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Journal of Asian Natural Products Research

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https://www.readbyqxmd.com/read/28081623/apocynin-derivatives-from-iris-tectorum
#1
Chun-Lei Zhang, Guo-Ru Shi, Yan-Fei Liu, Yan Wang, Ruo-Yun Chen, De-Quan Yu
Phytochemical investigation of the rhizomes of Iris tectorum resulted in the isolation and characterization of three new apocynin derivatives, apocynin-4-O-β-D-(6'-O-syringyl)glucopyranoside (1), scrophenoside C-7-ethyl ether (2, 3), together with a new naturally occurring compound but known by synthesis, apocynin-4-O-β-D-xylopyranoside (4), and five known ones (5-9). Their structures were elucidated on the basis of spectroscopic data interpretation.
January 12, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28043172/qinanmer-a-new-compound-from-chinese-agarwood-qi-nan-originating-from-aquilaria-sinensis
#2
Hang Shao, Fan-Dong Kong, Hao Wang, Wen-Li Mei, Hao-Fu Dai
Qinanmer (1), a new compound comprising 2-(2-phenylethyl)chromone and sesquiterpene moieties, together with two known 2-(2-phenylethyl)chromone derivatives (2-3), was isolated from the high-quality Chinese agarwood "Qi-Nan" originating from Aquilaria sinensis (Lour.) Glig. The structure of 1 was elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR), MS analyses, ECD spectra analyses, and quantum (13)C NMR calculations.
January 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28033721/a-novel-phloroglucinol-and-two-new-phenolic-glycosides-from-psidium-littorale
#3
Ji-Cheng Shu, Hang-Qing Cui, Yin-Zheng Huang, Jian-Qun Liu, Hui-Lian Huang
One novel phloroglucinol, psidosone A (1), and two new phenolic glycosides, psidoside A (2), and psidoside B (3), together with nine known phenol compounds (4-12), were isolated from the fruits of Psidium littorale Raddi. Their structures were elucidated using data obtained from MS, (1)H and (13)C NMR spectra, and correlation experiments (HMQC and HMBC), as well as by comparison with published data.
December 29, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28030961/three-new-xanthones-from-swertia-bimaculata-and-their-anti-5%C3%AE-reductase-activity
#4
Hai-Yan Wu, Yu Sheng, Xue-Qin Kan, Lin-Yun Mou, Qiu-Feng Hu, Gan-Peng Li
Three new xanthones (1-3), together with five known ones (4-8), were isolated from whole herb of Swertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively...
December 29, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28024413/ferulic-acid-induces-proliferation-and-differentiation-of-rat-osteoblasts-in-vitro-through-cgmp-pkgii-enac-signaling
#5
Jian-Lin Gao, Jun Chen, Guo-Zhu Yang, Li Lu, Xing-Yan Lu, Huan-Huan Jia, Xiao-Dong Jin, Hao Zhang, Qing-Nan Li
Ferulic acid (FA) is an active component of the traditional Chinese herb Angelica sinensis. Numerous health benefits have been attributed to FA, but few studies have investigated the effects of FA on osteoblasts (Obs). Our work studied the effects of FA on proliferation, differentiation, and mineralization of rat calvarial Obs and examined the signaling pathways involved. Cell proliferation and differentiation were evaluated by Cell Counting Kit-8 (CCK-8) and alkaline phosphatase (ALP) assay kit, respectively...
December 27, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28019108/two-new-compounds-from-the-seeds-of-vernonia-anthelmintica
#6
Zulipiya Maimaiti, Ablajan Turak, Haji Akber Aisa
Two new compounds, named benzoyl-vernovan (1) and 2-(4'-hydroxyphenyl)-6-methyl-4H-pyran-4-one (2), together with one biflavonoid (3), one aurone (4) and six flavonoids were isolated from the seeds of Vernonia anthelmintica. Their structures were elucidated by extensive spectroscopic analyses and comparison with published data, and their influence on melanin content in B16 melanoma cells were tested. 5 and 9 increased melanin content by 2.2% and 30.9% higher than positive control 8-methoxypsoralen.
December 25, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28019104/four-new-compounds-from-the-rhizome-of-aristolochia-championii
#7
Xin Wang, Guo-Ru Shi, Yan-Fei Liu, Ruo-Yun Chen, De-Quan Yu
Three new flavonoid glycosides (1-3) and one new aristololactam N-glycoside (4) were isolated from the rhizome of Aristolochia championii. The structures of compounds 1-4 were elucidated on the basis of their spectroscopic data and chemical evidence (UV, IR, HR-ESI-MS, 1D and 2D NMR). Their structures were determined as 8-(5-formyl-2-furanmethyl)-isorhamentin 3-O-robinobioside (1), 8-(5-methyl-2-furanoyl)-isorhamentin 3-O-robinobioside (2), 8-formylisorhamentin 3-O-robinobioside (3), and N-β-D-glucopyranosylaristololactam V (4), respectively...
December 25, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27989219/sesquiterpenoids-from-the-twigs-and-leaves-of-fokienia-hodginsii
#8
Xing-De Wu, Wen-Wen Zhong, Lin-Fen Ding, Wen-Chao Tu, Hui Yang, Xun Gong, Li-Yan Peng, Yan Li, Zhong-Zhi Xu, Qin-Shi Zhao
A rare carotane-type sesquiterpenoid, forkienin A (1), a new eudesmane-type sesquiterpenoid, forkienin B (2), and a new natural eudesmane-type sesquiterpenoid, forkienin C (3), were isolated from the twigs and leaves of Fokienia hodginsii, along with eight known sesquiterpenoids. The structures of the new compounds were elucidated on the basis of their spectroscopic analysis, including 1D and 2D NMR methods. All compounds were evaluated for cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines...
December 17, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27967214/three-new-benzolactones-from-lavandula-angustifolia-and-their-bioactivities
#9
Jian-Lian Shi, Shi-Yun Tang, Chun-Bo Liu, Ling Ye, Pei-Song Yang, Feng-Mei Zhang, Pei He, Zhi-Hua Liu, Ming-Ming Miao, Ya-Dong Guo, Qin-Peng Shen
Three new benzolactones (1-3), together with four known ones (4-7), were isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New compounds were evaluated for their anti-tobacco mosaic virus (TMV) activities and cytotoxic activities. The results revealed that compounds 1-3 showed obvious anti-TMV activities with inhibition rates of 26...
December 14, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27931113/a-new-naphthalenepropanoic-acid-analog-from-the-marine-derived-actinomycetes-micromonospora-sp-hs-hm-036
#10
Mei-Yue Gao, Huan Qi, Jian-Song Li, Hui Zhang, Ji Zhang, Ji-Dong Wang, Wen-Sheng Xiang
A new naphthalenepropanoic acid analog (1) was isolated from the broth of the actinomycetes Micromonospora sp. HS-HM-036. The structure of compound 1 was determined based on MS and extensive NMR analysis. A preliminary investigation of the biological activity of compound 1 was also described.
December 9, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27892687/three-new-drimane-sesquiterpenoids-from-cultures-of-the-fungus-penicillium-sp
#11
Jian-Hai Ding, Zhang-Gui Ding, Wei-Xun Chunyu, Jiang-Yuan Zhao, Hai-Bin Wang, Shi-Wei Liu, Fei Wang
Three new drimane sesquiterpenoids, 12-hydroxyalbrassitriol (1), drim-8(12)-en-6β,7α, 9α,11-tetraol (2), and drim-68(12)-dien-9α,11-diol (3), along with one known analog albrassitriol (4), were isolated from cultures of the tin mine tailings-associated fungus Penicillium sp. The new structures were determined on the basis of extensive spectroscopic analyses. All compounds were tested for their cytotoxicities against five human cancer cell lines.
November 28, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27875907/chemical-constituents-from-the-roots-of-tripterygium-wilfordii-and-their-cytotoxic-activity
#12
Chang Gao, Li-Li Lou, Di Wang, Yan Zhang, Xiao-Xiao Huang, Shao-Jiang Song
In our ongoing search for bioactive constituents, a new sesquiterpene polyol ester, named triptersinine U (1), together with five known triterpenes (2-6) and seven sesquiterpene pyridine alkaloids (7-13), were isolated from the roots of Tripterygium wilfordii Hook. f. Their chemical structures were elucidated using extensive spectroscopic analyses, including 1D and 2D NMR, and HRESIMS, as well as comparison with previously reported data. Cytotoxic activities of all compounds 1-13 were evaluated against six human tumor cell lines (HepG2, Hep3B, Bcap37, U251, MCF-7 and A549) using the MTT in vitro assay...
November 22, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27869484/two-new-monoterpenes-from-sibiraea-laevigata
#13
Yu Deng, Jian-Qiang Zhao, Li-Juan Mei, Yan-Duo Tao
Two new monoterpenes, 3-(2-oxo-4-methyl-3-pentenyl)furan-5H-2-one (1) and 3-[(2E)-4-hydroxyl-4-methyl-2-pentenyl)]furan-5H-2-one (2), along with eight known compounds (3-10), were isolated from the stalks and infructescence of Sibiraea laevigata. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR techniques. In addition, all of these isolates were evaluated for their cytotoxic and antioxidant activities. The results showed that compounds 5-7 displayed cytotoxicity with IC50 values ranging from 34...
November 21, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27848262/bioactive-spirans-and-other-constituents-from-the-leaves-of-cannabis-sativa-f-sativa
#14
Tian-Tian Guo, Jian-Chun Zhang, Hai Zhang, Qing-Chao Liu, Yong Zhao, Yu-Fei Hou, Lu Bai, Li Zhang, Xue-Qiang Liu, Xue-Ying Liu, Sheng-Yong Zhang, Nai-Sheng Bai
In this paper, 17 compounds (1-17) were isolated from the leaves of Hemp (Cannabis sativa f. sativa). Among the isolates, two were determined to be new spirans: cannabispirketal (1), and α-cannabispiranol 4'-O-β-D-glucopyranose (2) by 1D and 2D NMR spectroscopy, LC-MS, and HRESIMS. The known compounds 7, 8, 10, 13, 15, and 16 were isolated from Hemp (C. sativa f. sativa) for the first time. Furthermore, compounds 8 and 13 were isolated from the nature for the first time. All isolated compounds were evaluated for cytotoxicity on different tissue-derived passage cancer cell lines through cell viability and apoptosis assay...
November 16, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27838921/a-new-spectinabilin-derivative-with-cytotoxic-activity-from-ant-derived-streptomyces-sp-1h-gs5
#15
Chong-Xi Liu, Shuang-He Liu, Jun-Wei Zhao, Ji Zhang, Xiang-Jing Wang, Jian-Song Li, Ji-Dong Wang, Wen-Sheng Xiang
A new spectinabilin derivative (1) was isolated from the fermentation broth of the ant-derived Streptomyces sp. 1H-GS5, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human tumor cell lines A549, HCT-116, and HepG2 with IC50 values of 9.7, 12.8, and 9.1 μg/ml, respectively, which was relative higher than that of spectinabilin.
November 13, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27835936/neural-anti-inflammatory-sesquiterpenoids-from-the-endophytic-fungus-trichoderma-sp-xy24
#16
Min Zhang, Jin-Lian Zhao, Ji-Mei Liu, Ri-Dao Chen, Ke-Bo Xie, Da-Wei Chen, Ke-Ping Feng, Dan Zhang, Jun-Gui Dai
Three new sesquiterpenoids trichoacorenols B-C and cyclonerodiol B (1-3), along with three known ones (4-6), were isolated from the mangrove plant endophytic fungus Trichoderma sp. Xy24 using various column chromatography techniques. The structures of these compounds were determined on the basis of extensive spectroscopic data analyses. Compounds 1, 2, 4, and 5 were four acorane sesquiterpenes, 3 and 6 were two monocyclic sesquiterpenediols. Compounds 3 and 5 exhibited significant neural anti-inflammatory activity by inhibiting LPS-induced NO production in BV2 cells with the inhibitory rates of 75...
November 11, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27832701/oleanane-triterpene-saponins-with-cardioprotective-activity-from-clinopodium-polycephalum
#17
Yu-Xia Hu, Wei Zhang, Wen Zhang, Yin-Di Zhu, Guo-Xu Ma, Nai-Liang Zhu, Wen Sun, Ze-Xin Ma, Shi-Chun Yu, Xu-Dong Xu, Kai-Tuo Chen, Jun-Shan Yang
Two new triterpene saponins, clinopodiside VI (1) and saikosaponin c (2), along with six known saikosaponins (3-8), were isolated from the plant of Clinopodium polycephalum. Compounds 1-3 showed moderate inhibition against H9c2 cell damage induced by H2O2.
November 10, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27809606/design-synthesis-and-antibreast-cancer-mcf-7-cells-biological-evaluation-of-heterocyclic-analogs-of-resveratrol
#18
Cheng Du, Ming-Hui Dong, Yu-Jie Ren, Lu Jin, Cheng Xu
A new series of resveratrol heterocyclic analogs (4a-m) were designed and synthesized, and their inhibitiory effects on MCF-7 cells were evaluated to investigate structure-activity relationship. The effects of these analogs on human breast cancer MCF-7 cells were also determined. Results showed that MCF-7 cells could be inhibited more potently by these analogs than by resveratrol (IC50 = 80.0 μM). Among the analogs, compounds 4c, 4e, and 4k showed a significantly higher activity (IC50 = 42.7, 48.1, and 43...
November 3, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27802774/lipoxygenase-inhibiting-lignans-from-clematis-mandshurica
#19
Qiang Fu, Chuang Zhou, Yu Ma, Min Yang, Hai-Mei Yuan, Jiang Chen, Pei-Xi Liu
The EtOH extract of the roots and rhizomes of Clematis mandshurica afforded two new lignans clemomanshurinane C (1) and clemomanshurinane D (2), and three known compounds (3-5). Their structures were elucidated on the basis of spectroscopic means and hydrolysis products. All compounds displayed moderate inhibitory activity against enzyme lipoxygenase.
November 1, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27790920/four-new-c10-polyacetylene-glycosides-from-the-rhizomes-of-atractylodes-lancea
#20
Kuo Xu, Zi-Ming Feng, Ya-Nan Yang, Jian-Shuang Jiang, Pei-Cheng Zhang
An ongoing phytochemical investigation of the rhizomes of Atractylodes lancea resulted in the isolation of four new C10-type polyacetylene glycosides (1-4). Their structures were elucidated on the basis of extensive spectroscopic data (UV, IR, 1D and 2D NMR, and HRESIMS). The absolute configurations of compounds 2-4 were determined by comparing the specific rotations of their aglycones. Notably, compounds 2 and 3 exhibited significant hepatoprotective activities against APAP-induced HepG2 cell injury at a concentration of 10 μM...
October 28, 2016: Journal of Asian Natural Products Research
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