Ruitian Gao, Xin Yuan, Yanran Ma, Ting Wei, Luke Johnston, Yanfei Shao, Wenwen Lv, Tengteng Zhu, Yue Zhang, Junke Zheng, Guoqiang Chen, Jing Sun, Yu Guang Wang, Zhangsheng Yu
Spatial transcriptomics (ST) provides insights into the tumor microenvironment (TME), which is closely associated with cancer prognosis, but ST has limited clinical availability. In this study, we provide a powerful deep learning system to augment TME information based on histological images for patients without ST data, thereby empowering precise cancer prognosis. The system provides two connections to bridge existing gaps. The first is the integrated graph and image deep learning (IGI-DL) model, which predicts ST expression based on histological images with a 0...
April 29, 2024: Cell reports medicine