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Journal of Asian Natural Products Research

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https://www.readbyqxmd.com/read/28152617/further-brominated-polyacetylenes-with-pancreatic-lipase-inhibitory-activity-from-chinese-marine-sponge-xestospongia-testudinaria
#1
Min Yang, Lin-Fu Liang, Ting Wang, He-Yao Wang, Hai-Li Liu, Yue-Wei Guo
A new brominated polyacetylene, xestonariene I (1), along with three known related analogues (2-4), was obtained from Chinese marine sponge Xestospongia testudinaria. Its structure was determined on the basis of detailed spectroscopic analysis and by comparison with literature data. Compound 4 exhibited significant inhibitory activity against pancreatic lipase, which plays a key role in preventing obesity, with an IC50 value of 0.61 μM, being comparable to that of the positive control orlistat (IC50 = 0...
February 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28152615/a-new-n-methoxyl-carbonyl-benzylisoquinoline-from-litsea-cubeba
#2
Bin Tang, Hua Tu, Han-An Long, Jun Du, Jian-Min Guo, Hong-Jin Liu, Xin Hu, Li Yang, Xi Du
A new benzylisoquinoline alkaloid (•)-N-methoxycarbonyl-norjuziphine (1) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound 1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50 values of 18.1 and 15.0 μM, respectively, comparable to 3.1 and 17.5 μM of the cisplatin (positive control).
February 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28152609/three-new-anthraquinones-from-the-twigs-of-cassia-fistula-and-their-bioactivities
#3
Min Zhou, Huan-Huan Xing, Yan Yang, Yue-De Wang, Kun Zhou, Wei Dong, Gan-Peng Li, Wei-Yao Hu, Qiang Liu, Xue-Mei Li, Qiu-Fen Hu
Three previously unreported anthraquinones, fistulaquinones A-C (1-3), together with three known ones (4-6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20 μM concentration, even more potent than positive control. Additionally, compounds 1-6 exhibited moderate cytotoxicity with IC50 values ranging from 2...
February 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28152606/three-new-triterpenoids-from-ganoderma-theaecolum
#4
Li-Ying Liu, Zheng Yan, Jie Kang, Ruo-Yun Chen, De-Quan Yu
Three new triterpenoids (1-3), together with four known triterpenoids (4-7), were isolated from the fruiting bodies of Ganoderma theaecolum. Their structures were elucidated on the basis of their spectroscopic data and chemical evidence. Compounds 4 and 6 exhibited antitumor activities against H460 cells with IC50 values of 22.4 and 43.1 μM, respectively. And the cytotoxic activities of compounds 4 and 5 against MDA-MB-231 cancer cell lines were assayed with IC50 values of 49.1 and 75.8 μM, respectively...
February 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28145126/bioactive-steroids-and-sorbicillinoids-isolated-from-the-endophytic-fungus-trichoderma-sp-xy24
#5
Jin-Lian Zhao, Min Zhang, Ji-Mei Liu, Zhen Tan, Ri-Dao Chen, Ke-Bo Xie, Jun-Gui Dai
A new steroid glucoside (1), along with nine known steroids (2-10) and four known sorbicillinoids (11-14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data. Compounds 3, 5-7, 9, 10, and 13 exhibited significant inhibitory effects on HIV-1 virus with IC50 values ranging 1.9-9.3 μM; compounds 10, 13, and 14 showed potent inhibitory activity on LPS-induced NO production in BV2 microglia cells with inhibitory rates of 108...
February 1, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28145124/three-new-c-alkylated-flavonoids-from-desmodium-oblongum
#6
Yan-Ping Li, Qiu-Fen Hu, Gao-Xiong Rao
Three new C-alkylated flavonoids, 4'-hydroxy-8-isobutyryl-7-methoxy-6-methyl-flavone (1), 4',7-dimethoxy-8-isobutyryl-6-methyl-flavone (2), and 4',7-dimethoxy-8-isobutyryl-flavone (3), together with three know ones luteolin (4), kaemferol (5), and quercetin (6), were isolated from Desmodium oblongum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 1 showed cytotoxicity against NB4, SHSY5Y, and MCF7 cell lines with IC50 values of 8.5, 6.5, and 7...
February 1, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28140678/biotransformation-of-furanocoumarins-by-fungi-preparation-of-imperation-analogs
#7
Xiu-Lan Xin, Yan Wang, Ge Wang, Chao Wang, Shan-Shan Huang, Xiao-Kui Huo, Dong-Hai Su, Xiang-Ge Tian
Imperation analogs have the furanocoumarin skeleton, with the isopentenyl group, which displayed significant bioactivities. The biotransformation of furanocoumarins imperation, isoimperation and phellopterin (1-3) by fungi has been proved to be an efficient method for the structural modification. Ten transformed furanocoumarin analogs were obtained by fungal biotransformation, including one new highly oxygenated furanocoumarin (4c). Aspergillus niger AS 3.739 displayed selectively transformed capability toward furanocouamrins (1-3) with one or two major products...
January 31, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28140665/synthesis-and-antitumor-activity-evaluation-of-novel-oleanolic-acid-derivatives
#8
Yan-Qiu Meng, Yu-Wei Zhao, Zhen-Yu Kuai, Li-Wei Liu, Wei Li
Ten novel oleanolic acid (OA) derivatives were synthesized through modifications at positions of A ring and C-28. Inhibitory activities of the oleanolic acid derivatives against SGC7901 and A549 cell lines were evaluated and confirmed by the tetrazolium bromidesalt (MTT) assay. The lab results revealed that all these compounds displayed some antitumor activity against SGC-7901 and A-549 cell lines. Among them, II4 and II5 exhibited excellent antitumor activities against SGC7901 cells and A549 cells, compared with gefitinib...
January 31, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28140664/phenolic-acid-derivatives-with-neuroprotective-effect-from-the-aqueous-extract-of-clerodendranthus-spicatus
#9
Hai-Chun Zhou, Liu Yang, Rui-Zhu Guo, Ji Li
Two new phenolic acid helisterculins C (1) and D (2) were isolated from the whole plant of Clerodendranthus spicatus. Their structures were elucidated on the basis of 1D and 2D NMR, MS, and CD analysis. Compound 1 possesses an unusual bicyclol [2. 2. 2] octane moiety which is rare in the previously isolated phenolic acid derivatives. The two compounds were tested in vitro for neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells, and the result showed that compounds 1 and 2 displayed moderate neuroprotective activity with the IC50 values of 17...
January 31, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28140655/a-new-5-6%C3%A2-7-abeo-sterol-from-podocarpus-fleuryi
#10
Juan Liu, Zhao-Hong Gao, Ji-Chun Wu, Ye-Gao Chen
A new 5(6→7)abeo-sterol, podosterol (1), together with 20 known compounds, were isolated from the leaves of Podocarpus fleuryi. Their structures were elucidated by means of extensive spectroscopic analysis. Podosterol was assessed for its cytotoxicity against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and the result showed that it had no activity.
January 31, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28133978/recent-progression-in-the-utilization-of-autophagy-regulating-nature-compound-as-anti-liver-fibrosis-agents
#11
Mao-Xu Ge, Hong-Wei He, Rong-Guang Shao, Hong Liu
Hepatic fibrosis is a wound-healing response to chronic liver injury caused by various pathogenesis, such as hepatitis virus infection, drugs toxicity and autoimmune imbalances. Autophagy, a cellular process degrading damaged organelles or aggregative proteins, participates in multiple human diseases including hepatic fibrosis. However, the precise role of autophagy in the pathogenesis of hepatic fibrosis is yet to be elucidated. Accumulated evidences indicate that several nature compounds exhibit anti-fibrotic potential through modulating autophagy activity...
January 29, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28081623/apocynin-derivatives-from-iris-tectorum
#12
Chun-Lei Zhang, Guo-Ru Shi, Yan-Fei Liu, Yan Wang, Ruo-Yun Chen, De-Quan Yu
Phytochemical investigation of the rhizomes of Iris tectorum resulted in the isolation and characterization of three new apocynin derivatives, apocynin-4-O-β-D-(6'-O-syringyl)glucopyranoside (1), scrophenoside C-7-ethyl ether (2, 3), together with a new naturally occurring compound but known by synthesis, apocynin-4-O-β-D-xylopyranoside (4), and five known ones (5-9). Their structures were elucidated on the basis of spectroscopic data interpretation.
January 12, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28043172/qinanmer-a-new-compound-from-chinese-agarwood-qi-nan-originating-from-aquilaria-sinensis
#13
Hang Shao, Fan-Dong Kong, Hao Wang, Wen-Li Mei, Hao-Fu Dai
Qinanmer (1), a new compound comprising 2-(2-phenylethyl)chromone and sesquiterpene moieties, together with two known 2-(2-phenylethyl)chromone derivatives (2-3), was isolated from the high-quality Chinese agarwood "Qi-Nan" originating from Aquilaria sinensis (Lour.) Glig. The structure of 1 was elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR), MS analyses, ECD spectra analyses, and quantum (13)C NMR calculations.
January 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28033721/a-novel-phloroglucinol-and-two-new-phenolic-glycosides-from-psidium-littorale
#14
Ji-Cheng Shu, Hang-Qing Cui, Yin-Zheng Huang, Jian-Qun Liu, Hui-Lian Huang
One novel phloroglucinol, psidosone A (1), and two new phenolic glycosides, psidoside A (2), and psidoside B (3), together with nine known phenol compounds (4-12), were isolated from the fruits of Psidium littorale Raddi. Their structures were elucidated using data obtained from MS, (1)H and (13)C NMR spectra, and correlation experiments (HMQC and HMBC), as well as by comparison with published data.
December 29, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28030961/three-new-xanthones-from-swertia-bimaculata-and-their-anti-5%C3%AE-reductase-activity
#15
Hai-Yan Wu, Yu Sheng, Xue-Qin Kan, Lin-Yun Mou, Qiu-Feng Hu, Gan-Peng Li
Three new xanthones (1-3), together with five known ones (4-8), were isolated from whole herb of Swertia bimaculata. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-5α-reductase activity. The results revealed that all new compounds showed weak activity with reductase inhibitions of 40.5 ± 2.8, 38.6 ± 2.5, and 48.9 ± 3.0%, respectively...
December 29, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28024413/ferulic-acid-induces-proliferation-and-differentiation-of-rat-osteoblasts-in-vitro-through-cgmp-pkgii-enac-signaling
#16
Jian-Lin Gao, Jun Chen, Guo-Zhu Yang, Li Lu, Xing-Yan Lu, Huan-Huan Jia, Xiao-Dong Jin, Hao Zhang, Qing-Nan Li
Ferulic acid (FA) is an active component of the traditional Chinese herb Angelica sinensis. Numerous health benefits have been attributed to FA, but few studies have investigated the effects of FA on osteoblasts (Obs). Our work studied the effects of FA on proliferation, differentiation, and mineralization of rat calvarial Obs and examined the signaling pathways involved. Cell proliferation and differentiation were evaluated by Cell Counting Kit-8 (CCK-8) and alkaline phosphatase (ALP) assay kit, respectively...
December 27, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28019108/two-new-compounds-from-the-seeds-of-vernonia-anthelmintica
#17
Zulipiya Maimaiti, Ablajan Turak, Haji Akber Aisa
Two new compounds, named benzoyl-vernovan (1) and 2-(4'-hydroxyphenyl)-6-methyl-4H-pyran-4-one (2), together with one biflavonoid (3), one aurone (4) and six flavonoids were isolated from the seeds of Vernonia anthelmintica. Their structures were elucidated by extensive spectroscopic analyses and comparison with published data, and their influence on melanin content in B16 melanoma cells were tested. 5 and 9 increased melanin content by 2.2% and 30.9% higher than positive control 8-methoxypsoralen.
December 25, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28019104/four-new-compounds-from-the-rhizome-of-aristolochia-championii
#18
Xin Wang, Guo-Ru Shi, Yan-Fei Liu, Ruo-Yun Chen, De-Quan Yu
Three new flavonoid glycosides (1-3) and one new aristololactam N-glycoside (4) were isolated from the rhizome of Aristolochia championii. The structures of compounds 1-4 were elucidated on the basis of their spectroscopic data and chemical evidence (UV, IR, HR-ESI-MS, 1D and 2D NMR). Their structures were determined as 8-(5-formyl-2-furanmethyl)-isorhamentin 3-O-robinobioside (1), 8-(5-methyl-2-furanoyl)-isorhamentin 3-O-robinobioside (2), 8-formylisorhamentin 3-O-robinobioside (3), and N-β-D-glucopyranosylaristololactam V (4), respectively...
December 25, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27989219/sesquiterpenoids-from-the-twigs-and-leaves-of-fokienia-hodginsii
#19
Xing-De Wu, Wen-Wen Zhong, Lin-Fen Ding, Wen-Chao Tu, Hui Yang, Xun Gong, Li-Yan Peng, Yan Li, Zhong-Zhi Xu, Qin-Shi Zhao
A rare carotane-type sesquiterpenoid, forkienin A (1), a new eudesmane-type sesquiterpenoid, forkienin B (2), and a new natural eudesmane-type sesquiterpenoid, forkienin C (3), were isolated from the twigs and leaves of Fokienia hodginsii, along with eight known sesquiterpenoids. The structures of the new compounds were elucidated on the basis of their spectroscopic analysis, including 1D and 2D NMR methods. All compounds were evaluated for cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines...
December 17, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/27967214/three-new-benzolactones-from-lavandula-angustifolia-and-their-bioactivities
#20
Jian-Lian Shi, Shi-Yun Tang, Chun-Bo Liu, Ling Ye, Pei-Song Yang, Feng-Mei Zhang, Pei He, Zhi-Hua Liu, Ming-Ming Miao, Ya-Dong Guo, Qin-Peng Shen
Three new benzolactones (1-3), together with four known ones (4-7), were isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New compounds were evaluated for their anti-tobacco mosaic virus (TMV) activities and cytotoxic activities. The results revealed that compounds 1-3 showed obvious anti-TMV activities with inhibition rates of 26...
December 14, 2016: Journal of Asian Natural Products Research
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