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Two new chemical constituents from the aerial parts of Tripterygium wilfordii .
Natural Product Research 2024 April 18
Tripterygium wilfordii has been historically employed as a conventional botanical insecticide and a plant of medicinal significance. A new dihydroagarofuran sesquiterpene ( 1 ) and a new acyclic compound ( 2 ), along with seven known compounds ( 3-9 ), have been isolated from the aerial parts of Tripterygium wilfordii . The identification of the structures of novel compounds were accomplished through comprehensive spectroscopic analyses, encompassing HRESIMS, NMR, UV, IR, and a comparative analysis with spectroscopic data from compounds previously characterised. In in - vitro bioassay, compound 8 exhibited significant inhibitory activity for NO release in LPS-induced RAW 264.7 cells, with an IC50 value of 15.7 μ M.
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