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Clinical feasibility of the preoperative CALLY index to predict short- and long-term outcomes of gastric cancer patients.
Journal of Gastrointestinal Surgery 2024 April 18
BACKGROUND & AIMS: Gastric cancer (GC) is a major leading cause of cancer-related death worldwide. Systemic inflammation and the nutrition-based score are feasible prognostic markers for malignancies. Emerging evidence has also revealed the C-reactive protein -albumin-lymphocyte (CALLY) index to be a prognostic marker for several cancer types. However, its clinical significance to predict surgical and oncological outcomes of GC patients remains unclear.
METHODS: We assessed the preoperative CALLY index in 426 GC patients who received gastrectomy.
RESULTS: A low preoperative CALLY index was significantly correlated to all well-established clinicopathological factors for disease development, including an advanced T stage, the presence of venous invasion, lymphatic vessel invasion, lymph node metastasis, distant metastasis, and an advanced TNM stage. A low preoperative CALLY index was also an independent prognostic factor for overall survival [hazard ratio (HR): 2.64, 95% confidence interval (CI): 1.66-4.2; P<0.0001] and disease-free survival (HR: 1.76, 95% CI: 1.01-3.05; P=0.045). Additionally, a low preoperative CALLY index was an independent predictive factor for postoperative surgical site infection (odds ratio: 2.64, 95% CI: 1.42-4.89; P=0.002).
CONCLUSIONS: The preoperative CALLY index is valuable for perioperative and oncological management of GC patients.
METHODS: We assessed the preoperative CALLY index in 426 GC patients who received gastrectomy.
RESULTS: A low preoperative CALLY index was significantly correlated to all well-established clinicopathological factors for disease development, including an advanced T stage, the presence of venous invasion, lymphatic vessel invasion, lymph node metastasis, distant metastasis, and an advanced TNM stage. A low preoperative CALLY index was also an independent prognostic factor for overall survival [hazard ratio (HR): 2.64, 95% confidence interval (CI): 1.66-4.2; P<0.0001] and disease-free survival (HR: 1.76, 95% CI: 1.01-3.05; P=0.045). Additionally, a low preoperative CALLY index was an independent predictive factor for postoperative surgical site infection (odds ratio: 2.64, 95% CI: 1.42-4.89; P=0.002).
CONCLUSIONS: The preoperative CALLY index is valuable for perioperative and oncological management of GC patients.
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