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By Venkatesh Ariyamuthu Transplant Nephrologist at UT Southwestern Medical Center
Etienne Macedo, Ravindra L Mehta
No abstract text is available yet for this article.
October 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Stefano Romagnoli, Zaccaria Ricci, Claudio Ronco
In modern intensive care medicine, lungs and kidneys frequently are involved in the context of multiorgan failure. When organ dysfunction occurs, the primary clinical management of critically ill patients is based on support/replacement of organ function until recovery. Mechanical ventilation is the first-line intervention in case of respiratory failure, but in most severe cases may, itself, cause ventilator-induced lung injury. The same inflammatory mechanism also may harm the kidney through mediator spillover from the injured lungs into the bloodstream...
January 2016: Seminars in Nephrology
Matthew S Shotwell, Phillip N Madonia, Michael J Connor, Milen Amde, Charbel Salem, Olufemi A Aduroja, Seth R Bauer, Joseph J Groszek, William H Fissell
No abstract text is available yet for this article.
July 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Thomas D Nolin, George R Aronoff, William H Fissell, Lokesh Jain, Rajnikanth Madabushi, Kellie Reynolds, Lei Zhang, Shiew Mei Huang, Rajnish Mehrotra, Michael F Flessner, John K Leypoldt, Jennifer W Witcher, Issam Zineh, Patrick Archdeacon, Prabir Roy-Chaudhury, Stuart L Goldstein
The effect of AKI and modern continuous RRT (CRRT) methods on drug disposition (pharmacokinetics) and response has been poorly studied. Pharmaceutical manufacturers have little incentive to perform pharmacokinetic studies in patients undergoing CRRT because such studies are neither recommended in existing US Food and Drug Administration (FDA) guidance documents nor required for new drug approval. Action is urgently needed to address the knowledge deficit. The Kidney Health Initiative has assembled a work group composed of clinicians and scientists representing academia, the FDA, and the pharmaceutical and dialysis industries with expertise related to pharmacokinetics, AKI, and/or CRRT...
January 7, 2015: Clinical Journal of the American Society of Nephrology: CJASN
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