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Takefumi Nikaido, Yoshinori Tanino, Xintao Wang, Yuki Sato, Ryuichi Togawa, Masami Kikuchi, Kenichi Misa, Kazue Saito, Naoko Fukuhara, Takaya Kawamata, Mami Rikimaru, Takashi Umeda, Julia Morimoto, Tatsuhiko Koizumi, Yasuhito Suzuki, Kenichiro Hirai, Manabu Uematsu, Hiroyuki Minemura, Atsuro Fukuhara, Suguru Sato, Junpei Saito, Hiroshi Yokouchi, Kenya Kanazawa, Yoko Shibata
Background: Decorin is a small leucine-rich repeat proteoglycan that plays a critical role in collagen fibrillogenesis, and regulates inflammation, wound healing and angiogenesis. In idiopathic pulmonary fibrosis (IPF), decorin is expressed in fibrotic lesions; furthermore, intratracheal gene transfer of decorin has been demonstrated to inhibit bleomycin-induced pulmonary fibrosis. Although these results suggest the critical role of decorin in pulmonary fibrosis, the role of decorin in the acute exacerbation of idiopathic interstitial pneumonia (AE-IIP) has not been clarified in detail...
September 2018: Journal of Thoracic Disease
Daniel Simões Oliveira, José de Arimatéia Araújo Filho, Antonio Fernando Lins Paiva, Eduardo Seigo Ikari, Rodrigo Caruso Chate, César Higa Nomura
The diagnosis of idiopathic interstitial pneumonias (IIPs) involves a multidisciplinary scenario in which the radiologist assumes a key role. The latest (2013) update of the IIP classification by the American Thoracic Society/European Respiratory Society proposed some important changes to the original classification of 2002. The novelties include the addition of a new disease (idiopathic pleuroparenchymal fibroelastosis) and the subdivision of the IIPs into four main groups: chronic fibrosing IIPs (idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia); smoking-related IIPs (desquamative interstitial pneumonia and respiratory bronchiolitis-associated interstitial lung disease); acute or subacute IIPs (cryptogenic organizing pneumonia and acute interstitial pneumonia); rare IIPs (lymphoid interstitial pneumonia and idiopathic pleuroparenchymal fibroelastosis); and the so-called "unclassifiable" IIPs...
September 2018: Radiologia Brasileira
Aliza Romirowsky, Richard Zweig, Lauren Glick Baker, Jo Anne Sirey
OBJECTIVE: Personality pathology is associated with impaired social functioning in adults, though further evidence is needed to examine the individual contributions of personality traits and processes to social functioning in depressed older adults. This study is a secondary analysis examining the relationship between maladaptive personality traits and processes and social role impairment in depressed older adults in primary care. METHODS: Participants (N = 56) were 77% female and ranged in age between 55-89 (M = 66...
October 26, 2018: Clinical Gerontologist
Zhaozhao Chen, Junying Li, Khaled Sinjab, Gustavo Mendonca, Haiyang Yu, Hom-Lay Wang
OBJECTIVE: To compare the accuracy of computer-guided surgery and freehand surgery on flapless immediate implant placement (IIP) in the anterior maxilla. MATERIAL AND METHODS: In this split-mouth design, 24 maxillary incisors in 8 human cadaver heads were randomly divided into two groups: computer-guided surgery (n=12) and freehand surgery (n=12). Preoperatively, cone-beam computed tomography (CBCT) scans were acquired, and all implants were planned with a software (Blue Sky Plan3)...
October 22, 2018: Clinical Oral Implants Research
Spyridon N Papageorgiou, Theodore Eliades, Christoph H F Hämmerle
OBJECTIVES: The aim of this systematic review was to assess clinical evidence on adverse effects of osseointegrated implants placed among natural teeth of a residual dentition. METHODS: Seven databases were searched without restrictions up to January 2018 for clinical studies on implant infraposition (IIP) or proximal contact point (PCP) loss to the adjacent teeth. After duplicate selection, data extraction, and risk of bias assessment according to the Cochrane guidelines, random-effects meta-analyses of odds ratios (OR) or mean differences (MD) and their 95% confidence intervals (CI) were performed, followed by meta-regression and sensitivity analyses...
October 2018: Clinical Oral Implants Research
Peiyan Zheng, Xiaoqing Liu, Huimin Huang, Zijun Guo, Ge Wu, Haisheng Hu, Chuanxu Cai, Wenting Luo, Nili Wei, Qian Han, Baoqing Sun
Background: Idiopathic interstitial pneumonia (IIP) can induce type II alveolar epithelial cell proliferation and pulmonary basement membrane damage and subsequent release of Krebs von den Lungen-6 antigen (KL-6) to the bloodstream. This study investigated the diagnostic and prognostic value of serum KL-6 levels for IIP. Methods: One hundred five patients with lung disease were divided into IIP (n=75) and non-IIP groups (n=30) according to pathological and computed tomography findings...
August 2018: Journal of Thoracic Disease
Steen Larsen, Anne-Kristine M Lundby, Sune Dandanell, Laura Oberholzer, Stefanie Keiser, Andreas B Andersen, Thomas Haider, Carsten Lundby
Bed rest leads to impaired glucose tolerance. Whether this is linked to maladaptation's in skeletal muscle mitochondrial function and in particular to the level of reactive oxygen species (ROS) is at present unknown. The aim of this longitudinal study was to quantify skeletal muscle mitochondrial function (respiratory capacity and ROS production) together with glucose tolerance after 4 days of strict bed rest in healthy young male subjects (n = 14). Mitochondrial function was determined in permeabilized muscle fibers using high-resolution respirometry and fluorometry, mitochondrial content (citrate synthase [CS] activity) and antioxidant protein expression levels were assessed in parallel to this...
September 2018: Physiological Reports
Nele Assmann, Elisabeth Schramm, Levente Kriston, Martin Hautzinger, Martin Härter, Ulrich Schweiger, Jan Philipp Klein
BACKGROUND: Persistent depressive disorder (PDD) is associated with high rates of comorbid psychiatric disorders, mostly anxiety disorders (ADs). Comorbid AD was found to be associated with poorer treatment outcome in PDD patients. The effect of comorbid AD on disorder-specific treatment for PDD (Cognitive Behavioral Analysis System of Psychotherapy [CBASP]) has not been studied yet. METHODS: We analyzed whether the presence of a comorbid AD was moderating the effectiveness of disorder-specific (CBASP) versus nonspecific psychotherapy (supportive therapy [SP]) on depressive symptoms (24-item Hamilton Rating Scale for Depression [HRSD-24]) in a sample of unmedicated early-onset PDD outpatients (N = 268)...
October 2018: Depression and Anxiety
Daniele A Cardinale, Filip J Larsen, Tomas A Schiffer, David Morales-Alamo, Björn Ekblom, Jose A L Calbet, Hans-Christer Holmberg, Robert Boushel
Sexual dimorphism is apparent in humans, however, to date no studies have investigated mitochondrial function focusing on intrinsic mitochondrial respiration (i.e., mitochondrial respiration for a given amount of mitochondrial protein) and mitochondrial oxygen affinity (p50mito ) in relation to biological sex in human. A skeletal muscle biopsy was donated by nine active women, and ten men matched for maximal oxygen consumption (VO2max ) and by nine endurance trained men. Intrinsic mitochondrial respiration, assessed in isolated mitochondria, was higher in women compared to men when activating complex I (CIP ) and complex I+II (CI+IIP ) ( p < 0...
2018: Frontiers in Physiology
Kiminobu Tanizawa, Tomohiro Handa, Takeshi Kubo, Toyofumi F Chen-Yoshikawa, Akihiro Aoyama, Hideki Motoyama, Kyoko Hijiya, Akihiko Yoshizawa, Yohei Oshima, Kohei Ikezoe, Shinsaku Tokuda, Yoshinari Nakatsuka, Yuko Murase, Sonoko Nagai, Shigeo Muro, Toru Oga, Kazuo Chin, Toyohiro Hirai, Hiroshi Date
BACKGROUND: Radiological pleuroparenchymal fibroelastosis (PPFE) lesion is characterized by pleural thickening with associated signs of subpleural fibrosis on high-resolution computed tomography (HRCT). This study evaluated the clinical significance of radiological PPFE as an isolated finding or associated with other interstitial lung diseases (ILDs) in patients having fibrotic ILDs and registered for cadaveric lung transplantation (LT). METHODS: This retrospective study included 118 fibrotic ILD patients registered for LT...
August 30, 2018: Respiratory Research
Tomonori Tanaka, Kaori Ishida
CONTEXT: - In 2013, the revised American Thoracic Society and European Respiratory Society classification of idiopathic interstitial pneumonias (IIPs) described 2 rare IIPs and 2 rare histologic patterns. Because of the rarity of the disease, there is limited evidence related to the histology. Because the rare histologic patterns are provisional criteria, no unanimous consensus on histologic diagnostic criteria has yet been reached. OBJECTIVE: - To review the histologic features for rare IIPs and rare histologic patterns, and to provide diagnostic aids and discuss the differential diagnosis...
September 2018: Archives of Pathology & Laboratory Medicine
Justine Briand, Hélène Behal, Cécile Chenivesse, Lidwine Wémeau-Stervinou, Benoit Wallaert
BACKGROUND: Although the 6-min walk test (6MWT) is the gold standard for assessing exercise-induced impairment of gas exchange, it cannot easily be performed in a clinical office environment. The aim of this study was to compare the 1-min sit-to-stand test (1STST) with the 6MWT for the ability to assess exercise-induced oxygen desaturation in patients with interstitial lung diseases (ILDs). METHODS: A total of 107 patients were enrolled and classified into three groups: sarcoidosis, fibrotic idiopathic interstitial pneumonia (f-IIP), and other forms of ILD...
January 2018: Therapeutic Advances in Respiratory Disease
Anca Zimmermann, Rüdiger Zwerenz, Michael Droste, Christof Schöfl, Christian J Strasburger, Ursula Plöckinger, Athanasia Ziagaki, Jürgen Honegger, Anne Dixius, Bledar Millaku, Gerrit Toenges, Manfred E Beutel, Matthias M Weber
Objective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pituitary radiation, pituitary insufficiency and comorbidities. Design: Cross sectional, multicentric. Methods: 129 patients (M/W 65/64, 58.3 ± 12.7 years, 53/76 with active/controlled disease). Acromegalic patients completed the following inventories: NEO-FFI, IIP-D, and the Giessen Complaints List (GBB-24), after written informed consent...
2018: Frontiers in Endocrinology
Stefanie Otte, Judith Streb, Katharina Rasche, Irina Franke, Stefanie Nigel, Felix Segmiller, Zrinka Sosic-Vasic, Nenad Vasic, Manuela Dudeck
INTRODUCTION: Therapeutic relationship in forensic psychiatry is believed to be affected by the coercive setting and the role conflict of the therapists as both treaters and court-appointed experts. The aim of the study was to examine and compare the therapeutic relationship in forensic and general psychiatric settings. MATERIAL AND METHODS: 52 forensic patients and 66 general psychiatric patients filled in the Psychopathy Personality Inventory - Revised (PPI-R), the Inventory of Interpersonal Problems - German Version (IIP-D), the Questionnaire on Motivation for Psychotherapy (Fragebogen zur Erfassung der Psychotherapiemotivation (FPTM)) as well as the Working Alliance Inventory - Short Revised (WAI-SR)...
July 30, 2018: Fortschritte der Neurologie-Psychiatrie
Shengwen Peng, Hiroshi Mamitsuka, Shanfeng Zhu
The US National Library of Medicine (NLM) uses the Medical Subject Headings (MeSH) (see Note 1 ) to index almost all 24 million citations in MEDLINE, which greatly facilitates the application of biomedical information retrieval and text mining. Large-scale automatic MeSH indexing has two challenging aspects: the MeSH side and citation side. For the MeSH side, each citation is annotated by only 12 (on average) out of all 28,000 MeSH terms. For the citation side, all existing methods, including Medical Text Indexer (MTI) by NLM, deal with text by bag-of-words, which cannot capture semantic and context-dependent information well...
2018: Methods in Molecular Biology
Jieyao Deng, Qingjun Yuan, Hiroshi Mamitsuka, Shanfeng Zhu
Identifying drug-target interactions is crucial for the success of drug discovery. Approaches based on machine learning for this problem can be divided into two types: feature-based and similarity-based methods. By utilizing the "Learning to rank" framework, we propose a new method, DrugE-Rank, to combine these two different types of methods for improving the prediction performance of new candidate drugs and targets. DrugE-Rank is available at ...
2018: Methods in Molecular Biology
Roya Sedghi, Bahareh Heidari, Susan Kazemi
A novel ion-imprinted polymer (IIP) toward Pb(II) recognition was synthesized on the surface of magnetic multi-walled carbon nanotubes (magnetic MWCNTs). In order to prepare magnetic functionalized-MWCNT/IIP (magnetic f-MWCNT/IIP), copolymerization of methylenebisacrylamide (MBAm) and acrylamide (AM) in the presence of dithizone-Pb(II) complex was carried out on the surface of the magnetic f-MWCNTs. Selectivity of the new synthesized sorbent toward Pb(II) and the influence of a variety of foreign ions on the recognition, preconcentration, and removal of Pb(II) were evaluated using adsorption experiments in aqueous solution...
September 2018: Environmental Science and Pollution Research International
Abhishek A Mangaonkar, Alejandro Ferrer, Filippo Pinto E Vairo, Margot A Cousin, Ryan J Kuisle, Eric W Klee, Cassie C Kennedy, Steve G Peters, J P Scott, James P Utz, Misbah Baqir, Hiroshi Sekiguchi, Shakila P Khan, Vilmarie Rodriguez, Douglas A Simonetto, Patrick S Kamath, Roshini S Abraham, Mark E Wylam, Mrinal M Patnaik
Short telomere syndromes (STSs) are accelerated aging syndromes with multisystemic manifestations that present complex management challenges. In this article, we discuss a single-institution experience in diagnosing and managing patients with inherited STSs. In total, we identified 17 patients with short telomeres, defined by flow-fluorescence in-situ hybridization telomere lengths of less than first centile in granulocytes/lymphocytes OR the presence of a characteristic germline pathogenic variant in the context of a highly suggestive clinical phenotype...
July 2018: Mayo Clinic Proceedings
Agostino Brugnera, Gianluca Lo Coco, Laura Salerno, Rachel Sutton, Salvatore Gullo, Angelo Compare, Giorgio A Tasca
BACKGROUND: Patients with Binge Eating Disorder (BED) and obesity experience distressing relationships, which could trigger negative affect and over-eating. To date no studies compared the interpersonal profiles and prototypicality of both groups using the Interpersonal Circumplex. METHOD: A sample of 177 patients with BED (mean age: 41.0 ± 12.5 years; 11.3% males), 321 obese non-BED adults (mean age: 44.5 ± 13.4 years; 28% males), and 108 normal weight adults (mean age: 37...
August 2018: Comprehensive Psychiatry
Veronique Meignin, Francoise Thivolet-Bejui, Marianne Kambouchner, Claire Hussenet, Louise Bondeelle, Andrew Mitchell, Karine Chagnon, Hugues Begueret, Valerie Segers, Vincent Cottin, Abdellatif Tazi, Sylvie Chevret, Claire Danel, Anne Bergeron
AIMS: Non-infectious pulmonary complications (NIPCs) occur frequently following allogeneic haematopoietic stem cell transplantation (HSCT). As there is no consensus on the description of the related pulmonary pathological lesions, pathologist reports and clinical conclusions are largely inconsistent in routine practice. The aim of our study was to provide an accurate overview of post-allogeneic HSCT NIPCs from a large number of lung biopsies. METHODS AND RESULTS: We reviewed 61 lung biopsies in patients with an NIPC, including 51 surgical lung biopsies, four post-mortem biopsies and six lung explants...
June 28, 2018: Histopathology
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