Association of Infant Breastfeeding and Spondyloarthritis: A Case-Control Study.

OBJECTIVE: Given the multifactorial pathogenesis of juvenile spondyloarthritis (JSpA) and evidence of a protective effect in phenotypically similar diseases, we aimed to test whether breastfeeding is associated with the development and disease activity of JSpA.

METHODS: This single center retrospective case-control study included children with JSpA and age- and sex-matched controls with a 1:1 ratio. Univariable and multivariable conditional logistic regression modeling for matched pairs was used to test the association of infant factors with the development of JSpA, including infant nutrition and form of delivery. Linear regression was used to assess the association of JSpA disease activity (JSpA disease activity-6 [JSpADA-6) index) at presentation with breastfeeding exposure, form of delivery, and antibiotic exposure.

RESULTS: For the 195 case-control matched pairs, the mean age was 13.0 years old and 47.7% were female. 88.7% of controls and 69.2% of JSpA cases were exposed to breastfeeding of any duration, respectively ( P < 0.001). In the multivariable model, exclusive breastfeeding > 6 months was independently and significantly associated with a lower chance of JSpA development (odds ratio [OR] 0.47, 95% CI: 0.30 to 0.72, P < 0.001). The median JSpADA-6 index was not significantly associated with breastfeeding for >6 months. However, vaginal delivery was significantly associated with a lower JSpADA-6 (B= -0.65; 95% CI -1.13 to -0.17; P = 0.008).

CONCLUSION: This study suggests that infant factors that impact the microbiome may be associated with the occurrence and disease activity of JSpA at presentation.