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Chinese Journal of Natural Medicines

Pei-Lan Ding, Chang-Ming He, Zhi-Hong Cheng, Dao-Feng Chen
Sophorae Flavescentis Radix (Sophora flavescens Ait., SFR) and Sophorae Tonkinensis Radix et Rhizoma (S. tonkinensis Gapnep., STR) are two commonly used traditional Chinese medicines from Sophora (Leguminosae) plants, which are believed to possess similar bioactive components with entirely different clinical applications. In order to find out the characteristic chemical constituents potentially leading to the unique medicinal properties claimed for each of the two closely related TCMs, an HPLC fingerprint method was developed for analyses of the alkaloid and flavonoid constituents of SFR and STR, respectively, which were further evaluated and compared through similarity calculation and hierarchical clustering analysis (HCA)...
December 2018: Chinese Journal of Natural Medicines
Qiong Zhang, Qing-Hong Zheng, Yi-Shu Sang, Herman Ho-Yung Sung, Zhi-Da Min
Two new limonoids, 12-ethoxynimbolinins G and H (compounds 1 and 2), and one known compound, toosendanin (Chuanliansu) (compound 3), were isolated from the bark of Melia toosendan. Their structures were elucidated by spectroscopic analysis and X-ray techniques. The absolute configuration of toosendanin (3) was established by single-crystal X-ray diffraction. Compounds 1-3 were evaluated for their cytotoxicity against five tumor cell lines.
December 2018: Chinese Journal of Natural Medicines
Xue-Ying Han, Ya-Nan Wang, De-Qiang Dou
Recent studies have revealed that the property of drug is mainly associated with the body's substance and energy metabolism. The present study aimed to evaluate the drug property of Poria, called Fuling (FL) in traditional Chinese medicine (TCM), in terms of its effects on the substance and energy metabolism in rat models of cold-deficiency and heat-deficiency syndromes, compared with Aconiti Lateralis Radix Praeparaia, called Fuzi (FZ) in TCM, with hot property, and Anemarrhenae Rhizoma, called Zhimu (ZM) in TCM, with cold property, as reference drugs, respectively...
December 2018: Chinese Journal of Natural Medicines
Jian-Ping Bi, Ping Li, Xi-Xi Xu, Ting Wang, Fei Li
Notopterygium incisum (QH) has been used for the treatment of rheumatoid arthritis (RA), and volatile oils may be its mainly bioactive constituents. The present study was designed to analyze the volatile compounds in QH and to determine the anti-arthritic capacity of Notopterygium volatile oils and the potential mechanism of action. The volatile compounds analysis was conducted by GC-MS. The anti-arthritic capacity test of the volatile oils was conducted on adjuvant-induced arthritis (AIA) rats. The anti-inflammatory property was tested in NO release model in RAW 264...
December 2018: Chinese Journal of Natural Medicines
Jia-Wei Wang, Feng-Yin Liang, Xiang-Shuo Ouyang, Pei-Bo Li, Zhong Pei, Wei-Wei Su
Schisandra chinensis, a traditional Chinese medicine (TCM), has been used to treat sleep disorders. Zebrafish sleep/wake behavioral profiling provides a high-throughput platform to screen chemicals, but has never been used to study extracts and components from TCM. In the present study, the ethanol extract of Schisandra chinensis and its two main lignin components, schisandrin and schisandrin B, were studied in zebrafish. We found that the ethanol extract had bidirectional improvement in rest and activity in zebrafish...
December 2018: Chinese Journal of Natural Medicines
Wen Liu, Tian-Cong Wu, Dong-Mei Hong, Yue Hu, Ting Fan, Wen-Jie Guo, Qiang Xu
Cisplatin and other platinum-based drugs are used frequently for treatment of lung cancer. However, their clinical performance are usually limited by drug resistance or toxic effects. Carnosic acid, a polyphenolic diterpene isolated from Rosemary (Rosemarinus officinalis), has been reported to have several pharmacological and biological activities. In the present study, the combination effect of cisplatin plus carnosic acid on mouse LLC (Lewis lung cancer) xenografts and possible underlying mechanism of action were examined...
December 2018: Chinese Journal of Natural Medicines
Guo-Xun Yang, Guang-Lei Ma, Hao Li, Ting Huang, Juan Xiong, Jin-Feng Hu
In this review, we intensively focus on the advances in research of natural products (NPs) discovery carried out by domestic scholars in China from 2015 through 2017. In general, a total of 1811 publications (1479 in English and 332 in Chinese) were accumulated regarding newly isolated NPs from plants, microorganisms, and marine sources. As a result, 277 selected papers concerning naturally occurring compounds with extraordinary frameworks, origins, and promising activities were discussed in this review article, mainly organized according to their structural classes and novelties...
December 2018: Chinese Journal of Natural Medicines
Hao Qian, Fang-Jun Yu, Dan-Yi Lu, Bao-Jian Wu, Xing-Wang Zhang, Huan Wang, Zhi-Guo Ma
Poliumoside is representative of phenylethanoid glycosides, which are widely found in many plants. Poliumoside is also regarded as the main active component of Callicarpa kwangtungensis Chun (CK), though its oral bioavailability in rat is extremely low (0.69%) and its in vivo and in vitro metabolism has not yet been systematically investigated. In the present study, an ultra performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS) method was employed to identify the metabolites and investigate the metabolic pathways of poliumoside in rat after oral administration 1...
November 2018: Chinese Journal of Natural Medicines
Yan Shu, Tian-Peng Yin, Jia-Peng Wang, Dong Gan, Qin-Yan Zhang, Le Cai, Zhong-Tao Ding
In the present study, three new aconitine-type diterpenoid alkaloids brochyponines A-C (1-3) were isolated from the roots of Aconitum brevicalcaratum. Their structures were established on the basis of extensive spectroscopic analyses (IR, HR-ESI-MS, and 1D and 2D NMR). The NMR data of salt form for compound 1 in CDCl3 were also measured.
November 2018: Chinese Journal of Natural Medicines
Pérez-Gutiérrez Rosa Martha, Enriquez-Alvirde Susana Gabriela
The present study was designed to evaluate the therapeutic potential of bioactive compounds from chloroform extract of the leaves of Hylocereus undatus in the formation of advanced glycation end products (AGEs) in vitro. Bioactivity-guided fractionation of chloroform extract from Hylocereus undatus afforded two novel 12-ursen-type triterpenes, 3β, 16α, 23-trihydroxy-urs-12- en-28-oic acid (1) and 3β, 6β, 19α, 22α-tetrahydroxy-urs-12-en-28-oic acid (2), as well as four known triterpenes 2α, 3β, 23-tetrahydroxy-urs-11-en-28-oic acid (3), 3β-acetoxy-28-hydroxyolean-12-ene (4), 3β, 16α-dihidroxyolean-12-ene (5) and 3β-acetoxy-olean-12-ene (6)...
November 2018: Chinese Journal of Natural Medicines
Zheng-Jie Meng, Chao Wang, Ling-Tong Meng, Bei-Hua Bao, Jin-Hui Wu, Yi-Qiao Hu
Cardiac dysfunction, a common consequence of sepsis, is the major contribution to morbidity and mortality in patients. Sodium tanshinone IIA sulfonate (STS) is a water-soluble derivative of Tanshinone IIA (TA), a main active component of Salvia miltiorrhiza Bunge, which has been widely used in China for the treatment of cardiovascular and cerebral system diseases. In the present study, the effect of STS on sepsis-induced cardiac dysfunction was investigated and its effect on survival rate of rats with sepsis was also evaluated...
November 2018: Chinese Journal of Natural Medicines
Juan Chen, Jia Yue, Jiao Liu, Yun Liu, Kai-Lin Jiao, Meng-Ying Teng, Chun-Yan Hu, Jing Zhen, Mao-Xuan Wu, Ming Zhou, Zhong Li, Yuan Li
Postmenopausal women, who have reduced circulating estrogen levels, are more prone to develop obesity and related metabolic diseases than premenopausal women. The absence of safe and effective treatments for postmenopausal obesity has changed the focus to natural products as alternative remedies. Total salvianolic acids (TSA) are the major water-soluble ingredients of Danshen. Salvianolic acid (SA) is the major constituent of the TSA. Salvianolic acids, including TSA and SA, are widely used in traditional Chinese medicine...
November 2018: Chinese Journal of Natural Medicines
Qing-Qing Yao, Li Li, Ming-Cheng Xu, Hai-Hong Hu, Hui Zhou, Lu-Shan Yu, Su Zeng
Pharmacological activities and adverse side effects of ginkgolic acids (GAs), major components in extracts from the leaves and seed coats of Ginkgo biloba L, have been intensively studied. However, there are few reports on their hepatotoxicity. In the present study, the metabolism and hepatotoxicity of GA (17 : 1), one of the most abundant components of GAs, were investigated. Kinetic analysis indicated that human and rat liver microsomes shared similar metabolic characteristics of GA (17 : 1) in phase I and II metabolisms...
November 2018: Chinese Journal of Natural Medicines
Ben-Mei Zhang, Zhi-Bin Wang, Ping Xin, Qiu-Hong Wang, He Bu, Hai-Xue Kuang
The genus Ephedra of the Ephedraceae family contains more than 60 species of nonflowering seed plants distributed throughout Asia, America, Europe, and North Africa. These Ephedra species have medicinal, ecological, and economic value. This review aims to summarize the chemical constituents and pharmacological activities of the Ephedra species to unveil opportunities for future research. Comprehensive information on the Ephedra species was collected by electronic search (e.g., GoogleScholar, Pubmed, SciFinder, and Web of Science) and phytochemical books...
November 2018: Chinese Journal of Natural Medicines
Yu Zhou, Han-Bo Cao, Wen-Jun Li, Li Zhao
Chemokine 12 (CXCL12), also known as stromal cell derived factor-1 (SDF-1) and a member of the CXC chemokine subfamily, is ubiquitously expressed in many tissues and cell types. It interacts specifically with the ligand for the transmembrane G protein-coupled receptors CXCR4 and CXCR7. The CXCL12/CXCR4 axis takes part in a series of physiological, biochemical, and pathological process, such as inflammation and leukocyte trafficking, cancer-induced bone pain, and postsurgical pain, and also is a key factor in the cross-talking between tumor cells and their microenvironment...
November 2018: Chinese Journal of Natural Medicines
Wen-Juan Miao, Ying Hu, Li Jia, Chun-Xia Zhang, Wen-Zhi Yang, Ping Zhang, De-An Guo
Shenshao Tablet (SST), prepared from Paeoniae Radix Alba (PRA) and total ginsenoside of Ginseng Stems and Leaves (GSL), is a traditional Chinese medicine (TCM) preparation prescribed to treat coronary heart disease. However, its chemical composition and the components that can migrate into blood potentially exerting the therapeutic effects have rarely been elucidated. We developed an HPLC/DAD/ESI-MSn approach aiming to comprehensively profile and identify both the chemical components of SST and its absorbed ingredients (and metabolites) in rat plasma and urine...
October 2018: Chinese Journal of Natural Medicines
Lin Yan, Yu-Xuan Dai, Guo-Long Gu, Miao-Bo Pan, Shuai-Cong Wu, Yu Cao, Wen-Long Huang
A series of new hybrids of dehydroandrographolide (TAD), a biologically active natural product, bearing nitric oxide (NO)-releasing moieties were synthesized and designated as NO-donor dehydroandrographolide. The biological activities of target compounds were studied in human erythroleukemia K562 cells and breast cancer MCF-7 cells. Biological evaluation indicated that the most active compound I-5 produced high levels of NO and inhibited the proliferation of K562 (IC50 1.55 μmol·L-1 ) and MCF-7 (IC50 2.91 μmol·L-1 ) cells, which were more potent than the lead compound TAD and attenuated by an NO scavenger...
October 2018: Chinese Journal of Natural Medicines
Ling Yao, Ling-Ling Wu, Qian Li, Qin-Mei Hu, Shu-Yuan Zhang, Kang Liu, Jian-Qin Jiang
A series of berberine derivatives were synthesized by introducing substituted benzyl groups at C-9. All these synthesized compounds (4a-4m) were screened for their in vitro antibacterial activity against four Gram-positive bacteria and four Gram-negative bacteria and evaluated for their antifungal activity against three pathogenic fungal strains. All these compounds displayed good antibacterial and antifungal activities, compared to reference drugs including Ciprofloxacin and Fluconazole; Compounds 4f, 4g, and 4l showed the highest antibacterial and antifungal activities...
October 2018: Chinese Journal of Natural Medicines
Rakotomalala Manda Heriniaina, Jing Dong, Praveen Kumar Kalavagunta, Hua-Li Wu, Dong-Sheng Yan, Jing Shang
Several chemical compounds can restore pigmentation in vitiligo through mechanisms that vary according to disease etiology. In the present study, we investigated the melanogenic activity of six structurally distinct compounds, namely, scopoletin, kaempferol, chrysin, vitamin D3 , piperine, and 6-benzylaminopurine. We determined their effectiveness, toxicity, and mechanism of action for stimulating pigmentation in B16F10 melanoma cells and in a zebrafish model. The melanogenic activity of 6-benzylaminopurine, the compound identified as the most potent, was further verified by measuring green fluorescent protein concentration in tyrp1 a: eGFP (tyrosinase-related protein 1) zebrafish and mitfa: eGFP (microphthalmia associated transcription factor) zebrafish and antioxidative activity...
October 2018: Chinese Journal of Natural Medicines
Yun-Xia Luo, Xin-Yue Wang, Yu-Jie Huang, Shu-Huan Fang, Jun Wu, Yong-Bin Zhang, Tian-Qin Xiong, Cong Yang, Jian-Gang Shen, Chuan-Lan Sang, Qi Wang, Jian-Song Fang
Liver injury remains a significant global health problem and has a variety of causes, including oxidative stress (OS), inflammation, and apoptosis of liver cells. There is currently no curative therapy for this disorder. Sanwei Ganjiang Prescription (SWGJP), derived from traditional Chinese medicine (TCM), has shown its effectiveness in long-term liver damage therapy, although the underlying molecular mechanisms are still not fully understood. To explore the underlining mechanisms of action for SWGJP in liver injury from a holistic view, in the present study, a systems pharmacology approach was developed, which involved drug target identification and multilevel data integration analysis...
October 2018: Chinese Journal of Natural Medicines
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