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Journal of Rheumatology

Cosimo Bruni, Tanaka Ngcozana, Francesca Braschi, Tiziana Pucci, Guya Piemonte, Laura Benelli, Melissa Poli, Yossra A Suliman, Serena Guiducci, Silvia Bellando-Randone, Silvia Balduzzi, Jonathan Grotts, Christopher P Denton, Laura Rasero, CarloMaurizio Montecucco, Daniel E Furst, Marco Matucci-Cerinic
OBJECTIVE: To date, "healed/non-healed" and clinical judgment are the only available assessment tools for digital ulcers (DU) in patients with systemic sclerosis (SSc). The aim of our study is to examine a preliminary composite DU clinical assessment score (DUCAS) for SSc for face, content, and construct validity. METHODS: Patients with SSc presenting at least 1 finger DU were enrolled and assessed with the Health Assessment Questionnaire-Disability Index, Cochin scale, visual analog scale (VAS) for DU-related pain, patient global DU status, and global assessment as patient-reported outcomes (PRO), and physician VAS for DU status (phyGDU) as an SSc-DU expert physician/nurse measure...
November 15, 2018: Journal of Rheumatology
Bruce M Rothschild
Janus kinase (JAK) inhibitors are a relatively new addition to our tools for treatment of rheumatoid arthritis (RA)1 They are responsible for transduction of more than 38 cytokinases2 , with diffuse metabolic/immunologic implications.
November 15, 2018: Journal of Rheumatology
Karina Raimundo, Joshua J Solomon, Amy L Olson, Amanda M Kong, Ashley L Cole, Aryeh Fischer, Jeffrey J Swigris
OBJECTIVE: Interstitial lung disease (ILD) is commonly associated with rheumatoid arthritis (RA) and can have significant morbidity and mortality. The objective of this study was to calculate the prevalence, incidence, healthcare costs, and mortality of RA-related ILD (RA-ILD) in the United States. METHODS: This retrospective cohort analysis used the Truven Health MarketScan Commercial and Medicare Supplemental health insurance databases from 2003 to 2014 and the Social Security Administration death database...
November 15, 2018: Journal of Rheumatology
Jeffrey R Curtis, Fenglong Xie, Shuo Yang, Maria I Danila, Justin K Owensby, Lang Chen
OBJECTIVE: The clinical utility of the multibiomarker disease activity (MBDA) test for rheumatoid arthritis (RA) management in routine care in the United States has not been thoroughly studied. METHODS: Using 2011-2015 Medicare data, we linked each patient with RA to their MBDA test result. Initiation of a biologic or Janus kinase (JAK) inhibitor in the 6 months following MBDA testing was described. Multivariable adjustment evaluated the likelihood of adding or switching biologic/JAK inhibitor, controlling for potential confounders...
November 15, 2018: Journal of Rheumatology
Keisuke Maeshima, Koji Ishii, Hirotaka Shibata
Primary immunodeficiency diseases (PID) are a heterogeneous group of diseases with variable genetic etiologies. Although immunodeficiency is a hallmark of susceptibility to infection, autoimmunity is clearly a prevalent feature.
November 15, 2018: Journal of Rheumatology
Dan Østergaard Pradsgaard, Arne Hørlyck, Anne Helene Spannow, Carsten Heuck, Troels Herlin
OBJECTIVE: Joint space narrowing (JSN) is a measurable outcome of tissue degeneration in arthritis. JSN is usually assessed by conventional radiography. Ultrasonographic (US) measurement of joint cartilage thickness has been validated in healthy children, and US measurement of the distal femoral cartilage has been validated in a group of patients with juvenile idiopathic arthritis (JIA). Our aim was to compare the measures of cartilage thickness of the proximal cartilage site in the second metacarpophalangeal (MCP), second proximal interphalangeal (PIP), and knee joints as assessed by US to joint space width (JSW) as measured by computerized radiography in children with JIA...
November 15, 2018: Journal of Rheumatology
Zsuzsanna H McMahan, Tracy Frech, Veronica Berrocal, David Lim, Cosimo Bruni, Marco Matucci-Cerinic, Vanessa Smith, Karin Melsens, Susanna Proudman, Jinyu Zhang, Fabian Mendoza, Melanie Woods, Dinesh Khanna
OBJECTIVE: Validated gastrointestinal (GI) symptoms scales are used in clinical practice to assess patient-reported GI involvement. We sought to determine whether University of California, Los Angeles (UCLA) GI Tract Questionnaire (GIT) 2.0 Reflux scale, Patient-Reported Outcomes Measurement Information System (PROMIS) Reflux scale, and the Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD) are sensitive to identifying changes in GI symptoms following therapeutic intervention in participants with systemic sclerosis (SSc) and gastroesophageal reflux disease (GERD)...
November 15, 2018: Journal of Rheumatology
Amanda M Eudy, Gary McDaniel, William W Hurd, Megan E B Clowse
OBJECTIVE: We sought to identify causes for infertility in women with and without rheumatoid arthritis (RA). METHODS: Women with RA were matched to healthy controls. Differences in anti-Müllerian hormone (AMH) and anovulation were analyzed. RESULTS: Women with RA had lower AMH (β -1.05, 95% CI -2.09 to -0.005), but no difference was observed when AMH was log-transformed. No difference in anovulation was observed. Infertility prevalence was similar between groups, primarily attributable to polycystic ovary syndrome in healthy controls but largely unexplained in women with RA...
November 15, 2018: Journal of Rheumatology
Jung Sun Lee, Jebum Won, Oh Chan Kwon, Seung Soo Lee, Ji Seon Oh, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo, Seokchan Hong
OBJECTIVE: Febuxostat has superior renal safety to allopurinol, but data on its hepatic safety are limited. Thus we compared the hepatotoxicity of febuxostat and allopurinol, and the clinical factors associated with hepatotoxicity, in patients with gout and fatty liver disease (FLD). METHODS: We included gout patients treated with allopurinol or febuxostat who were diagnosed with fatty liver based on ultrasonography or computed tomography. Hepatotoxicity was defined as follows: (1) elevation of aspartate aminotransferase (AST)/alanine aminotransferase (ALT) at least 3× the upper limit of normal, when the baseline AST/ALT was normal; or (2) doubling of the baseline AST/ALT, when the baseline AST/ALT was elevated...
November 15, 2018: Journal of Rheumatology
Benjamin Rose-Davis, Janet Curran, Julia Wright, Tania Cellucci, Ciarån M Duffy, Lori B Tucker, Michelle Batthish, Adam M Huber, Bianca Lang, Deborah M Levy, Dax G Rumsey, Karen N Watanabe Duffy, Elizabeth Stringer
OBJECTIVE: To determine barriers and facilitators to the uptake of findings from the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh-Out) study into clinical care by pediatric rheumatologists (PR) and allied health professionals (AHP) caring for children with juvenile idiopathic arthritis (JIA) in Canada. METHODS: PR and AHP participated in this qualitative study through telephone interviews. Interview guides were developed using the Theoretical Domains Framework and focused on the use of information from the ReACCh-Out study in the practice of counseling patients and families...
November 15, 2018: Journal of Rheumatology
Marco Sebastiani, Konstantinos Triantafyllias, Andreina Manfredi, Miguel Angel González-Gay, Natalia Palmou-Fontana, Giulia Cassone, Ulrich Drott, Christiane Delbrück, Jorge Rojas-Serrano, Chiara Bertolazzi, Laura Nuño, Margherita Giannini, Florenzo Iannone, Esther F Vicente, Santos Castañeda, Albert Selva-O'Callaghan, Ernesto Trallero Araguas, Giacomo Emmi, Annamaria Iuliano, Jutta Bauhammer, Nikolaus Miehle, Simone Parisi, Lorenzo Cavagna, Veronica Codullo, Carlomaurizio Montecucco, Francisco Javier Lopez-Longo, Julia Martínez-Barrio, Juan Carlos Nieto-González, Silvia Vichi, Marco Confalonieri, Paola Tomietto, Raoul Bergner, Alberto Sulli, Francesco Bonella, Federica Furini, Carlo Alberto Scirè, Alessandra Bortoluzzi, Christof Specker, Simone Barsotti, Rossella Neri, Marta Mosca, Marzia Caproni, Julia Weinmann-Menke, Andreas Schwarting, Vanessa Smith, Maurizio Cutolo
OBJECTIVE: To describe nailfold videocapillaroscopy (NVC) features of patients with antisynthetase syndrome (AS) and to investigate possible correlations with clinical and serological features of the disease. METHODS: We retrospectively analyzed NVC images of 190 patients with AS [females/males 3.63, mean age 49.7 ± 12.8 yrs, median disease duration 53.7 mos (interquartile range 82), 133 anti-Jo1 and 57 non-anti-Jo1-positive patients]. For each patient, we examined number of capillaries, giant capillaries, microhemorrhages, avascular areas, ramified capillaries, and the presence of systemic sclerosis (SSc)-like pattern...
November 15, 2018: Journal of Rheumatology
Julianna Desmarais, Cong-Qiu Chu
OBJECTIVE: To evaluate the efficacy and safety of anakinra in inpatient management of acute gout and pseudogout. METHODS: Hospitalized patients with acute gout (n = 77) or pseudogout (n = 11) or both (n = 3) were analyzed for response to anakinra and adverse effects. RESULTS: Half of all patients had comorbidities limiting the treatment choice. Anakinra was well tolerated, and 92% of gout flares and 79% of pseudogout flares responded to treatment...
November 15, 2018: Journal of Rheumatology
Xiaodong Zhou, Hongye Li, Shicheng Guo, Jiucun Wang, Chunhua Shi, Maribel Espitia, Xinjian Guo, Qingwen Wang, Mengyuan Liu, Shervin Assassi, John D Reveille, Maureen D Mayes
OBJECTIVE: Findings from previous genome-wide association studies indicated an association of the NOTCH4 gene with systemic sclerosis (SSc). This is a followup study to fine-map exonic variants of NOTCH4 in SSc. METHODS: All exons of NOTCH4 were sequenced and analyzed in a total of 1006 patients with SSc and 1004 controls of US white ancestry with the Ion Torrent system. Identified SSc-associated variants were confirmed with Sanger sequencing, and then examined in a Chinese Han cohort consisting of 576 patients with SSc and 574 controls...
November 15, 2018: Journal of Rheumatology
Cristian Caimmi, Eugenia Bertoldo, Anna Venturini, Paola Caramaschi, Luca Frulloni, Rachele Ciccocioppo, Sabrina Brunelli, Luca Idolazzi, Davide Gatti, Maurizio Rossini, Ombretta Viapiana
OBJECTIVE: To evaluate the relationship between fecal calprotectin (FC) and interstitial lung disease (ILD) in systemic sclerosis (SSc). METHODS: The study enrolled 129 outpatients with SSc. Data about disease characteristics, in particular lung involvement, were collected and FC was measured. RESULTS: Patients with ILD (35, 27.1%) had higher values of FC (p < 0.001). In multivariate analysis, these variables were associated with increased risk of ILD: diffuse disease subset, higher modified Rodnan skin score, longer disease duration, higher severity scores, steroid treatment, and higher FC levels, while diverticulosis was protective...
November 15, 2018: Journal of Rheumatology
Nimmisha Govind, Richard J Reynolds, Bridget Hodkinson, Claudia Ickinger, Michele Ramsay, S Louis Bridges, Mohammed Tikly
OBJECTIVE: To investigate the association of specific amino acid positions, residues, and haplotypes of HLA-DRB1 in black South Africans with autoantibody-positive rheumatoid arthritis (RA). METHODS: High-resolution HLA-DRB1 genotyping was performed in 266 black South Africans with autoantibody-positive RA and 362 ethnically and geographically matched controls. The alleles were converted to specific amino acid residues at polymorphic sites for downstream analyses...
November 1, 2018: Journal of Rheumatology
Musaab Elmamoun, Ying Ying Leung, Denis O'Sullivan, Ingrid Steinkoenig, Vinod Chandran, Dafna D Gladman, Oliver M FitzGerald, Ana-Maria Orbai, Lihi Eder
OBJECTIVE: Systemic inflammation is assessed through measurement of acute-phase reactants such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). With few exceptions, most randomized controlled trials (RCT) have assessed acute-phase reactants (CRP and ESR) as part of the American College of Rheumatology (ACR) 20 response criteria. As part of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)-Outcome Measures in Rheumatology (OMERACT) working group, we performed a systematic review of the literature to assess the performance of inflammatory biomarkers in psoriatic arthritis (PsA)...
November 1, 2018: Journal of Rheumatology
George A W Bruyn, Heidi J Siddle, Petra Hanova, Félicie Costantino, Annamaria Iagnocco, Andrea Delle Sedie, Marwin Gutierrez, Hilde B Hammer, Elizabeth Jernberg, Damien Loeille, Mihaela C Micu, Ingrid Moller, Carlos Pineda, Bethan Richards, Maria S Stoenoiu, Takeshi Suzuki, Lene Terslev, Violeta Vlad, Robert Wonink, Maria-Antonietta d'Agostino, Richard J Wakefield
OBJECTIVE: To evaluate the intraobserver and interobserver reliability of the ultrasonographic (US) assessment of subtalar joint (STJ) synovitis in patients with rheumatoid arthritis (RA). METHODS: Following a Delphi process, 12 sonographers conducted an US reliability exercise on 10 RA patients with hindfoot pain. The anteromedial, posteromedial, and posterolateral STJ was assessed using B-mode and power Doppler (PD) techniques according to an agreed US protocol and using a 4-grade semiquantitative grading score for synovitis [synovial hypertrophy (SH) and signal] and a dichotomous score for the presence of joint effusion (JE)...
November 1, 2018: Journal of Rheumatology
Silvia Federici, Federica Vanoni, Eldad Ben-Chetrit, Luca Cantarini, Joost Frenkel, Raphaela Goldbach-Mansky, Ahmet Gul, Hal Hoffman, Isabelle Koné-Paut, Jasmin Kuemmerle-Deschner, Helen J Lachmann, Alberto Martini, Laura Obici, Seza Ozen, Anna Simon, Michael Hofer, Nicolino Ruperto, Marco Gattorno
OBJECTIVE: Provisional evidence-based classification criteria for hereditary periodic fever (HPF) have been recently developed. However, no consensus on how to combine clinical criteria, laboratory tests, and results of molecular analysis has been reached. The objective of this study is to understand which variables physicians consider important for the classification of patients with HPF. METHODS: Two Delphi surveys were sent to health professionals in the field of autoinflammation...
November 1, 2018: Journal of Rheumatology
Rianne E van Bentum, Sjoerd C Heslinga, Michael T Nurmohamed, Andreas H Gerards, Ed N Griep, Charlotte B J M Koehorst, Marc R Kok, Anna M Schilder, Marijn Verhoef, Irene E van der Horst-Bruinsma
OBJECTIVE: Acute anterior uveitis (AAU) is common in ankylosing spondylitis (AS). Golimumab (GOL), a tumor necrosis factor-α inhibitor (TNFi), has proven to be effective in the treatment of AS. To date, the effect of GOL on the incidence of AAU in AS is unknown. The objective was to study the AAU occurrence rate in patients with AS during GOL treatment and secondarily, the efficacy of GOL in daily clinical practice. METHODS: The study was a multicenter prospective study in a real-world setting in patients with AS who were treated with GOL for 12 months...
November 1, 2018: Journal of Rheumatology
Amy Kang, Marilina Antonelou, Nikki L Wong, Anisha Tanna, Nishkantha Arulkumaran, Frederick W K Tam, Charles D Pusey
OBJECTIVE: To determine the incidence of arterial thrombotic events (ATE) and venous thromboembolism (VTE) in antineutrophil cytoplasmic antibody-associated vasculitis (AAV). METHODS: This is a retrospective cohort study presenting the incidence of ATE (coronary events or ischemic stroke) and VTE [pulmonary embolism (PE) or deep venous thrombosis (DVT)] in patients diagnosed with AAV between 2005 and 2014. RESULTS: There were 204 patients with AAV who were identified...
November 1, 2018: Journal of Rheumatology
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