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Journal of Rheumatology

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https://www.readbyqxmd.com/read/29449506/whole-body-magnetic-resonance-imaging-in-axial-spondyloarthritis-reduction-of-sacroiliac-spinal-and-entheseal-inflammation-in-a-placebo-controlled-trial-of-adalimumab
#1
Simon Krabbe, Mikkel Østergaard, Iris Eshed, Inge J Sørensen, Bente Jensen, Jakob M Møller, Lone Balding, Ole R Madsen, Karsten Asmussen, Grith Eng, Niklas R Jørgensen, Susanne J Pedersen
OBJECTIVE: To investigate whether adalimumab (ADA) reduces whole-body (WB-) magnetic resonance imaging (MRI) indices for inflammation in the entheses, peripheral joints, sacroiliac joints, spine, and the entire body in patients with axial spondyloarthritis (axSpA). METHODS: An investigator-initiated, randomized, placebo-controlled, double-blinded 48-week followup trial included 49 patients with axSpA, who had Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) ≥ 4...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449505/detection-of-crohn-disease-in-patients-with-spondyloarthropathy-the-space-capsule-study
#2
Uri Kopylov, Michael Starr, Craig Watts, Serge Dionne, Marc Girardin, Ernest G Seidman
OBJECTIVE: Inflammatory bowel disease (IBD) is generally reported to be associated with spondylarthropathies (SpA) in 5%-15% of cases. Systematic colonoscopic assessment by protocol demonstrated mucosal inflammation characteristic of Crohn disease (CD) in up to one-third of patients with SpA. Video capsule endoscopy (CE) is a superior diagnostic tool to detect small bowel mucosal disease. Our study compared the accuracy of CE to standard colonoscopy for detection of inflammatory bowel lesions in patients with SpA, and to describe predictors of small bowel inflammation (SBI) in this cohort...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449504/response-to-tumor-necrosis-factor-inhibition-in-male-and-female-patients-with-ankylosing-spondylitis-data-from-a-swiss-cohort
#3
Monika Hebeisen, Regula Neuenschwander, Almut Scherer, Pascale Exer, Ulrich Weber, Giorgio Tamborrini, Raphael Micheroli, Lukas M Wildi, Pascal Zufferey, Michael J Nissen, Peter M Villiger, Jürg Bernhard, Axel Finckh, Irene E van der Horst-Bruinsma, Joachim Sieper, Robert Landewé, Désirée van der Heijde, Adrian Ciurea
OBJECTIVE: To investigate sex differences in connection with the effectiveness of tumor necrosis factor inhibitors (TNFi) in patients with ankylosing spondylitis (AS). METHODS: A total of 440 patients with AS (294 men; 146 women) initiating a first TNFi in the prospective Swiss Clinical Quality Management Cohort were included. We evaluated the proportion of patients achieving the 20% and 40% improvement in the Assessment of Spondyloarthritis international Society criteria (ASAS20 and ASAS40) as well as Ankylosing Spondylitis Disease Activity Score (ASDAS) improvement and status scores at 1 year...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449503/early-renin-angiotensin-system-blockade-improved-short-term-and-longterm-renal-outcomes-in-systemic-lupus-erythematosus-patients-with-antiphospholipid-associated-nephropathy
#4
Cai Yue, Guanhong Li, Yubing Wen, Xuemei Li, Ruitong Gao
OBJECTIVE: To investigate the renal protective effects of early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN). METHODS: Medical data of 57 SLE patients with biopsy-proven aPLN were analyzed. Early RAAS blockade was defined as administration of RASI within 3 months after kidney biopsy and continued for ≥ 12 months...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449502/the-crescentic-implication-of-renal-outcomes-in-proliferative-lupus-nephritis
#5
Fanghao Cai, Fei Han, Hongya Wang, Haidongqin Han, Jingyun Le, Lan Lan, Ying Xu, Jianghua Chen
OBJECTIVE: To determine the association between crescents and renal outcomes, and the implications on therapeutic choices. METHODS: There were 231 patients with biopsy-proven proliferative lupus nephritis (PLN) who were divided into 4 groups: 59 patients were in the noncrescent group (NC); 59 patients exclusively with segmental crescents were in the segmental crescent group (SC); patients with circumferential crescents were categorized into 2 groups according to the crescentic ratio (C1 had 64 patients with ≤ 25%, and C2 had 49 patients with > 25%)...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449501/diffusion-weighted-imaging-is-a-sensitive-and-specific-magnetic-resonance-sequence-in-the-diagnosis-of-ankylosing-spondylitis
#6
Linda A Bradbury, Kelly A Hollis, Benoît Gautier, Sateesh Shankaranarayana, Philip C Robinson, Nivene Saad, Kim-Anh Lê Cao, Matthew A Brown
OBJECTIVE: We tested the discriminatory capacity of diffusion-weighted magnetic resonance imaging (DWI) and its potential as an objective measure of treatment response to tumor necrosis factor inhibition in ankylosing spondylitis (AS). METHODS: Three cohorts were studied prospectively: (1) 18 AS patients with Bath Ankylosing Spondylitis Disease Activity Index > 4, and erythrocyte sedimentation rate > 25 and/or C-reactive protein > 10 meeting the modified New York criteria for AS; (2) 20 cases of nonradiographic axial spondyloarthritis (nr-axSpA) as defined by the Assessment of Spondyloarthritis international Society (ASAS) criteria; and (3) 20 non-AS patients with chronic low back pain, aged between 18 and 45 years, who did not meet the imaging arm of the ASAS criteria for axSpA...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449500/the-cost-effectiveness-of-biannual-serum-urate-su-monitoring-after-reaching-target-in-gout-a-health-economic-analysis-comparing-su-monitoring
#7
Philip C Robinson, Nicola Dalbeth, Peter Donovan
OBJECTIVE: The 2012 American College of Rheumatology gout management guidelines recommend monitoring serum urate (SU) every 6 months after target SU has been achieved. Our objective was to determine through modeling whether this testing would be cost-effective, considering financial cost, quality of life, and estimated change in adherence. METHODS: A cost-utility analysis was completed with a 3-arm model: (1) no regular urate monitoring; (2) annual urate monitoring; and (3) biannual urate monitoring...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449499/clinical-correlates-outcomes-and-predictors-of-inflammatory-ocular-disease-associated-with-rheumatoid-arthritis-in-the-biologic-era
#8
Cristian Caimmi, Cynthia S Crowson, Wendy M Smith, Eric L Matteson, Ashima Makol
OBJECTIVE: Inflammatory ocular disease (IOD) is a rare but severe extraarticular manifestation of rheumatoid arthritis (ExRA) with high mortality. The aim of our study was to examine clinical characteristics of IOD in rheumatoid arthritis (RA) and their effect on disease severity and outcomes in recent years. METHODS: A retrospective cohort of RA patients with IOD evaluated between 1996 and 2013 was assembled and compared to RA comparators without IOD and matched for age, sex, and disease duration...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449498/early-psoriatic-arthritis-versus-early-seronegative-rheumatoid-arthritis-role-of-dermoscopy-combined-with-ultrasonography-for-differential-diagnosis
#9
Alen Zabotti, Enzo Errichetti, Francesca Zuliani, Luca Quartuccio, Stefania Sacco, Giuseppe Stinco, Salvatore De Vita
OBJECTIVE: Exclusion of psoriatic skin/nail lesions is important in differentiating early seronegative rheumatoid arthritis (ERA) from early polyarticular psoriatic arthritis (EPsA) and such manifestations may go unnoticed in atypical or minimally expressed cases. The aim of this study is to assess the usefulness of integrated rheumatological-dermatological evaluation in highlighting dermatological lesions missed on rheumatological examination and to investigate the role of ultrasonography (US) and dermoscopy in improving the recognition of subclinical psoriatic findings...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449497/rheumatologists-views-and-experiences-in-managing-rheumatoid-arthritis-in-elderly-patients-a-qualitative-study
#10
Jill Nawrot, Annelies Boonen, Ralph Peeters, Mirian Starmans, Marloes van Onna
OBJECTIVE: In this qualitative study we analyzed the (1) influence of age, comorbidity, and frailty on management goals in elderly patients with RA; (2) experiences of rheumatologists regarding the use of the Disease Activity Score at 28 joints (DAS28) to monitor disease activity; and (3) differences in management strategies in elderly patients with RA compared to their younger counterparts. METHODS: Rheumatologists were purposively sampled for a semistructured interview...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449496/patient-reported-outcomes-resource-use-and-social-participation-of-patients-with-rheumatoid-arthritis-treated-with-biologics-in-alberta-experience-of-indigenous-and-non-indigenous-patients
#11
Cheryl Barnabe, Louise Crane, Tyler White, Brenda Hemmelgarn, Gilaad G Kaplan, Liam Martin, Walter P Maksymowych
OBJECTIVE: To characterize patient-reported outcomes, resource use, and social participation during the course of biologic therapy for indigenous and non-indigenous patients with rheumatoid arthritis (RA). METHODS: Patients initiating biologic therapy (2004 to 2012) were characterized longitudinally for patient-reported outcomes including physical function measured by the Health Assessment Questionnaire, EQ-5D, well-being [Medical Outcomes Study Short Form-36 (SF-36)], and visual analog scales for pain, fatigue, sleep, stiffness, and patient's global assessment...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449495/evaluation-of-self-reported-patient-experiences-insights-from-digital-patient-communities-in-psoriatic-arthritis
#12
Prashanth Sunkureddi, Stephen Doogan, John Heid, Samir Benosman, Alexis Ogdie, Layne Martin, Jacqueline B Palmer
OBJECTIVE: To evaluate the types of experiences and treatment access challenges of patients with psoriatic arthritis (PsA) using self-reported online narratives. METHODS: English-language patient narratives reported between January 2010 and May 2016 were collected from 31 online sources (general health social networking sites, disease-focused patient forums, treatment reviews, general health forums, mainstream social media sites) for analysis of functional impairment and 40 online sources for assessment of barriers to treatment...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29419474/frequency-diagnosis-treatment-and-outcome-of-gastrointestinal-disease-in-granulomatosis-with-polyangiitis-and-microscopic-polyangiitis
#13
Per Eriksson, Mårten Segelmark, Olof Hallböök
OBJECTIVE: Involvement of the gastrointestinal (GI) tract is a rare complication of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). The aim was to describe frequency, diagnosis, treatment, and outcome of GI disease in a large series of patients in a single center. METHODS: A database that includes all patients with GPA and MPA diagnosed since 1997 in a defined area of southeastern Sweden as well as prevalent older cases and tertiary referral patients was screened for patients with GI disease...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29419473/feasibility-validity-and-reliability-of-the-10-item-patient-reported-outcomes-measurement-information-system-global-health-short-form-in-outpatients-with-systemic-lupus-erythematosus
#14
Shanthini Kasturi, Jackie Szymonifka, Jayme C Burket, Jessica R Berman, Kyriakos A Kirou, Alana B Levine, Lisa R Sammaritano, Lisa A Mandl
OBJECTIVE: To assess the feasibility, validity, and reliability of the Patient Reported Outcomes Measurement Information System Global Health Short Form (PROMIS10) in outpatients with systemic lupus erythematosus (SLE). METHODS: SLE outpatients completed PROMIS10, Medical Outcomes Study Short Form-36 (SF-36), LupusQoL-US, and selected PROMIS computerized adaptive tests (CAT) at routine visits at an SLE Center of Excellence. Construct validity was evaluated by correlating PROMIS10 physical and mental health scores with PROMIS CAT, legacy instruments, and physician-derived measures of disease activity and damage...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29419472/application-of-recommendations-regarding-the-use-of-subcutaneous-tumor-necrosis-factor-inhibitors-in-spondyloarthritis-by-rheumatologists-in-daily-practice
#15
Céline Pereira-Gillion, Mathilde Marot, Isabelle Griffoul-Espitalier, Lucia Andras, Philippe Goupille, Carine Salliot
OBJECTIVE: To assess the implementation of European recommendations for use of TNF inhibitors for spondyloarthritis (SpA), rheumatologists' level of knowledge of and adherence to the recommendations, and potential barriers to the application of recommendations. METHODS: We conducted a retrospective study among 42 rheumatologists who initiated a first subcutaneous TNF inhibitor for SpA in 2013 or 2014. Thirty items from national and international recommendations were separated into 3 domains: indication, pretherapeutic monitoring, and management under TNF inhibitors...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29419471/increased-levels-of-soluble-programmed-death-ligand-1-associate-with-malignancy-in-patients-with-dermatomyositis
#16
He Chen, Qinglin Peng, Hanbo Yang, Liguo Yin, Jingli Shi, Yamei Zhang, Guochun Wang
OBJECTIVE: To investigate the levels of soluble programmed death ligand 1 (sPD-L1) and evaluate its association with malignancy in patients with dermatomyositis (DM). METHODS: Levels of sPD-L1 were measured in serum from 88 DM patients without malignancies (sDM), 40 with cancer-related DM (CRDM), and 30 healthy controls (HC) using ELISA. The CRDM subjects were divided into new-onset cancers (nCRDM) and stable cancers (sCRDM). Receiver-operating characteristic (ROC) curve analysis was performed to determine the cutoff sPD-L1 value that distinguished patients with nCRDM from those who were sDM...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29419470/occupation-physical-workload-factors-and-disability-retirement-as-a-result-of-hip-osteoarthritis-in-finland-2005-2013
#17
Svetlana Solovieva, Tea Kontio, Eira Viikari-Juntura
OBJECTIVE: To identify occupations with a high risk of disability retirement as a result of hip osteoarthritis (OA), and to examine the effect of physical workload factors on the occupational differences in disability retirement. METHODS: A total of 1,135,654 (49.4% women) Finns aged 30-60 years in gainful employment were followed from 2005 to 2013 for full disability retirement as a result of hip OA. Information on pensions, occupation, and education were obtained from national registers...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29419469/risk-factors-for-relapse-of-antineutrophil-cytoplasmic-antibody-associated-vasculitis-in-japan-a-nationwide-prospective-cohort-study
#18
Akinori Hara, Takashi Wada, Ken-Ei Sada, Koichi Amano, Hiroaki Dobashi, Masayoshi Harigai, Yoshinari Takasaki, Hidehiro Yamada, Hitoshi Hasegawa, Taichi Hayashi, Shouichi Fujimoto, Eri Muso, Tamihiro Kawakami, Sakae Homma, Masaharu Yoshida, Junichi Hirahashi, Noriyoshi Ogawa, Satoshi Ito, Hirofumi Makino, Yoshihiro Arimura
OBJECTIVE: The aim was to elucidate the prognosis and risk factors associated with relapse during longterm remission maintenance therapy for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). METHODS: Patients with newly diagnosed AAV (n = 156) were registered in the Remission Induction Therapy in Japanese patients with ANCA-associated Vasculitides (RemIT-JAV) study, and among them, 83 patients who achieved remission were enrolled and followed up for 24 additional months in our nationwide, prospective cohort study (Co-RemIT-JAV; registration number UMIN 000006373)...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29419468/disparities-in-outcomes-for-blacks-versus-whites-undergoing-total-hip-arthroplasty-a-systematic-literature-review
#19
Bella Y Mehta, Anne R Bass, Rie Goto, Linda A Russell, Michael L Parks, Mark P Figgie, Susan M Goodman
OBJECTIVE: Total hip replacement (THA) surgery is a successful procedure, yet blacks in the United States undergo THA less often and reflect poorer outcomes than whites. The purpose of this study is to systematically review the literature on health-related quality of life after THA, comparing blacks and whites. METHODS: A librarian-assisted search was performed in Medline through PubMed, Embase, and Cochrane Library on February 27, 2017. Original cohort studies examining pain, function, and satisfaction in blacks and whites 1 year after elective THA were included...
February 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29419467/barriers-to-adherence-in-juvenile-idiopathic-arthritis-a-multicenter-collaborative-experience-and-preliminary-results
#20
Leslie A Favier, Janalee Taylor, Kristin Loiselle Rich, Karla B Jones, Sheetal S Vora, Julia G Harris, Beth S Gottlieb, Lisa Robbins, Jamie T Lai, Tzielan Lee, Melanie Kohlheim, Jennifer Gill, Laura Bouslaugh, Angela Young, Nancy Griffin, Esi M Morgan, Avani C Modi
OBJECTIVE: Nonadherence is currently an underrecognized and potentially modifiable obstacle to care in juvenile idiopathic arthritis (JIA). The purpose of our study was to design and implement a standardized approach to identifying adherence barriers for youth with JIA across 7 pediatric rheumatology clinics through the Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) and to assess the frequency of adherence barriers in patients and their caregivers across treatment modalities...
February 1, 2018: Journal of Rheumatology
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