journal
MENU ▼
Read by QxMD icon Read
search

Journal of Asian Natural Products Research

journal
https://www.readbyqxmd.com/read/28303722/two-new-compounds-from-the-green-peel-of-juglans-mandshurica
#1
Jing Li, Kang-Ping Xu, Zhen-Xing Zou, Hui Zou, Hong-Ping Long, Lei-Hong Tan, Rui-Huan Liu, Yi-Kun Wang, Ping-Sheng Xu, Gui-Shan Tan
A new cyclic diarylheptanoid (1) and a new flavone glucoside (2), along with seven known compounds, were isolated from the green peel of Juglans mandshurica. Their structures were elucidated based on extensive spectroscopic analyses. Moreover, the cytotoxicity against NCI-H460, A549, and K562 cancer cells of compounds 1-6 was evaluated. The results showed that compound 3 exhibited moderate inhibitory potency against the growth of three cell lines.
March 17, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28276758/two-new-%C3%AE-pyrone-derivatives-from-an-endolichenic-fungus-tolypocladium-sp
#2
Chu-Hong Hu, Yan-Hui Zhou, Fei Xie, Yue-Lan Li, Zun-Tian Zhao, Hong-Xiang Lou
Two new α-pyrone derivatives, tolypocladones A (1) and B (2), together with five known compounds were isolated from an endolichenic fungus Tolypocladium sp. (4259a). The structures of all the compounds were determined by analysis of their MS and NMR data. Among them, compound 1 was an enantiomeric mixture and the configuration was established by single-crystal X-ray diffraction analysis using Cu-Kα radiation. Also, this is the first report of the presence of compound 3 (glycine, N-(2,3-dihydroxybenzoyl)-methyl ester) and compound 4 (2H-pyran-2-one, 4-methoxy-6-(1,3-pentadienyl)) as natural products...
February 28, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28276759/cloning-and-functional-analysis-of-two-sterol-c24-methyltransferase-1-smt1-genes-from-paris-polyphylla
#3
Hong-Yu Guan, Ping Su, Yu-Jun Zhao, Xia-Nan Zhang, Zhu-Bo Dai, Juan Guo, Yu-Ru Tong, Yu-Jia Liu, Tian-Yuan Hu, Yan Yin, Lin-Hui Gao, Wei Gao, Lu-Qi Huang
The biosynthetic pathways of phytosterols and steroidal saponins are located in two adjacent branches which share cycloartenol as substrate. The rate-limiting enzyme S-adenosyl-L-methionine-sterol-C24-methyltransferase 1 (SMT1) facilitates the metabolic flux toward phytosterols. It catalyzes the methylation of the cycloartenol in the side chain of the C24-alkyl group, to generate 24(28)-methylene cycloartenol. In this study, we obtained two full-length sequences of SMT1 genes from Pari polyphylla, designated PpSMT1-1 and PpSMT1-2...
February 23, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28276761/abscisic-acid-type-sesquiterpenes-and-ansamycins-from-amycolatopsis-alba-dsm-44262
#4
Xiao-Mei Li, Xiao-Man Li, Chun-Hua Lu
Two new abscisic acid-type sesquiterpenes (1, 2), and one new ansamycin (3), together with four known ansamycins, namely ansacarbamitocins 4-7, were isolated from the fermentation extract of Amycolatopsis alba DSM 44262. The structures of the new compounds were elucidated to be (E)-3-methyl-5-(2,6,6-trimethyl-3-oxocyclohex-1-enyl)pent-2-enoic acid (1) and (E)-3-methyl-5-(2,6,6-trimethyl-4-oxocyclohex-2-enyl)pent-2-enoic acid (2), and 9-O-methylansacarbamitocin A1 (3), on the basis of comprehensive analysis of spectroscopic data, respectively...
February 22, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28276760/the-first-total-synthesis-of-anemarchalconyn-and-anemarcoumarin-a
#5
Jing-Xia Zhang, Zhe-Yu Li, Yu-Chi Wang, Wen-Bo Ma, Ming Hou, Sheng-Hua Cao, Ke-Hui Tang, Hong-Bo Dong
Anemarchalconyn (1) and anemarcoumarin A (2), the natural bioactive compounds isolated from the rhizomes of Anemarrhena asphodeloides Bunge (Liliaceae), were first totally synthesized using easily available materials in short, convenient routes with overall yields of 32 and 48%.
February 22, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28276763/coumarins-from-the-bark-of-juglans-mandshurica-exhibited-anti-hepatoma-activities-via-inducing-apoptosis
#6
Guo-Dong Yao, Zhuo-Yang Cheng, Xin-Yue Shang, Pin-Yi Gao, Xiao-Xiao Huang, Shao-Jiang Song
Hepatocellular carcinoma (HCC), the most common type of liver cancer, has high morbidity and mortality rates, and its prognosis is poor. The treatment options of HCC are limited by the lack of effective chemotherapy. Therefore, looking for effective drugs with little toxicity is very urgent. The aim of this study was to search for small molecule targeting on liver cancer from Juglans mandshurica, which has been used to treat cancers for a long time in China. Under the guide of anti-hepatoma activity, a new coumarin (1), together with eight reported analogs (2‒9), was isolated from the 75% EtOH extract...
February 19, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28276762/ruticarpsides-a-c-three-new-ester-glycosides-from-the-fruits-of-tetradium-ruticarpum
#7
Wei He, Yong Jiang, Ming-Bo Zhao, Ke-Wu Zeng, Peng-Fei Tu
In the course of our ongoing phytochemical investigation on the n-butanol extract of the fruits of Tetradium ruticarpum (Rutaceae), three new compounds, ruticarpsides A-C (1-3), were obtained and their structures were elucidated by a comprehensive analysis of NMR and MS data. Compound 3 showed a weak inhibition effect on nitric oxide production in BV-2 microglial cells stimulated with lipopolysaccharide.
February 19, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28276765/six-new-furostanol-glycosides-from-smilax-glauco-china-and-their-cytotoxic-activity
#8
Xing Liu, Jian Liang, Ling-Ling Pan, Jian-Yong Chen, Rong-Hua Liu, Gen-Hua Zhu, Hui-Lian Huang, Ji-Cheng Shu, Feng Shao, Yong-Hong Liang, Jiang-Li Yu
Six new steroidal saponins, namely glauco-chinaosides A-F, and one known compound were isolated from the tubers of Smilax glauco-china. Their structures were elucidated by a combination of spectroscopic analysis and hydrolysis followed by spectral and chromatographic analysis. Compounds 1-7 were tested in vitro for their cytotoxic activities against four human tumor cell lines (SH-SY5Y, SGC-7901, HCT-116, and Lovo). Compounds 1, 2, and 5 exhibited cytotoxic activity against SGC-7901, with IC50 values of 2.7, 11...
February 17, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28276764/phenolic-compounds-from-bletilla-striata
#9
Li-Ning Wang, Yong-Zhi He, Qi-Duo Zhao, Yan-Ru Deng, Pei-Qian Wu, Yan-Jun Zhang
Two new malic acid derivatives, namely eucomic acid 1-methyl ester (2) and 6'''-acetylmilitaline (7), together with ten known compounds (1, 3-6, 8-12), were isolated from the dry tubers of Bletilla striata (Thunb.) Reichb. F., a perennial traditional Chinese medicinal herb, which was used for the treatment of pneumonophthisis, pneumonorrhagia, tuberculosis, and hemorrhage of the stomach or lung. Their structures were elucidated by spectroscopic analyses, including 1D-, 2D-NMR, and HR-ESI-MS.
February 17, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28276766/two-new-phthalide-dimers-from-the-rhizomes-of-ligusticum-chuanxiong
#10
Wei Wei, Wei Xu, Xiu-Wei Yang
Two pairs of diastereoisomers, namely (3'Z)-(3S,8S,3a'S,6'R)-4,5-dehydro-3.3a',8.6'-diligustilide (1) and (3'Z)-(3S,8R,3a'S,6'R)-4,5-dehydro-3.3a',8.6'-diligustilide (3), chuanxiongdiolide R3 (2), and chuanxiongdiolide R1 (4), were isolated from the 95% ethanolic aqueous extract of the rhizomes of Ligusticum chuanxiong. Among these Phthalide dimers, compounds 1 and 2 were new ones. The structures of the new isolates were elucidated based on spectroscopic data analyses, and their absolute configurations were determined by comparison of experimental and calculated electronic circular dichroism spectra...
February 16, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28276767/six-new-c-21-steroidal-glycosides-from-dregea-sinensis-hemsl
#11
Xiu-Jie Liu, Yu Shi, Shao-Hua Jia, Yu-Lin Deng, Fang Lv, Rong-Ji Dai
Six new C-21 steroidal glycosides (1-6) were separated from the root of Dregea sinensis Hemsl. and their structures were elucidated using extensive nuclear magnetic resonance, mass spectrometry, and infrared spectral analyses. Isolated compounds were evaluated for antitumor activity, which showed that compound 3 had moderate activity in Jurkat cells (IC50 19.54 ± 0.91 μM), and compounds 1-4 had significant effects against IL-2R and TNFR2 (IC50 1.518 ± 0.06 μM to 5.9 ± 0.07 μM).
February 13, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28152617/further-brominated-polyacetylenes-with-pancreatic-lipase-inhibitory-activity-from-chinese-marine-sponge-xestospongia-testudinaria
#12
Min Yang, Lin-Fu Liang, Ting Wang, He-Yao Wang, Hai-Li Liu, Yue-Wei Guo
A new brominated polyacetylene, xestonariene I (1), along with three known related analogues (2-4), was obtained from Chinese marine sponge Xestospongia testudinaria. Its structure was determined on the basis of detailed spectroscopic analysis and by comparison with literature data. Compound 4 exhibited significant inhibitory activity against pancreatic lipase, which plays a key role in preventing obesity, with an IC50 value of 0.61 μM, being comparable to that of the positive control orlistat (IC50 = 0...
February 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28152615/a-new-n-methoxyl-carbonyl-benzylisoquinoline-from-litsea-cubeba
#13
Bin Tang, Hua Tu, Han-An Long, Jun Du, Jian-Min Guo, Hong-Jin Liu, Xin Hu, Li Yang, Xi Du
A new benzylisoquinoline alkaloid (•)-N-methoxycarbonyl-norjuziphine (1) was isolated from Litsea cubeba. Its structure was identified by extensively spectroscopic techniques and confirmed by the single-crystal X-ray diffraction analysis. Compound 1 showed cytotoxicity against HL-60 and MCF-7 cells, with IC50 values of 18.1 and 15.0 μM, respectively, comparable to 3.1 and 17.5 μM of the cisplatin (positive control).
February 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28152609/three-new-anthraquinones-from-the-twigs-of-cassia-fistula-and-their-bioactivities
#14
Min Zhou, Huan-Huan Xing, Yan Yang, Yue-De Wang, Kun Zhou, Wei Dong, Gan-Peng Li, Wei-Yao Hu, Qiang Liu, Xue-Mei Li, Qiu-Fen Hu
Three previously unreported anthraquinones, fistulaquinones A-C (1-3), together with three known ones (4-6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of extensive NMR and MS spectroscopic analyses. All the isolated compounds were tested for their anti-tobacco mosaic virus (anti-TMV) activity, and compound 3 showed significant activity with inhibition rate of 34.5% at 20 μM concentration, even more potent than positive control. Additionally, compounds 1-6 exhibited moderate cytotoxicity with IC50 values ranging from 2...
February 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28152606/three-new-triterpenoids-from-ganoderma-theaecolum
#15
Li-Ying Liu, Zheng Yan, Jie Kang, Ruo-Yun Chen, De-Quan Yu
Three new triterpenoids (1-3), together with four known triterpenoids (4-7), were isolated from the fruiting bodies of Ganoderma theaecolum. Their structures were elucidated on the basis of their spectroscopic data and chemical evidence. Compounds 4 and 6 exhibited antitumor activities against H460 cells with IC50 values of 22.4 and 43.1 μM, respectively. And the cytotoxic activities of compounds 4 and 5 against MDA-MB-231 cancer cell lines were assayed with IC50 values of 49.1 and 75.8 μM, respectively...
February 2, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28145126/bioactive-steroids-and-sorbicillinoids-isolated-from-the-endophytic-fungus-trichoderma-sp-xy24
#16
Jin-Lian Zhao, Min Zhang, Ji-Mei Liu, Zhen Tan, Ri-Dao Chen, Ke-Bo Xie, Jun-Gui Dai
A new steroid glucoside (1), along with nine known steroids (2-10) and four known sorbicillinoids (11-14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data. Compounds 3, 5-7, 9, 10, and 13 exhibited significant inhibitory effects on HIV-1 virus with IC50 values ranging 1.9-9.3 μM; compounds 10, 13, and 14 showed potent inhibitory activity on LPS-induced NO production in BV2 microglia cells with inhibitory rates of 108...
February 1, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28145124/three-new-c-alkylated-flavonoids-from-desmodium-oblongum
#17
Yan-Ping Li, Qiu-Fen Hu, Gao-Xiong Rao
Three new C-alkylated flavonoids, 4'-hydroxy-8-isobutyryl-7-methoxy-6-methyl-flavone (1), 4',7-dimethoxy-8-isobutyryl-6-methyl-flavone (2), and 4',7-dimethoxy-8-isobutyryl-flavone (3), together with three know ones luteolin (4), kaemferol (5), and quercetin (6), were isolated from Desmodium oblongum. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 1 showed cytotoxicity against NB4, SHSY5Y, and MCF7 cell lines with IC50 values of 8.5, 6.5, and 7...
February 1, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28140678/biotransformation-of-furanocoumarins-by-fungi-preparation-of-imperation-analogs
#18
Xiu-Lan Xin, Yan Wang, Ge Wang, Chao Wang, Shan-Shan Huang, Xiao-Kui Huo, Dong-Hai Su, Xiang-Ge Tian
Imperation analogs have the furanocoumarin skeleton, with the isopentenyl group, which displayed significant bioactivities. The biotransformation of furanocoumarins imperation, isoimperation and phellopterin (1-3) by fungi has been proved to be an efficient method for the structural modification. Ten transformed furanocoumarin analogs were obtained by fungal biotransformation, including one new highly oxygenated furanocoumarin (4c). Aspergillus niger AS 3.739 displayed selectively transformed capability toward furanocouamrins (1-3) with one or two major products...
January 31, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28140665/synthesis-and-antitumor-activity-evaluation-of-novel-oleanolic-acid-derivatives
#19
Yan-Qiu Meng, Yu-Wei Zhao, Zhen-Yu Kuai, Li-Wei Liu, Wei Li
Ten novel oleanolic acid (OA) derivatives were synthesized through modifications at positions of A ring and C-28. Inhibitory activities of the oleanolic acid derivatives against SGC7901 and A549 cell lines were evaluated and confirmed by the tetrazolium bromidesalt (MTT) assay. The lab results revealed that all these compounds displayed some antitumor activity against SGC-7901 and A-549 cell lines. Among them, II4 and II5 exhibited excellent antitumor activities against SGC7901 cells and A549 cells, compared with gefitinib...
January 31, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28140664/phenolic-acid-derivatives-with-neuroprotective-effect-from-the-aqueous-extract-of-clerodendranthus-spicatus
#20
Hai-Chun Zhou, Liu Yang, Rui-Zhu Guo, Ji Li
Two new phenolic acid helisterculins C (1) and D (2) were isolated from the whole plant of Clerodendranthus spicatus. Their structures were elucidated on the basis of 1D and 2D NMR, MS, and CD analysis. Compound 1 possesses an unusual bicyclol [2. 2. 2] octane moiety which is rare in the previously isolated phenolic acid derivatives. The two compounds were tested in vitro for neuroprotective activities against 6-OHDA-induced cell death in SH-SY5Y cells, and the result showed that compounds 1 and 2 displayed moderate neuroprotective activity with the IC50 values of 17...
January 31, 2017: Journal of Asian Natural Products Research
journal
journal
34676
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"