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Discovery of palmatine derivatives as potent neuroprotective agents.
Journal of Asian Natural Products Research 2024 April 16
Alzheimer's disease is a neurodegenerative disorder characterized by the presence of neurodegenerative lesions and cognitive impairment. In this study, a series of novel palmatine derivatives were designed and synthesized through the introduction of a heteroatom using carbodiimide-mediated condensation. The synthesized compounds were then screened for toxicity and potency, leading to the identification of compound 2q , which exhibited low toxicity and high potency. Our findings demonstrated that compound 2q displayed significant neuroprotective activity in vitro , emerging as a promising candidate for Alzheimer's disease treatment.
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