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Journal of Asian Natural Products Research

Ji-Fa Zhang, Yu Li, Feng Gao, Lian-Hai Shan, Xian-Li Zhou
Four new C20 -diterpenoid alkaloids, rotundifosines D-G (1-4), along with eight known ones (5-12) were isolated from the whole plant of Aconitum rotundifolium Kar. & Kir. The structures of the compounds were elucidated on the basis of spectroscopic analyses, including HR-ESI-MS and 1D, 2D NMR. Rotundifosine F (3) is a rare C20 -diterpenoid alkaloid with quaternary ammonium salt. Alkaloids 1-4, 5, 6, 9, and 12 were evaluated for cytotoxicity against MCF-7, HCT-116 and HepG2 human cancer cell lines.
May 14, 2018: Journal of Asian Natural Products Research
Xu-Da Wang, Qing-Hua Han, Jun Zhang, Qing-Ying Zhang, Peng-Fei Tu, Hong Liang
Three new triterpenoid saponins, julibrosides A5 -A7 (1-3), together with five known saponins (4-8), were isolated from the stem bark of Albizia julibrissin. Their structures were elucidated on the basis of extensive spectroscopic data analysis of MS, 1D and 2D NMR, and chemical methods. Compounds 7 and 8 were isolated from the genus Albizia for the first time. The new compounds showed no cytotoxicity and anti-inflammatory activity.
May 14, 2018: Journal of Asian Natural Products Research
Jian-Wei Dong, Le Cai, Xue-Jiao Li, Ya-Xian Shi, Jia-Peng Wang, Rui-Feng Mei, Zhong-Tao Ding
A new menthane-type monoterpenoid, illigerate E (1), as well as two known ones, (1R* ,3R* ,4S* ,6R* )-6,8-dihydroxymenthol (2) and cis-4-hydroxy-5-(1-hydroxy-1-methylethyl)-2-methyl-2-cyclohexene-1-one (3), were isolated from fermented Illigera aromatica with Clonostachys rogersoniana 828H2. Their structures were identified by HRESIMS and 1D/2D NMR spectra. Their inhibitory effects of NO production in RAW 264.7 macrophages were estimated.
May 11, 2018: Journal of Asian Natural Products Research
Hong-Xin Liu, Hai-Bo Tan, Sai-Ni Li, Yu-Chan Chen, Hao-Hua Li, Sheng-Xiang Qiu, Wei-Min Zhang
Two new polyketide metabolites, the 12-membered macrolides 4-hydroxy-12-methyloxacyclododecane-2,5,6-trione (1) and 12-methyloxacyclododecane-2,5,6-trione (2), were isolated from the endophytic fungal strain Cladosprium colocasiae A801 of the plant Callistemon viminalis, together with five known derivatives. Their structures were fully characterized by means of detailed spectroscopic analysis for new structures, and in comparison with published data for known compounds. The antibacterial, cytotoxic, and α-glucosidase inhibitory activities of the new compounds 1 and 2 were evaluated...
May 9, 2018: Journal of Asian Natural Products Research
Salman Zafar, Faiz -Ur-Rehman, Zafar Ali Shah, Abdur Rauf, Aziz Khan, Muhammad Humayun Khan, Khaliq Ur Rahman, Serab Khan, Abid Ullah, Farzana Shaheen
Inspired from the leishmanicidal and antibacterial potential of the fractions obtained from the crude extract of Olea ferruginea stem, the anti-leishmanial ethyl acetate fraction was subjected to chromatographic separation, leading to the isolation of a new compound ferruginan (1) and a known compound (+)- cycloolivil (2). The structures of 1 and 2 were determined by various spectroscopic techniques and were assayed for their in vitro antibacterial and leishmanicidal potential. Compound 1 showed 75% inhibition after 24 h of incubation and 98% inhibition after 48 h of incubation against Leishmania tropica KWH23 promastigotes at 100 μg/mL concentration, while compound 2 exhibited 73% and 96% inhibition at the same concentration and incubation time...
May 7, 2018: Journal of Asian Natural Products Research
Yan-Qiu Meng, Zhen-Yu Kuai, Shen-Wen Zhan, Chun-Lin Li, Hong-Rong Chen
Using the techniques of computer-aided drug design, the docking of survivin and known active small molecules was simulated and then the key amino acid residue fragments of the target protein were analyzed. It led to the discovery of active groups capable of binding to the critical sites. Through the use of the natural product, oleanolic acid, as a lead compound, the introduction of the active groups onto the A-ring, and the modification of the carboxyl group at the C-28 position using esterification or amidation, 20 new oleanolic acid derivatives had been designed and synthesized...
May 7, 2018: Journal of Asian Natural Products Research
Hong-Xiu Hu, Ran-Ran Gao, Zhao-Hui Gao, Yue Qiao, Xin-Ran Dong, Gang Ding, Di-An Sun
Three new (6, 9, and 12) and nine known steroidal saponins were obtained from the fermentation broth of pseudoprotodioscin (PPD) incubated with a fungus Gibberella fujikuroi CGMCC 3.4663. Structures of the metabolites were elucidated by 1-D (1 H, 13 C), 2-D (HMBC, HSQC, NOESY) NMR, and HR-MS analyses. The biotransformation pathway of pseudoprotodioscin by Gibberella fujikuroi CGMCC 3.4663 was proposed. Compounds 1-11 were tested in vitro for their cytotoxic activities against two human cancer cell lines (HepG2 and Hela)...
May 7, 2018: Journal of Asian Natural Products Research
Xiao-Qin Li, Ya-Nan Song, Su-Juan Wang, Khalid Rahman, Jian-Yong Zhu, Hong Zhang
Over the past decades, a number of phytochemicals have been reported to possess potent pharmacological effects. Saikosaponins represent a group of oleanane derivatives, usually as glucosides, which are commonly found in medicinal plants Bupleurum spp., which have been used as traditional Chinese medicine for more than 1,000 years in China. Emerging evidence suggests that saikosaponins have many pharmacological effects, including sedation, anticonvulsant, antipyretic, antiviral, immunity, anti-inflammation, antitumor properties, protecting liver and kidney and so on...
May 4, 2018: Journal of Asian Natural Products Research
Chang Liu, Rong-Rong Cheng, Zhu-Zhen Han, Ying-Bo Yang, Yue Zhou, Li Yang, Zheng-Tao Wang
Nigakialcohol A (1), as unusual cyclization ionone derivative, together with eight known ones (2-9), were isolated from the leaves of Picrasma quassioides (D. Don) Benn (Simaroubaceae). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. Compound 2 showed a weak inhibitory effect on NO production at non-cytotoxic concentration (100 μM) with inhibitory rate of 59%, and thus it should be regarded as potential anti-inflammatory agents.
May 2, 2018: Journal of Asian Natural Products Research
Tian-Yi Yuan, Zi-Ran Niu, Di Chen, Yu-Cai Chen, Hui-Fang Zhang, Lian-Hua Fang, Guan-Hua Du
The aim of this study is to investigate the vasorelaxant effect of quercetin on cerebral basilar artery in vitro and provide a preliminary discussion concerning the underlying mechanisms. Using a DMT-isolated micro vessel system, quercetin was found to exhibit a vasodilatory effect on basilar arteries contracted by potassium chloride (KCl), endothelin-1 (ET-1), and 5-hydroxytryptamine (5-HT). The vasorelaxant effect of quercetin was partially attenuated when endothelium cells were removed. L-NAME, indomethacin, and ODQ treatment also decreased the potency of quercetin...
April 25, 2018: Journal of Asian Natural Products Research
Ying-Ying Si, Ming-Xu Tang, Shuang Lin, Gang Chen, Hui-Ming Hua, Jiao Bai, Yu-Bo Wang, Hai-Feng Wang, Yue-Hu Pei
A new fumiquinazoline-type alkaloid 2-methyl-versiquinazoline C (1), together with six known compounds (2-7), was isolated from Aspergillus flavipes PJ03-11 using OSMAC method. Their structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configuration of compound 1 was determined by the experimental and calculated ECD data. In addition, the cytotoxic activities against three human cancer cell lines (HL-60, THP-1, and PC-3) were evaluated.
April 25, 2018: Journal of Asian Natural Products Research
Lin Chen, Guang-Wei Wu, Dong Liu, Wen-Ying Zhuang, Wen-Bing Yin
Two new polyketide derivatives, trichodermatides E (1) and F (2), are unprecedented examples of a polyketide with 6/6/6/6 tetracyclic skeleton, together with five known analogs koninginin B (3), koninginin D (4), 7-O-methylkoninginin D (5), koninginins E and F (6-7), were isolated from the plant endophytic fungus Trichoderma applanatum. The structures of these two compounds were determined by NMR data and HR-ESI-MS analysis. The putative biosynthesis of compounds 1-7 was presented.
April 23, 2018: Journal of Asian Natural Products Research
Narayana Rao Gundoju, Ramesh Bokam, Nageswara Rao Yalavarthi, Sudheer Kumar Buddana, R S Prakasham, Mangala Gowri Ponnapalli
The total syntheses of four polyketides, surinone B (1), alatanones A-B (2-3), and trineurone A (4) were accomplished through an efficient and unified strategy via one-pot C-acylation reaction coupling 1,3-cyclohexadiones with EDC-activated acids under mild conditions. Alatanone A (2) was found to be a potent anti-microbial agent against Gram-positive and Gram-negative bacteria with MIC 31.25 μg/ml while alatanone B (3) was found to be a potent anti-fungal agent against Cladosporium cladosporioides with MIC 62...
April 23, 2018: Journal of Asian Natural Products Research
Min-Hong Jiang, Yue Hu, Lin Jiao, Pan Dong, Sheng Yin, Zhi-Min Zhao, De-Po Yang, Dong-Mei Wang
Five fractions prepared from the crude extract of Leonurus japonicus were examined in order to determine their cytotoxic potential. Under the bioassay guidance, a new labdane-type diterpenoid (1), and nine known ones (2-10) along with a seco-labdane (11) were isolated from the aerial parts of Leonurus japonicus. The structure elucidation was primarily based on comprehensive spectroscopic analyses, including HRESIMS, IR, and 1D and 2D NMR methods. Compound 4 (6β-hydroxy-15,16-epoxylabda-8,13(16),14-trien-7-one) exhibited potential cytotoxicity against HeLa cell line (IC50  = 23...
April 23, 2018: Journal of Asian Natural Products Research
Qi Chang, Yu-Lei Li, Xia Zhao
Samoamide A is a cyclic octapeptide rich in proline and phenylalanine residues isolated from an American Samoa marine cyanobacterium, which exhibits potent activity against H460 human non-small-cell lung cancer cells (IC50 of 1.1 μM). The first total synthesis of samoamide A was achieved by employing a strategy of a solid-phase peptide synthesis (SPPS) and a head-to-tail cyclization selecting free steric-hinrance connection sites. Then the final product was purified and identified. This strategy not only provides a basis in producing potent cytotoxic agents for drug discovery, but also provides a reference to the total synthesis of proline-rich peptides...
April 19, 2018: Journal of Asian Natural Products Research
Ning-Ning Yang, Ning Jiang, Qing-Yun Ma, Fan-Dong Kong, Qing-Yi Xie, Li-Man Zhou, Zhi-Fang Yu, You-Xing Zhao
Chemical investigation on the cultures of the fungus Cordyceps spp., a strain from cell fusion between Cordyceps militaris and Cordyceps cicadae, resulted in the isolation of 13 compounds including 2 new ones named 2-(5-(3-oxobutyl) furan-2-yl) acetic acid (1) and cordycepone (2). Their structures were elucidated from the analysis of 1D/2D NMR and CD data. Among them, compounds 1, 7-9, at a concentration of 50 μg/ml, showed weak inhibitory activity against AChE. Moreover, compounds 6, 9, and 11 showed moderate inhibitory activity against the nematode Panagrellus redivivus with mortality ratio of 79...
April 19, 2018: Journal of Asian Natural Products Research
Chuan Qin, Di-Ya Yu, Xu-Dong Zhou, Min Zhang, Qing-Lai Wu, Jun-Kai Li
To improve the physical and chemical properties of phenazine-1-carboxylic acid (PCA) and find higher antifungal compounds, a series of PCA amide analogues were designed and synthesized and their structures were confirmed by 1 H NMR, HRMS, and X-ray. Most compounds showed some antifungal activities in vitro. Particularly, compound 3d exhibited inhibition effect against Pyriculariaoryzac Cavgra with EC50 value of 28.7 μM and compound 3q exhibited effect against Rhizoctonia solani with EC50 value of 24.5 μM, more potently active than that of the positive control PCA with its EC50 values of 37...
April 18, 2018: Journal of Asian Natural Products Research
J D Yuvenesan Jagabalan, Vikneswaran Murugaiyah, Hadzliana Zainal, Sharif Mahsufi Mansor, Surash Ramanathan
The intestinal permeability of mitragynine was investigated in situ using a single pass intestinal perfusion (SPIP) absorption model, in small intestine of rat using mitragynine in the absence/presence of the permeability markers, P-gp and/or CYP3A4 inhibitors. Mitragynine demonstrated high intestinal permeability (Peff of 1.11 × 10-4  cm/s) that is in the range of highly permeable drugs such as propranolol (Peff of 1.27 × 10-4  cm/s) indicating that it readily crosses the intestine. The addition of azithromycin (P-glycoprotein inhibitor) and ciprofloxacin (CYP3A4 inhibitor) or combination of both has no effect on intestinal permeability of mitragynine across the rat small intestine...
April 18, 2018: Journal of Asian Natural Products Research
Sheng-Nan Zhang, Jin Zeng, Ya-Nan Tan, Rui-Jing Ma, Gui-Jie Zhang, Heng-Shan Wang, Qin-Gang Tan
A new natural product, 3α,19-dihydroxyl-ent-pimara-8(14),15-diene (1), which possesses an α-orientation hydroxymethyl at C-4 and ∆8,14 groups, as well as eight known compounds, was isolated from the rhizomes of Ricinus communis. The structure of 1 was elucidated by extensive spectroscopic methods and its absolute configurations were confirmed by X-ray crystallographic analysis. The inhibitory rate of 1 against protein tyrosine phosphatase 1B (PTP1B) was 49.49% at the concentration of 6.58 × 10-5  mol/L...
April 18, 2018: Journal of Asian Natural Products Research
Kai-Ting Duan, Zheng-Hui Li, Wen-Xuan Wang, He-Ping Chen, Huan Sun, Rong Huang, Tao Feng, Ji-Kai Liu
Three new vibralactone derivatives, namely vibralactones U-W (1-3), together with vibralactone (4), have been isolated from cultures of the basidiomycete Boreostereum vibrans. Their structures were determined on the basis of spectroscopic methods and literature data. All compounds showed no activities to five human cancer cell lines.
April 18, 2018: Journal of Asian Natural Products Research
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