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Justine Briand, Hélène Behal, Cécile Chenivesse, Lidwine Wémeau-Stervinou, Benoit Wallaert
BACKGROUND: Although the 6-min walk test (6MWT) is the gold standard for assessing exercise-induced impairment of gas exchange, it cannot easily be performed in a clinical office environment. The aim of this study was to compare the 1-min sit-to-stand test (1STST) with the 6MWT for the ability to assess exercise-induced oxygen desaturation in patients with interstitial lung diseases (ILDs). METHODS: A total of 107 patients were enrolled and classified into three groups: sarcoidosis, fibrotic idiopathic interstitial pneumonia (f-IIP), and other forms of ILD...
January 2018: Therapeutic Advances in Respiratory Disease
Anca Zimmermann, Rüdiger Zwerenz, Michael Droste, Christof Schöfl, Christian J Strasburger, Ursula Plöckinger, Athanasia Ziagaki, Jürgen Honegger, Anne Dixius, Bledar Millaku, Gerrit Toenges, Manfred E Beutel, Matthias M Weber
Objective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pituitary radiation, pituitary insufficiency and comorbidities. Design: Cross sectional, multicentric. Methods: 129 patients (M/W 65/64, 58.3 ± 12.7 years, 53/76 with active/controlled disease). Acromegalic patients completed the following inventories: NEO-FFI, IIP-D, and the Giessen Complaints List (GBB-24), after written informed consent...
2018: Frontiers in Endocrinology
Stefanie Otte, Judith Streb, Katharina Rasche, Irina Franke, Stefanie Nigel, Felix Segmiller, Zrinka Sosic-Vasic, Nenad Vasic, Manuela Dudeck
INTRODUCTION: Therapeutic relationship in forensic psychiatry is believed to be affected by the coercive setting and the role conflict of the therapists as both treaters and court-appointed experts. The aim of the study was to examine and compare the therapeutic relationship in forensic and general psychiatric settings. MATERIAL AND METHODS: 52 forensic patients and 66 general psychiatric patients filled in the Psychopathy Personality Inventory - Revised (PPI-R), the Inventory of Interpersonal Problems - German Version (IIP-D), the Questionnaire on Motivation for Psychotherapy (Fragebogen zur Erfassung der Psychotherapiemotivation (FPTM)) as well as the Working Alliance Inventory - Short Revised (WAI-SR)...
July 30, 2018: Fortschritte der Neurologie-Psychiatrie
Shengwen Peng, Hiroshi Mamitsuka, Shanfeng Zhu
The US National Library of Medicine (NLM) uses the Medical Subject Headings (MeSH) (see Note 1 ) to index almost all 24 million citations in MEDLINE, which greatly facilitates the application of biomedical information retrieval and text mining. Large-scale automatic MeSH indexing has two challenging aspects: the MeSH side and citation side. For the MeSH side, each citation is annotated by only 12 (on average) out of all 28,000 MeSH terms. For the citation side, all existing methods, including Medical Text Indexer (MTI) by NLM, deal with text by bag-of-words, which cannot capture semantic and context-dependent information well...
2018: Methods in Molecular Biology
Jieyao Deng, Qingjun Yuan, Hiroshi Mamitsuka, Shanfeng Zhu
Identifying drug-target interactions is crucial for the success of drug discovery. Approaches based on machine learning for this problem can be divided into two types: feature-based and similarity-based methods. By utilizing the "Learning to rank" framework, we propose a new method, DrugE-Rank, to combine these two different types of methods for improving the prediction performance of new candidate drugs and targets. DrugE-Rank is available at ...
2018: Methods in Molecular Biology
Roya Sedghi, Bahareh Heidari, Susan Kazemi
A novel ion-imprinted polymer (IIP) toward Pb(II) recognition was synthesized on the surface of magnetic multi-walled carbon nanotubes (magnetic MWCNTs). In order to prepare magnetic functionalized-MWCNT/IIP (magnetic f-MWCNT/IIP), copolymerization of methylenebisacrylamide (MBAm) and acrylamide (AM) in the presence of dithizone-Pb(II) complex was carried out on the surface of the magnetic f-MWCNTs. Selectivity of the new synthesized sorbent toward Pb(II) and the influence of a variety of foreign ions on the recognition, preconcentration, and removal of Pb(II) were evaluated using adsorption experiments in aqueous solution...
July 5, 2018: Environmental Science and Pollution Research International
Abhishek A Mangaonkar, Alejandro Ferrer, Filippo Pinto E Vairo, Margot A Cousin, Ryan J Kuisle, Eric W Klee, Cassie C Kennedy, Steve G Peters, J P Scott, James P Utz, Misbah Baqir, Hiroshi Sekiguchi, Shakila P Khan, Vilmarie Rodriguez, Douglas A Simonetto, Patrick S Kamath, Roshini S Abraham, Mark E Wylam, Mrinal M Patnaik
Short telomere syndromes (STSs) are accelerated aging syndromes with multisystemic manifestations that present complex management challenges. In this article, we discuss a single-institution experience in diagnosing and managing patients with inherited STSs. In total, we identified 17 patients with short telomeres, defined by flow-fluorescence in-situ hybridization telomere lengths of less than first centile in granulocytes/lymphocytes OR the presence of a characteristic germline pathogenic variant in the context of a highly suggestive clinical phenotype...
July 2018: Mayo Clinic Proceedings
Agostino Brugnera, Gianluca Lo Coco, Laura Salerno, Rachel Sutton, Salvatore Gullo, Angelo Compare, Giorgio A Tasca
BACKGROUND: Patients with Binge Eating Disorder (BED) and obesity experience distressing relationships, which could trigger negative affect and over-eating. To date no studies compared the interpersonal profiles and prototypicality of both groups using the Interpersonal Circumplex. METHOD: A sample of 177 patients with BED (mean age: 41.0 ± 12.5 years; 11.3% males), 321 obese non-BED adults (mean age: 44.5 ± 13.4 years; 28% males), and 108 normal weight adults (mean age: 37...
August 2018: Comprehensive Psychiatry
Véronique Meignin, Françoise Thivolet-Bejui, Marianne Kambouchner, Claire Hussenet, Louise Bondeelle, Andrew Mitchell, Karine Chagnon, Hugues Begueret, Valérie Segers, Vincent Cottin, Abdellatif Tazi, Sylvie Chevret, Claire Danel, Anne Bergeron
Noninfectious pulmonary complications (NIPCs) frequently occur following allogeneic hematopoietic stem cell transplantation (HSCT). As there is no consensus on the description of the related pulmonary pathological lesions, pathologist reports and clinical conclusions are largely inconsistent in routine practice. The aim of our study was to provide an accurate overview of post allogeneic HSCT NIPCs from a large number of lung biopsies. We reviewed 61 lung biopsies in patients with an NIPC, including 51 surgical lung biopsies, 4 post mortem biopsies and 6 lung explants...
June 28, 2018: Histopathology
Chao Zhu, Tianjue Hu, Lin Tang, Guangming Zeng, Yaocheng Deng, Yue Lu, Siyuan Fang, Jingjing Wang, Yani Liu, Jiangfang Yu
The rapid, efficient and selective extraction of heavy metal ions is significant for wastewater pretreatment and metal ion recycle. Using montmorillonite as the template substrate and Pb2+ as template ions, a novel two-dimensional montmorillonite-based surface ion imprinted polymer (IIP-MMT) adsorbent is successfully synthesized via activators generated by electron transfer for atom transfer radical polymerization (AGET-ATRP). Batch adsorption experiments are performed to assess the properties of the imprinted polymer sorbent, along with its selectivity and reusability in practical extraction of Pb2+ ...
June 15, 2018: Chemosphere
Hironao Hozumi, Yoshiyuki Oyama, Hideki Yasui, Yuzo Suzuki, Masato Kono, Masato Karayama, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Naoki Inui, Yutaro Nakamura, Takafumi Suda
OBJECTIVE: Although a possible association among myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA), microscopic polyangiitis (MPA), and idiopathic pulmonary fibrosis (IPF) has been suggested, the clinical significance of MPO-ANCA in idiopathic interstitial pneumonias (IIPs), including IPF and non-IPF, remains unclear. We aimed to investigate the frequency of MPO-ANCA positivity, as well as MPA incidence and risk factors for development in patients initially diagnosed with IIP...
2018: PloS One
Baptiste Chéhère, Valérie Bougault, Cécile Chenivesse, Jean-Marie Grosbois, Benoit Wallaert
BACKGROUND: Pulmonary rehabilitation (PR) improves performance in the 6-min walk test (6MWT) in a subset of patients with fibrotic idiopathic interstitial pneumonia (f-IIP); however, a large proportion of patients do not respond to PR. AIM: To investigate the effects of a PR program on cardiorespiratory responses during a 6MWT and to identify the characteristics of patients who do not show improved performance after PR. DESIGN: An observational study...
June 14, 2018: European Journal of Physical and Rehabilitation Medicine
Frederik Nanne Croles, René Mulder, André B Mulder, Michaël V Lukens, Karina Meijer
Hereditary antithrombin deficiency is associated with a high incidence of venous thromboembolism (VTE), but VTE risk differs between families. Beta-antithrombin is reported to be the most active isoform of antithrombin in vivo. Whether β-antithrombin activity and subtypes in antithrombin deficiency have impact on VTE risk has not been investigated outside the proband setting. We performed a retrospective family cohort study to investigate whether subtypes of antithrombin deficiency or β-antithrombin levels are associated with the risk of first or recurrent VTE...
June 2, 2018: Thrombosis Research
Yantus A B Neolaka, Ganden Supriyanto, Handoko Darmokoesoemo, Heri Septya Kusuma
In this paper, we report for the first time modification of Indonesia (Ende-Flores) natural zeolite Cr(VI)-imprinted-poly(4-VP-co-EGDMA)-ANZ (IIP-ANZ) as a selective adsorbent for Cr(VI) from aqueous solution. The IIP-ANZ was synthesized from Cr(VI) as a template, 4-vinylphiridine (4-VP) as complex agent and as functional monomer, ethylene glycol dimethyl acrylate (EGDMA) as a cross-linker agent, benzoyl peroxide (BPO) as initiator and ethanol/acetone as a porogen. The optimization adsorption parameters optimization such as adsorbent amount, initial pH of sample solution, contact time and temperature were studied...
April 2018: Data in Brief
Yantus A B Neolaka, Ganden Supriyanto, Handoko Darmokoesoemo, Heri Septya Kusuma
The adsorption performance of Cr(VI) on the Cr(VI)-imprinted poly(4-VP-co-MMA) (IIP) supported on Activated Indonesia (Ende-Flores) natural zeolite (ANZ) structure for Cr(VI) removal from aqueous solution have been studied. Cr(VI)-imprinted-poly(4-VP-co-MMA)-ANZ (IIP-ANZ) was synthesized using Cr(VI) as a template, 4-vinylphiridine (4-VP) as a complex agent, methyl methacrylate (MMA) as a monomer agent, ethylene glycol dimethylacrylate (EGDMA) as cross-linker and benzoyl peroxide (BPO) as an initiator. XRD, FTIR, SEM-EDX and BET was performed to characterize the synthesized materials...
April 2018: Data in Brief
Shuping Wu, Xiangzi Dai, Tingting Cheng, Songjun Li
A sensitive and selective electrochemical sensor based on ion-imprinted chitosan-graphene nanocomposites (IIP-S) has been developed for the determination of Cr(VI). The ion-imprinted polymers were constructed by one-step electrodeposition. The morphology and structure of IIP-S were characterized by SEM, TEM, XRD, FTIR and EDS, respectively. Meanwhile, the electrochemical behavior of IIP-S was investigated using CV, EIS and DPV. The linear range of IIP-S was from 1.0 × 10-9 to 1.0 × 10-5  mol/L, with the low detection limit of 6...
September 1, 2018: Carbohydrate Polymers
Cassandra Bailey, Anna Abate, Carla Sharp, Amanda Venta
The Inventory of Interpersonal Problems 32 (IIP-32; Horowitz, Aiden, Wiggins, & Pincus, 2000) is a brief, 32-item, self-report questionnaire used to screen for interpersonal problems. While studies of the IIP-32's psychometric properties have been conducted in other nations, and studies have examined the psychometric properties of the IIP-32's circumplex structure, no studies have examined the factor-analytic structure in the United States since the original standardization sample. The aim of this study was to examine the psychometric properties of the IIP-32 in American college women for the first time and explore its structural validity as a circumplex measure and its concurrent validity with measures of attachment...
2018: Bulletin of the Menninger Clinic
Lili Fang, Xiaoye Min, Renfei Kang, Haiyan Yu, Spyros G Pavlostathis, Xubiao Luo
A novel cyclic functional monomer (CFM) was used to develop an As(III)-ion imprinted polymer (As-IIP). CFM possesses a positively charged imidazolium moiety and its specific cyclic size matches that of As(III). Batch adsorption experiments showed that the As-IIP has a maximum As(III) adsorption capacity of 55 mg/g, while that of the control polymer (CP) is only 25 mg As(III)/g. Adsorption isotherms for As(III) agree with the Langmuir model, suggesting monolayer adsorption. Kinetic studies showed that the adsorption process followed pseudo-second-order kinetics...
October 15, 2018: Science of the Total Environment
Jannie M B Sand, Yoshinori Tanino, Morten A Karsdal, Takefumi Nikaido, Kenichi Misa, Yuki Sato, Ryuichi Togawa, Xintao Wang, Diana J Leeming, Mitsuru Munakata
BACKGROUND: Idiopathic interstitial pneumonia (IIP) is characterized by an increased rate of extracellular matrix (ECM) remodeling resulting in fibrosis. Acute exacerbations of IIP represent periods of increased disease activity, thus we hypothesized that ECM remodeling was altered during acute exacerbations and investigated this by serological neo-epitope biomarkers. METHODS: Patients who were sequentially admitted to the hospital with acute exacerbations of IIP were retrospectively analyzed for ECM remodeling at time of exacerbation (AE-IIP) and at clinical stability (S-IIP)...
May 4, 2018: Respiratory Research
Karolin Lindberg, Lauri Nevonen, Sanna Aila Gustafsson, Erika Nyman-Carlsson, Claes Norring
AIM: The aim of the study was to explore the psychometric properties of the Inventory of Interpersonal Problems (IIP-64) and to compare levels of interpersonal distress in Swedish female outpatients with anorexia nervosa or bulimia nervosa with age- and gender-matched controls. METHODS: Totally, 401 participants were included; anorexia nervosa (n = 74), bulimia nervosa (n = 85) and controls (n = 242). All participants completed the IIP-64. The eating disorder (ED) patients also filled out the Eating Disorder Inventory-2/3 (EDI)...
April 27, 2018: Nordic Journal of Psychiatry
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