Structurally Diverse Alkaloids with Anti-Renal-Fibrosis Activity from the Centipede Scolopendra subspinipes mutilans .

Twelve new alkaloids, scolopenolines A-L ( 1 - 7 , 9 - 11 , 13 , 14 ), along with six known analogues, were isolated from Scolopendra subspinipes mutilans , identified by analysis of spectroscopic data and quantum chemical and computational methods. Scolopenoline A ( 1 ), a unique guanidyl-containing C14 quinoline alkaloid, features a 6/6/5 ring backbone. Scolopenoline B ( 2 ) is a novel sulfonyl-containing heterodimer comprising quinoline and tyramine moieties. Scolopenoline G ( 7 ) presents a rare C12 quinoline skeleton with a 6/6/5 ring system. Alkaloids 1 , 8 , 10 , and 15 - 18 display anti-inflammatory activity, while 10 and 16 - 18 also exhibit anti-renal-fibrosis activity. Drug affinity responsive target stability and RNA-interference assays show that Lamp2 might be a potentially important target protein of 16 for anti-renal-fibrosis activity.