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Chinese Journal of Natural Medicines

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https://www.readbyqxmd.com/read/30197129/metabonomics-delineates-allergic-reactions-induced-by-shuang-huang-lian-injection-in-rats-using-ultra-performance-liquid-chromatography-mass-spectrometry
#1
Yuan-Yuan Gu, Lang Shi, Dan-Dan Zhang, Xin Huang, Da-Zhong Chen
Shuang-huang-lian Injection (SHLI) is the first successfully developed drug from traditional Chinese medicine (TCM) powder for injection, since its use for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. At the same time, its allergic reactions have also emerged, which limits clinical applications. However, few scholars pay attention to the mechanism of allergic reactions. In this present study, metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction; we and analyzed the metabolites, metabolic pathway, and the mechanism which were closely related to the allergic reactions...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197128/novel-sesquiterpenoids-isolated-from-chimonanthus-praecox-and-their-antibacterial-activities
#2
Hua-Yong Lou, Yu Zhang, Xiao-Pan Ma, Sai Jiang, Xiang-Pei Wang, Ping Yi, Guang-Yi Liang, Hong-Mei Wu, Jing Feng, Feng-Yun Jin, Wei-Dong Pan
In the present study, four new sesquiterpenoids, chimonols A-D (compounds 1-4), together with four known compounds (5-8) were isolated from the EtOAc extract of Chimonanthus praecox Link. The structures of these new compounds were elucidated on the basis of spectroscopic techniques (UV, IR, MS, and 1D and 2D NMR), and their absolute configurations were established by comparing experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1-8 were evaluated for antimicrobial activities and the minimum inhibitory concentrations (MICs) were determined by the broth microdilution method in 96-well culture plates...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197127/new-flavonoids-and-methylchromone-isolated-from-the-aerial-parts-of-baeckea-frutescens-and-their-inhibitory-activities-against-cyclooxygenases-1-and-2
#3
Jun-Neng Zhou, Ming Yan, Peng Gao, Ji-Qin Hou, Thi-Anh Pham, Hao Wang
In the present study, we carried out a phytochemical investigation of the ethanol extract of the aerial parts of Baeckea frutescens, which resulted in the isolation of two new flavonoid glycosides, myricetin 3-O-(5″-O-galloyl)-α-L-arabinofuranoside (1), 6-methylquercetin 7-O-β-D-glucopyranoside (2), one new methylchromone glycoside, 7-O-(4', 6'-digalloyl)-β-D-glucopyranosyl-5-hydroxy-2-methylchromone (3), together with three known compounds (4-6). The structures of these isolated compounds were established on the basis of 1D and 2D NMR techniques and chemical methods...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197126/two-new-c-21-steroidal-glycosides-isolated-from-cynanchum-komarovii
#4
Dan Zhao, Shan-Shan Su, Shao-Fei Chen, Xiao-Jie Lu, Gang Chen, Yu-Bo Wang, Guang-Yue Su, Yue-Hu Pei
The present study was designed to further investigate the C21 steroidal glycosides in Cynanchum plants. Two new steroidal glycosides based on a 13, 14:14, 15-disecopregnane-type aglycone, komaroside P (1) and komaroside Q (2), together with three known compounds (3-5) were isolated from the whole herbs of Cynanchum komarovii. The aglycones of compounds 1 and 2 were two new disecopregnane. Their structures were elucidated on the basis of 1D, 2D NMR spectroscopic data and acid hydrolysis. All the compounds (1-5) showed potent inhibitory activities against human leukemia cell lines (HL-60) with IC50 values ranging from 16...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197125/1-methoxycarbony-%C3%AE-carboline-from-picrasma-quassioides-exerts-anti-angiogenic-properties-in-huvecs-in-vitro-and-zebrafish-embryos-in-vivo
#5
Qing-Hua Lin, Wei Qu, Jian Xu, Feng Feng, Ming-Fang He
Angiogenesis is a crucial process in the development of inflammatory diseases, including cancer, psoriasis and rheumatoid arthritis. Recently, several alkaloids from Picrasma quassioides had been screened for angiogenic activity in the zebrafish model, and the results indicated that 1-methoxycarbony-β-carboline (MCC) could effectively inhibit blood vessel formation. In this study, we further confirmed that MCC can inhibit, in a concentration-dependent manner, the viability, migration, invasion, and tube formation of human umbilical vein endothelial cells (HUVECs) in vitro, as well as the regenerative vascular outgrowth of zebrafish caudal fin in vivo...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197124/global-gene-expression-analysis-in-liver-of-db-db-mice-treated-with-catalpol
#6
Jing Liu, He-Ran Zhang, Yan-Bao Hou, Xiao-Long Jing, Xin-Yi Song, Xiu-Ping Shen
Catalpol, a major bioactive component from Rehmannia glutinosa, which has been used to treat diabetes. The present study was designed to elucidate the anti-diabetic effect and mechanism of action for catalpol in db/db mice. The db/db mice were randomly divided into six groups (10/group) according to their blood glucose levels: db/db control, metformin (positive control), and four dose levels of catalpol treatment (25, 50, 100, and 200 mg·kg-1 ), and 10 db/m mice were used as the normal control. All the groups were administered orally for 8 weeks...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197123/quercetin-modulates-iron-homeostasis-and-inos-expression-of-splenic-macrophages-in-a-rat-model-of-iron-deficiency-anemia
#7
Maryam Mazhar, Nurul Kabir, Shabana U Simjee
Iron deficiency anemia is one of the most common micronutrient deficient conditions around the globe with various consequences, including the weakened immune system. Quercetin is widely distributed bioflavonoid; it has been debated for its dual roles in iron regulation. Quercetin-iron interaction in the body is a complex mechanism which has not been completely understood. The present study aimed to investigate the effect of quercetin on iron supplementation in iron deficiency anemia and on iNOS expression in splenic macrophages...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197122/hypolipidemic-effect-of-sipi-7623-a-derivative-of-an-extract-from-oriental-wormwood-through-farnesoid-x-receptor-antagonism
#8
Yi-Fang Deng, Xiao-Ling Huang, Mei Su, Peng-Xia Yu, Zhen Zhang, Quan-Hai Liu, Guo-Ping Wang, Min-Yu Liu
Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily of ligand-activated transcription factors. As a metabolic regulator, FXR plays key roles in bile acid and cholesterol metabolism and lipid and glucose homeostasis. Therefore, FXR is a potential drug target for several metabolic syndromes, especially those related to lipidemia disorders. In the present study, we identified small molecule SIPI-7623, a derivative of an extract from Oriental wormwood (Artemisia capillaris), and found that it specifically upregulated the expression of cholesterol-7-alpha-hydroxylase (CYP7A1), downregulated the expression of sterol-regulatory element-binding protein 1c (SREBP-1c) in the liver, and inhibited the expression of ileal bile acid binding-protein (IBABP) in the ileum of rats...
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30197121/application-of-alkaloids-in-reversing-multidrug-resistance-in-human-cancers
#9
REVIEW
Meng Wang, Ze-Fa Liu, Hua Tang, Bao-An Chen
Multidrug resistance (MDR) in human cancer is one of greatest challenges in cancer therapy. Natural products, especially the alkaloids, exert reversed effects on MDR with low toxicity, by interacting with various targets. In this review article, we summarize the recent progress made in the research of the main alkaloids, including classification, function, mechanism, research status, and application in reversing MDR.
August 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30080653/identification-and-screening-of-cardiac-glycosides-in-streptocaulon-griffithii-using-an-integrated-data-mining-strategy-based-on-high-resolution-mass-spectrometry
#10
Xiao-Yu Zhu, Jia-Zhuo Liu, Zhen-Huan Dong, Feng Feng, Wen-Yuan Liu
The present study was designed to develop a practical strategy to tackle the problem of lacking standard compounds and limited references for identifying structure-related compounds in Streptocaulon griffithii Hook. f., especially those in trace concentrations, with a focus on antitumor activity. The cardiac glycosides (CGs)-enriched part was determined using in vitro bioactive assays in three cancer cell lines and then isolated using macroporous resins. The MS and MS/MS data were acquired using a high performance liquid chromatography coupled with hybrid quadrupole-time of flight (HPLC-Q-TOF-MS) system...
July 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30080652/identification-and-characterization-of-major-constituents-in-juglans-mandshurica-using-ultra-performance-liquid-chromatography-coupled-with-time-of-flight-mass-spectrometry-uplc-esi-q-tof-ms
#11
Jin-Hai Huo, Xiao-Wei DU, Guo-Dong Sun, Wen-Ting Dong, Wei-Ming Wang
The present study was designed to identify and characterize the major constituents in Juglans mandshurica Maxim. A simple, efficient and sensitive ultra performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-ESI-Q-TOF/MS) method was established and validated under positive and negative ion modes. The separation was performed on a Waters ACQUITY UPLC BEH C18 column (2.1 mm × 100 mm, 1.7 μm) by gradient elution with a mobile phase (Phase A: 0.1% aqueous formic acid solution, Phase B: 0...
July 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30080651/identification-of-active-compound-combination-contributing-to-anti-inflammatory-activity-of-xiao-cheng-qi-decoction-via-human-intestinal-bacterial-metabolism
#12
Xing-Yan Liu, Li Li, Xue-Qing Li, Bo-Yang Yu, Ji-Hua Liu
Human intestinal bacteria play an important role in the metabolism of herbal medicines, leading to the variations in their pharmacological profile. The present study aimed to investigate the metabolism of Xiao-Cheng-Qi decoction (XCQD) by human intestinal bacteria and to discover active component combination (ACC) contributing to the anti-inflammatory activity of XCQD. The water extract of XCQD was anaerobically incubated with human intestinal bacteria suspensions for 48 h at 37 °C. A liquid chromatography-hybrid quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) method was performed for identification of the metabolites...
July 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30080650/carbazole-alkaloids-isolated-from-the-branch-and-leaf-extracts-of-clausena-lansium
#13
Wen-Wen Peng, Li-Xia Zheng, Chang-Jiu Ji, Xu-Gen Shi, Zhong-Hua Xiong, Xin-Chen Shangguan
The present study carried out a phytochemical investigation of the methanol extract of the branches and leaves of Clausena lansium and afforded nine carbazole alkaloids (compounds 1-9) including two new carbazole alkaloids, claulansiums A and B (compounds 1 and 2). The new compounds were elucidated on the basis of extensive spectroscopic data (MS, NMR, IR, and UV) and the known compounds were identified by comparing spectroscopic data with those reported in literature. All the isolated compounds were tested for their cytotoxic activity against A549 and Hela cancer cell lines...
July 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30080649/two-new-phenolic-glycosides-isolated-from-ginkgo-seeds
#14
Shu-Jun Shan, Pan-Pan Zhang, Jun Luo, Ling-Yi Kong
Two new phenolic glycosides, 7S, 8R-urolignoside-9'-O-β-D-glucoside (1) and scrophenoside G (2), were isolated and identified from the seeds of Ginkgo biloba L., a famous traditional medicine and functional food around the world. Their structures were elucidated by spectroscopic methods (1D and 2D NMR, HR-ESI-MS, and CD), and the comparisons of spectroscopic data with the reported values in the literature.
July 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30080648/new-steroidal-alkaloid-and-furostanol-glycosides-isolated-from-solanum-lyratum-with-cytotoxicity
#15
Yun-Ling Xu, Jia Lv, Wei-Fang Wang, Yue Liu, Ya-Juan Xu, Tun-Hai Xu
Two previously undescribed steroidal compounds, 16, 23-epoxy-22, 26-epimino-cholest-22(N), 23, 25(26)-trien-3β-ol-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (1) and 26-O-β-D-glucopyranosyl-(25R)-5α-furost-20(22)-en-3β, 26-diol (2), together with 7 known ones including 26-O-β-D-glucopyranosyl-(25R)-5, 20(22)-dien-furost-3β, 26-diol (3), (25R)-5-en-spirost-3β-ol-O-β-D-glucopyranosyl-(1→4)-[α-L-rhmanopyranosyl-(1→2)]-β-D-galactopyranoside (4), funkioside D (5), aspidistrin (6), tigogenin-3-O-β-D-lucotrioside (7), desglucolanatigonin II (8), and degalactotigonin (9), were isolated from Solanum lyratum Thunb...
July 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30080647/moutan-cortex-radicis-inhibits-the-nigrostriatal-damage-in-a-6-ohda-induced-parkinson-s-disease-model
#16
Yeong-Gon Choi, Yeon-Mi Hong, Li-Hua Kim, Sujung Yeo, Sabina Lim
The traditionally used oriental herbal medicine Moutan Cortex Radicis [MCR; Paeonia Suffruticosa Andrews (Paeoniaceae)] exerts anti-inflammatory, anti-spasmodic, and analgesic effects. In the present study, we investigated the therapeutic effects of differently fractioned MCR extracts in a 6-hydroxydopamine (OHDA)-induced Parkinson's disease model and neuro-blastoma B65 cells. Ethanol-extracted MCR was fractionated by n-hexane, butanol, and distilled water. Adult Sprague-Dawley rats were treated first with 20 μg of 6-OHDA, followed by three MCR extract fractions (100 or 200 mg·kg-1 ) for 14 consecutive days...
July 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30080646/inhibitory-effect-of-different-dendrobium-species-on-lps-induced-inflammation-in-macrophages-via-suppression-of-mapk-pathways
#17
Qiang Zeng, Chun-Hay Ko, Wing-Sum Siu, Kai-Kai Li, Chun-Wai Wong, Xiao-Qiang Han, Liu Yang, Clara Bik-San Lau, Jiang-Miao Hu, Ping-Chung Leung
Dendrobii Caulis (DC), named 'Shihu' in Chinese, is a precious herb in traditional Chinese medicine. It is widely used to nourish stomach, enhance body fluid production, tonify "Yin" and reduce heat. More than thirty Dendrobium species are used as folk medicine. Some compounds from DC exhibit inhibitory effects on macrophage inflammation. In the present study, we compared the anti-inflammatory effects among eight Dendrobium species. The results provided evidences to support Dendrobium as folk medicine, which exerted its medicinal function partially by its inhibitory effects on inflammation...
July 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30047469/optimization-and-characterization-of-deoxypodophyllotoxin-loaded-mpeg-pdlla-micelles-by-central-composite-design-with-response-surface-methodology
#18
Ying-Lan Yu, Ya-Nan Li, Yong Zhang, Ru-Ning Sun, Jia-Sheng Tu, Yan Shen
The therapeutic application of deoxypodophyllotoxin (DPT) is limited due to its poor water solubility and stability. In the present study, the micelles assembled by the amphiphilic block copolymers (mPEG-PDLLA) were constructed to improve the solubility and safety of DPT for their in vitro and in vivo application. The central composite design was utilized to develop the optimal formulation composed of 1221.41 mg mPEG-PDLLA, the weight ratio of 1 : 4 (mPEG-PDLLA : DPT), 30 mL hydration volume and the hydration temperature at 40 °C...
June 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30047468/chemical-constituents-and-antibacterial-activities-of-aspidistra-typica
#19
Xiao-Xia Liang, Lin-Xi Kong, Wen-Bo Fei, Min He
In the present investigation, we carried a phytochemical study of an ethanol-soluble extract from the root barks of Aspidistra typica Baill., a traditional food and herb medicine, leading to the isolation of four different kinds of compounds, including one benzene substituted coumarin, two organic phosphonic compounds, and one xanthone. The novel benzene substituted coumarin typicacoumarin A (1) was a new type of coumarin, and the two new organic phosphonic compounds, typicalphosphine A (2) and typicalphosphine B (3) were isolated for the first time, and their structures were elucidated by spectral techniques, viz...
June 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/30047467/scopariusols-l-t-nine-new-ent-kaurane-diterpenoids-isolated-from-isodon-scoparius
#20
Hua-Yi Jiang, Xiao-Nian Li, Han-Dong Sun, Hong-Bin Zhang, Pema-Tenzin Puno
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 0.6 μmol·L-1 .
June 2018: Chinese Journal of Natural Medicines
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