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Free ribosomal proteins as culprits for nucleolar stress.

Ina Huppertz
Molecular Cell 2024 April 19
Nucleolar stress has been consistently linked to age-related diseases. In this issue, Sirozh et al.1 find that the common molecular signature of nucleolar stress is the accumulation of free ribosomal proteins, which leads to premature aging in mice; however, it can be reversed by mTOR inhibition.

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