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Journal of Asian Natural Products Research

Hui-Qiang Wang, Jin Hu, Hai-Yan Yan, Shuo Wu, Yu-Huan Li
Enterovirus 71 (EV71) is a huge threat to the worldwide public health and there is no approved antiviral drug for EV71-induced disease therapy. Corydaline exists antiallergic and antinociceptive activities, but the anti-EV71 activity of corydaline is still not reported. In this study, corydaline could suppress the expression of viral structural and non-structural proteins. Furthermore, corydaline inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro...
October 15, 2017: Journal of Asian Natural Products Research
Wei Li, Xiao-Bin Li, Hong-Xiang Lou
p-Terphenyls consisting of a C-18 tricyclic or polycyclic C-18 aromatic skeleton, have diverse structures because of the variation of the middle ring and the connections between the rings, and to the main skeleton. p-Terphenyls have recently been found to exhibit various biological activities such as cytotoxic, α-glucosidase inhibitory, antioxidant, and antimicrobial activity. In this review, we briefly summarized the structural varieties, biosyntheses, and bioactivities of natural p-terphenyl derivatives referring to the recent 10 years' publications...
October 13, 2017: Journal of Asian Natural Products Research
Yue Zhou, Yun-Hai Li, Hao-Bing Yu, Xiao-Yu Liu, Xiao-Ling Lu, Bing-Hua Jiao
A new furanone derivative, butanolide A (1), and a new sesquiterpene, guignarderemophilane F (2), together with six known compounds, were isolated from the fungus Penicillium sp. S-1-18 derived from Antarctic marine. The new structures were determined by spectroscopic studies such as 1D- and 2D-NMR and MS analyses. The absolute configuration of 1 was determined by the modified Mosher's method, while the absolute configuration of 2 was determined by calculated ECD spectroscopy. The isolated secondary metabolites were evaluated for their protein tyrosine phosphatase 1B (PTP1B) inhibitory activity...
October 9, 2017: Journal of Asian Natural Products Research
Ting Chen, Yong-Jun Kan, Gui-Xin Chou, Cheng-Gang Zhang
A new highly oxygenated pregnane steroid, pregn-7-ene-2β,3α,15α,20-tetrol (1) and two new 5-hydroxymethylfurfural derivatives, (5-formylfuran-2-yl)methyl 2-hydroxypropanoate (2) and (5-formylfuran-2-yl)methyl 2-(4-hydroxyphenyl)acetate (3), together with four known compounds, were isolated from the water decoction of Poria cocos. Their structures were established on the basis of extensive spectroscopic analysis. Compound 1 showed moderate inhibitory activity and a known compound (3S,6S)-3-[(1R)-1-hydroxyethyl]-6-(phenylmethyl)-2,5-piperazinedione (5) showed weak inhibitory activity against α-glucosidase, respectively...
October 9, 2017: Journal of Asian Natural Products Research
Hong-Ni Wang, Wen-Li Mei, Wen-Hua Dong, Fan-Dong Kong, Wei Li, Jing-Zhe Yuan, Hao-Fu Dai
Two new 2-(2-hydroxy-2-phenylethyl)chromones (1‒2), along with three known 2-(2-phenylethyl)chromones (3‒5), were isolated from the agarwood originating from Aquilaria crassna Pierre ex Lecomte. Their structures were determined by the spectroscopic methods including 1D and 2D NMR analysis and comparison with reported data in the literature. All the compounds were isolated from agarwood of A. crassna for the first time. Compounds 1 and 2 exhibited inhibitory activity against acetylcholinesterase (AChE) with 17...
October 6, 2017: Journal of Asian Natural Products Research
A Elena Mamaeva, S Saltanat Kaliyeva, A Abdigali Bakibaev, K Auezkhan Tashenov, E Yenglik Nurpeiis
A new single-stage synthesis of betulin phenylcarbamates is suggested that uses 1-phenylurea as a reagent for betulin O-carbamoylation. A chemoselectivity of hydroxyl-groups in carbamoylation of betulin with 1-phenylurea appeared to occur. Synthesized nitrogen-containing betulin derivatives - phenylcarbamates are valuable as bioactive substances.
October 5, 2017: Journal of Asian Natural Products Research
Habib Ghaznavi, Iman Fatemi, Heibatullah Kalantari, Seyed Mohammad Taghi Hosseini Tabatabaei, Mehrnaz Mehrabani, Babak Gholamine, Mojtaba Kalantar, Saeed Mehrzadi, Mehdi Goudarzi
The major side effect of gentamicin (GEN) is nephrotoxicity which in turn restricts the clinical use of this drug. In this study, the effect of gallic acid (GA) on gentamicin-induced nephrotoxicity was studied. A total number of 28 male Wistar rats were randomly divided into four experimental groups: control, GEN (100 mg/kg/day), GEN + GA (30 mg/kg/day), GA (30 mg/kg/day). All drug administrations were done intraperitoneally (i.p) for eight consecutive days. Twenty-four hours after the last administration, blood samples were collected to determine serum creatinine (Cr), blood urea nitrogen (BUN)...
October 5, 2017: Journal of Asian Natural Products Research
Li-Han Zhu, Tian-Hui Bao, Yue Deng, Hua Li, Li-Xia Chen
A phthalide glycoside, (3R, 4R)-4-O-β-D-glucopyranosyl-senkyunolide (1), and a megastigmane glycoside, (6S, 7R)-3-oxo-megastigma-4, 8-dien-7-O-β-D-glucoside (2), along with two known aglycones (3-4), were isolated from the 70% EtOH extract of fresh whole grass of Apium graveolens L. Their structures were elucidated by extensive spectroscopic analysis. All of these compounds were tested for their inhibitory effects on nitric oxide (NO) production in the RAW 264.7 macrophages. Among them, compounds 3 and 4 showed potent inhibitory activity against LPS-induced nitric oxide production in RAW 264...
October 3, 2017: Journal of Asian Natural Products Research
Meng-Yue Wang, Yan Yang, Xi-Yan Zhou, Shang-Shang Wang, Shi-Xin Duan, Xiao-Bo Li
A new ceramide urticamide (1), two new secolignans urticalactones I (2) and Ⅱ (3), and a new flavonoid glycoside urticaside (4), together with 15 known compounds (4-19), were isolated from the leaves of Urtica fissa, a folk medicine for rheumatism arthritis in China. The active evaluation results showed that 1, 2, 3, 8, and 13 possessed the potent anti-inflammatory. They could inhibit the release of NO and TNF-α in lipopolysaccharide (LPS) stimulated RAW 264.7 cells, with IC50 values less than 4.0 μM.
October 3, 2017: Journal of Asian Natural Products Research
Wen-Yu Wu, Yue Zhong, Yu-Ting Lu, Ying Sun, Nian-Guang Li, Zhi-Hao Shi, Ze-Xi Dong, Ting Gu, Xin Xue, Fang Fang, He-Min Li, Yu-Ping Tang, Jin-Ao Duan
Scutellarin (1) possesses protective effects against neuronal injury, while 6-O-methyl-scutellarein (3), as the main metabolite of scutellarin in vivo, has not been reported about its protective effects previously. The present study mainly investigated whether the neural injury caused by ischemia/reperfusion would be influenced by different doses of 6-O-methyl-scutellarein (3). The results of behavioral, neurological, and histological examinations indicated that 6-O-methyl-scutellarein (3) could improve neuronal injury, and exhibit significant difference among the various doses...
October 3, 2017: Journal of Asian Natural Products Research
Ying Li, Zhe-Tong Cao, Xin-Yue Wang, Xi-Zhen Ge
Berberine (BBR) is a traditional Chinese medicine in various applications due to its antibacterial effect. Here we investigated the increased bacterial resistance of E. coli toward BBR. The median effective concentration (EC50) of BBR against E. coli was increased when TetA efflux protein (TEP) was introduced. Sixty-five percent of the intracellular BBR was expelled and molecular docking demonstrated the intensive interaction of TEP to BBR. Finally, the combined antibacterial experiment identified that BBR acted as an inhibitor of TEP in detoxification of tetracycline...
September 28, 2017: Journal of Asian Natural Products Research
Bing Cui, Jin-Mei Yu
Autophagy is a major intracellular degradation pathway that sequesters multiple cytoplasmic components, including accumulated proteins, damaged organelles, or invading micro-organisms and delivers them to lysosomes for degradation. Autophagy dysregulation is implicated in the pathogenesis of multiple diseases, such as aging, cancers, diabetes. The latest insights into molecular mechanisms of autophagy lead to the discovery of potential drug targets. Traditional drugs with new clinical applications are not only commonly found in western medicines, but also highlighted in traditional Chinese medicines (TCMs)...
September 27, 2017: Journal of Asian Natural Products Research
Xin Liu, Gui-Hua Tang, Han-Zhuang Weng, Jun-Sheng Zhang, You-Kai Xu, Sheng Yin
Five selaginellin derivatives (1 and 3-6) including a new one, selaginellin T (1), and a new triarylbenzophenone analog, selagibenzophenone A (2), were isolated from the whole plants of Selaginella pulvinata. Their structures were determined by 1D- and 2D-NMR and HR-ESI-MS data. Selagibenzophenone A (2) is the first example of naturally occurring triarylbenzophenone. The results of the phosphodiesterase-4 (PDE4) inhibitory screening assays showed that compounds 1-6 exhibited potent activities with the IC50 values in the range of 1...
September 27, 2017: Journal of Asian Natural Products Research
Jamal Kasaian, Ameneh Mohammadi
Farnesiferol C (FC) is a sesquiterpene coumarin, with a unique chemical structure, isolated from Ferula (Apiaceae) species including Ferula assa-foetida and Ferula szowitsiana. The compound is an important natural product with different biological activities. Recently, researchers have been interested in FC and begun to investigate its biological effects. They have shown that FC possesses various biological properties including cytotoxic, apoptotic, MDR reversal, antitumor, antimutagenic, and antiviral activity...
September 26, 2017: Journal of Asian Natural Products Research
Hong-Bo Dong, Ming Hou, Wen-Bo Ma, Jing-Xia Zhang, Zhe-Yu Li, Hong-Bing Luo, Ke-Hui Tang, Sheng-Hua Cao
Phenylpropanoid glycoside compound 1, the natural anti-tumor compound isolated from the erial parts of Cirsium japonicum, was first totally synthesized using easily available materials in short, convenient route with overall yield of 13.9%.
September 26, 2017: Journal of Asian Natural Products Research
Xiao-Ning Zhang, Ming Bai, Zhuo-Yang Cheng, Zhi-Guo Yu, Xiao-Xiao Huang
Phytochemical investigation of the barks of Juglans mandshurica Maxim led to the isolation, purification, and identification of one new lignan named Juglansol A (1), along with nine known compounds (2-10). Their structures were determined by the results of UV, IR, CD, HRESIMS, 1D, and 2D NMR spectroscopic analysis. Compounds 1-10 were evaluated for their cytotoxicities against A549, HepG2, Hep3B, Bcap-37, and MCF-7 cell lines. The results showed that compound 2 possessed stronger cytotoxicities against the tested tumor cell lines compared with positive control 5-fluorouracil...
September 26, 2017: Journal of Asian Natural Products Research
Yun-Long Wei, Zhen-Long Yu, Xiao-Kui Huo, Xiang-Ge Tian, Lei Feng, Shan-Shan Huang, Sa Deng, Xiao-Chi Ma, Jing-Ming Jia, Chao Wang
Chemical investigation has been performed on the roots of Euphorbia fischeriana, a traditional Chinese medicine. Three diterpenoids were obtained using various chromatographic techniques, and their structures were determined by spectroscopic data including HRESIMS, 1D NMR, 2D NMR, ECD, and calculated ECD, which gave two new diterpenoids, daphnane type (1) and ent-pimarene type (3). Additionally, the isolated compounds (1-3) displayed moderate inhibitory effects against α-glucosidase in an in vitro bioassay...
September 25, 2017: Journal of Asian Natural Products Research
Ji-Xiang Shi, Yu-Han Li, Xin Wang, Yu-Qin Qin, Chun-Yan Zhang, Xu Zhang, Cheng-Rong Li, Meng-Qi An, Ling-Rui Li, Shi-Hui Lu, Jing Huang
A new diterpenoid, 17-methyl-8, 13-labdadien-15, 16-olid-19-oic acid methyl ester (1), along with two known compounds 2 and 3, were isolated from the leaves of Platycladus orientalis (L.) Franco. The structures were confirmed based on the analysis of HR-MS, 1D-NMR, and 2D-NMR spectra and the configuration of 1 was confirmed by the single-crystal X-ray diffraction.
September 25, 2017: Journal of Asian Natural Products Research
Yan Song, Sen-Sen Yan, Hai-Jun Lin, Jian-Lin Li, Xu-Guang Zhai, Jie Ren, Guang-Tong Chen
The microbial transformation of 20(R)-panaxadiol (PD) by the fungus Absidia coerulea AS 3.3382 afforded three new and three known metabolites. The structures of the metabolites were characterized as 3-oxo-20(R)-panaxadiol (1), 3-oxo-7β- hydroxyl-20(R)-panaxadiol (2), 3-oxo-22β-hydroxyl-20(R)-panaxadiol (3), 3-oxo- 7β,22β-dihydroxyl-20(R)-panaxadiol (4), 3-oxo-7β,24β-dihydroxyl-20(R)-panaxadiol (5), and 3-oxo-7β,24α-dihydroxyl-20(R)-panaxadiol (6). Among them, 2-4 were new compounds. In addition, compounds 3 and 4 exhibited significant anti-hepatic fibrosis activity...
September 25, 2017: Journal of Asian Natural Products Research
Jing-Chen Wei, Peng-Cheng Wang, Xian-Li Zhou, Kun Tang, Qin Luo, Qin Xu, Xue-Jiao Chen, Cheng-Qin Liang, Xu Chen
Five caffeoyl phenylethanoid glycosides, including two new ones linderruelliosides A (1) and B (2), were isolated from the leaves and stems of Lindernia ruellioides. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR and MS spectra. In addition, all these compounds were tested for their anti-HBV activity. Compounds 1, 3, and 4 showed anti-HBV activities, with IC50 values of 54.87, 30.74, and 69.02 μM for HBsAg and 26.70, 5.17, and 7.08 μM for HBeAg, respectively...
September 25, 2017: Journal of Asian Natural Products Research
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