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Journal of Rheumatology

Josef S Smolen, Mark C Genovese, Tsutomu Takeuchi, David L Hyslop, William L Macias, Terence Rooney, Lei Chen, Christina L Dickson, Jennifer Riddle Camp, Tracy E Cardillo, Taeko Ishii, Kevin L Winthrop
OBJECTIVE: Baricitinib is an oral, once-daily selective Janus kinase (JAK1/JAK2) inhibitor for adults with moderately to severely active rheumatoid arthritis (RA). We evaluated baricitinib's safety profile through 288 weeks (up to September 1, 2016) with an integrated database [8 phase III/II/Ib trials, 1 longterm extension (LTE)]. METHODS: The "all-bari-RA" group included patients who received any baricitinib dose. Placebo comparison was based on the 6 studies with 4 mg and placebo up to Week 24 ("placebo-4 mg" dataset)...
September 15, 2018: Journal of Rheumatology
Christine A Peschken, Yishu Wang, Michal Abrahamowicz, Janet Pope, Earl Silverman, Amyn Sayani, Sandra Iczkovitz, Jorge Ross, Michel Zummer, Lori Tucker, Christian Pineau, Deborah Levy, Marie Hudson, Carol A Hitchon, Adam M Huber, C Douglas Smith, Antonio Avina-Zubieta, Hector Arbillaga, Gaëlle Chédeville, Willy Wynant, Paul R Fortin
OBJECTIVE: Persistent systemic lupus erythematosus (SLE) disease activity is associated with increased morbidity and mortality. In a multicenter cohort of patients with prevalent SLE, we described persistence, patterns, and predictors of change in disease activity over time. METHODS: Based on SLE Disease Activity Index (SLEDAI)-2K scores at cohort entry, patients were classified into 4 groups: low (score < 4; LOW), moderate (4 to < 6; MOD), moderately high (6 to ≤ 10; MHIGH), and very high (> 10; VHIGH)...
September 15, 2018: Journal of Rheumatology
Mark Berman, Devy Zisman, Jonathan Wollman, David Levartovsky, Eli Rimon, Ori Elkayam, Daphna Paran
OBJECTIVE: To evaluate the effect of pregnancy on disease activity in psoriatic arthritis (PsA). METHODS: This is a retrospective case series. Review of the medical files of all female patients followed at the PsA clinic of 2 medical centers identified those with at least 1 pregnancy during followup and 1 visit during or soon after pregnancy. RESULTS: Twenty-five women with PsA (out of 107 women of reproductive age followed up in our PsA clinics) and 35 pregnancies were enrolled...
September 15, 2018: Journal of Rheumatology
Suzanne C Li, Xiaohu Li, Elena Pope, Katie Stewart, Gloria C Higgins, C Egla Rabinovich, Kathleen M O'Neil, Kathleen A Haines, Ronald M Laxer, Marilynn Punaro, Heidi Jacobe, Tracy Andrews, Knut Wittkowski, Themba Nyirenda, Ivan Foeldvari, Kathryn S Torok
OBJECTIVE: To identify clinical features that define disease activity in pediatric localized scleroderma (LS), and determine their specificity and importance. METHODS: We conducted a multicenter prospective study of patients with active and inactive LS skin lesions. A standardized evaluation of a single designated study lesion per subject was performed at 3 visits. We evaluated the pattern and correlation between assessed features and physician's global assessments of activity (PGA-A)...
September 15, 2018: Journal of Rheumatology
Mu Qiao, Bang-Ping Qian, Yong Qiu, Sai-Hu Mao, Yi-Hua Wang
OBJECTIVE: To investigate the pathogenesis of pseudarthrosis in ankylosing spondylitis (AS) based on the pathological analysis of specimens harvested during surgery. METHODS: Radiographic and clinical data for 17 consecutive AS patients with pseudarthrosis were retrospectively analyzed. Meanwhile, the pathological analysis of specimens obtained during surgery was also performed. RESULTS: In total, 18 extensive Andersson lesions were included...
September 15, 2018: Journal of Rheumatology
Christopher A Mecoli, Jin Kyun Park, Helene Alexanderson, Malin Regardt, Merrilee Needham, Ingrid de Groot, Catherine Sarver, Ingrid E Lundberg, Beverley Shea, Marianne de Visser, Yeong Wook Song, Clifton O Bingham, Lisa Christopher-Stine
OBJECTIVE: Patient-reported outcome measures (PROM) that incorporate the patient perspective have not been well established in idiopathic inflammatory myopathies (IIM). As part of our goal to develop IIM-specific PROM, the Outcome Measures in Rheumatology (OMERACT) Myositis special interest group sought to determine which aspects of disease and its effects are important to patients and healthcare providers (HCP). METHODS: Based on a prior qualitative content analysis of focus groups, an initial list of 24 candidate domains was constructed...
September 15, 2018: Journal of Rheumatology
Myrthe Alexandra Maria van Delft, Sjoerd van Beest, Margreet Kloppenburg, Leendert Adrianus Trouw, Andreea Ioan-Facsinay
OBJECTIVE: To investigate whether 3 rheumatoid arthritis-associated antibodies [rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA) or anticarbamylated protein (anti-CarP) antibodies] are present in hand osteoarthritis (HOA) and associate with erosive OA (EOA). METHODS: Anti-CarP IgG was measured by ELISA in baseline sera of patients with HOA from 3 cohorts: HOSTAS (n = 510, 27.2% EOA), ECHO (n = 47), and EHOA (n = 23), and in sera of healthy controls (HC; n = 196, mean age 44...
September 15, 2018: Journal of Rheumatology
Laura C Coates, Ennio Lubrano, Fabio Massimo Perrotta, Paul Emery, Philip G Conaghan, Philip S Helliwell
OBJECTIVE: Recommendations regarding "treat to target" in psoriatic arthritis (PsA) have stated that the target should be remission or inactive disease. Potential definitions include very low disease activity (VLDA), PsA Disease Activity Score (PASDAS) near remission, Disease Activity Index for PsA (DAPSA) or clinical DAPSA (cDAPSA) remission. Our aim was to investigate the proportion of patients who fulfill these definitions and how much residual active disease remained. METHODS: This analysis used 2 datasets: first, trial data from the Tight Control of PsA (TICOPA) study, which included 206 patients with recent-onset (< 2 yrs) PsA receiving standard and biological disease-modifying antirheumatic drugs (DMARD); and second, an observational clinical dataset from Italy of patients receiving biological DMARD...
September 15, 2018: Journal of Rheumatology
Hai V Nguyen, Darren D O'Rielly, Proton Rahman
We previously published an analytical validation of the HLA-B*27 tag-single-nucleotide polymorphism (SNP) assay in The Journal 1 based on the initial identification of the HLA-B*27 tag-SNP by the International Genetics of Ankylosing Spondylitis Consortium. Our tag-SNP assay is much cheaper than the traditional HLA-B locus testing, and has been implemented at the Provincial Medical Genetics Laboratory of Eastern Health (St. John's, Newfoundland, Canada) since August 1, 2016. The data on the use of this assay have been systematically collected...
September 15, 2018: Journal of Rheumatology
Christian Morgenstern, Nora Renz, Sabrina Cabric, Carsten Perka, Andrej Trampuz
OBJECTIVE: To prospectively evaluate automated multiplex PCR and isothermal microcalorimetry tests for rapid and accurate diagnosis of septic arthritis. METHODS: Patients with acute arthritis were prospectively included from October 2014 to September 2015. In synovial fluid (SF), leukocyte count and differential, culture, PCR, and microcalorimetry were determined. Septic arthritis was diagnosed by positive SF culture or (1) local clinical signs and symptoms, (2) increased SF leukocyte count, and (3) exclusion of noninfectious causes of inflammatory arthropathy...
September 15, 2018: Journal of Rheumatology
Stanislas Faguer, Julie Belliere, David Ribes
Dermatomyositis (DM) is a rare autoimmune disease that belongs to the group of idiopathic inflammatory myopathies (IIM). The usual treatment of DM was based on steroids, methotrexate, and azathioprine. Intravenous immunoglobulin (IVIG), rituximab (RTX), or other biological treatments recently emerged as steroid-sparing agents.
September 15, 2018: Journal of Rheumatology
Caroline McCulley, Patricia Katz, Laura Trupin, Edward H Yelin, Jennifer L Barton
OBJECTIVE: Rheumatoid arthritis (RA) patients' adherence to disease-modifying antirheumatic drugs (DMARD) is often suboptimal. We examined associations among medication beliefs, self-efficacy, and adherence to medications in RA. METHODS: Data were from a longitudinal observational cohort of persons with RA. Subjects completed telephone interviews on self-reported adherence, self-efficacy, demographics, and the Beliefs about Medicines Questionnaire (BMQ), which assesses beliefs in necessity and beliefs about taking medication...
September 15, 2018: Journal of Rheumatology
Rudolf Puchner, Judith Sautner, Johann Gruber, Elia Bragagna, Andrea Trenkler, Gertraud Lang, Gabriele Eberl, Alois Alkin, Herwig Pieringer
OBJECTIVE: To evaluate the effect of rheumatoid arthritis (RA) on impairing women's sexuality regarding motivation, activity, and satisfaction, and to assess the correlation of disease-related physical impairment within sexual functioning. METHODS: An anonymous survey among women with RA and healthy controls (HC) using standardized questionnaires, predominantly the Changes in Sexual Functioning Questionnaire-short form (CSFQ-14). In addition, disease activity, depression, and disability were evaluated...
September 1, 2018: Journal of Rheumatology
April M Jorge, Na Lu, Sarah F Keller, Sharan K Rai, Yuqing Zhang, Hyon K Choi
OBJECTIVE: Systemic autoimmune rheumatic diseases (SARD) are associated with an increased risk of premature cardiovascular disease (CVD) and all-cause mortality. We examined the potential survival benefit of statin use among patients with SARD in a general population setting. METHODS: We conducted an incident user cohort study using a UK general population database. Our population included patients with a SARD as determined by Read code diagnoses of systemic lupus erythematosus, systemic sclerosis, Sjögren syndrome, dermatomyositis, polymyositis, mixed connective tissue disease, Behçet disease, or antineutrophil cytoplasmic antibodies-associated vasculitis between January 1, 2000, and December 31, 2014...
September 1, 2018: Journal of Rheumatology
Shivani Garg, Katina Tsagaris, Raluca Cozmuta, Aliza Lipson
OBJECTIVE: The risk of developing invasive pneumococcal infection is 13 times higher in patients with systemic lupus erythematosus (SLE) in comparison with the general population. The US Centers for Disease Control and Prevention anticipates a US$7.6 million medical cost reduction by providing pneumococcal vaccination. The objective of this study was to improve the rate of combination pneumococcal vaccination (pneumococcal polysaccharide vaccine 23 + pneumococcal conjugate vaccine 13) in patients with SLE in our adult academic rheumatology practice...
September 1, 2018: Journal of Rheumatology
Gurjit S Kaeley, Daryl K MacCarter, Aileen L Pangan, Xin Wang, Jasmina Kalabic, Veena K Ranganath
OBJECTIVE: Obese patients with rheumatoid arthritis (RA) report more joint swelling and tenderness and often have poorer responses to therapy than nonobese patients. The aim of this posthoc analysis of the MUSICA trial was to compare imaging and clinical disease activity measures in obese and nonobese patients with RA. METHODS: MUSICA evaluated methotrexate (MTX) 20 mg/week versus 7.5 mg/week in combination with adalimumab (ADA) in RA patients with an inadequate response to MTX...
September 1, 2018: Journal of Rheumatology
Stephanie O Keeling, Zainab Alabdurubalnabi, Antonio Avina-Zubieta, Susan Barr, Louise Bergeron, Sasha Bernatsky, Josiane Bourre-Tessier, Ann Clarke, Alexandra Baril-Dionne, Jan Dutz, Stephanie Ensworth, Aurore Fifi-Mah, Paul R Fortin, Dafna D Gladman, Derek Haaland, John G Hanly, Linda T Hiraki, Sara Hussein, Kimberly Legault, Deborah Levy, Lily Lim, Mark Matsos, Emily G McDonald, Jorge Medina-Rosas, Jordi Pardo Pardi, Christine Peschken, Christian Pineau, Janet Pope, Tamara Rader, Jen Reynolds, Earl Silverman, Konstantinos Tselios, Manon Suitner, Murray Urowitz, Zahi Touma, Evelyne Vinet, Nancy Santesso
OBJECTIVE: To develop recommendations for the assessment of people with systemic lupus erythematosus (SLE) in Canada. METHODS: Recommendations were developed using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach. The Canadian SLE Working Group (panel of Canadian rheumatologists and a patient representative from Canadian Arthritis Patient Alliance) was created. Questions for recommendation development were identified based on the results of a previous survey of SLE practice patterns of members of the Canadian Rheumatology Association...
September 1, 2018: Journal of Rheumatology
Hitomi Kobayashi, Yasuyuki Kobayashi, Isamu Yokoe, Noboru Kitamura, Atsuma Nishiwaki, Masami Takei, Jon T Giles
OBJECTIVE: Individuals with rheumatoid arthritis (RA) are at a heightened risk of sudden cardiac death, an outcome increased in those with prolongation of the corrected electrocardiographic QT interval (QTc). We compared QTc between patients with RA and demographically matched controls and studied the change in QTc after treatment with the interleukin 6 inhibitor tocilizumab (TCZ). METHODS: Standard 12-lead electrocardiograms were obtained and QTc was measured in patients with RA at baseline and after 24 weeks of TCZ treatment, then compared with non-RA controls who were frequency-matched on age and sex...
September 1, 2018: Journal of Rheumatology
Tone Wikene Nystad, Yngvil Solheim Husum, Ove Nord Furnes, Bjørg-Tilde Svanes Fevang
OBJECTIVE: To investigate the incidence of orthopedic procedures in patients with psoriatic arthritis (PsA), and how patient characteristics, time of diagnosis, and treatment affect the need for surgery. METHODS: We reviewed the medical history of 1432 patients with possible PsA at Haukeland University Hospital in Bergen, Norway. There were 590 patients (mean age 49 yrs, 52% women) who had sufficient journal information and a confirmed diagnosis of PsA, and who were included in the present study...
September 1, 2018: Journal of Rheumatology
Katie Bechman, Lieke Tweehuysen, Toby Garrood, David L Scott, Andrew P Cope, James B Galloway, Margaret H Y Ma
OBJECTIVE: To investigate predictors of flare in rheumatoid arthritis (RA) patients with low disease activity (LDA) and to evaluate the effect of flare on 12-month clinical outcomes. METHODS: Patients with RA who were taking disease-modifying antirheumatic drugs and had a stable 28-joint count Disease Activity Score (DAS28) < 3.2 were eligible for inclusion. At baseline and every 3 months, clinical (DAS28), functional [Health Assessment Questionnaire-Disability Index (HAQ-DI), EQ-5D, Functional Assessment of Chronic Illness Therapy Fatigue scale (FACIT-F), Medical Outcomes Study Short Form-36 (SF-36)], serum biomarkers [multibiomarker disease activity (MBDA) score, calprotectin, CXCL10], and imaging data were collected...
September 1, 2018: Journal of Rheumatology
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