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Journal of Asian Natural Products Research

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https://www.readbyqxmd.com/read/28511558/three-new-indole-alkaloid-derivatives-from-the-roots-of-murraya-paniculata
#1
Xiao-Ting Wang, Ke-Wu Zeng, Ming-Bo Zhao, Peng-Fei Tu, Jun Li, Yong Jiang
Three new indole alkaloid derivatives, named paniculidines D‒F (1‒3), and six known analogs (4‒9) were isolated from the roots of Murraya paniculata. The structures were elucidated on the basis of comprehensive HRESIMS, UV, IR, and NMR spectroscopic data analysis and comparison with the data reported in literature. The absolute configurations of new compounds were assigned via the determination of specific optical rotation, Mosher's method, and ECD spectra. Compound 3 is the first heterodimer of C-N linked indole and coumarin derivatives...
May 17, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28508676/two-new-compounds-from-the-fruiting-bodies-of-ganoderma-philippii
#2
Shuang Yang, Qing-Yun Ma, Fan-Dong Kong, Qing-Yi Xie, Sheng-Zhuo Huang, Li-Man Zhou, Hao-Fu Dai, Zhi-Fang Yu, You-Xing Zhao
Two new compounds, philippin (1) and 3β,9α,14α-trihydroxy-(22E,24R)-ergost-22-en-7-one (2), were isolated from the fruiting bodies of Ganoderma philippii. Their structures were elucidated on the basis of the spectroscopic technologies, including 1D and 2D NMR as well as MS. The bioassay of inhibitory activity against acetylcholinesterase (AChE) showed compound 1 exhibited weak inhibitory activity against AChE.
May 16, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28508668/total-synthesis-and-neuroprotective-effect-of-o-methylmurrayamine-a-and-7-methoxymurrayacine
#3
Ying-Da Zang, Chuang-Jun Li, Xiu-Yun Song, Jie Ma, Jing-Zhi Yang, Nai-Hong Chen, Dong-Ming Zhang
O-Methylmurrayamine A (7) and 7-methoxymurrayacine (8) are natural products isolated from Murraya koenigii and Murraya siamensis, respectively. In this paper, we report the synthesis of 7 and 8 which are featured in the key step of cyclization to form carbazole intermediate 5 with mild conditions. The structures were confirmed by (1)H NMR, (13)C NMR, and HR-ESI-MS. In addition, compounds 7 and 8 were tested for their neuroprotective effects against H2O2-induced PC12 cell damage. The results showed that compounds 7 and 8 have neuroprotective effect...
May 16, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28508666/biotransformation-of-total-coumarins-of-radix-glehniae-by-lecanicillium-attenuatum-w-1-9
#4
Qi Dong, Ye Yuan, Yue Zhou, Yi-Xin Zhang, Jian-Peng Zhang, Hao-Bing Yu, Bing-Hua Jiao, Xiao-Yu Liu, Xiao-Ling Lu
The biotransformation of total coumarins of Radix Glehniae by Lecanicillium attenuatum W-1-9 yielded three new products, lecaniside A (1), lecaniside B (2), and lecaniside C (3). The chemical structures of these metabolites were elucidated based on extensive spectral data, including 2D NMR and HRMS. The hydrogenation, dealkylation, glycosylation, and O-methylation reactions of these metabolites were observed in the present study. In the in vitro assays, compound 1 displayed a little PTP1B inhibitory activity...
May 16, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28503941/pyrrolo-2-1-a-isoquinoline-and-pyrrole-alkaloids-from-sinomenium-acutum
#5
Hai-Ning Lv, Ke-Wu Zeng, Ming-Bo Zhao, Yong Jiang, Peng-Fei Tu
Two pyrrolo[2,1-a]isoquinolines (1 and 2) and three pyrrole alkaloids (3-5), including three new ones, named sinopyrines A-C (1-3), were isolated from the 95% EtOH extract of the stems and rhizomes of Sinomenium acutum (Thumb.) Rehd. et Wils. The structures of the new compounds were elucidated on the basis of spectroscopic data. This is the first report of pyrrole-bearing natural compounds from the family Menispermaceae.
May 15, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28492090/synthesis-and-structure-activity-relationship-of-theasapogenol-galactosides-against-magnaporthe-oryzae
#6
Guang-Hua Huo, Xu-Tao Chen, Zhi-Min Li, Cheng-Fu Liu, Da-Jin Xiao
Camellia oleifera is expected to provide alternative aglycone to synthesize some saponins similar to that from Schima superba with inhibitory activity against Magnaporthe oryzae. Eight theasapogenol galactosides were synthesized via protection of adjacent hydroxyl groups by a benzylidene for regioselective glycosylation in the multi-hydroxyl sapogenin. Water soluble galactose chain connected far from liposoluble end was a key group in inhibiting the growth of M. oryzea unless theasapogenol was modified by two galactosyl groups or by one galactosyl group and one benzylidene group...
May 11, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28485622/the-synthesis-of-dendroflorin
#7
Yi Deng, Kun Jiang, Mao-Jun Cai, Shi-Jin Qu, Yi-Ru Dai, Chang-Heng Tan
The first synthesis of dendroflorin has been achieved in 10 steps with an overall yield of 5.5%. The key step in the synthesis features the biphenyl structure is built through Suzuki-Miyaura reaction. In addition, the ortho-localization effect induced by aromatic substituent during the bromination of intermediate 8 is also observed and discussed.
May 9, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28478698/novel-chaetospirolactone-and-orsellide-f-from-an-endophytic-fungus-chaetomium-sp
#8
Qin-Lan Xu, Yong-Sheng Xiao, Ye Shen, Hui-Min Wu, Xuan Zhang, Xin-Zhao Deng, Ting-Ting Wang, Wei Li, Ren-Xiang Tan, Rui-Hua Jiao, Hui-Ming Ge
Chaetospirolactone (1), a novel spiro-lactone bearing a rare 1-oxaspiro [4.4] non-7-ene-2,6-dione skeleton, and orsellide F (2), together with six known compounds (3-8), were isolated from an endophytic fungus Chaetomium sp. NF00754. Their structures were determined by interpretation of spectroscopic data. The absolute configurations of 1 and 2 were established by analysis of single X-ray crystallographic data and CD spectra. Compounds 3, 4, and 6 showed moderate acetylcholinesterase inhibitory activity with IC50 values of 7...
May 8, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28480745/bioactivity-guided-synthesis-of-gramine-derivatives-as-new-mt1-and-5-ht1a-receptors-agonists
#9
Xiu-Juan Yin, Xiao-Yan Huang, Yun-Bao Ma, Chang-An Geng, Tian-Ze Li, Xing-Long Chen, Tong-Hua Yang, Jun Zhou, Xue-Mei Zhang, Ji-Jun Chen
Twenty-four gramine derivatives were synthesized and evaluated on MT1 and 5-HT1A receptors in vitro. Among them, seven derivatives (7, 8, 16, 19, 20, 21, and 24) exhibited higher agonisting activities on MT1 or 5-HT1A receptors. Compared with gramine, derivatives 7, 8, 16, 19, 20, 21, and 24 displayed 1.6-3.5-fold increase in agonistic rates on 5-HT1A receptor. Particularly, derivatives 7, 19, and 21 exhibited significant agonistic activities on MT1 and 5-HT1A receptors with EC50 values of 0.51, 0.39, 0.50 mΜ and 0...
May 7, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28480740/two-new-p-coumaroylated-sesquiterpenoids-from-pilea-cavaleriei
#10
Heng-Chun Ren, Jun Zhang, Hong Liang
A new p-coumaroylated santalane-type sesquiterpenoid, 8-p-coumaroyl-α-santalene (1), a new p-coumaroylated oplopanane-type sesquiterpenoid, 8-β-p-coumaroyl-oplopanone (2), and three known p-coumaroylated humulene-type sesquiterpenoids (3-5) were isolated from the ethanol extract of the whole herbs of Pilea cavaleriei. Their structures were elucidated based on the combination of 1D and 2D NMR and HRMS methods. Compound 2 was found to show anti-tuberculosis activity with MIC of 16 μg/ml.
May 7, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28475367/diglycosidic-indole-alkaloid-derivatives-from-an-aqueous-extract-of-isatis-indigotica-roots
#11
Ling-Jie Meng, Qing-Lan Guo, Cheng-Bo Xu, Cheng-Gen Zhu, Yu-Feng Liu, Ming-Hua Chen, Sheng Lin, Yu-Huan Li, Jian-Dong Jiang, Jian-Gong Shi
Six new indole alkaloid diglycosides named isatigotindolediosides A-F (1-6), along with three known analogs (7-9), were isolated from an aqueous extract of the Isatis indigotica roots (ban lan gen). Their structures including the absolute configurations were determined by comprehensive spectroscopic data analysis, combined with enzyme or acid hydrolysis, and comparison of experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra. In the preliminary assays, compounds 3, 5, and 8 showed antiviral activity against Coxsackie virus B3...
May 5, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28470116/anti-neuroinflammatory-diterpenoids-from-the-endangered-conifer-podocarpus-imbricatus
#12
Chang-Ling Hu, Juan Xiong, Chen-Xi Xiao, Yu Tang, Guang-Lei Ma, Jiang Wan, Jin-Feng Hu
Ten diterpenoids including three new abietanes (1-3) were isolated from the twigs and needles of Podocarpus imbricatus, an endangered conifer growing in a Cantonese garden. The new structures were established by means of spectroscopic methods. Among the isolates, 3β-hydroxy-abieta-8,11,13-trien-7-one (5), decandrin G (6), and 7,15-pimaradien-18-oic acid (8) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells, with IC50 values of 3...
May 4, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28463577/triterpenoids-with-antioxidant-activities-from-myricaria-squamosa
#13
Heng Xu, Zhen-Zhen Yuan, Xiao Ma, Chi Wang, You-Rui Suo, Hong-Lun Wang, Xiao-Yan Wang, Bo Bai
A new triterpenoid, namely myricarin C (compound 1), together with three known compounds myricarin A (compound 2) and myricarin B (compound 3), 3α-hydroxy-D-friedoolean-14-en-28-oic acid (compound 4), was isolated from the overground part of Myricaria squamosa. Compound 2 and compound 3 existed in the solution by the form of cis-trans isomers. Their structures were elucidated by means of extensive spectroscopic methods, including 1D-NMR, 2D-NMR, and HR-ESI-MS. The antioxidant properties of all compounds were calculated based on the DPPH radical scavenging activities...
May 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28463565/selective-dual-cholinesterase-inhibitors-from-aconitum-laeve
#14
Hanif Ahmad, Shujaat Ahmad, Syed Adnan Ali Shah, Hidayat Ullah Khan, Farman Ali Khan, Mumtaz Ali, Abdul Latif, Farzana Shaheen, Manzoor Ahmad
New lycoctonine-type dual cholinesterase inhibitor, swatinine-C (1), along with three known norditerpenoid alkaloids, hohenackerine (2), aconorine (5) and lappaconitine (6) and two synthetically known but phytochemically new benzene derivatives, methyl 2-acetamidobenzoate (3) and methyl 4-[2-(methoxycarbonyl)anilino]-4-oxobutanoate (4), was isolated from the roots of A. laeve. Structures of new and known compounds (1-6) were established on the basis of latest spectroscopic techniques and by close comparison with the data available in literature...
May 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28463530/cytotoxic-triterpenes-from-the-acid-hydrolyzate-of-gynostemma-pentaphyllum-saponins
#15
Lin Shi, De-Hong Tan, Ting-Cai Yan, Dong-Hua Jiang, Ming-Xiao Hou
One new dammarane-type triterpene, gypsapogenin A (1), was isolated from the acid hydrolyzate of total saponins from Gynostemma pentaphyllum (Thunb.) Makino, together with two known compounds, (20S,24S)-3β,20,21β,23β,25-pentahydroxy-21,24-cyclodammarane (2) and (23S)-3β-hydroxydammar-20,24-dien-21-oic acid 21,23-lactone (3). Its structural elucidations were accomplished mainly on the basis of the interpretation of spectroscopic data, such as IR, HR-TOF-MS, and NMR. The cytotoxic activities were evaluated against HepG2 and A549 human cancer cell lines...
May 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28447469/two-pairs-of-rare-naturally-occurring-4-hydroxy-4-methyl-2-5-heptanedione-derivatives-from-the-red-alga-chondria-crassicaulis
#16
Lin Tong, Yi Zhang, Ai-Hong Liu, Li-Gong Yao, Yue-Wei Guo, Shui-Chun Mao, Bin Wang
Two pairs of rare naturally occurring racemic lipids, (±)-4,7-dihydroxy-4-methyl-2,5-heptanedione (1), and (±)-7-butoxy-4-hydroxy-4-methyl-2,5-heptanedione (2) were isolated from the red alga Chondria crassicaulis Harv. The structures of the racemic mixtures of 1 and 2 were elucidated by detailed spectroscopic techniques, including 1D and 2D NMR ((1)H and (13)C NMR, (1)H-(1)H COSY, HSQC, and HMBC) as well as mass spectrometry and optical rotation experiments, and by comparison with data for related known analogs...
April 27, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28446036/fusaripeptide-a-new-antifungal-and-anti-malarial-cyclodepsipeptide-from-the-endophytic-fungus-fusarium-sp
#17
Sabrin R M Ibrahim, Hossam M Abdallah, Ehab S Elkhayat, Nawal M Al Musayeib, Hani Z Asfour, Mohamed F Zayed, Gamal A Mohamed
From the culture of the endophytic fungus Fusarium sp. isolated from the roots of Mentha longifolia L. (Labiatae) growing in Saudi Arabia, a new cyclodepsipeptide, namely fusaripeptide A (1), along with three known compounds adenosine (2), 2[(2-hydroxypropionyl)amino]benzamide (3), and cyclopentanol (4), have been isolated. Their structures were determined, using extensive 1D and 2D NMR and HRESI and GC mass spectral data. That is the first report for the isolation of compound 4 from natural source. In addition, compounds 2 and 3 are reported here for the first time from Fusarium sp...
April 27, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28446029/sugar-free-pregnane-type-steroids-from-the-roots-of-cynanchum-stauntonii
#18
An-Jun Deng, Dan Zhang, Qian Li, Zhi-Hui Zhang, Zhi-Hong Li, Hai-Lin Qin
Two new sugar-free 14,15-secopregnane-type steroids, 14-O-methyl-3-epi-hirundigenin (1) and 2-deoxyamplexicogenin A (2), along with two known sugar-free pregnane-type steroids, were isolated from the 95% ethanol extract of the roots of Cynanchum stauntonii. The structures of the new compounds were characterized on the basis of extensive spectroscopic analyses, mainly 1D and 2D NMR methods, albeit the MS experiments did not display the molecular ion peaks. Compound 2 was the aglycones of stauntosides J and K, etc...
April 27, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28440085/actinomycin-d-synergistically-enhances-the-cytotoxicity-of-cddp-on-kb-cells-by-activating-p53-via-decreasing-p53-mdm2-complex
#19
Lin Wang, Xiao-Cong Pang, Zi-Ru Yu, Sheng-Qian Yang, Ai-Lin Liu, Jin-Hua Wang, Guan-Hua Du
The aim of this study is to investigate the synergism of low dose of actinomycin D (LDActD) to the cytotoxicity of cisplatin (CDDP) on KB cells. The role of P53 reactivation by LDActD in the synergism and its mechanism were further studied. Cell viability was determined by MTT assay. Apoptosis was determined by AnnexinV-FITC/PI staining. Mitochondrial membrane potential (MMP) was detected by JC-1 staining. Expression of proteins was detected by Western blotting (WB) and/or immunofluorescence (IF). Molecular docking of actinomycin D (ACTD) to Mouse double minute 2 homolog (MDM2) and Mouse double minute 2 homolog X (MDMX)...
April 25, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28436701/two-cytotoxic-6-7-seco-spiro-lacton-ent-kauranoids-from-isodon-rubescens
#20
Guo-Yong Luo, Rui Deng, Jing-Jie Zhang, Jiang-Hai Ye, Lu-Tai Pan
The present study was performed to investigate the chemical components of the branches and leaves of Isodon rubescens. Two 6,7-seco-spiro-lacton-ent-kauranoids were obtained. Based on the extensive spectroscopic analyses, their structures were elucidated as 6-epi-11-O-acetylangustifolin (1) and 11-O-acetylangustifolin (2), respectively. The structure of 2 was further comfirmed by X-ray crystallography analysis. MTT method was employed to evaluate their cytotoxity against human lung cancer cell lines A549 and leukemia cell lines K562...
April 24, 2017: Journal of Asian Natural Products Research
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