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International Journal of Lower Extremity Wounds

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https://www.readbyqxmd.com/read/28682732/microrna-155-inhibition-promoted-wound-healing-in-diabetic-rats
#1
Junna Ye, Yutian Kang, Xiaofang Sun, Pengwen Ni, Minjie Wu, Shuliang Lu
Diabetes leads to amputation in approximately 15% to 20% of patients and is associated with high morbidity and mortality. Thus, improving the quality of wound healing in this condition is essential. Diabetes is associated with acute/chronic inflammation affecting all organs especially the foot, while, inhibition of microRNA-155 (miR-155) has been reported to improve or reduce inflammatory situation. However, the role of miR-155 inhibition in promoting diabetic wound healing is not clear. To further study the potential benefit of miR-155 inhibition, a study of male Sprague-Dawley rats was conducted and diabetes was induced by injection of streptozotocin...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682731/end-stage-renal-disease-negatively-affects-physical-quality-of-life-in-patients-with-diabetic-foot-complications
#2
Katherine M Raspovic, Junho Ahn, Javier La Fontaine, Larry A Lavery, Dane K Wukich
The aim of this study was to evaluate the impact of end-stage renal disease (ESRD) on health-related quality of life (QOL) in patients with diabetic foot disease. We compared a group of 30 diabetic patients with ESRD requiring dialysis to a group of 60 diabetic patients without ESRD. Both groups consisted of patients with active diabetic foot disease (ulcer, Charcot, infection) and were matched with regard to age and gender. Self-reported QOL was assessed using the Short Form-36 (SF-36) physical and mental component summary (PCS and MCS) scores and the region-specific Foot and Ankle Ability Measure (FAAM)...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682730/the-influence-of-ages-environment-on-proliferation-apoptosis-homeostasis-and-endothelial-cell-differentiation-of-human-adipose-stem-cells
#3
Jia-Hong Gong, Jiao-Yun Dong, Ting Xie, Shu-Liang Lu
The aim of this study was to evaluate the changes of proliferation, apoptosis, homeostasis, and differentiation of human adipose-derived stem cells (hASCs) in the simulated diabetic microenvironment and discuss the potential of the mesenchymal stem cell in the treatment of chronic diabetic wound. We simulated diabetic microenvironment with glycation end products (AGEs) in vitro and studied the changes of hASCs in proliferation and apoptosis. We found that AGEs inhibited the proliferation and lead to hASCs apoptosis, and the endothelial cell directed differentiation was also inhibited...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682729/the-extract-of-lycium-depressum-stocks-enhances-wound-healing-in-streptozotocin-induced-diabetic-rats
#4
Siamak Naji, Leila Zarei, Masoumeh Pourjabali, Rahim Mohammadi
In diabetes, impaired wound healing and other tissue abnormalities are considered major concerns. The aim of the present study was to assess the wound-healing activity of methanolic extracts of the extract of Lycium depressum leaves. A total of 60 healthy male Wistar diabetic rats weighing approximately 160 to 180 g and 7 weeks of age were randomized into 10 groups for incision and excision wound models: sham surgery group (SHAM), including creation of wounds and no treatment; base formulation group (FG) with creation of wounds and application of base formulation ointment; treatment group 1 (TG1) with 1 g of powder extract of the plant material in ointment; treatment group 2 (TG2) with 2 g; and treatment group 4 (TG3) with 4 g of powder extract of the plant material in ointment...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682728/improved-quality-of-life-after-transtibial-amputation-in-patients-with-diabetes-related-foot-complications
#5
Dane K Wukich, Junho Ahn, Katherine M Raspovic, Javier La Fontaine, Larry A Lavery
The purpose of this study was to evaluate health-related quality of life after major lower-extremity amputation in a cohort of patients with diabetes mellitus. We evaluated 81 patients with diabetes and transtibial amputation (TTA) who had a minimum of 1 year of follow-up. Of these 81 patients, 50.6% completed the Short Form Survey (SF-36) and the Foot and Ankle Ability Measure (FAAM) preoperatively and postoperatively. Outcome measures before and after TTA were compared using Welch's ANOVA for continuous variables and Fisher's exact test for categorical variables...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682727/bacterial-prevalence-and-antibiotic-resistance-in-clinical-isolates-of-diabetic-foot-ulcers-in-the-northeast-of-tamaulipas-mexico
#6
Mario Sánchez-Sánchez, Wendy Lizeth Cruz-Pulido, Eduardo Bladinieres-Cámara, Rodrigo Alcalá-Durán, Gildardo Rivera-Sánchez, Virgilio Bocanegra-García
Diabetic foot ulcers (DFUs) are a serious and common problem in patients with diabetes mellitus and constitute one of the major causes of lower extremity amputation. The microbiological profile of DFUs depends on the acute or chronic character of the wound. Aerobic gram-positive cocci are the predominant organisms isolated from DFUs. Diabetic foot biopsies from patients admitted to the Angiology and Vascular Surgery Hospital of the Northeast, in Reynosa, Tamaulipas from December 2011 to April 2016 were analyzed...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682726/the-effectiveness-of-calf-muscle-electrostimulation-on-vascular-perfusion-and-walking-capacity-in-patients-living-with-type-2-diabetes-mellitus-and-peripheral-artery-disease
#7
Christian Ellul, Cynthia Formosa, Alfred Gatt, Auon Abbas Hamadani, David G Armstrong
The aim of the study was to explore calf muscle electrostimulation on arterial inflow and walking capacity in claudicants with peripheral artery disease and diabetes mellitus. A prospective, 1-group, pretest-posttest study design was used on 40 high-risk participants (n = 40) who exhibited bilateral limb ischemia (ankle brachial pressure index [ABPI] <0.90), diabetes mellitus, and calf muscle claudication. A program of calf muscle electrical stimulation with varying frequency (1-250 Hz) was prescribed for 1 hour per day for 12 weeks...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682725/a-randomized-controlled-trial-on-the-outcome-in-comparing-an-alginate-silver-dressing-with-a-conventional-treatment-of-a-necrotizing-fasciitis-wound
#8
Jarernchon Meekul, Arnon Chotirosniramit, Woraluck Himakalasa, Saritphat Orrapin, Antika Wongthanee, Orapin Pongtam, Kanokwan Kulprachakarn, Kittipan Rerkasem
Necrotizing fasciitis (NF) is a high morbidity and mortality disease and also demands high economic resources. The standard treatment of NF is surgical debridement and proper dressing for wound bed preparation. The efficacy of silver alginate dressing can inhibit the growth of microorganisms and keep the environment clean for wound bed preparation. However an optimal dressing to manage such wounds has yet to emerge. NF patients who were admitted between April 2013 and May 2016 were randomized to have wound dressing using either silver dressing (Ag group) or normal saline solution gauze (NSS group)...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682724/does-everything-that-s-counted-count-value-of-inflammatory-markers-for-following-therapy-and-predicting-outcome-in-diabetic-foot-infection
#9
Eric Ong, Sumaya Farran, Michelle Salloum, Summer Gardner, Nicholas Giovinco, David G Armstrong, Kathryn R Matthias, David E Nix, Mayar Al Mohajer
To assess the severity of inflammation associated with diabetic foot infection (DFI), values of inflammatory markers such as white blood count (WBC), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and neutrophil to lymphocyte ratio (NLR) are often measured and tracked over time. It remains unclear if these markers can aid the clinician in the diagnosis and management of DFI, and ensure more rational use of antibiotics. Hospitalized adult patients (n = 379) with DFI were retrospectively assessed for abnormal inflammatory markers, correlation between values of inflammatory markers, and clinical diagnosis on initial admission and on last follow-up...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682723/treating-giant-congenital-nevus-with-integra-dermal-regeneration-template-in-a-9-year-old-girl
#10
Zoran Barcot, Dakovic Bacalja Inga, Bozidar Zupancic, Vedran Bacalja
Integra dermal regeneration template has been well established in treating deep extensive burns, but there are very few cases reported of treating large full-thickness skin defects such as giant nevi. Apart from psychological and cosmetic burdens, the giant congenital nevus carries increased risk of malignant alteration. We present the case of a 9-year-old girl with a giant congenital nevus on her left lower leg. A total excision was done and she was successfully treated with Integra (LifeSciences Corp, Plainsboro, NJ)...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682722/seeking-answers
#11
Kittipan Rerkasem, Raj Mani
No abstract text is available yet for this article.
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682680/a-clinicoepidemiological-profile-of-chronic-wounds-in-wound-healing-department-in-shanghai
#12
Xiaofang Sun, Pengwen Ni, Minjie Wu, Yao Huang, Junna Ye, Ting Xie
The aim of the study was to update the clinical database of chronic wounds in order to derive an evidence based understanding of the condition and hence to guide future clinical management in China. A total of 241 patients from January 1, 2011 to April 30, 2016 with chronic wounds of more than 2 weeks' duration were studied in wound healing department in Shanghai. Results revealed that among all the patients the mean age was 52.5 ± 20.2 years (range 2-92 years). The mean initial area of wounds was 30.3 ± 63...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682679/influence-of-epidemiologic-and-patient-behavior-related-predictors-on-amputation-rates-in-diabetic-patients-systematic-review-and-meta-analysis
#13
Jin Yong Shin, Si-Gyun Roh, Nae-Ho Lee, Kyung-Moo Yang
Amputation of patients with diabetic foot is a major issue worldwide, particularly from a medical and economic standpoint. This meta-analysis aimed to identify significant risk factors of high amputation rate among epidemiologic and patient behavior-related predictors in diabetic patients. A systematic literature review and meta-analysis were performed using MEDLINE, EMBASE, and Cochrane databases. Seven variables were extracted from the included studies and evaluated based on amputation rate. The Newcastle-Ottawa scale was used to assess the quality of the studies...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682678/comparison-of-the-neutrophil-lymphocyte-ratio-and-c-reactive-protein-levels-in-patients-with-amputation-for-diabetic-foot-ulcers
#14
Hasan Metineren, Turan Cihan Dülgeroğlu
This study compared the effectiveness of the neutrophil/lymphocyte ratio (NLR) versus C-reactive protein (CRP) for evaluating the prognosis and degree of inflammation in patients with amputation for a diabetic foot ulcer (DFU). This study enrolled 56 patients with amputations for DFU with gangrene and compared the CRP levels and NLR measured before and after surgery. Overall, 24 patients (42%) died within 2 weeks postoperatively. Mortality increased with a preoperative/postoperative CRP difference ≤1.5 ( P < ...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682677/randomized-controlled-trial-of-polyhexanide-betaine-gel-versus-silver-sulfadiazine-for-partial-thickness-burn-treatment
#15
Saruta Wattanaploy, Kusuma Chinaroonchai, Nantaporn Namviriyachote, Pornprom Muangman
Silver sulfadiazine is commonly used in the treatment of partial-thickness burns, but it sometimes forms pseudo-eschar and delays wound healing. Polyhexanide/betaine gel, a new wound cleansing and moisturizing product, has some advantages in removing biofilm and promotes wound healing. This study was designed to compare clinical efficacy of polyhexanide/betaine gel with silver sulfadiazine in partial-thickness burn treatment. From September 2013 to May 2015, 46 adult patients with partial-thickness burn ≥10% total body surface area that were admitted to the Burn Unit of Siriraj Hospital within 48 hours after injury were randomly allocated into 2 groups...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682676/a-double-blind-placebo-controlled-randomized-evaluation-of-the-effect-of-low-level-laser-therapy-on-venous-leg-ulcers
#16
Julian Vitse, Farid Bekara, Stephanie Byun, Christian Herlin, Luc Teot
This study aimed to determine the effect of low-level laser therapy (LLLT) on chronic venous leg ulcers (VLUs). A double-blinded prospective randomized controlled trial was conducted to compare incidence of complete wound closure, ulcer size and pain reduction in patients randomized to 24 treatments of placebo or LLLT (635 nm) over 12 weeks. Patients presented with a 6-week history of VLUs ranging in size from 5 to 20 cm(2). Venous origin was confirmed by Doppler ultrasound and an ankle brachial index of 0...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682675/expression-and-influence-of-matrix-metalloproteinase-9-tissue-inhibitor-of-metalloproteinase-1-and-vascular-endothelial-growth-factor-in-diabetic-foot-ulcers
#17
Gongchi Li, Xinhua Zou, Youpeng Zhu, Jing Zhang, Lijun Zhou, Dan Wang, Binghui Li, Zhenbing Chen
A high matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 (MMP9/TIMP1) ratio is associated with poor ulcer healing, yet how the ratio of MMP9/TIMP1 changes in diabetic foot ulcers (DFUs) with infection and how these changes may affect wound healing remain unclear. Therefore, the objective of this investigation was to explore relationships among the MMP9/TIMP1 ratio, infection, and DFUs. After being informed of the details of this study, 32 patients signed consent forms. Skin biopsies were performed for all patients...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682674/free-flap-transfer-for-coverage-of-transmetatarsal-amputation-stump-to-preserve-residual-foot-length
#18
Hyung Min Hahn, Kwang Sik Jeong, Myong Chul Park, Dong Ha Park, Il Jae Lee
Surgical management of soft-tissue defects of the forefoot and midfoot caused by trauma or diabetic complications can be challenging because locoregional tissue is insufficient to provide adequate flap. This deficiency necessitates higher-level amputations, such as Chopart or even transtibial amputation, resulting in far more debilitating functional outcomes than are seen with partial foot amputation. The purpose of this study was to examine the surgical outcomes after transmetatarsal amputation and a free-flap transfer to preserve foot length...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682673/osteoclasis-for-the-treatment-of-recalcitrant-diabetic-forefoot-ulceration-a-case-study
#19
Colin Graney, Jakob C Thorud, Douglas Murdoch
Recurrence after diabetic foot ulceration is a common occurrence after healing. Curative surgery has been suggested to reduce the incidence of recurrent ulcerations. Osteoclasis is a simple procedure used to fracture the metatarsal head in attempt to reduce pressure under the affected metatarsal without transferring excessive pressure to adjacent metatarsals. We present a case study of a 65-year-old diabetic male with multiple attempts to heal and maintain a healed ulceration who underwent an osteoclasis procedure...
March 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28682672/sickle-cell-anemia-and-comorbid-leg-ulcer-treated-with-curative-peripheral-blood-stem-cell-transplantation
#20
Joseph L Connor, Caterina P Minniti, John F Tisdale, Matthew M Hsieh
Allogeneic bone marrow transplantation or peripheral blood stem cell transplantation (PBSCT) are the only curative therapies for patients with sickle cell disease (SCD). Once the patients have successfully undergone transplantation and engrafted, the hallmark of hemolytic anemia resolves, and normal hemoglobin levels are achieved. Some transplant protocols exclude patients with open wounds, including leg ulcers, because of infection risks associated with transplantation and long-term immunosuppression required to prevent graft-versus-host disease...
March 2017: International Journal of Lower Extremity Wounds
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