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Journal of Asian Natural Products Research

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https://www.readbyqxmd.com/read/29210302/two-new-sesquiterpene-lactones-from-leaves-of-yacon-smallanthus-sonchifolius
#1
Xiao-Ku Ran, Khin Khin Win Aung, Jun Bai, Pei-Yuan Dou, Zheng Zeng, De-Qiang Dou
The chemical constituents of 95% EtOH extract of yacon leaves were separated to yield two new sesquiterpene lactones, together with three known compounds. The two new compounds were characterized to be 8β-angeloyloxy-13-methoxyl-11, 13-dihydromelampolid-14-oic acid methyl ester (1) and 8β-(3-methylbut-2-enoyl) oxy-13-methoxyl-11, 13-dihydromelampolid-14-oic acid methyl ester (2) on the basis of NMR spectra, HR-MS and other spectroscopic methods. The cytotoxicity of compounds 1-5 were evaluated on human hepatoma cell Bel-7402 and all the compounds showed moderate cytotoxicity...
December 6, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29210296/c-glycosides-from-the-stems-of-calophyllum-membranaceum
#2
Ling-Juan Zhu, Sen Yi, Xue Li, Hai-Feng Chen, Meng Ming, Xue Zhang, Xin-Sheng Yao
Three new C-glycosides, calophymembransides D-F (1-3), were isolated from the stems of Calophyllum membranaceum Gardn. et Champ.. The structures were assigned on the basis of spectroscopic data. RXRα transcriptional inhibition and α-glucosidase inhibition assays indicated that all the isolates were inactive.
December 6, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29210285/new-tetralone-derivatives-from-the-leaves-of-cyclocarya-paliurus
#3
Xian-Li Zhou, Qin Luo, Si-Xin Huang, Peng-Cheng Wang, Qin Xu, Xiao Huang, Cheng-Qin Liang, Xu Chen
Two new tetralone derivatives, named cyclopalosides A (1) and B (2), were isolated from the leaves of Cyclocarya paliurus by column chromatography on silica gel, reversed-phase C18 silica gel and preparative HPLC. Their chemical structures were established on the basis of extensive analyses of spectroscopic data. Their structural characteristic is tetralone glycoside with a caffeoyl unit. The antioxidant activities of compound 1 were evaluated by using hydroxyl, superoxide anion, and DPPH radical scavenging assay...
December 6, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29191050/isoprenylated-phenolic-compounds-with-tyrosinase-inhibition-from-morus-nigra
#4
Xiao Hu, Mei-Hua Yu, Gui-Rui Yan, He-Yao Wang, Ai-Jun Hou, Chun Lei
A new isoprenylated sanggenon-type flavanone, nigrasin K (1), together with three known analogs (2-4) and five known Diels-Alder adducts (5-9), were isolated from the twigs of Morus nigra. Their structures were elucidated by spectroscopic methods. Sanggenon M (2), chalcomoracin (5), sorocein H (6), kuwanon J (7), sanggenon C (8), and sanggenon O (9) showed significant inhibitory effects on mushroom tyrosinase.
November 30, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29188728/triterpenoids-from-the-aerial-parts-of-lantana-camara
#5
Anjum Ayub, Sabira Begum, Syed Nawazish Ali, Syed Tahir Ali, Bina Shaheen Siddiqui
Two new pentacyclic triterpenoids lancamarinic acid and lancamarinin have been obtained from the aerial parts of Lantana camara Linn. They were characterized as 22β-acetoxy-3,25-epoxy-3α-hydroxyolean-12-en-28-oic acid and methyl 3,25-epoxy-3α-hydroxy-11-oxo-22β-senecioyloxyolean-12-en-28-oate, respectively, through chemical transformation and exhaustive spectroscopic studies.
November 30, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29188722/three-new-sesquiterpenes-from-the-stems-of-nicotiana-tabacum-and-their-bioactivities
#6
Pei-Song Yang, Shi-Yun Tang, Chun-Bo Liu, Ling Ye, Feng-Mei Zhang, Pei He, Zhi-Hua Liu, Yong-Kuan Chen, Ming-Ming Miao, Qin-Peng Shen, Jia-Qiang Wang
Three new sesquiterpenes, methyl 4-isopropyl-7-methoxy-6-methylnaphthalene-1-carboxylate (1), methyl 2-hydroxy-4-isopropyl-7-methoxy-6-methylnaphthalene-1-carboxylate (2), and methyl 2-hydroxy-6-(hydroxymethyl)-4-isopropyl-7-methoxynaphthalene-1-carboxylate (3), together with three known sesquiterpenes (4-6), were isolated from the stems of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. The results showed that compounds 2, 3, and 5 exhibited high anti-TMV activity with inhibition rates of 33...
November 30, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29185348/a-new-chromone-and-a-new-aliphatic-ester-isolated-from-daldinia-eschscholtzii
#7
Yu Luo, Ling Qiu, Yun Deng, Xiao-Hong Yuan, Ping Gao
A new chromone and a new aliphatic ester were isolated from the EtOAc extract of myceliums of Daldinia eschscholtzii. Their structures were elucidated as (R)-5-hydroxy-8-methoxy-2-methylchroman-4-one (1) and (E)-6-(non-3-en-1-yl) -2H-pyran-2-one (2) by interpretation of the spectroscopic evidence.
November 29, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29182020/new-cycloartanes-and-new-iridoids-from-dolichandrone-spathacea-collected-in-the-mangrove-forest-of-soc-trang-province-vietnam
#8
Van Tuan Nguyen, Le Quyen Do, The Anh Nguyen, Tuan Thanh Nguyen, Van Loc Tran, Ngoc Anh Ho, Van Chien Tran, Van Sung Tran, Thi Phuong Thao Tran
Two new cycloartanes, named dolichandrone A (1) and dolichandrone B (2), as well as two new iridoids, named [6-O-[(E)-4-methoxycinnamoyl]-1β-hydroxy-dihydrocatalpolgenin (3) and 6-O-[(E)-4-methoxycinnamoyl]-1α-hydroxy-dihydrocatalpolgenin (4), together with four known iridoids (5-8), were isolated from the leaves and barks of Dolichandrone spathacea. Their structures were elucidated by means of extensive analysis of their HRESIMS, 1D and 2D NMR spectroscopic data. All of these compounds have been isolated for the first time from this plant...
November 28, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29182014/emodin-attenuates-cell-injury-and-inflammation-in-pancreatic-acinar-ar42j-cells
#9
Jia-Yu Zhao, Jia-Qi Wang, Li Wu, Feng Zhang, Zhi-Peng Chen, Wei-Dong Li, Hao Cai, Xiao Liu
The study was intended to investigate the protective effects of emodin against cell injury and inflammation in AR42J cells. We determined trypsin and lipase activity, intracellular ROS and MMP using specific assay kits. The related protein expression and TNF-α and IL-6 in the medium were assayed by Western blot and ELISA kits. Results showed that emodin could protect AR42J cells against cell injury caused by cerulein and lipopolysaccharide which were possibly associated with inhibition of mitochondrial damage, ROS production, and then significantly inhibited ROS-mediated pathway, and ameliorated pancreatic cells injury by depleting the levels of inflammatory cytokines...
November 28, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29171306/corrigendum
#10
(no author information available yet)
No abstract text is available yet for this article.
November 24, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29171292/two-new-steroidal-saponins-from-the-roots-of-cynanchum-limprichtii
#11
Jia-Chuan Liu, Li-Li Yu, Ming-Xu Tang, Xiao-Jie Lu, Dan Zhao, Hai-Feng Wang, Gang Chen, Guang-Yue Su, Yue-Hu Pei
As a part of our continuing research for bioactive constituents from Cynanchum limprichtii Schltr., two new C21 steroidal glycosides limproside A (1) and limproside B (2) were isolated from the roots of Cynanchum limprichtii. Their structures were elucidated on the basis of 1D- and 2D-NMR spectroscopic data as well as HR-ESI-MS analysis. The cytotoxicity of two compounds against two selected human cancer cell lines was assayed.
November 24, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29168395/polyketides-from-pestalotiopsis-zonata-and-structure-revision-of-pestalrones-a-and-b
#12
Xin Xu, Chang Liu, Ya-Jing Dong, Fang-Ru Liu, Xiu-Mei Xu, De-Sheng Li, Dan-Yi Li, Zhan-Lin Li
The structures of pestalrones A-B were revised via reinterpretation of the NMR data and a brief chemical transformation from the co-occurring polyketides, in our investigation on the secondary metabolites of Pestalotiopsis zonata, which also afforded a new α-pyrone derivative, pestazonatic acid, and four known analogs.
November 23, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29168389/a-new-steroidal-saponin-from-polygonatum-sibiricum
#13
Hong-Yang Zhang, Wei-Cheng Hu, Guo-Xu Ma, Nai-Liang Zhu, Xiao-Bo Sun, Hai-Feng Wu, Xu-Dong Xu
A new furostan type steroidal saponin, kingianoside Z (1), along with four known compounds (2-5), was isolated from the ethanolic extract of Polygonatum sibiricum Delar. ex Redoute. Their structures were determined by spectroscopical method and by comparison with previously reported spectroscopic data. Compounds 3-5 showed significant cytotoxicity against HepG2 cell lines with IC50 values of 14.2, 12.1 and 8.5 μM, respectively.
November 23, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29160111/new-cytotoxic-sesquiterpene-lactones-from-achillea-cretica-l-growing-in-tunisia
#14
Fayçal Hichri, Mansour Znati, Jalloul Bouajila, Hichem Ben Jannet
The phytochemical study of Achillea cretica growing in Tunisia led to the isolation of two novel sesquiterpene lactones, which have been designated achicretin 1 and achicretin 2. Their chemical structures were further confirmed by mass spectroscopy (ESI-MS) and by extensive application of one- and two-dimensional NMR spectroscopy. The isolated compounds were tested for their cytotoxic activity against four human cancer cell lines, IGROV-1, OVCAR-3, MCF-7, and HCT-116 using the MTT assay. It has been found that achicretin 2 exhibited more potent inhibitory activity with IC50 = values of 14...
November 21, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29156987/antiviral-phenolics-from-antenoron-filiforme-var-neofiliforme
#15
Shi-Zhong Ma, Shu-Hua Luan, Ling-Juan Zhu, Xue Zhang, Xin-Sheng Yao
Two new phenolics, 1,3-di-O-p-coumaroyl-2',6'-di-O-acetylsucrose (1) and quercetin 3-O-β-D-apiofuranoyl-(1→2)-α-L-rhamnopyranoside (2), along with nine known compounds (3-11), were isolated from the whole plants of Antenoron filiforme var. neofiliforme. Their chemical structures were characterized on the basis of various spectroscopic techniques. This is the first report of the isolation of phenylpropanoid sucrose (1, 3-4) from the genus Antenoron. The bioassay results showed that compound 11 exhibited antiviral activity against the Coxsackie virus B3 (CVB3)...
November 21, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29156982/cytotoxic-ring-a-seco-triterpenoids-from-the-stem-bark-of-dysoxylum-lukii
#16
Rui Huang, Ying Zhao, Ying Wang, Lei Zhou, Yu-Feng Chen, Jin-Feng Wang
A chemical investigation of the 70% ethanol extract from the stem bark of Dysoxylum lukii afforded three new ring A-seco triterpenoids, dysoxylukiines A-C (1-3). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC, and NOESY) analyses. The isolated compounds were evaluated in vitro for cytotoxic properties. Consequently, compound 3 exhibited modest cytotoxic activities against four osteosarcoma cell lines (SOSP-9607, MG-63, Saos-2, and M663) with IC50 values less than 10 μM...
November 21, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29156968/cytotoxic-monoterpenoid-type-alkaloids-from-the-aerial-parts-of-melodinus-morsei
#17
Jia-Fu Yin, Xia Mao, Jiang Hu, Yan Song
Three new monoterpenoid alkaloids, melomorines A-C (1-3), along with melohemsine B (4), were isolated from the 70% ethanol extract of the aerial parts of Melodinus morsei. Structural elucidation of all the compounds was performed on the basis of spectral data. All the compounds were tested in vitro for cytotoxic activities. As a result, alkaloids 1, 2, and 4 exhibited cytotoxicities against all the five tested tumor cell lines with IC50 value of less than 20 μM.
November 21, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29156976/two-new-saponins-from-the-leaves-of-panax-notoginseng
#18
Ji-Wu Huang, Fang-You Chen, Chuang-Jun Li, Jing-Zhi Yang, Jie Ma, Xiao-Guang Chen, Dong-Ming Zhang
Two new saponins, notoginsenosides Ng1 (1) and Ng2 (2), together with seven known compounds (3-9), were isolated from the leaves of Panax notoginseng. Their structures were elucidated by UV, IR, HRESIMS, and NMR experiments. Compounds 6 and 7 showed moderate cytotoxic activities against HCT-116, with IC50 values of 4.98 and 0.64 μmol/L, respectively.
November 20, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29126363/the-intestinal-absorption-properties-of-flavonoids-in-hippopha%C3%A3-rhamnoides-extracts-by-an-in-situ-single-pass-intestinal-perfusion-model
#19
Lei Xin, Xiao-Hui Liu, Jun Yang, Hong-Yi Shen, Guang Ji, Xiu-Feng Shi, Yan Xie
The purpose of this study was to investigate the absorption properties of isorhamnetin (IS), quercetin (QU), and kaempferol (KA) in total flavones of Hippophaë rhamnoides L. (TFH) by an in situ single-pass intestinal perfusion model. The results indicated that IS, QU, and KA in TFH were absorbed site-dependently, and both enterohepatic circulation and intestinal flora could participate in their absorption processes. The absorption mechanisms of IS, QU, and KA in TFH were involved in both passive diffusion and active transport, and the mediation of efflux transporter multidrug resistance-associated proteins (MRPs) should not be neglected...
November 10, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/29119831/lanostane-triterpenoids-and-ergostane-type-steroids-from-the-cultured-mycelia-of-ganoderma-capense
#20
Zhen Tan, Jin-Lian Zhao, Ji-Mei Liu, Min Zhang, Ri-Dao Chen, Ke-Bo Xie, Da-Wei Chen, Jun-Gui Dai
Two new lanostane triterpenoids (1 and 2), two new ergostane-type steroids (3 and 4) together with two known lanostane triterpenoids (5 and 6) and one known steroid (7) were isolated from the cultured mycelia of Ganoderma capense (CGMCC 5.71). Their structures were determined on the basis of extensive spectroscopic (HRESIMS, 1D NMR, 2D NMR) data analyses. Compound 1 exhibited moderate cytotoxic activity against the human cancer cell line NCI-H1650 with an IC50 value of 22.3 μM, and 7 displayed cytotoxic activity against the human cancer cell line HCT116 with an IC50 value of 17...
November 9, 2017: Journal of Asian Natural Products Research
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