Efficacy of Hyaluronic Acid/Collagenase Ointment in the Treatment of Chronic Wounds: A Retrospective Observational Study.

BACKGROUND: Chronic wounds, including diabetic ulcers, posttraumatic ulcers, and pressure sores, present a significant challenge in healthcare due to their complex nature and resistance to conventional treatments. This retrospective observational study aimed to evaluate the efficacy of an ointment containing hyaluronic acid and collagenase in treating such wounds.

METHODS: The study included 70 patients with various chronic wounds treated in our clinic from January 1, 2020, to October 1, 2023. The patients were selected according to specific inclusion and exclusion criteria, and comprehensive baseline data was collected. The treatment involved the application of a hyaluronic acid and collagenase ointment, followed by regular follow-up and data analysis.

RESULTS: Significant improvements in wound bed scores (WBS) were observed, with a reduction in healing times for all types of wounds. High patient satisfaction rates were reported, along with efficient debridement and notable pain reduction. Diabetic ulcers showed the most significant improvement in terms of healing time and WBS.

CONCLUSIONS: Hyaluronic acid and collagenase ointment demonstrated promising results in the treatment of chronic wounds. This treatment may offer a valuable addition to current wound care practices, particularly in challenging cases such as diabetic ulcers. More research is recommended, including randomized controlled trials, to validate these findings.