in a population-based, retrospective, cohort study. METHODS: Using Taiwan National Health Insurance claims data, we collected data on a cohort of 14,690 patients with PLA diagnosed from 2000 to 2007. A reference cohort of 58,760 persons without PLA (controls) was selected from the same database, frequency matched by age, sex, and index year...
January 2014: Gastroenterology
https://www.readbyqxmd.com/read/24024557/annexin-a10-is-an-immunohistochemical-marker-for-adenocarcinoma-of-the-upper-gastrointestinal-tract-and-pancreatobiliary-system
#14
Su-Hsi Lu, Ray-Hwang Yuan, Yu-Ling Chen, Hey-Chi Hsu, Yung-Ming Jeng
AIMS: Annexin A10 (ANXA10) is a calcium- and phospholipid-binding protein expressed normally in the gastric mucosa. In this study, we evaluated the potential use of ANXA10 as a diagnostic marker. METHODS AND RESULTS: We observed ANXA10 expression in the gastric mucosa, the Brunner gland of the duodenum and the urothelium, but absence of expression in other normal organs. Following the screening of 1327 primary carcinomas of major organs, we identified ANXA10 expression in 46% of gastric, 72% of ampullary, 78% of pancreatic and 33% of biliary adenocarcinomas...
November 2013: Histopathology
https://www.readbyqxmd.com/read/22622863/diabetes-mellitus-as-a-risk-factor-for-gastrointestinal-cancers-among-postmenopausal-women
#15
Juhua Luo, Rowan Chlebowski, Simin Liu, Katherine A McGlynn, Niyati Parekh, Donna L White, Karen L Margolis
OBJECTIVES: While diabetes has been linked to several cancers in the gastrointestinal (GI) tract, findings have been mixed for sites other than colorectal and liver cancer. We used the Women's Health Initiative (WHI) data and conducted a comprehensive assessment of associations between diabetes and GI malignancy (esophagus, stomach, liver, biliary, pancreas, colon, and rectal). METHODS: A total of 145,765 postmenopausal women aged 50-79 enrolled in the WHI were followed for a mean 10...
March 2013: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/22482767/underuse-of-curative-surgery-for-early-stage-upper-gastrointestinal-cancers-in-the-united-states
#16
Lee J McGhan, David A Etzioni, Richard J Gray, Barbara A Pockaj, Kathryn E Coan, Nabil Wasif
BACKGROUND: Surgery is the cornerstone of potentially curative therapy for upper gastrointestinal cancer. We analyzed the patterns of treatment regarding the use of surgery for early-stage upper gastrointestinal cancer in the United States. METHODS: The Surveillance, Epidemiology, and End Research database was used to identify patients with cancer of the esophagus, stomach, pancreas, liver, gallbladder, biliary tract, or duodenum (2004-2007). Only patients with potentially resectable stage I and II disease were selected...
September 2012: Journal of Surgical Research
https://www.readbyqxmd.com/read/21998039/preoperative-diagnosis-of-metastatic-ovarian-cancer-is-related-to-origin-of-primary-tumor
#17
MULTICENTER STUDY
S Guerriero, J L Alcazar, M A Pascual, S Ajossa, B Olartecoechea, L Hereter
OBJECTIVE: To describe the gray-scale and color Doppler ultrasound features as well as some clinical and biochemical features of metastatic ovarian tumors according to the origin of the primary tumor in a large study population, METHODS: This was a retrospective analysis of 116 masses in 92 patients (mean age, 51 years) evaluated and treated at three European university centers for a metastatic tumor in the ovary. All patients had undergone transvaginal color Doppler ultrasound according to a standardized protocol prior to surgery and tumor removal...
May 2012: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/21103287/the-society-for-gastrointestinal-intervention-are-we-as-an-organization-of-disparate-disciplines-cooperative-or-competitive
#18
Richard A Kozarek
This is the Fourth Annual Meeting of the Society for Gastrointestinal Intervention, a multi-disciplinary group of practitioners committed to a minimally invasive approach to both the diagnosis and treatment of digestive disorders. The key concepts are minimally invasive and multi-disciplinary which can be construed as practicing in parallel with occasional lines of procedural and clinical interaction or inter-disciplinary in which patients are acutely cared for by a team, with treatments tailored to the patient and not the discipline that touches the patient first...
September 2010: Gut and Liver
https://www.readbyqxmd.com/read/20537166/surrogate-endpoints-for-overall-survival-in-digestive-oncology-trials-which-candidates-a-questionnaires-survey-among-clinicians-and-methodologists
#19
Nicolas Methy, Laurent Bedenne, Franck Bonnetain
BACKGROUND: Overall survival (OS) is the gold standard for the demonstration of a clinical benefit in cancer trials. Replacement of OS by a surrogate endpoint allows to reduce trial duration. To date, few surrogate endpoints have been validated in digestive oncology. The aim of this study was to draw up an ordered list of potential surrogate endpoints for OS in digestive cancer trials, by way of a survey among clinicians and methodologists. Secondary objective was to obtain their opinion on surrogacy and quality of life (QoL)...
2010: BMC Cancer
https://www.readbyqxmd.com/read/20491524/trends-in-survival-of-patients-diagnosed-with-cancer-of-the-digestive-organs-in-the-nordic-countries-1964-2003-followed-up-to-the-end-of-2006
#20
COMPARATIVE STUDY
Asa Klint, Gerda Engholm, Hans H Storm, Laufey Tryggvadóttir, Mette Gislum, Timo Hakulinen, Freddie Bray
UNLABELLED: Cancers of the digestive organs (including the oesophagus, stomach, small intestine, colon, rectum and anus, liver, gallbladder, and pancreas) constitute one-fifth of all cancer cases in the Nordic countries and is a group of diseases with diverse time trends and varying consequences for public health. In this study we examine trends in relative survival in relation to the corresponding incidence and mortality rates in the Nordic countries during the period 1964-2003. MATERIAL AND METHODS: Data were retrieved from the NORDCAN database for the period 1964 to 2003, grouped into eight 5-year periods of diagnosis...
June 2010: Acta Oncologica
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