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Chinese Journal of Natural Medicines

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https://www.readbyqxmd.com/read/29329654/uhplc-ltq-orbitrap-based-metabolomics-coupled-with-metabolomics-pathway-analysis-method-for-exploring-the-protection-mechanism-of-kudiezi-injection-in-a-rat-anti-ischemic-cerebral-reperfusion-damage-model
#1
Si-Yi Liu, Wei Cai, Fei Wang, Ying Liu, Zhan-Peng Shang, Xiu-Ping Zhang, Zi-Jian Wang, Jian-Qiu Lu, Jia-Yu Zhang
Kudiezi injection has been used extensively in the treatment of cerebrovascular and cardiovascular diseases. However, its therapeutic effects and underlying mechanism of action are not fully understood. The aim of the present study was to clarify the protective mechanisms of Kudiezi injection on cerebral ischemic injury, using metabolomics methods. Middle cerebral artery occlusion (MCAO) was introduced in rats to build the cerebral ischemic damage. UHPLC-LTQ-Orbitrap-based analytical method was established for analysis of the metabolites...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329653/cycloartane-triterpenoid-and-its-glucoside-isolated-from-cassia-occidentalis
#2
Shi-Fei Li, Shun-Lin Li
In the present study, one new cycloartane triterpenoid, named cycloccidentalic acid C (1) and its glucoside, cycloccidentaliside VI (2) were isolated from the whole plant of Cassia occidentalis. Their structures were elucidated by a combinational analyses of 1D and 2D NMR data and HRMS. Compound 2 showed modest anti-HIV-1 activity with EC50 value of 1.44 μmol·L-1 and TI (Therapeutic Index) value of 15.59.
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329652/three-new-anthraquinone-derivatives-isolated-from-symplocos-racemosa-and-their-antibiofilm-activity
#3
Umar Farooq, Sara Khan, Sadia Naz, Ajmal Khan, Afsar Khan, Ayaz Ahmed, Abdur Rauf, Syed Majid Bukhari, Shujaat Ali Khan, Arfa Kamil, Nadia Riaz, Abdur Rahman Khan
Three new alkyl substituted anthraquinone derivatives, trivially named as symploquinones A-C (Compounds 1-3) were isolated from Symplocos racemosa. The structures of these compounds were determined on the basis of extensive spectroscopic analyses (UV, IR, Mass, 1H- and 13C-NMR, and two-dimensional (2D) NMR techniques). The resulting data were also compared with the reported literature. These compounds were then subjected to antibacterial or antibiofilm testing. Compounds 1 and 3 exhibited good antibacterial activity in the concentration range of 160-83 μg·mL-1 against Streptococcus mutans, methicillin resistant Staphylococcus aureus and Proteus mirabilis...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329651/lignans-and-diterpenes-isolated-from-tirpitzia-ovoidea-and-their-biological-activities
#4
Xue-Yan Yang, Yi-Fan Zhang, Li-Jia Liu, Yi Wang, Ming-Ying Shang, Feng Xu, Guang-Xue Liu, Shao-Qing Cai
A new lignan, tirpitzin A (17) together with 20 known compounds (1-16, and 18-21) were isolated from the ethyl acetate soluble fraction of ethanol extract of the aerial parts of Tirpitzia ovoidea. The structure of new compound was elucidated by means of spectroscopic analysis. Of the known compounds, 7-21 were isolated from Linaceae family for the first time. The pharmacological activity of the crude extracts was tested using a mouse inflammation model induced by dimethyl benzene. The results demonstrated that the ethyl acetate soluble fraction had anti-inflammatory activity...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329650/synthesis-and-anti-hepatocellular-carcinoma-activity-of-novel-o2-vinyl-diazeniumdiolate-based-nitric-oxide-releasing-derivatives-of-oleanolic-acid
#5
Yu Zou, Chang Yan, Jing-Chao Liu, Zhang-Jian Huang, Jin-Yi Xu, Jin-Pei Zhou, Hui-Bin Zhang, Yi-Hua Zhang
Considering that high levels of nitric oxide (NO) exert anti-cancer effect and the derivatives of oleanolic acid (OA) have shown potent anti-cancer activity, new O2-vinyl diazeniumdiolate-based NO releasing derivatives (5a-l, 11a-l) of OA were designed, synthesized, and biologically evaluated in the present study. These derivatives could release different amounts of NO in liver cells. Among them, 5d, 5i, 5j, 11g, 11h, and 11j released more NO in SMMC-7721 cells and displayed stronger proliferative inhibition against SMMC-7721 and HepG2 cells than OA and other tested compounds...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329649/hppr-encodes-the-hydroxyphenylpyruvate-reductase-required-for-the-biosynthesis-of-hydrophilic-phenolic-acids-in-salvia-miltiorrhiza
#6
Guo-Quan Wang, Jun-Feng Chen, Bo Yi, He-Xin Tan, Lei Zhang, Wan-Sheng Chen
Salvia miltiorrhiza is a medicinal plant widely used in the treatment of cardiovascular and cerebrovascular diseases. Hydrophilic phenolic acids, including rosmarinic acid (RA) and lithospermic acid B (LAB), are its primary medicinal ingredients. However, the biosynthetic pathway of RA and LAB in S. miltiorrhiza is still poorly understood. In the present study, we accomplished the isolation and characterization of a novel S. miltiorrhiza Hydroxyphenylpyruvate reductase (HPPR) gene, SmHPPR, which plays an important role in the biosynthesis of RA...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329648/preparation-and-physicochemical-characterization-of-t-oa-plga-microspheres
#7
Jing Fu, Xiao-Xu Dong, Zu-Ping Zeng, Xing-Bin Yin, Fa-Wei Li, Jian Ni
As the carrier of water-insoluble drugs, microspheres can play a role in increasing solubility and delaying releasing essence. The objective of this study was to improve the solubility and to delay the release of a newly discovered antitumor compound 3β-hydroxyolea-12-en-28-oic acid-3, 5, 6-trimethylpyrazin-2-methyl ester (T-OA). Early-stage preparation discovery concept (EPDC) was employed in the present study. The preparation, physicochemical characterization, and drug release properties of PLGA microspheres were evaluated...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329647/atractylodes-lancea-rhizome-water-extract-reduces-triptolide-induced-toxicity-and-enhances-anti-inflammatory-effects
#8
Yuan Wei, Dan-Juan Sui, Hai-Miao Xu, Zhen Ouyang, Na Wu, Du-Jun Wang, Xiao-Yan Zhang, Da-Wei Qian
The present study was designed to explore the influence of water extracts of Atractylodes lancea rhizomes on the toxicity and anti-inflammatory effects of triptolide (TP). A water extract was prepared from A. lancea rhizomes and co-administered with TP in C57BL/6 mice. The toxicity was assayed by determining serum biochemical parameters and visceral indexes and by liver histopathological analysis. The hepatic CYP3A expression levels were detected using Western blotting and RT-PCR methods. The data showed that the water extract of A...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329646/effects-of-gardenia-jasminoides-extracts-on-cognition-and-innate-immune-response-in-an-adult-drosophila-model-of-alzheimer-s-disease
#9
Wei-Wei Ma, Ye Tao, Yan-Ying Wang, I-Feng Peng
Herbal extracts have been extensively used worldwide for their application on memory improvement, especially among aged and memory-deficit populations. In the present study, the memory loss induced by human Abeta protein over-expression in fruitfly Alzheimer's disease (AD) model was rescued by multiple extracts from Gardenia jasminoides. Three extracts that rich with gardenia yellow, geniposide, and gardenoside components showed distinct rescue effect on memory loss. Further investigation on adding gardenoside into a formula of Ganoderma lucidum, Panax notoginseng and Panax ginseng (GPP) also support its therapeutic effects on memory improvement...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329645/polysaccharides-extracted-from-the-roots-of-bupleurum-chinense-dc-modulates-macrophage-functions
#10
Zhi-De Zhang, Hong Li, Fen Wan, Xiao-Yu Su, Yan Lu, Dao-Feng Chen, Yun-Yi Zhang
The present study aimed to investigate the effects of polysaccharides extracted from Bupleurum chinense DC (BCPs) on macrophage functions. In the in vivo experiment, 1 mL of 5% sodium thioglycollate was injected into the abdomen of the mice on Day 0 and macrophages were harvested on Day 4. The macrophages were cultured in plates and treated with different concentrations of BCPs and stimulus. Effects of BCPs on macrophage functions were assessed by chemotaxis assay, phagocytosis assay and Enzyme-Linked Immunosorbent Assay (ELISA)...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329644/anticancer-carbazole-alkaloids-and-coumarins-from-clausena-plants-a-review
#11
REVIEW
Li Huang, Zhe-Ling Feng, Yi-Tao Wang, Li-Gen Lin
Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena (family Rutaceae) is a genus of flowering plants and includes several kinds of edible fruits and vegetables. Phytochemical and pharmacological studies show that carbazole alkaloids and coumarins from Clausena plants exhibit anticancer activity...
December 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329615/synthesis-and-cytotoxicity-evaluation-of-3-amino-2-hydroxypropoxygenistein-derivatives
#12
Xiao-Ting Geng, Jing-Jing Tang, Kun-Peng Cheng, Yuan-Tao Fu, Rong Hu, Jin-Rong Lu
Soy isoflavones exhibit various biological activities, such as antioxidant, anti-tumor, anti-inflammatory, and cardiovascular protective effects. The present study was designed to investigate the effects of sixteen synthesized 3-amino-2-hydroxypropoxy genistein derivatives on cell proliferation and activation of Nrf2 (Nuclear factor erythroid 2-related factor 2)/ARE (antioxidant response elements) pathway in human cancer cell lines. Most of the tested compounds exerted greater cytotoxic activity than genistein, as measured by MTT assay...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329614/bioassay-guided-isolation-of-novel-and-selective-urease-inhibitors-from-diospyros-lotus
#13
Abdur Rauf, Ghias Uddin, Bina S Siddiqui, Ajmal Khan, Umar Farooq, Farhan A Khan, Syed Majid Bukhari, Sher Bahadar Khan
Two new dimeric naphthoquinones, 5',8'-dihydroxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (1; Di-naphthodiospyrol D) and 5',8'-dihydroxy-5,8-dimethoxy-6,6'-dimethyl-7,3'-binaphthyl-1,4,1',4'-tetraone (2; Di-naphthodiospyrol E), along with known naphthoquinones diospyrin (3) and 8-hydroxy diospyrin (4) were isolated from the chloroform fraction of extract of Diospyros lotus roots. Their structures were elucidated by advanced spectroscopic analyses, including HSQC, HMBC, NOESY, and J-resolved NMR experiments...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329613/new-diterpenoids-isolated-from-leonurus-japonicus-and-their-acetylcholinesterase-inhibitory-activity
#14
Han-Kui Wu, Ting Sun, Feng Zhao, Li-Ping Zhang, Gang Li, Jie Zhang
Three new labdane diterpenoids, leojaponicone A (1), isoleojaponicone A (2) and methylisoleojaponicone A (3), were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1D and 2D NMR, including HMQC, and HMBC spectroscopic techniques. All the new compounds were tested in vitro for their acetylcholinesterase and α-glucosidase inhibitory activity. Compounds 1-3 exhibited low inhibitory effects on α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329612/clavuridins-a-and-b-two-new-trinor-guaiane-sesquiterpenes-isolated-from-the-xisha-soft-coral-clavularia-viridis
#15
Yuan Gao, Wei Xiao, Hong-Chun Liu, Jian-Rong Wang, Li-Gong Yao, Ping-Kai Ouyang, De-Cai Wang, Yue-Wei Guo
In the present study, two new trinor-guaiane sesquiterpenes, named clavuridins B (1), and A (2), along with three known sesquiterpenes (3-5), were isolated from the Xisha soft coral Clavularia viridis. Their structures and absolute configurations were determined on the basis of spectroscopic analysis, X-ray diffraction analysis with Cu Kα radiation and by comparison with related model compounds. Compounds 1 and 3-5 were evaluated for their cytotoxic activity.
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329611/early-intervention-with-didang-decoction-delays-macrovascular-lesions-in-diabetic-rats-through-regulating-amp-activated-protein-kinase-signaling-pathway
#16
Dan-Dan Ren, Jing Li, Bai Chang, Chun-Shen Li, Ju-Hong Yang
The study aimed to investigate the intervening role of Didang decoction (DDD) at different times in macrovascular endothelial defense function, focusing on its effects on the AMP-activated protein kinase (AMPK) signaling pathway. The effects of DDD on mitochondrial energy metabolism were also investigated in rat aortic endothelial cells (RAECs). Type 2 diabetes were induced in rats by streptozotocin (STZ) combined with high fat diet. Rats were randomly divided into non-intervention group, metformin group, simvastatin group, and early-, middle-, late-stage DDD groups...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329610/bacopa-monnieri-extracts-prevent-hydrogen-peroxide-induced-oxidative-damage-in-a-cellular-model-of-neuroblastoma-imr32-cells
#17
Gaurav Bhatia, Vikram Dhuna, Kshitija Dhuna, Manpreet Kaur, Jatinder Singh
Neurodegenerative diseases are the consequences of imbalance between the production of oxidative stress and its nullification by cellular defense mechanisms. Hydrogen peroxide (H2O2), a precursor of deleterious reactive oxygen species, elicits oxidative stress, resulting in severe brain injuries. Bacopa monnieri is well known for its nerve relaxing and memory enhancing properties. The present study was designed to evaluate the protective effects of extracts from Bacopa monnieri against H2O2 induced oxidative stress using a cellular model, neuroblastoma IMR32 cell line...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329609/garcinia-xanthochymus-extract-protects-pc12-cells-from-h2o2-induced-apoptosis-through-modulation-of-pi3k-akt-and-nrf2-ho-1-pathways
#18
Jing Xu, Sheng Gan, Jun Li, De-Bing Wand, Yu Chen, Xin Hu, Guang-Zhong Yang
The aim of the present study was to investigate the protective effects and underlying mechanisms of Garcinia xanthochymus, a perennial medicinal plant native to Yunnan, China, against H2O2-induced oxidative damage in rat pheochromacytoma PC12 cells. Preincubation of PC12 cells with fruit EtOAc fraction (fruit-EFr., 12.5-50 µmol·L-1) of G. xanthochymus for 24 h prior to H2O2 exposure markedly improved cell viability and increased the activities of antioxidant enzymes (superoxide dismutase, catalase, and heme oxygenase-1 [HO-1]), prevented lactate dehydrogenase release and lipid peroxidation malondialdehyde production, attenuated the decrease of matrix metalloproteinases (MMP), and scavenged reactive oxygen species (ROS)...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329608/polyphenols-isolated-from-acacia-mearnsii-bark-with-anti-inflammatory-and-carbolytic-enzyme-inhibitory-activities
#19
Jia Xiong, Mary H Grace, Debora Esposito, Slavko Komarnytsky, Fei Wang, Mary Ann Lila
The present study was designed to characterize the polyphenols isolated from Acacia mearnsii bark crude extract (B) and fractions (B1-B7) obtained by high-speed counter-current chromatography (HSCCC) and evaluate their anti-inflammatory and carbolytic enzymes (α-glucosidase and α-amylase) inhibitory activities. Fractions B4, B5, B6, B7 (total phenolics 850.3, 983.0, 843.9, and 572.5 mg·g-1, respectively; proanthocyanidins 75.7, 90.5, 95.0, and 44.8 mg·g-1, respectively) showed significant activities against reactive oxygen species (ROS), nitric oxide (NO) production, and expression of pro-inflammatory genes interleukin-1β (IL-1β) and inducible nitric oxide synthase (iNOS) in a lipopolysaccharide (LPS)-stimulated mouse macrophage cell line RAW 264...
November 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29329607/the-genus-liriope-phytochemistry-and-pharmacology
#20
Zhan-Peng Shang, Fei Wang, Jia-Yu Zhang, Zi-Jian Wang, Jian-Qiu Lu, Huai-You Wang, Ning Li
Liriope (Liliaceae) species have been used as folk medicines in Asian countries since ancient times. From Liriope plants (8 species), a total of 132 compounds (except polysaccharides) have been isolated and identified, including steroidal saponins, flavonoids, phenols, and eudesmane sesquiterpenoids. The crude extracts or monomeric compounds from this genus have been shown to exhibit anti-tumor, anti-diabetic, anti-inflammatory, and neuroprotective activities. The present review summarizes the results on phytochemical and biological studies on Liriope plants...
November 2017: Chinese Journal of Natural Medicines
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