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Chinese Journal of Natural Medicines

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https://www.readbyqxmd.com/read/30322613/profiling-and-identification-of-chemical-components-of-shenshao-tablet-and-its-absorbed-components-in-rats-by-comprehensive-hplc-dad-esi-ms-n-analysis
#1
Wen-Juan Miao, Ying Hu, Li Jia, Chun-Xia Zhang, Wen-Zhi Yang, Ping Zhang, De-An Guo
Shenshao Tablet (SST), prepared from Paeoniae Radix Alba (PRA) and total ginsenoside of Ginseng Stems and Leaves (GSL), is a traditional Chinese medicine (TCM) preparation prescribed to treat coronary heart disease. However, its chemical composition and the components that can migrate into blood potentially exerting the therapeutic effects have rarely been elucidated. We developed an HPLC/DAD/ESI-MSn approach aiming to comprehensively profile and identify both the chemical components of SST and its absorbed ingredients (and metabolites) in rat plasma and urine...
October 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30322612/design-synthesis-and-biological-evaluation-of-novel-nitric-oxide-releasing-dehydroandrographolide-derivatives
#2
Lin Yan, Yu-Xuan Dai, Guo-Long Gu, Miao-Bo Pan, Shuai-Cong Wu, Yu Cao, Wen-Long Huang
A series of new hybrids of dehydroandrographolide (TAD), a biologically active natural product, bearing nitric oxide (NO)-releasing moieties were synthesized and designated as NO-donor dehydroandrographolide. The biological activities of target compounds were studied in human erythroleukemia K562 cells and breast cancer MCF-7 cells. Biological evaluation indicated that the most active compound I-5 produced high levels of NO and inhibited the proliferation of K562 (IC50 1.55 μmol·L-1 ) and MCF-7 (IC50 2.91 μmol·L-1 ) cells, which were more potent than the lead compound TAD and attenuated by an NO scavenger...
October 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30322611/novel-berberine-derivatives-design-synthesis-antimicrobial-effects-and-molecular-docking-studies
#3
Ling Yao, Ling-Ling Wu, Qian Li, Qin-Mei Hu, Shu-Yuan Zhang, Kang Liu, Jian-Qin Jiang
A series of berberine derivatives were synthesized by introducing substituted benzyl groups at C-9. All these synthesized compounds (4a-4m) were screened for their in vitro antibacterial activity against four Gram-positive bacteria and four Gram-negative bacteria and evaluated for their antifungal activity against three pathogenic fungal strains. All these compounds displayed good antibacterial and antifungal activities, compared to reference drugs including Ciprofloxacin and Fluconazole; Compounds 4f, 4g, and 4l showed the highest antibacterial and antifungal activities...
October 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30322610/effects-of-six-compounds-with-different-chemical-structures-on-melanogenesis
#4
Rakotomalala Manda Heriniaina, Jing Dong, Praveen Kumar Kalavagunta, Hua-Li Wu, Dong-Sheng Yan, Jing Shang
Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology. In the present study, we investigated the melanogenic activity of six structurally distinct compounds, namely, scopoletin, kaempferol, chrysin, vitamin D3 , piperine, and 6-benzylaminopurine. We determined their effectiveness, toxicity, and mechanism of action for stimulating pigmentation in B16F10 melanoma cells and in a zebrafish model. The melanogenic activity of 6-benzylaminopurine, the compound identified as the most potent, was further verified by measuring green fluorescent protein concentration in tyrp1 a: eGFP (tyrosinase-related protein 1) zebrafish and mitfa: eGFP (microphthalmia associated transcription factor) zebrafish and antioxidative activity...
October 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30322609/systems-pharmacology-based-investigation-of-sanwei-ganjiang-prescription-related-mechanisms-in-liver-injury
#5
Yun-Xia Luo, Xin-Yue Wang, Yu-Jie Huang, Shu-Huan Fang, Jun Wu, Yong-Bin Zhang, Tian-Qin Xiong, Cong Yang, Jian-Gang Shen, Chuan-Lan Sang, Qi Wang, Jian-Song Fang
Liver injury remains a significant global health problem and has a variety of causes, including oxidative stress (OS), inflammation, and apoptosis of liver cells. There is currently no curative therapy for this disorder. Sanwei Ganjiang Prescription (SWGJP), derived from traditional Chinese medicine (TCM), has shown its effectiveness in long-term liver damage therapy, although the underlying molecular mechanisms are still not fully understood. To explore the underlining mechanisms of action for SWGJP in liver injury from a holistic view, in the present study, a systems pharmacology approach was developed, which involved drug target identification and multilevel data integration analysis...
October 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30322608/discovery-of-differential-sequences-for-improving-breeding-and-yield-of-cultivated-ophiocordyceps-sinensis-through-its-sequencing-and-phylogenetic-analysis
#6
Qi-Qing Cheng, Chun-Song Cheng, Yue Ouyang, Chi-Chou Lao, Hao Cui, Yu Xian, Zhi-Hong Jiang, Wen-Jia Li, Hua Zhou
To accelerate the breeding process of cultivated Ophiocordyceps sinensis and increase its yield, it is important to identify molecular fingerprint of dominant O. sinensis. In the present study, we collected 3 batches of industrially cultivated O. sinensis product with higher yield than the others and compared their internal transcribed spacer (ITS) sequences with the wild and the reported. The ITS sequence was obtained by bidirectional sequencing and analyzed with molecular systematics as a DNA barcode for rapid and accurate identification of wild and cultivated O...
October 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30322607/advances-in-the-antitumor-activities-and-mechanisms-of-action-of-steroidal-saponins
#7
Ya-Zheng Zhao, Yuan-Yuan Zhang, Han Han, Rui-Ping Fan, Yang Hu, Liang Zhong, Jun-Ping Kou, Bo-Yang Yu
The steroidal saponins are one of the saponin types that exist in an unbound state and have various pharmacological activities, such as anticancer, anti-inflammatory, antiviral, antibacterial and nerves-calming properties. Cancer is a growing health problem worldwide. Significant progress has been made to understand the antitumor effects of steroidal saponins in recent years. According to reported findings, steroidal saponins exert various antitumor activities, such as inhibiting proliferation, inducing apoptosis and autophagy, and regulating the tumor microenvironment, through multiple related signaling pathways...
October 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30322606/ethnopharmacology-phytochemistry-and-pharmacology-of-sterculia-lychnophora-hance-pangdahai
#8
Mahmood Brobbey Oppong, Yang Li, Prince Osei Banahene, Shi-Ming Fang, Feng Qiu
The matured, ripen, and dried seeds of Scaphium affine (Mast.) Pierre, known as Pangdahai (PDH) in Chinese and recorded as Sterculia lychnophora Hance (scientific synonym) in the 2015 edition of the Chinese Pharmacopeia, have been widely used in traditional Chinese medicine, Japanese folk medicine, Vietnamese traditional medicine, traditional Thai medicine and Indian traditional medicine. The decoctions of the seeds are used as a remedy for pharyngitis, laryngitis, constipation, cough, menorrhagia, and pain management...
October 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30269848/metabolomics-analysis-and-rapid-identification-of-changes-in-chemical-ingredients-in-crude-and-processed-astragali-radix-by-uplc-qtof-ms-combined-with-novel-informatics-unifi-platform
#9
Peng-Peng Liu, Guo-Shun Shan, Fan Zhang, Jiang-Ning Chen, Tian-Zhu Jia
Astragali Radix, the root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge., is widely used as a tonic decoction pieces in the clinic of traditional Chinese medicine (TCM). Astragali Radix has various processed products with varying pharmacological actions. There is no modern scientific evidence to explain the differences in pharmacological activities and related mechanisms. In the present study, we explore the changes in chemical components in Astragali Radix after processing, by ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) combined with novel informatics UNIFI platform and multivariate statistical analysis...
September 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30269847/protective-effects-of-extracts-of-schisandra-chinensis-stems-against-acetaminophen-induced-hepatotoxicity-via-regulation-of-mapk-and-caspase-3-signaling-pathways
#10
Yan-Zi Li, Zhi-Na Ma, Yin-Shi Sun, Shen Ren, Shuang Jiang, Wei-Zhe Zhang, Zi Wang, Wei Li
The present study was designed to evaluate protective activity of an ethanol extract of the stems of Schisandra chinensis (SCE) and explore its possible molecular mechanisms on acetaminophen (APAP) induced hepatotoxicity in a mouse model. The results of HPLC analysis showed that the main components of SCE included schisandrol A, schisandrol B, deoxyschisandrin, schisandrin B, and schisandrin C and their contents were 5.83, 7.11, 2.13, 4.86, 0.42 mg·g-1 , respectively. SCE extract was given for 7 consecutive days before a single hepatotoxic dose of APAP (250 mg·kg-1 ) was injected to mice...
September 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30269846/gambogic-acid-induces-cell-apoptosis-through-endoplasmic-reticulum-stress-triggered-inhibition-of-akt-signaling-pathways-in-extranodal-nk-t-cell-lymphoma-cells
#11
Wei Peng, Bao-An Chen
As the chemotherapeutic resistance of extranodal NK/T-cell lymphoma (ENKTL) rises year by year, searching for novel chemoprevention compounds has become imminent. Gambogic acid (GA) has recently been shown to have anti-tumor effects, but its role and underling mechanism in ENKTL are rather elusive. In the present study, we showed that GA inhibited the cell growth and potently induced the apoptosis of ENKTL cells in vitro in a time- and concentration-dependent manner. Furthermore, GA induced cell death through endoplasmic reticulum stress (ERS) mediated suppression of Akt signaling pathways and finally the release of the caspase-3 proteases...
September 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30269845/discovery-of-synergistic-anti-inflammatory-compound-combination-from-herbal-formula-guge-fengtong-tablet
#12
Le-Le Liu, Qun Liu, Ping Li, E-Hu Liu
Multi-components in herbal formulae exert holistic effects in synergistic or additive manners. However, appropriate strategies and supportive evidences are still lacking to uncover the synergistic or additive combinations. The present investigation aimed at seeking a screening strategy to identify the targeted combinations in GuGe FengTong Tablet (GGFTT), an herbal formula. Two compounds, belonging to different chemical classes, were combined with different concentration ratios and their anti-inflammation effects were investigated...
September 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30269844/polysaccharide-extracts-of-astragalus-membranaceus-and-atractylodes-macrocephala-promote-intestinal-epithelial-cell-migration-by-activating-the-polyamine-mediated-k-channel
#13
Dan Zeng, Can Hu, Ru-Liu Li, Chuan-Quan Lin, Jia-Zhong Cai, Ting-Ting Wu, Jing-Jing Sui, Wen-Biao Lu, Wei-Wen Chen
Astragalus membranaceus (Radix Astragali, RA) and Atractylodes macrocephala (Rhizoma Atractylodis Macrocephalae, RAM) are often used to treat gastrointestinal diseases. In the present study, we determined the effects of polysaccharides extracts from these two herbs on IEC-6 cell migration and explored the potential underlying mechanisms. A migration model with IEC-6 cells was induced using a single-edged razor blade along the diameter of cell layers in six-well polystyrene plates. The cells were grown in control media or media containing spermidine (5 μmol·L-1 , SPD), alpha-difluoromethylornithine (2...
September 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30269843/anti-parasitic-effects-of-water-soluble-alkaloid-fractions-from-ethanolic-extracts-of-sophora-moorcroftiana-seeds-in-caenorhabditis-elegans
#14
Yan-Ping Luo, Yuan Zhang, Hui-Min Zhang, Hong Zhang, Lin Zhang, Hong-Juan Yu, Ming-Qiang Cao, Yan-Bin Shi, De-Juan Zhi, Xing-Ming Ma, Kai-Zhong Dong
Parasite infections of humans and animals remain a major global health problem, with limited choice of drugs being available to the treatment of parasitosis in the clinic. Sophora moorcroftiana (S. moorcroftiana) is a shrub that grows in Tibet Plateau of China. Decoction of the seeds has been used as a traditional Tibetan medicine to treat parasitosis for years. But the anti-parasitic effects of water-soluble fractions in the seeds need further investigation. In the present study, the water-soluble alkaloid fractions (E2) were obtained from S...
September 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30269842/the-role-of-neutrophils-in-triptolide-induced-liver-injury
#15
Xin-Zhi Wang, Shen-Ye Zhang, Yao Xu, Lu-Yong Zhang, Zhen-Zhou Jiang
Triptolide (TP) induces severe liver injury, but its hepatotoxicity mechanisms are still unclear. Inflammatory responses may be involved in the pathophysiology. Neutrophils are the first-line immune effectors for sterile and non-sterile inflammatory responses. Thus, the aim of the present study was to investigate the neutrophilic inflammatory response in TP-induced liver injury in C57BL/6 mice. Our results showed that neutrophils were recruited and accumulated in the liver, which was parallel to or slightly after the development of liver injury...
September 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30269841/stems-and-leaves-of-aconitum-carmichaelii-debx-as-potential-herbal-resources-for-treating-rheumatoid-arthritis-chemical-analysis-toxicity-and-activity-evaluation
#16
Ya-Nan He, Shui-Ping Ou, Xi Xiong, Yuan Pan, Jin Pei, Run-Chun Xu, Fu-Neng Geng, Li Han, Ding-Kun Zhang, Ming Yang
According to folk usage of Aconitum carmichaelii Debx., the present study was designed to determine the feasibility of the stems and leaves of Aconitum carmichaelii Debx. as a new medicinal resource. Fourteen alkaloids in mother roots, fibrous roots, stems, and leaves of Aconitum carmichaelii Debx. were measured by HPLC-MS/MS. And multivariate analysis methods, such as clustering analysis and principal component analysis, were applied to analyze the difference among various parts. In addition, the acute toxicity, analgesia, and anti-inflammatory tests were carried out...
September 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30269840/anticancer-activity-and-underlying-mechanism-of-neogambogic-acid
#17
REVIEW
Rui Sun, Hong-Ming Zhang, Bao-An Chen
Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that the main active monomer gambogic acid isolated from garcinia can inhibit the growth of various cancer cells. Neogambogic acid is an isolated compound with a similar chemical structure as gambogic acid...
September 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197129/metabonomics-delineates-allergic-reactions-induced-by-shuang-huang-lian-injection-in-rats-using-ultra-performance-liquid-chromatography-mass-spectrometry
#18
Yuan-Yuan Gu, Lang Shi, Dan-Dan Zhang, Xin Huang, Da-Zhong Chen
Shuang-huang-lian Injection (SHLI) is the first successfully developed drug from traditional Chinese medicine (TCM) powder for injection, since its use for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. At the same time, its allergic reactions have also emerged, which limits clinical applications. However, few scholars pay attention to the mechanism of allergic reactions. In this present study, metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction; we and analyzed the metabolites, metabolic pathway, and the mechanism which were closely related to the allergic reactions...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197128/novel-sesquiterpenoids-isolated-from-chimonanthus-praecox-and-their-antibacterial-activities
#19
Hua-Yong Lou, Yu Zhang, Xiao-Pan Ma, Sai Jiang, Xiang-Pei Wang, Ping Yi, Guang-Yi Liang, Hong-Mei Wu, Jing Feng, Feng-Yun Jin, Wei-Dong Pan
In the present study, four new sesquiterpenoids, chimonols A-D (compounds 1-4), together with four known compounds (5-8) were isolated from the EtOAc extract of Chimonanthus praecox Link. The structures of these new compounds were elucidated on the basis of spectroscopic techniques (UV, IR, MS, and 1D and 2D NMR), and their absolute configurations were established by comparing experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1-8 were evaluated for antimicrobial activities and the minimum inhibitory concentrations (MICs) were determined by the broth microdilution method in 96-well culture plates...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197127/new-flavonoids-and-methylchromone-isolated-from-the-aerial-parts-of-baeckea-frutescens-and-their-inhibitory-activities-against-cyclooxygenases-1-and-2
#20
Jun-Neng Zhou, Ming Yan, Peng Gao, Ji-Qin Hou, Thi-Anh Pham, Hao Wang
In the present study, we carried out a phytochemical investigation of the ethanol extract of the aerial parts of Baeckea frutescens, which resulted in the isolation of two new flavonoid glycosides, myricetin 3-O-(5″-O-galloyl)-α-L-arabinofuranoside (1), 6-methylquercetin 7-O-β-D-glucopyranoside (2), one new methylchromone glycoside, 7-O-(4', 6'-digalloyl)-β-D-glucopyranosyl-5-hydroxy-2-methylchromone (3), together with three known compounds (4-6). The structures of these isolated compounds were established on the basis of 1D and 2D NMR techniques and chemical methods...
August 2018: Chinese Journal of Natural Medicines
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