Deciphering Bisphenol A degradation by Coelastrella sp. M60: Unravelling metabolic insights through metabolomics analysis.

Microalgae, owing to their efficacy and eco-friendliness have emerged as a promising solution for mitigating Bisphenol A (BPA), a hazardous environmental pollutant. This study mainly investigated the BPA degradation by Coelastrella sp. M60 at various concentrations (10 to 50 mg/L) using GC-MS analysis. Further, the metabolic profiling of Coelastrella sp. M60 was performed via the MetaboAnalyst and results revealed that BPA exposure modulated the metabolites profile with the presence of intermediates like 4-hydroxybenzoic acid and benzene. Moreover, the highest lipid (54 %) and pigment content (40 %) at 10 mg/L of BPA exposure. Fatty acid methyl esters were quantified in Coelastrellasp. M60, with enhanced recovery facilitated by Cuprous oxide nanoparticle (Cu2 O NPs) synthesized from Spatoglossum asperum. Thus, this study persuades a potential of Coelastrella sp. M60 for effective BPA degradation, suggesting avenues to enhance the degradation efficiency of emerging contaminants in polluted water bodies via targeted metabolite expression modulation in microalgae.