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Journal of Asian Natural Products Research

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https://www.readbyqxmd.com/read/28429624/impact-of-high-dose-oleuropein-on-cisplatin-induced-oxidative-stress-genotoxicity-and-pathological-changes-in-rat-stomach-and-lung
#1
Fatime Geyikoglu, Hatice Isikgoz, Hakan Onalan, Suat Colak, Salim Cerig, Murat Bakir, Mirkhalil Hosseinigouzdagani, Kubra Koc, Huseyin Serkan Erol, Yavuz Selim Saglam, Serkan Yildirim
The current systemic treatments of the various solid tumors involve Cisplatin (CIS)-based chemotherapy. Due to its cytotoxicity, this approach is limited. Moreover, the safety of CIS is only discussed especially in breast and stomach cancers. Therefore, we, for the first time, explored the restorative efficacy of oleuropein (OLE), in stomach and lung injuries induced by CIS. Sprague-Dawley rats were divided into eight groups: control CIS, OLE and CIS + OLE. Single dose of (7 mg/kg) CIS was administered intraperitoneally to CIS and CIS + OLE groups...
April 21, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28429610/tomentodione-e-a-new-sec-pentyl-syncarpic-acid-based-meroterpenoid-from-the-leaves-of-rhodomyrtus-tomentosa
#2
Jie Liu, Jian-Guo Song, Jun-Cheng Su, Xiao-Jun Huang, Wen-Cai Ye, Ying Wang
A new meroterpenoid, tomentodione E (1), along with four known ones (2-5) were isolated from the leaves of Rhodomyrtus tomentosa. Their structures were elucidated based on extensive spectroscopic data as well as computational methods. Compound 1 represents the first example of meroterpenoid possessing a sec-pentyl syncarpic acid motif coupled with a caryophyllene. Compounds 1-4 were evaluated for their in vitro antiviral activity against respiratory syncytial virus (RSV) with cytopathic effect (CPE) reduction assay, and 2 showed potent in vitro anti-RSV effect...
April 21, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28421816/cytotoxic-steroid-derivatives-from-the-vietnamese-soft-coral-sinularia-brassica
#3
Hong Hanh Thi Tran, Phong Nguyen Viet, Thanh Nguyen Van, Huong Thu Tran, Cuong Nguyen Xuan, Nam Nguyen Hoai, Thung Do Cong, Kiem Phan Van, Minh Chau Van
Using various chromatographic separations, six ergostane-type steroids, including one new compound sinubrassione (1), and two pregnene-type steroid glycosides, including one new compound sinubrassioside (7), were isolated from methanol extract of the Vietnamese soft coral Sinularia brassica. The structure elucidation was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-MS. The cytotoxic activities of all the isolated compounds against three human cancer cell lines were also evaluated using MTT-based colorimetric assays...
April 19, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28414246/ganoderin-a-a-novel-9-11-secosterol-from-ganoderma-lucidum-spores-oil
#4
Fa-Huan Ge, Ming-Hui Duan, Jing Li, Qing-Long Shi
In this study, four sterols were isolated from the Ganoderma lucidum spores oil obtained via supercritical CO2 extraction. Four chemical constituents were ganoderin A (1), chaxine B (2), ergosterol, (3) and stellasterol (4). All the separated ingredients were characterized using spectral data interpretation and by comparing with reported data. Noticeably, stellasterol and chaxine B were both firstly isolated from Ganoderma lucidum spores oil and ganoderin A was shown to bear an unprecedented skeleton.
April 17, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28402149/a-new-prenylated-flavone-from-pleione-bulbocodioides
#5
Yuan Li, Ze-Hong Wu, Ke-Wu Zeng, Ming-Bo Zhao, Yong Jiang, Jun Li, Peng-Fei Tu
A new prenylated flavone, 3,5,7,3'-tetrahydroxy-8,4'-dimethoxy-6-(3-methylbut-2- enyl)flavone (1), together with three known flavone derivatives (2-4), two known dihydrophenanthrenes (5-6), two known lignin derivatives (7-8), and three known phenolic glycoside compounds (9-11) were isolated from the n-BuOH extract of Pleione bulbocodioides. High-resolution electrospray ionization mass spectroscopy (HRESIMS), FTIR spectroscopy, and NMR techniques were used to elucidate the structures of these compounds. Biological investigations showed that compound 5, 4,7-dihydroxy-2-methoxy-9,10-dihydrophenanthrene, exhibited potent anti-inflammatory activity on LPS-stimulated NO production in BV-2 microglial cells, with IC50 value of 5...
April 12, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28397534/a-new-polyketide-glycoside-from-the-rhizospheric-clonostachys-rogersoniana-associated-with-panax-notoginseng
#6
Tian-Peng Yin, Yun Xing, Le Cai, Jing Yu, Ping Luo, Zhong-Tao Ding
A new polyketide glycoside rogerson A (1), along with two known compounds, rogerson B (2) and (22E)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (3), was obtained from the solid fermentation of Clonostachys rogersoniana, which was isolated from the rhizosphere soil of Panax notoginseng. Rogerson B (2) was isolated for the first time from a natural source. Their structure was determined by extensive analyses of NMR and MS studies. Compounds 1 and 2 were tested for its cytotoxicity against five human cancer cell lines...
April 11, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28395537/three-new-amino-acid-derivatives-from-edible-mushroom-pleurotus-ostreatus
#7
Xiao-Jie Lu, Bao-Min Feng, Shao-Fei Chen, Dan Zhao, Gang Chen, Hai-Feng Wang, Yue-Hu Pei
Three new amino acid derivatives, oxalamido-L-phenylalanine methyl ester (1), oxalamido-L-leucine methyl ester (2), and lumichrome hydrolyzate (3), together with nine known compounds (4-12), were isolated from the solid culture of edible mushroom Pleurotus ostreatus. Their structures were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations of 1 and 2 were established by the chiral synthesis and confirmed by circular dichroism (CD) analysis of their total synthesis products and natural isolates...
April 11, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28395521/a-new-p-hydroxybenzoic-acid-derivative-from-an-endophytic-fungus-penicillium-sp-of-nerium-indicum
#8
Yang-Min Ma, Ke Qiao, Yang Kong, Lin-Xin Guo, Meng-Yun Li, Chao Fan
A new p-hydroxybenzoic acid derivative named 4-(2'R, 4'-dihydroxybutoxy) benzoic acid (1) was isolated from the fermentation of Penicillium sp. R22 in Nerium indicum. The structure was elucidated by means of spectroscopic (HR-ESI-MS, NMR, IR, UV) and X-ray crystallographic methods. The antibacterial and antifungal activity of compound 1 was tested, and the results showed that compound 1 revealed potent antifungal activity against Colletotrichum gloeosporioides, Alternaria alternata, and Alteranria brassicae with MIC value of 31...
April 11, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28395517/four-new-monoterpenoids-from-an-endophytic-fungus-periconia-sp-f-31
#9
Ji-Mei Liu, De-Wu Zhang, Wen-Yu Du, Min Zhang, Jin-Lian Zhao, Ri-Dao Chen, Ke-Bo Xie, Jun-Gui Dai
Five monoterpenoids were isolated from the endophytic fungus Periconia sp. F-31, including three new carene-type monoterpenoids, 2-carene-5,8-diol (1), 2-carene-8,10-diol (2), 2-carene-8-acetamide (3), one new menthene-type monoterpenoid 8-hydroxy-1,7-expoxy-2-menthene (4), and one known monoterpenoid anethofuran (5). The structures of all compounds were elucidated based on a comprehensive spectroscopic data analysis, electronic circular dichroism (ECD), and calculated ECD.
April 11, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28393571/monoterpenoid-indole-alkaloids-from-alstonia-mairei-and-their-cytotoxicity
#10
Ting-Liang Yan, Dun-Xin Han, Jiang Hu, Xiao-Yun Huang, Hong-Kun Wang
Phytochemical investigation on the 70% ethanol extract of the leaves of Alstonia mairei resulted in the isolation of three new monoterpenoid indole alkaloids, alstomairines A-C (1-3), along with one known compound, alpneumine A (4). Structural elucidation of all the compounds was accomplished by spectral methods such as 1D and 2D NMR, IR, UV, and HRESIMS. The isolated compounds were tested in vitro for cytotoxic activities against four osteosarcoma cell lines. Consequently, alkaloids 2 and 3 exhibited cytotoxic activities for all tested tumor cell lines with IC50 values from 9...
April 9, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28393564/an-efficient-semi-synthesis-of-1-hydroxyl-oleanolic-acid-analogs
#11
Da-Hui Zhang, Wei-Shuo Fang, Shao-Rong Wang
An efficient route for the semi-synthesis of either 1α- or 1β-OH epimers of 1-hydroxy-3-deoxyolean-12-en-28-oic acid (1), 6-8 steps from oleanolic acid is reported. The synthesis involves stereoselective formation of α,β-unsaturated epoxy ketone and subsequent Wharton reaction as key steps, offering a new access to the 1-O-substituted oleanolic acid-type pentacyclic triterpenoids.
April 9, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28376675/aromatic-monoterpenoid-glycosides-from-the-seeds-of-paeonia-ostii
#12
Jun-Jun Qin, Ying-Yi Mao, Jin-Long Li, Yan Guan, Wei-Min Zhao
Phytochemical investigation into the seeds of Paeonia ostii T. Hong et J. X. Zhang (Paeoniaceae) led to the identification of three new aromatic monoterpenoid glycosides, named paeostisides A-C (1-3), along with one known compound. Their structures were identified by spectroscopic analysis and chemical method.
April 5, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28376654/enhancement-of-recombinant-bmk-angm1-production-in-pichia-pastoris-by-regulating-gene-dosage-co-expressing-with-chaperones-and-fermenting-in-fed-batch-mode
#13
Qing-Hua Wang, Lan Liang, Wan-Cang Liu, Ting Gong, Jing-Jing Chen, Qi Hou, Jin-Ling Yang, Ping Zhu
The scorpion peptide BmK AngM1 was reported to exhibit evident analgesic effect, but its yield by extraction from scorpion venom limits the research and application. The heterologous expression of BmK AngM1 was achieved in Pichia pastoris in our previous study. In order to realize high-level expression of recombinant BmK AngM1 (rBmK AngM1), the gene dosage of BmK AngM1 was optimized in engineered strains. The yield of rBmK AngM1 in the four-copy strain reached up to 100 mg/L, which was further enhanced to 190 mg/L by co-expressing with chaperones of PDI, BiP, and HAC1...
April 5, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28374633/soulieoside-o-a-new-cyclolanostane-triterpenoid-glycoside-from-souliea-vaginata
#14
Hai-Feng Wu, Peng-Fei Li, Yin-Di Zhu, Xiao-Po Zhang, Guo-Xu Ma, Xu-Dong Xu, Yi-Lin Liu, Zheng-Hong Luo, Di-Zhao Chen, Qiong-Yu Zou, Zi-Jian Zhao
A new cyclolanostane triterpenoid glycoside, soulieoside O (1), together with 25-O-acetylcimigenol-3-O-β-d-xylopyranoside (2) and cimigenol-3-O-β-d-xylopyranoside (3), was isolated from the rhizomes of Souliea vaginata. Their structures were characterized by spectroscopic analysis and chemical methods. The new compound showed moderate inhibitory activity against three human cancer cell lines with IC50 values of 9.3-22.5 μM.
April 4, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28374632/phorbol-ester-type-diterpenoids-from-the-twigs-and-leaves-of-croton-tiglium
#15
Lin Jiang, Yu-Bo Zhang, Si-Qi Jiang, Yi-Duo Zhou, Ding Luo, Qian-Wen Niu, Yi-Rui Qian, Yao-Lan Li, Guo-Cai Wang
Phytochemical investigation of the ethanol extract from the twigs and leaves of Croton tiglium led to the isolation of two new phorbol esters (1-2) and seven known ones (3-9). Their structures were elucidated by the analyses of extensive spectroscopic data (IR, MS, and 1D and 2D NMR) and comparing with related compounds. Meanwhile, compounds 1-9 were determined for their cytotoxic activities on human lung cancer cell line A549. Among them, 1-2 were inactive against the cell line A549 (IC50 > 100 μM), but compounds 3 and 7 showed weak activities...
April 4, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28374625/two-new-biflavonones-from-coreopsis-tinctoria
#16
Ren-Jie Yan, Mo-Ying Li, Hai-Feng Zhou, De-Yun Kong, Tong Wu
Two new biflavonone compounds, sikokianin D (1) and sikokianin E (2), were isolated from the capitulum of Coreopsis tinctoria. The structures of these compounds were elucidated by spectroscopic techniques including NMR, HRESIMS and circular dichroism (CD).
April 4, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28366017/two-new-triterpenes-from-euphorbia-alatavica
#17
Rushangul Rozimamat, Nurmuhammat Kehrimen, Jie Gao, Hai-Rong Ma, Haji Akber Aisa
A phytochemical investigation on Euphorbia alatavica Boiss resulted in the isolation of nine compounds, including two new ones, alatavolide and alatavoic acid (1-2). Chemical structures of these compounds were established on the basis of 1D, 2D NMR, and HR-MS techniques, and by comparison with data reported in the literature. Compounds 1, 2, 4, 6, 8, and 9 were screened for cytotoxicity using the MTT assay. Among these compounds, the new compound 2 showed moderate cytotoxicity against Hela, MCF-7 and A549 cell lines (IC50 values of 16...
April 3, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28366021/a-new-nortriterpenoid-and-an-ergostane-type-steroid-from-the-fruiting-bodies-of-the-fungus-ganoderma-resinaceum
#18
Xian-Qiang Chen, Ling-Xiao Chen, Shao-Ping Li, Jing Zhao
One new expoxy nortriterpenoid (1) and one new ergostane-type steroid (2), together with seven known steroids (3-9), were obtained from the fruiting bodies of the fungus Ganoderma resinaceum. The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature.
April 1, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28366016/two-new-compounds-from-a-marine-derived-streptomyces-sp
#19
Si-Yu Zhou, Yan-Lin Zou, Guo-Wei Wang, Zhi-Hua Liao, Min Chen
Two new long-chain unsaturated compounds, (2E, 6E)-10-methoxy-3,7-dimethyl-10-oxodeca-2,6-dienoic acid (1) and (2E, 6E)-3,7,11-trimethyldodeca-2,6-dienedioic acid (2), together with seven known compounds were isolated from a marine-derived Streptomyces sp. Their structures were determined by spectroscopic methods, including 2D NMR techniques. Compounds 1 and 2 were investigated for their antibacterial activities.
April 1, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28361583/two-new-unsaturated-fatty-acids-from-the-whole-plant-of-pothos-chinensis
#20
Jin-Guang Si, Hao-Li Sun, Tao Zhang, Qiu-Bo Zhang, Meng-Hua Wang, Jia-Huan Chen, Ling-Yu Li, Zhong-Mei Zou
Two new unsaturated fatty acids, (Z)-octadec-13-en-11-ynoic acid (1) and (Z)-octadec-16-en-12,14-diynoic acid (2), along with six known compounds were isolated from the whole plant of Pothos chinensis. The structures of these compounds were elucidated by detailed spectroscopic analysis, including 1D and 2D NMR data. Compound 2 showed moderate antibacterial activity against Staphylococcus aureus.
March 31, 2017: Journal of Asian Natural Products Research
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