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Chinese Journal of Natural Medicines

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https://www.readbyqxmd.com/read/28629539/uplc-esi-qtof-ms-based-metabolomics-survey-on-the-toxicity-of-triptolide-and-detoxication-of-licorice
#1
Zhuo Wang, Jian-Qun Liu, Jin-Di Xu, He Zhu, Ming Kong, Guo-Hua Zhang, Su-Min Duan, Xiu-Yang Li, Guang-Fu Li, Li-Fang Liu, Song-Lin Li
Triptolide (TP) from Tripterygium wilfordii has been demonstrated to possess anti-inflammatory, immunosuppressive, and anticancer activities. TP is specially used for the treatment of awkward rheumatoid arthritis, but its clinical application is confined by intense side effects. It is reported that licorice can obviously reduce the toxicity of TP, but the detailed mechanisms involved have not been comprehensively investigated. The current study aimed to explore metabolomics characteristics of the toxic reaction induced by TP and the intervention effect of licorice water extraction (LWE) against such toxicity...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629538/bioassay-guided-isolation-of-saikosaponins-with-agonistic-activity-on-5-hydroxytryptamine-2c-receptor-from-bupleurum-chinense-and-their-potential-use-for-the-treatment-of-obesity
#2
Chang-Li Sun, Chang-An Geng, Xiao-Yan Huang, Yun-Bao Ma, Xiao-Hong Zheng, Tong-Hua Yang, Xing-Long Chen, Xiu-Juan Yin, Xue-Mei Zhang, Ji-Jun Chen
5-Hydroxytryptamine 2C (5-HT2C) receptor is one of the major targets of anti-obesity agents, due to its role in regulation of appetite. In the present study, the 70% EtOH extract of the roots of Bupleurum chinense was revealed to have agonistic activity on 5-HT2C receptor, and the subsequent bioassay-guided isolation led to identification of several saikosaponins as the active constituents with 5-HT2C receptor agonistic activity in vitro and anti-obesity activity in vivo. The new compound, 22-oxosaikosaponin d (1), was determined by extensive spectroscopic analyses (HR-ESI-MS, IR, and 1D and 2D NMR)...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629537/triterpenoid-saponins-from-the-roots-of-cyathula-officinalis-and-their-inhibitory-effects-on-nitric-oxide-production
#3
Yun-Tao Jiang, Wen-Jing Yan, Chu-Lu Qi, Ji-Qin Hou, Yan-Ying Zhong, Hui-Jun Li, Hao Wang, Ping Li
The present study was designed to investigate the chemical constituents of the roots of Cyathula officinalis. Compounds were isolated by silica gel, Sephadex LH-20, ODS column chromatography, and preparative HPLC. Their structures were determined on the basis of 1D and 2D NMR techniques, mass spectrometry, and chemical methods. One new oleanane-type triterpenoid saponin, 28-O-[α-L-rhamnopyranosyl-(1→3)-β-D-glucuronopyranosyl-(1→3)-β-D-glucopyranosyl] hederagenin (1), was isolated from the roots of Cyathula officinalis...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629536/two-new-diterpenoid-lactones-isolated-from-andrographis-paniculata
#4
Gui-Yang Wang, Ting Wen, Fei-Fei Liu, Hai-Yan Tian, Fan Chun-Lin, Xiao-Jun Huang, Wen-Cai Ye, Ying Wang
In the present study, two new diterpenoid lactones, 3-deoxy-andrographoside (1) and 14-deoxy-15-methoxy-andrographolide (2), were isolated from the aerial parts of Andrographis paniculata. Their structures were elucidated by combination of NMR, MS, and chemical methods. The configurations of 1 and 2 were established based on the analysis of ROESY data and single crystal X-ray diffraction experiment.
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629535/enhanced-absorption-and-inhibited-metabolism-of-emodin-by-2-3-5-4-tetrahydroxystilbene-2-o-%C3%AE-d-glucopyranoside-possible-mechanisms-for-polygoni-multiflori-radix-induced-liver-injury
#5
Qiong Yu, Li-Long Jiang, Na Luo, Ya-Xi Fan, Jiang Ma, Ping Li, Hui-Jun Li
Polygoni Multiflori Radix (PMR) has been commonly used as a tonic in China for centuries. However, PMR-associated hepatotoxicity is becoming a safety issue. In our previous in vivo study, an interaction between stilbenes and anthraquinones has been discovered and a hypothesis is proposed that the interaction between stilbene glucoside-enriching fraction and emodin may contribute to the side effects of PMR. To further support our previous in vivo results in rats, the present in vitro study was designed to evaluate the effects of 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside (TSG) on the cellular absorption and human liver microsome metabolism of emodin...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629534/heparin-derived-oligosaccharide-inhibits-vascular-intimal-hyperplasia-in-balloon-injured-carotid-artery
#6
Jie-Ru Liu, Jie Wu, Xin-Chao Yu, Xuan Qian, Rui Xiong, Hui-Fang Wang, Dan-Feng Yu, Fei-Fei Liu, Shu-Ying He
The aims of the present study were to determine the effects of heparin-derived oligosaccharides (HDOs) on vascular intimal hyperplasia (IH) in balloon-injured carotid artery and to elucidate the underlying mechanisms of action. An animal model was established by rubbing the endothelia within the common carotid artery (CCA) in male rabbits. The rabbits were fed a high-cholesterol diet. Arterial IH was determined by histopathological changes to the CCA. Serum lipids were detected using an automated biochemical analysis...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629533/design-of-new-traditional-chinese-medicine-herbal-formulae-for-treatment-of-type-2-diabetes-mellitus-based-on-network-pharmacology
#7
Rui-Feng Hu, Xiao-Bo Sun
In the present study, 28 Chinese medicinal herbs belonging to traditional Chinese medicine (TCM) for the treatment of type 2 diabetes were selected to explore the application of network pharmacology in developing new Chinese herbal medicine formulae for the treatment of type 2 diabetes mellitus (T2DM). These herbs have the highest appearance rate in the literature, and their compounds are listed. The human protein-protein interaction network and the T2DM disease protein interaction network were constructed...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629532/hypaconitine-inhibits-tgf-%C3%AE-1-induced-epithelial-mesenchymal-transition-and-suppresses-adhesion-migration-and-invasion-of-lung-cancer-a549-cells
#8
Hai-Tao Feng, Wen-Wen Zhao, Jin-Jian Lu, Yi-Tao Wang, Xiu-Ping Chen
Epithelial-mesenchymal transition (EMT) has been implicated in tumor invasion and metastasis and provides novel strategies for cancer therapy. Hypaconitine (HpA), a diester-diterpenoid alkaloid isolated from the root of the Aconitum species, exhibits anti-inflammatory, analgesic, and especially, cardiotoxic activities. Here, we reported the anti-metastatic potentials of HpA in transforming growth factor-β1 (TGF-β1)-induced EMT in lung cancer A549 cells. The cytotoxic effect of HpA was determined by MTT assay...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629531/survey-of-traditional-dai-medicine-reveals-species-confusion-and-potential-safety-concerns-a-case-study-on-radix-clerodendri-japonicum
#9
Bao-Zhong Duan, Hai-Lan Fang, Xi-Wen Li, Lin-Fang Huang, Wang Ping, Shi-Lin Chen
The adulteration of herbal products is a threat to consumer safety. In the present study, we surveyed the species composition of commercial Radix Clerodendri Japonicum products using DNA barcoding as a supervisory method. A reference database for plant-material DNA-barcode was successfully constructed with 48 voucher samples from 12 Clerodendrum species. The database was used to identify 27 Radix Clerodendri Japonicum decoction piece samples purchased from drug stores and hospitals. The DNA sequencing results revealed that only 1 decoction piece (3...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28629530/novel-natural-product-therapeutics-targeting-both-inflammation-and-cancer
#10
Jiangjiang Qin, Wei Wang, Ruiwen Zhang
Inflammation is recently recognized as one of the hallmarks of human cancer. Chronic inflammatory response plays a critical role in cancer development, progression, metastasis, and resistance to chemotherapy. Conversely, the oncogenic aberrations also generate an inflammatory microenvironment, enabling the development and progression of cancer. The molecular mechanisms of action that are responsible for inflammatory cancer and cancer-associated inflammation are not fully understood due to the complex crosstalk between oncogenic and pro-inflammatory genes...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28558875/characterization-and-quantitation-of-aristolochic-acid-analogs-in-different-parts-of-aristolochiae-fructus-using-uhplc-q-tof-ms-and-uhplc-qqq-ms
#11
Wen-Wen Mao, Wen Gao, Zhi-Tao Liang, Ping Li, Zhong-Zhen Zhao, Hui-Jun Li
Aristolochiae Fructus, a Chinese herbal medicine derived from the fruit of Aristolochia contorta Bge., contains nephrotoxic aristolochic acid analogues (AAAs). According to ancient medical texts, various medicinal parts of the fruit of A. contorta were ever used. In order to reveal which part could be safely and effectively used, it is necessary to analyze the chemical profiles of different medicinal parts. Herein we compared the chemical compositions and determined aristolochic acid I (AA-I) and aristolochic acid II (AA-II) in the four parts viz...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28558874/identification-of-c-geranylated-flavonoids-from-paulownia-catalpifolia-gong-tong-fruits-by-hplc-dad-esi-ms-ms-and-their-anti-aging-effects-on-2bs-cells-induced-by-h2o2
#12
Wen-Zhao Tang, Ying-Ai Wang, Tian-Yang Gao, Xiao-Jing Wang, Yun-Xue Zhao
The fruits of Paulownia catalpifolia Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new C-geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new C-geranylated flavone, paucatalinone C (1) and five known C-geranylated flavanones (2-6) were isolated. In addition, a total of 34 C-geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH2Cl2 extract of P...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28558873/mechanism-for-ginkgolic-acid-15-1-induced-mdck-cell-necrosis-mitochondria-and-lysosomes-damages-and-cell-cycle-arrest
#13
Qing-Qing Yao, Zhen-Hua Liu, Ming-Cheng Xu, Hai-Hong Hu, Hui Zhou, Hui-Di Jiang, Lu-Shan Yu, Su Zeng
Ginkgolic acids (GAs), primarily found in the leaves, nuts, and testa of ginkgo biloba, have been identified with suspected allergenic, genotoxic and cytotoxic properties. However, little information is available about GAs toxicity in kidneys and the underlying mechanism has not been thoroughly elucidated so far. Instead of GAs extract, the renal cytotoxicity of GA (15 : 1), which was isolated from the testa of Ginkgo biloba, was assessed in vitro by using MDCK cells. The action of GA (15 : 1) on cell viability was evaluated by the MTT and neutral red uptake assays...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28558872/nuclear-magnetic-resonance-based-metabolomic-differentiation-of-different-astragali-radix
#14
Ai-Ping Li, Zhen-Yu Li, Ting-Li Qu, Xue-Mei Qin, Guan-Hua DU
Astragali Radix (AR) is one of the most popular herbal medicines in traditional Chinese medicine (TCM). Wild AR is believed to be of high quality, and substitution with cultivated AR is frequently encountered in the market. In the present study, two types of ARs (wild and cultivated) from Astragalus membranaceus (Fisch.) Bge. and A. membranaceus var. mongholicus (Bge.) Hsiao, growing in different regions of China, were analyzed by NMR profiling coupled with multivariate analysis. Results showed that both could be differentiated successfully and cultivation patterns or growing years might have greater impact on the metabolite compositions than the variety; the metabolites responsible for the separation were identified...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28558871/a-lipophilic-prodrug-of-danshensu-preparation-characterization-and-in-vitro-and-in-vivo-evaluation
#15
Xue-Jiao Guo, Xue-Jiao Fan, Bin Qiao, Zhi-Qiang Ge
Danshensu [3-(3, 4-dihydroxyphenyl) lactic acid, DSS], one of the significant cardioprotective components, is extracted from the root of Salvia miltiorrhiza. In the present study, an ester prodrug of Danshensu (DSS), palmitoyl Danshensu (PDSS), was synthesized with the aim to improve its oral bioavailability and prolong its half-life. The in vitro experiments were carried out to evaluate the physicochemical properties and stability of PDSS. Although the solubility of PDSS in water was only 0.055 mg·mL(-1), its solubility in FaSSIF and FeSSIF reached 4...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28558870/synthesis-and-evaluation-of-2-cyano-3-12-dioxooleana-1-9-11-en-28-oate-13%C3%AE-28-olide-as-a-potent-anti-inflammatory-agent-for-intervention-of-lps-induced-acute-lung-injury
#16
Yi Mou, Yan-Lin Jian, Tong Chen, Zhang-Jian Huang, Yi-Xue Qiao, Si-Xun Peng, Da-Yong Zhang, Hui Ji, Yi-Hua Zhang
The present study was designed to synthesize 2-Cyano-3, 12-dioxooleana-1, 9(11)-en-28-oate-13β, 28-olide (1), a lactone derivative of oleanolic acid (OA) and evaluate its anti-inflammatory activity. Compound 1 significantly diminished nitric oxide (NO) production and down-regulated the mRNA expression of iNOS, COX-2, IL-6, IL-1β, and TNF-α in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Further in vivo studies in murine model of LPS-induced acute lung injury (ALI) showed that 1 possessed more potent protective effects than the well-known anti-inflammatory drug dexamethasone by inhibiting myeloperoxidase (MPO) activity, reducing total cells and neutrophils, and suppressing inflammatory cytokines expression, and thus ameliorating the histopathological conditions of the injured lung tissue...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28558869/triptolide-reduces-prostate-size-and-androgen-level-on-testosterone-induced-benign-prostatic-hyperplasia-in-sprague-dawley-rats
#17
Yu-Rong Wang, Yuan Xu, Zhen-Zhou Jiang, Lu-Yong Zhang, Tao Wang
Benign prostatic hyperplasia (BPH) is an age-related disease of unknown etiology, characterized by prostatic enlargement coincident with distinct alterations in tissue histology. In the present study, we investigated whether triptolide can prevent testosterone-induced prostatic hyperplasia in rats. Castration was performed via the scrotal route after urethane aesthesia. BPH was induced in experimental groups by daily subcutaneous injections of testosterone propionate (TP) for two weeks. Triptolide was administered daily by oral gavage at a dose of 100 and 50 μg·kg(-1) for 2 weeks, along with the TP injections...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28558868/anti-hyperuricemic-and-anti-inflammatory-actions-of-vaticaffinol-isolated-from-dipterocarpus-alatus-in-hyperuricemic-mice
#18
Yu-Sheng Chen, Chao-Jun Chen, Wei Yan, Hui-Ming Ge, Ling-Dong Kong
The present study was designed to examine the anti-hyperuricemic and anti-inflammatory effects and possible mechanisms of vaticaffinol, a resveratrol tetramer isolated from ethanol extracts of Dipterocarpus alatus, in oxonate-induced hyperuricemic mice. At 1 h after 250 mg·kg(-1) potassium oxonate was given, vaticaffinol at 20, 40, and 60 mg·kg(-1) was intragastrically administered to hyperuricemic mice once daily for seven consecutive days. Vaticaffinol significantly decreased serum uric acid levels and improved kidney function in hyperuricemic mice...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28558867/apigenin-s-anticancer-properties-and-molecular-mechanisms-of-action-recent-advances-and-future-prospectives
#19
Jumah Masoud Mohammad Salmani, Xiao-Ping Zhang, Joe Antony Jacob, Bao-An Chen
Cancer is a major health concern and leading burden on economy worldwide. An increasing effort is devoted to isolation and development of plant-derived dietary components as effective chemo-preventive products. Phytochemical compounds from natural resources such as fruits and vegetables are responsible for decreasing the risk of certain cancers among the consuming populations. Apigenin, a flavonoid phytochemical found in many kinds of fruits and vegetables, has been shown to exert significant biological effects, such as anti-oxidant, anti-inflammatory and most particularly anti-neoplastic properties...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28527517/holistic-evaluation-of-san-huang-tablets-using-a-combination-of-multi-wavelength-quantitative-fingerprinting-and-radical-scavenging-assays
#20
Yan Wang, Guo-Xiang Sun, Yang Jin, Xiu-Man Xie, Ying-Chun Liu, Di-Di Ma, Jing Zhang, Jia-Yue Gao, Yan-Fei Li
The present study was designed to establish a multi-wavelength quantitative fingerprinting method for San-Huang Tablets (SHT), a widely used and commercially available herbal preparation, where high performance liquid chromatography (HPLC) with a diode array detector (DAD) was employed to obtain the fingerprint profiles. A simple linear quantitative fingerprint method (SLQFM) coupled with multi-ingredient simultaneous determination was developed to evaluate the quality consistency of the tested samples qualitatively and quantitatively...
April 2017: Chinese Journal of Natural Medicines
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