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Hyparillums A and B: polycyclic polyprenylated acylphloroglucinols from Hypericum patulum.
Chinese Journal of Natural Medicines 2024 March
Hyparillums A (1) and B (2), two previously unidentified polycyclic polyprenylated acylphloroglucinols (PPAPs) with intricate architectures, were isolated from Hypericum patulum Thunb. Hyparillum A was the first PPAP with eight-carbon rings based on an unprecedented 6/6/5/6/6/5/6/4 octocyclic system featuring a rare heptacyclo[10.8.1.11,10 .03,8 .08,21 .012,19 .014,17 ]docosane core. In contrast, hyparillum B featured a novel heptacyclic architecture (6/6/5/6/6/5/5) based on a hexacyclo[9.6.1.11,9 .03,7 .07,18 .011,16 ]nonadecane motif. Furthermore, hyparillums A and B demonstrated promising inhibitory effects on the proliferation of murine splenocytes stimulated by anti-CD3/anti-CD28 monoclonal antibodies and lipopolysaccharide, exhibiting half-maximal inhibitory concentration (IC50 ) values ranging from 6.13 ± 0.86 to 12.69 ± 1.31 μmol·L-1 .
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