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Journal of Asian Natural Products Research

Pu-Ming Zhang, Zhi-Bo Wu, Chen Zhang, Ke-Wu Zeng, Yong Jiang, Peng-Fei Tu
Two new chromene derivatives, songaricachromenes A (1) and B (2), were isolated from Artemisia songarica, along with 10 known compounds (3-12). The structures and stereochemistry of the new compounds were elucidated by analyses of the NMR, MS, and electronic circular dichroism (ECD) data. All the isolates (1-12) were evaluated for their NO inhibitory effects on LPS-stimulated BV-2 microglial cells. [Formula: see text].
November 11, 2018: Journal of Asian Natural Products Research
Dan He, Wang-Yan Liu, Jiao Xiong, Jun-Ju Xu, Yong Shen
Four new C19-diterpenoid alkaloids, hemaconitines A-D (1-4), were isolated from the roots of Aconitum hemsleyanum var. circinatum. Their structures were elucidated as 19R-hydroxyl-secoyunnaconitine (1), (3R)-hydroxyl-liwaconitine (2), 14-anisoyl-leucanthumsine E (3), and 19R -acetonyl-8-O-methyltalatisamine (4) by extensive spectroscopic analysis (IR, UV, HR-ESI-MS, 1D, and 2D NMR).
November 11, 2018: Journal of Asian Natural Products Research
Pan Xiang, Chao-Jiang Xiao, Wei Xu, Hua Shan, Lin Qiu, Yang Li, Xiang Dong, Bei Jiang
Two new abietane diterpenoid glucosides, talienosides A and B (1 and 2), along with four known compounds (3 - 6), were isolated from the ethyl acetate soluble portion of 70% acetone extract of the underground parts of Isodon taliensis. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochemical properties. The two new compounds were tested for their bioactivities against malaria and diabetes by β-hematin formation inhibition and α-glycosidase inhibition experiments, respectively...
November 11, 2018: Journal of Asian Natural Products Research
Yunes Panahi, Parisa Kianpour, Reza Mohtashami, Sara Saffar Soflaei, Amirhossein Sahebkar
Curcumin is a safe and dietary phytochemical that can improve different pathophysiologic features of non-alcoholic fatty liver disease (NAFLD). Here, we investigated the efficacy of phospholipidated curcumin supplementation in NAFLD patients. In this single-arm study, 36 patients were recruited. Each patient received three capsules a day (each containing 500 mg of phospholipidated curcumin [overall content of curcuminoids per capsule: 100 mg]) for a period of 8 weeks. The results indicated that phospholipidated curcumin supplementation reduced NAFLD severity and ameliorated ultrasonographic and biochemical measures (including liver transaminases and lipid profile) associated with disease progression...
November 11, 2018: Journal of Asian Natural Products Research
Wei-Zhuo Tang, Zhong-Zhen Yang, Fan Sun, Shu-Ping Wang, Fan Yang, Wei-Hua Jiao, Hou-Wen Lin
LC-DAD/MS-based dereplication of organic extract of a calcareous sponge Leucetta chagosensis afforded one new chiral aminoimidazole-containing alkaloid, (-)-calcaridine B (1), along with one achiral imidazole analog leucettamine E (2) as well as one known imidazole derivative (2E, 9E)-pyronaamidine-9-(N-methylimine) (3). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literature. The cytotoxic activities of all isolates were evaluated against three human cancer cell lines, and compounds 1 and 3 exhibited mild cytotoxicities toward the MCF-7 cell line with IC50 values of 25...
November 11, 2018: Journal of Asian Natural Products Research
Jia-Meng Dai, Yan-Hong Li, Xiao-Yun Pu, Cui Yang, Jing-Xian Sun, Roger Ruan, Xiao-Nian Li, Kai Tian, Xiang-Zhong Huang
Phytochemical investigation on Hemiphragma heterophyllum led to the isolation of two new compounds, heterophyllumin A (1) and heterophylliol (3), along with nine known compounds, (‒)-sibiricumin A (2), iridolactone (4), jatamanin A (5), dihydrocatalpolgenin (6), 25-hydroperoxycycloart-23-en-3β-ol (7), 24-methylenecycloartanol (8), (+)-pinoresinol (9), hexadec-(4Z)-enoic acid (10), and 9,12, 15-octadecatrienoic acid (11). Their structures were elucidated on the basis of detailed spectroscopic analyses and by comparison with literature data...
November 11, 2018: Journal of Asian Natural Products Research
Qi-Lin Li, An-Jun Deng, Ming Ji, Zhi-Hong Li, Xiao-Guang Chen, Hai-Lin Qin
A method was developed to synthesize 2,3:7,8-di(alkylenedioxy)-extended analogs of quaternary sanguinarine chloride. 1-Bromo-2-bromomethyl-3,4-alkylenedioxy benzenes and 6,7-alkylenedioxynaphthalen-1-amines were synthesized first. Reactions to construct the target compounds with these two series of synthons involved alterations on a published method for synthesizing 2,3,7,8-tetraoxygenated derivatives of benzo[c]phenanthridinium, substituting benzyl bromides for benzoic aldehydes, prolonging the radical annulation time, and conducting N-methylation with formic acid and NaBH4 ...
November 11, 2018: Journal of Asian Natural Products Research
Pei Wang, Yan Cui, Cai-Hong Cai, Fang-Dong Kong, Hui-Qin Chen, Li-Man Zhou, Xin-Ming Song, Wen-Li Mei, Hao-Fu Dai
A new cytochalasin derivative xylarisin B (1), together with four known compounds astropyrone (2), guaidiol (3), xylaropyrone B (4), and xylaropyrone C (5), were isolated from the fermentation broth of Xylaria sp. HNWSW-2. Their structures were elucidated by spectroscopic data. Among them, compounds 2 and 3 at a concentration of 50 μg/ml showed weak inhibitory activity against AChE with inhibition rates of 10.4 and 12.9%, respectively. In addition, compound 2 also exhibited inhibitory activity against α-glycosidase with inhibition rate of 77...
November 11, 2018: Journal of Asian Natural Products Research
Ming Zhong, Hui-Qiang Wang, Hai-Yan Yan, Shuo Wu, Zheng-Yi Gu, Yu-Huan Li
Influenza A virus (IAV) causes high morbidity and significant mortality worldwide. Given the limitations of existing vaccination and antiviral drugs, it is urgent to develop new anti-influenza drugs. Flavonoids are natural polyphenolic compounds with broad applications to treatments for influenza infection. In this study, we demonstrated that santin, a flavonoid compound, showed anti-influenza activity in MDCK and THP-1 cells. Mechanistic studies revealed that santin depressed the phosphorylation of p38 MAPK, JNK/SAPK, ERK, and NF-κB factor and subsequently attenuated the expression of inflammatory cytokines in IAV-infected cells...
November 10, 2018: Journal of Asian Natural Products Research
Xin Wang, Chong-Hui Liu, Jin-Jie Li, Bo Zhang, Lin-Lin Ji, Xiao-Ya Shang
Four new iridoid glycosides named cornusphenosides A-D (1-4) were isolated from an ethanol extract of the fruits of Cornus officinalis (shan zhu yu). The structures of these compounds were elucidated on the basis of spectroscopic data (UV, IR, HRESIMS, and 1D and 2D NMR) and chemical evidence. The neuroprotective effects of compounds 1-4 were also assessed in vitro.GRAPHICAL ABSTRACT[Formula: see text].
November 8, 2018: Journal of Asian Natural Products Research
Wei Zhang, Zheng Li, Feng-Qing Xu, Ya-Shuo Ren, Shuang-Wang Xu, Tong-Sheng Wang, Jin-Song Liu, De-Ling Wu
Two new 11-methoxyl substituted triterpenoids, named as mimengosides J (1) and K (2), along with seven known compounds, were isolated from the fruits of Buddleja lindleyana. Their structures were elucidated on the basis of spectroscopic analysis. In addition, the new ones were evaluated for protective effects against damage of SH-SY5Y cells induced by 1-methyl-4-phenylpyridinium ion (MPP+ ) and the results indicated that those may be one of the candidate compositions of Buddleja lindleyana for the treatment of neurodegenerative disease...
November 7, 2018: Journal of Asian Natural Products Research
Wei-Wen Chen, Ying-Feng Huang, Zhi-Bing Hu, Yi-Min Liu, Hong-Xia Xiao, Da-Bin Liu, Ying-Zi Zhuang
Microarray expression profiles of lncRNAs and mRNAs were investigated in HepG2 cells treated with 20 μg/ml ginsenoside Rh2 as well as in ginsenoside Rh2-untreated cells. Microarray analysis showed 618 upregulated lncRNAs and 161 downregulated lncRNAs in HepG2 cells treated with ginsenoside Rh2 compared with the control group. Moreover, three differentially expressed lncRNAs were validated by quantitative real-time polymerase chain reaction (qRT-PCR). This may be beneficial to patients as an anti-cancer treatment and potentially provide novel targets for HCC (hepatocellular carcinoma) therapy...
November 4, 2018: Journal of Asian Natural Products Research
Youcai Hu, Yi Tang
No abstract text is available yet for this article.
October 1, 2018: Journal of Asian Natural Products Research
Feng Gao, Yue-Jiao Qian, Fei-Hu Chen, Hai-Bo Zhu
To compare the stimulation and binding characteristics of adenosine analogs including AMP, IMM-H007, and M1, to AMPK, and to explore the potential mechanism underlying the regulation effect of adenosine analogs on AMPK activity, [γ-32 P]ATP assay, circular dichroism experiments and molecular docking test were performed. We found that the interactions with Thr86, Thr88, and His150 in site 1 are probably the reason why the affinities of IMM-H007, M1, and adenosine are comparable but their allosteric activation on AMPK varies greatly, partly interpreting the mechanism of AMPK activity regulated by adenosine analogs...
September 6, 2018: Journal of Asian Natural Products Research
Shu Dong, Li-Yan Ma, Yue-Tao Liu, Meng Yu, Hong-Mei Jia, Hong-Wu Zhang, Chang-Yuan Yu, Zhong-Mei Zou
Costunolide and dehydrocostuslactone are the main active ingredients of Radix Aucklandiae (RA). An accurate and sensitive LC-MS/MS method was established to simultaneously determine contents of costunolide and dehydrocostuslactone in plasma. There were significant differences in pharmacokinetic parameters (AUC0-t , Cmax,1 , Cmax,2 , Tmax,1 , Vd, and CL) of costunolide and dehydrocostuslactone between RA group and costunolide group or dehydrocostuslactone group. The relative bioavailability of costunolide or dehydrocostuslactone of RA extract was improved...
August 21, 2018: Journal of Asian Natural Products Research
Ting Zhao, Lu-Lin Xu, Yan Zhang, Zheng-Hong Lin, Tao Xia, Deng-Feng Yang, Ye-Miao Chen, Xiao-Long Yang
Three new 3,4,6-trisubstituted α-pyrone derivatives, namely 6-(2'R-hydroxy-3'E,5'E-diene-1'-heptyl)-4-hydroxy-3-methyl-2H-pyran-2-one (1), 6-(2'S-hydroxy-5'E-ene-1'-heptyl)-4-hydroxy-3-methyl-2H-pyran-2-one (2), and 6-(2'S-hydroxy-1'-heptyl)-4 -hydroxy-3-methyl-2H-pyran-2-one (3), together with one known compound trichodermic acid (4), were isolated from the solid-substrate fermentation culture of Penicillium ochrochloronthe associated the roots of Taxus media. Compounds 1-4 displayed the antimicrobial activity selectively against tested fungal and bacterial strains with minimum inhibitory concentration (MIC) values ranging from 12...
August 21, 2018: Journal of Asian Natural Products Research
Mo-Nan Liu, Meng-Meng Zhang, Jing-Ya Li, Jia Li, Yao-Yue Fan, Jian-Min Yue
Six new ent-labdane-type diterpeniods (1‒6), along with one known compound, were identified from the twigs and leaves of Croton laevigatus. Their structures were elucidated on the basis of extensive spectroscopic interpretation. Compounds 2 and 7 showed inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 4.11 and 8.33 μg/ml, respectively.
August 21, 2018: Journal of Asian Natural Products Research
Zhen Liu, Jing-Yi Zhao, Sen-Feng Sun, Yong Li, Yun-Bao Liu
A large number of remarkable studies on the secondary metabolites of fungi have been conducted in recent years. This review gives an overview of one hundred and sixty-seven molecules with novel skeletons and their bioactivities that have been reported in seventy-nine articles published from 2013 to 2017. Our statistical data showed that endophytic fungi and marine-derived fungi are the major sources of novel bioactive secondary metabolites.
July 26, 2018: Journal of Asian Natural Products Research
Hui Meng, De-Li Chen, Yun Yang, Yang-Yang Liu, Jian-He Wei
Two new sesquiterpenoids, named dalodorin A (1) and dalodorin B (2), together with four known sesquiterpenoids, were isolated from the heartwood of Dalbergia odorifera. Their structures were elucidated on the basis of spectroscopic analysis including 1D and 2D NMR techniques and HR-ESI-MS. Evaluation of the isolated compounds for cytotoxicity against two human cancer cell lines (Hela and HepG-2) showed moderate activities (25.22-60.45 μM).
July 26, 2018: Journal of Asian Natural Products Research
Chang-Ling Duan, Yu-Juan Li, Feng-Yun Wang, Lan Miao, Xu-Dong Tang
Two new steroidal glycosides (named fibrophiopogonins A, B), along with one known glycoside, were isolated from the fibrous roots of Ophiopogon japonicus (Liliaceae). Comprehensive spectroscopic analysis, including 2D NMR spectroscopy, and the results of acid hydrolysis allowed the chemical structure of the compounds to be assigned as 26-[(O-β-D-glucopyranosyl-(1 → 6)-D-glucopyranosyl)]-barogenin- 3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside and (25R)-26-[(O- β-D-glucopyranosyl-(1→6)-β-D-glucopyranosyl)]- 3β,22α,26- trihydroxyfurost- 5-ene-3-O-[α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside...
July 17, 2018: Journal of Asian Natural Products Research
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