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Journal of Rheumatology

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https://www.readbyqxmd.com/read/29961696/do-poor-prognostic-factors-in-rheumatoid-arthritis-affect-treatment-choices-and-outcomes-analysis-of-a-us-rheumatoid-arthritis-registry
#1
Evo Alemao, Heather J Litman, Sean E Connolly, Sheila Kelly, Winnie Hua, Lisa Rosenblatt, Sabrina Rebello, Joel M Kremer, Leslie R Harrold
OBJECTIVE: To characterize patients with rheumatoid arthritis (RA) by number of poor prognostic factors (PPF: functional limitation, extraarticular disease, seropositivity, erosions) and evaluate treatment acceleration, clinical outcomes, and work status over 12 months by number of PPF. METHODS: Using the Corrona RA registry (January 2005-December 2015), biologic-naive patients with diagnosed RA having 12-month (± 3 mos) followup were identified and categorized by PPF (0-1, 2, ≥ 3)...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961695/reproducibility-and-utility-of-the-6-minute-walk-test-in-systemic-sclerosis
#2
Grégory Pugnet, Zora Marjanovic, Christophe Deligny, Karine Boussardon, Ilham Benzidia, Mathieu Puyade, Pauline Lansiaux, Els Vandecasteele, Vanessa Smith, Dominique Farge
OBJECTIVE: To assess the reproducibility and the utility of the 6-minute walk test (6MWT) in systemic sclerosis (SSc). METHODS: All patients with SSc who underwent at least two 6MWT within a minimum 3-month interval plus simultaneous routine clinical, biological, and functional evaluations were consecutively enrolled in this observational study over 6 years. Following American Thoracic Society guidelines, each 6MWT was repeated twice to assess the 6-minute walk distance (6MWD) reproducibility, with the highest value being reported for subsequent analysis...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961694/sarcoidosis-in-patients-with-antisynthetase-syndrome-presentation-and-outcome
#3
Priscille Couture, Pierre-Yves Brillet, Stéphane Varin, Benoît Le Goff, Alain Meyer, Jean Sibilia, Stéphane Jouneau, Dominique Valeyre, Baptiste Hervier, Yurdagül Uzunhan
OBJECTIVE: To investigate the uncommon co-occurrence of antisynthetase syndrome (AS) and sarcoidosis. METHODS: From 2000 to 2015, patients with sarcoidosis were extracted from a retrospective multicentric cohort of 352 patients with AS. RESULTS: Ten patients (2.8%; 6 men, 8 whites, 5 smokers, median age 50 yrs) had both AS and sarcoidosis. Most of the time, sarcoidosis and AS occurred simultaneously (n = 7). Antibody testing revealed anti-Jo1 (n = 5), anti-PL12 (n = 4), or anti-PL7 (n = 1)...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961693/increased-rates-of-both-knee-and-hip-arthroplasties-in-older-patients-with-ankylosing-spondylitis
#4
Michael M Ward
OBJECTIVE: To determine the risks of primary total hip arthroplasty (THA) and total knee arthroplasty (TKA) in older patients with ankylosing spondylitis (AS). METHODS: We used administrative data from 1999 to 2013 on US Medicare beneficiaries to identify patients (< 75 yrs old) with AS and a comparison group without AS. Rates of primary THA and primary TKA were computed for each group, and standardized for age, sex, and race. We also examined risks of primary TKA among patients with AS by their THA status...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961692/maternal-and-fetal-outcomes-in-a-cohort-of-patients-exposed-to-tumor-necrosis-factor-inhibitors-throughout-pregnancy
#5
Geneviève Genest, Karen A Spitzer, Carl A Laskin
OBJECTIVE: Tumor necrosis factor inhibitors (TNFi) are increasingly used in pregnancy but are frequently withheld in the second or third trimesters. We evaluated the maternal and fetal outcomes of women who continued their TNFi throughout pregnancy compared to women who interrupted TNFi during pregnancy. METHODS: We retrospectively analyzed the outcomes of women seen in clinic with rheumatoid arthritis (RA), psoriatic arthritis, juvenile idiopathic arthritis (JIA), or ankylosing spondylitis, who were exposed to TNFi during pregnancy...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961691/influence-of-axial-involvement-on-clinical-characteristics-of-psoriatic-arthritis-analysis-from-the-corrona-psoriatic-arthritis-spondyloarthritis-registry
#6
Philip J Mease, Jacqueline B Palmer, Mei Liu, Arthur Kavanaugh, Renganayaki Pandurengan, Christopher T Ritchlin, Chitra Karki, Jeffrey D Greenberg
OBJECTIVE: We analyzed the characteristics of patients with psoriatic arthritis (PsA) with and without axial involvement in the US-based Corrona Psoriatic Arthritis/Spondyloarthritis Registry. METHODS: All patients were included who had PsA and data on axial involvement, defined as physician-reported presence of spinal involvement at enrollment, and/or radiograph or magnetic resonance imaging showing sacroiliitis. Demographics, clinical measures, patient-reported outcomes, and treatment characteristics were assessed at enrollment...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961690/kl-6-but-not-ccl-18-is-a-predictor-of-early-progression-in-systemic-sclerosis-related-interstitial-lung-disease
#7
Gloria A Salazar, Masataka Kuwana, Minghua Wu, Rosa M Estrada-Y-Martin, Jun Ying, Julio Charles, Maureen D Mayes, Shervin Assassi
OBJECTIVE: The 2 pneumoproteins, KL-6 and CCL-18, are promising biomarkers in systemic sclerosis (SSc)-related interstitial lung disease (ILD). Our goal was to determine their predictive significance for forced vital capacity % (FVC%) decline within the first year of followup in patients with early SSc-ILD. METHODS: Early SSc patients with imaging-verified ILD enrolled in the Genetics versus Environment in Scleroderma Outcome Study (GENISOS) cohort were included...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961689/frequency-of-impaired-spinal-mobility-in-patients-with-chronic-back-pain-compared-to-patients-with-early-axial-spondyloarthritis
#8
Camilla Fongen, Hanne Dagfinrud, Inger Jorid Berg, Sofia Ramiro, Floris van Gaalen, Robert Landewé, Roberta Ramonda, Désirée van der Heijde, Karen Minde Fagerli
OBJECTIVE: To examine the frequency of impaired spinal mobility in patients with chronic back pain of short duration and to compare it with the frequency of impaired spinal mobility in patients with axial spondyloarthritis (axSpA), possible SpA, and no SpA. METHODS: The SpondyloArthritis Caught Early (SPACE) cohort includes patients with chronic back pain (≥ 3 mos, ≤ 2 yrs, onset < 45 yrs). Spinal mobility was assessed with lateral spinal flexion, chest expansion, cervical rotation, occiput-to-wall distance, and lumbar flexion...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961688/monitoring-of-osteonecrosis-in-systemic-lupus-erythematosus-patients-a-systematic-review-and-metaanalysis
#9
Sara Hussein, Manon Suitner, Sarah Béland-Bonenfant, Alexandra Baril-Dionne, Ben Vandermeer, Nancy Santesso, Stephanie Keeling, Janet E Pope, Aurore Fifi-Mah, Josiane Bourré-Tessier
OBJECTIVE: Nontraumatic osteonecrosis (ON) is a well-recognized complication causing disability and affecting quality of life in patients with systemic lupus erythematosus (SLE). The aim of this study was to identify the risk factors for ON, and to identify the minimal investigation(s) needed to optimally monitor the risk of ON in patients with SLE. METHODS: A systematic review was conducted using MEDLINE and EMBASE. These databases were searched up to January 2016 using the Medical Subject Heading (MeSH) terms "Osteonecrosis," "Systemic lupus erythematosus," and synonymous text words...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961687/assessing-vasculitis-in-giant-cell-arteritis-by-ultrasound-results-of-omeract-patient-based-reliability-exercises
#10
Valentin S Schäfer, Stavros Chrysidis, Christian Dejaco, Christina Duftner, Annamaria Iagnocco, George A Bruyn, Greta Carrara, Maria Antonietta D'Agostino, Eugenio De Miguel, Andreas P Diamantopoulos, Ulrich Fredberg, Wolfgang Hartung, Alojzija Hocevar, Aaron Juche, Tanaz A Kermani, Matthew J Koster, Tove Lorenzen, Pierluigi Macchioni, Marcin Milchert, Uffe Møller Døhn, Chetan Mukhtyar, Cristina Ponte, Sofia Ramiro, Carlo A Scirè, Lene Terslev, Kenneth J Warrington, Bhaskar Dasgupta, Wolfgang A Schmidt
OBJECTIVE: To test the reliability of Outcome Measures in Rheumatology Clinical Trials (OMERACT) consensus-based ultrasound definitions for normal and vasculitic temporal and axillary arteries in patients with giant cell arteritis (GCA) and in controls. METHODS: A preliminary 1-day meeting and a full 3-day meeting fulfilling OMERACT Ultrasound Group guidelines were held. Temporal and axillary arteries were examined at 2 timepoints by 12 sonographers on 4 patients with GCA and 2 controls...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961686/growth-during-tocilizumab-therapy-for-polyarticular-course-juvenile-idiopathic-arthritis-2-year-data-from-a-phase-iii-clinical-trial
#11
Kamal N Bharucha, Hermine I Brunner, Inmaculada Calvo Penadés, Irina Nikishina, Nadina Rubio-Pérez, Sheila Oliveira, Katarzyna Kobusinska, Heinrike Schmeling, Flavio Sztajnbok, Frank Weller-Heinemann, Elena Zholobova, Francesco Zulian, Roger Allen, Jeffrey Chaitow, James Frane, Chris Wells, Nicolino Ruperto, Fabrizio De Benedetti
OBJECTIVE: Evaluate growth in patients with polyarticular-course juvenile idiopathic arthritis (pcJIA) treated with tocilizumab (TCZ) for up to 2 years in a phase III trial. METHODS: Patients with pcJIA lasting at least 6 months and inadequate response to methotrexate received open-label TCZ intravenously every 4 weeks (randomly assigned to 8 or 10 mg/kg if they weighed < 30 kg; received 8 mg/kg if they weighed ≥ 30 kg) for 16 weeks. Patients with JIA American College of Rheumatology 30 response at Week 16 were randomly assigned to TCZ or placebo for 24 weeks, with an open-label extension through Week 104...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961685/influence-of-disease-manifestations-on-health-related-quality-of-life-in-early-psoriatic-arthritis
#12
Kim Wervers, Jolanda J Luime, Ilja Tchetverikov, Andreas H Gerards, Marc R Kok, Cathelijne W Y Appels, Wiebo L van der Graaff, Johannes H L M van Groenendael, Lindy-Anne Korswagen, Josien J Veris-van Dieren, Johanna M W Hazes, Marijn Vis
OBJECTIVE: Psoriatic arthritis (PsA) is a multifaceted disease. Affecting joints, skin, entheses, and dactylitis, its effect on health-related quality of life (HRQOL) could be substantial. We aim to assess HRQOL in patients newly diagnosed with PsA and analyze its associations with disease manifestations. METHODS: Data collected at time of diagnosis from patients with PsA included in the Dutch southwest Early Psoriatic Arthritis cohort (DEPAR) study were used. HRQOL was assessed using 8 domains of the Medical Outcomes Study Short Form-36 (SF-36) questionnaire...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961684/associations-between-cardiorespiratory-fitness-and-arterial-stiffness-in-ankylosing-spondylitis-a-cross-sectional-study
#13
Inger Jorid Berg, Anne Grete Semb, Silje H Sveaas, Camilla Fongen, Désirée van der Heijde, Tore K Kvien, Hanne Dagfinrud, Sella A Provan
OBJECTIVE: To assess associations between cardiorespiratory fitness (CRF), measured as peak oxygen uptake (VO2 peak), and cardiovascular disease (CVD) risk, measured by arterial stiffness, in patients with ankylosing spondylitis (AS). METHODS: VO2 peak was assessed by a maximal walking test on a treadmill. Arterial stiffness was measured noninvasively (Sphygmocor apparatus). Cross-sectional associations between VO2 peak and arterial stiffness were analyzed using backward multivariable linear regression...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29961683/hospitalization-increases-the-risk-of-acute-arthritic-flares-in-gout-a-population-based-study-over-2-decades
#14
Nour Zleik, Mohanad M Elfishawi, Zoran Kvrgic, Clement J Michet, Cynthia S Crowson, Eric L Matteson, Tim Bongartz
OBJECTIVE: To assess in-hospital gout flares in patients with gout. METHODS: Hospitalizations were evaluated for gout flares in a cohort of Olmsted County, Minnesota, residents with incident gout in 1989-1992 or 2009-2010. RESULTS: There were 429 patients followed up to 5 years. Of these, 169 patients experienced 454 hospitalizations. Hospitalization rates increased without reaching statistical significance from 1989-1992 to 2009-2010 [rate ratio (RR) 1...
July 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29907675/high-reproducibility-of-an-automated-measurement-of-mobility-for-patients-with-axial-spondyloarthritis
#15
Juan L Garrido-Castro, Rafael Curbelo, Ramón Mazzucchelli, María E Domínguez-González, Cristina Gonzalez-Navas, Bryan J Flores Robles, Pedro Zarco, Juan Mulero, Luis Cea-Calvo, María J Arteaga, Pilar Font-Ugalde, Loreto Carmona, Eduardo Collantes-Estevez
OBJECTIVE: Conventional measures of spinal mobility used in the assessment of patients with axial spondyloarthritis (axSpA), such as the Bath Ankylosing Spondylitis Metrology Index and its components, are subject to interobserver variability. The University of Córdoba Ankylosing Spondylitis Metrology Index (UCOASMI) is a validated composite index based on a motion video-capture system, UCOTrack. Our objective was to assess its reproducibility in clinical practice settings. METHODS: We carried out an observational study of repeated measures in 3 centers...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29907674/feasibility-of-measurement-and-adherence-to-system-performance-measures-for-rheumatoid-arthritis-in-5-models-of-care
#16
Claire E H Barber, J Carter Thorne, Vandana Ahluwalia, Jennifer Burt, Diane Lacaille, Deborah A Marshall, Glen S Hazlewood, Dianne Mosher, Lisa Denning, Ildiko Szamjo, Ricky Chin, Sean Hamilton, Susanne Benseler, Marinka Twilt, Natalie J Shiff, Vivian Bykerk, Joanne Homik, Cheryl Barnabe
OBJECTIVE: To test the feasibility of reporting on 4 national performance measures for patients with rheumatoid arthritis (RA) in 5 different models of care. METHODS: The following performance measures were evaluated in 5 models of care: waiting time (WT) to rheumatologist consultation, percentage of patients seen in yearly followup (FU), percentage taking disease-modifying antirheumatic drugs (DMARD), and time to starting DMARD. All models aimed to improve early access and care for patients with RA...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29907673/role-of-mir-98-and-its-underlying-mechanisms-in-systemic-lupus-erythematosus
#17
Lin Xie, Jinhua Xu
OBJECTIVE: T-lymphocyte apoptosis plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE). However, the underlying regulatory mechanisms of apoptosis in SLE remain unclear. The aim of this study was to explore the role of miR-98 in SLE and its underlying mechanisms. METHODS: Western blotting and quantitative reverse transcription PCR (qRT-PCR) were used to analyze miR-98 and Fas expression. Luciferase reporter assays were performed to identify miR-98 targets...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29907672/sex-associated-treatment-differences-and-their-outcomes-in-rheumatoid-arthritis-results-from-the-meteor-register
#18
Sytske Anne Bergstra, Cornelia F Allaart, Sofia Ramiro, Arvind Chopra, Nimmisha Govind, Cândida Silva, Elizabeth A Murphy, Robert B M Landewé
OBJECTIVE: To assess differences in initial treatment and treatment response in male and female patients with rheumatoid arthritis (RA) in daily clinical practice. METHODS: The proportion of patients with RA starting different antirheumatic treatments (disease-modifying antirheumatic drugs; DMARD) and the response to treatment were compared in the international, observational METEOR register. All visits from start of the first DMARD until the first DMARD switch or the end of followup were selected...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29907671/fecal-calprotectin-to-detect-inflammatory-bowel-disease-in-juvenile-idiopathic-arthritis
#19
Giovanna Ferrara, Serena Pastore, Lara Sancin, Lucio Torelli, Oriano Radillo, Matteo Bramuzzo, Chiara Bibalo, Alberto Tommasini, Alessandro Ventura, Andrea Taddio
OBJECTIVE: This study aimed to test fecal calprotectin (FC) as a screening tool to identify inflammatory bowel disease (IBD) among patients with juvenile idiopathic arthritis (JIA). METHODS: FC level < 100 g/kg was considered normal. Patients with 2 consecutive FC dosage ≥ 100 g/kg underwent endoscopic evaluation. RESULTS: There were 113 patients with JIA enrolled. FC was raised in 7 patients out of 113. All patients had IBD. In 3/7 patients, high FC levels were the only sign consistent with IBD...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29907670/the-lectin-pathway-of-complement-activation-in-patients-with-systemic-lupus-erythematosus
#20
Anne Troldborg, Steffen Thiel, Marten Trendelenburg, Justa Friebus-Kardash, Josephine Nehring, Rudi Steffensen, Søren Werner Karlskov Hansen, Magdalena Janina Laska, Bent Deleuran, Jens Christian Jensenius, Anne Voss, Kristian Stengaard-Pedersen
OBJECTIVE: The pathogenesis of systemic lupus erythematosus (SLE) involves complement activation. Activation of complement through the classical pathway (CP) is well established. However, complement activation through pattern recognition not only happens through the CP, but also through the lectin pathway (LP). We investigated the hypothesis that the LP is activated in SLE and involved in the pathogenesis of the disease. METHODS: Using immunoassays developed in-house, we measured concentrations of LP proteins in a cohort of 372 patients with SLE and 170 controls...
June 15, 2018: Journal of Rheumatology
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