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Chinese Journal of Natural Medicines

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https://www.readbyqxmd.com/read/27914532/identification-of-antioxidant-activity-of-two-new-aromatic-ring-butyrolactone-derivatives-from-dictamnus-dasycarpus-turcz
#1
Li-Na Guo, Yue-Hu Pei, Fei-Xiang Xie, Lei Liu, Huan Cong, Hong-Xia Cui, Xiao-Li Wang, Wen-Jing Li, Bai-Yu Jian, Ji-Cheng Liu
The present study carried out a phytochemical investigation on the root barks of Dictamnus dasycarpus Turcz, leading to the isolation and characterization of two new aromatic ring butyrolactone derivatives, dasycarpusphenol acid A (1) and dasycarpusphenol acid B (2). Their structures were elucidated by using spectroscopic techniques and HR-FAB-MS. Compounds 1 and 2 exhibited antioxidant activity, with their IC50 values being 28.95 and 41.76 mg·mL(-1), respectively.
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27914531/isolation-and-characterization-of-two-new-2-isobutylmalates-from-bletilla-striata
#2
Huan-Yu Guan, Yan Yan, Yong-Lin Wang, Ai-Min Wang, Jun-Hong Liu, Xun He, Yong-Jun Li, Yong Huang, Shang-Gao Liao
The present study isolated 17 compounds from the tubers of Bletilla striata (Orchidaceae), using various chromatographic techniques. Their structures were identified based on their physical-chemical properties and spectroscopic analyses. Among them, two new 2-isobutylmalates, named bletimalates A (1) and B (2), together with other fifteen known compounds (3-17), were isolated and identified. Additionally, compounds 3, 4, and 8 were isolated from this plant for the first time.
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27914530/isochlorogenic-acid-a-affects-p450-and-ugt-enzymes-in-vitro-and-in-vivo
#3
Jing Wang, Hong Wang, Ying Peng, Guang-Ji Wang, Hai-Ping Hao
Isochlorogenic acid A (ICQA), which has anti-inflammatory, hepatoprotective, and antiviral properties, is commonly presented in fruits, vegetables, coffee, plant-based food products, and herbal medicines. These herbal medicines are usually used in combination with other medicines in the clinic. However, little is known about the regulatory effects of ICQA on drug-metabolizing enzymes and the herb-drug interactions. In the present study, we evaluated the inhibitory potentials of ICQA on CYP1A2, CYP2C9, CYP2C19, CYP3A4, CYP2D6, and CYP2E1 in vitro based on a cocktail approach...
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27914529/agglutinin-isolated-from-arisema-heterophyllum-blume-induces-apoptosis-and-autophagy-in-a549-cells-through-inhibiting-pi3k-akt-pathway-and-inducing-er-stress
#4
Li-Xing Feng, Peng Sun, Tian Mi, Miao Liu, Wang Liu, Si Yao, Yi-Min Cao, Xiao-Lu Yu, Wan-Ying Wu, Bao-Hong Jiang, Min Yang, De-An Guo, Xuan Liu
Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis (RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema heterophyllum Blume (AHA) and explore the possible mechanisms in human non-small-cell lung cancer A549 cells. AHA with purity up to 95% was isolated and purified from Arisaema heterophyllum Blume using hydrophobic interaction chromatography...
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27914528/food-advanced-glycation-end-products-aggravate-the-diabetic-vascular-complications-via-modulating-the-ages-rage-pathway
#5
Xing Lv, Gao-Hong Lv, Guo-Ying Dai, Hong-Mei Sun, Hui-Qin Xu
The aim of this study was to investigate the effects of high-advanced glycation end products (AGEs) diet on diabetic vascular complications. The Streptozocin (STZ)-induced diabetic mice were fed with high-AGEs diet. Diabetic characteristics, indicators of renal and cardiovascular functions, and pathohistology of pancreas, heart and renal were evaluated. AGEs/RAGE/ROS pathway parameters were determined. During the experiments, the diabetic mice exhibited typical characteristics including weight loss, polydipsia, polyphagia, polyuria, high-blood glucose, and low-serum insulin levels...
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27914527/prophylactic-effects-of-alkaloids-from-ba-lotus-seeds-on-l-nna-induced-hypertension-in-mice
#6
Peng Sun, Kai Zhu, Cun Wang, Wei-Wei Liu, De-Guang Peng, Xin Zhao
Alkaloids from Ba lotus seeds (ABLS) are a kind of important functional compounds in lotus seeds. The present study was designed to determine its hypertension prophylactic effects in the L-NNA-induced mouse hypertension model. The mice were treated with ABLS, the serum and tissues levels of NO, MDA, ET-1, VEGF, and CGRP were determined using the experimental kits, the mRNA levels of various genes in the heart muscle and blood vessel tissues were further determined by RT-PCR assay. ABLS could reduce the systolic blood pressure (SBP), mean blood pressure (MBP), and diastolic blood pressure (DBP), compared to that of the model control group...
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27914526/jiawei-erzhiwan-improves-menopausal-metabolic-syndrome-by-enhancing-insulin-secretion-in-pancreatic-%C3%AE-cells
#7
Xiao-Meng Wan, Mu Zhang, Pei Zhang, Zhi-Shen Xie, Feng-Guo Xu, Ping Zhou, Shi-Ping Ma, Xiao-Jun Xu
Menopausal metabolic syndrome (MMS) is a series of syndrome caused by ovarian function decline and hormone insufficiency, and is a high risk factor for cardiovascular diseases (CVD) and type II diabetes mellitus (T2DM). Erzhiwan (EZW), composed of Herba Ecliptae and Fructus Ligustri Lucidi, is a traditional Chinese herbal formula that has been used to treat menopausal syndrome for many years. We added Herba Epimedii, Radix Rehmanniae, and Fructus Corni into EZW, to prepare a new formula, termed Jiawei Erzhiwan (JE)...
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27914525/protective-effects-of-huanglian-wendan-decoction-aganist-cognitive-deficits-and-neuronal-damages-in-rats-with-diabetic-encephalopathy-by-inhibiting-the-release-of-inflammatory-cytokines-and-repairing-insulin-signaling-pathway-in-hippocampus
#8
Yue-Bi Li, Wei-Hua Zhang, Hua-Dong Liu, Zhou Liu, Shi-Ping Ma
Huanglian Wendan decoction (HLWDD) has been used for the treatment of symptom of "Re", one of major causes in diabetes and metabolic disorders, according to the theory of traditional Chinese medicine. The present study aimed at investigating the cerebral protective effects of HLWDD on diabetic encephalopathy (DE), one of the major diabetic complications. The effects of HLWDD and metformin were analyzed in the streptozocin (STZ) + high-glucose-fat (HGF) diet-induced DE rats by gastric intubation. In the present study, the effects of HLWDD on cognition deficits were investigated after 30-day intervention at two daily dose levels (3 and 6 g·kg(-1))...
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27914524/the-phenylalanine-ammonia-lyase-gene-family-in-isatis-indigotica-fort-molecular-cloning-characterization-and-expression-analysis
#9
Rui-Fang Ma, Qian-Zi Liu, Ying Xiao, Lei Zhang, Qing Li, Jun Yin, Wan-Sheng Chen
Phenolic compounds, metabolites of the phenylpropanoid pathway, play an important role in the growth and environmental adaptation of many plants. Phenylalanine ammonia-lyase (PAL) is the first key enzyme of the phenylpropanoid pathway. The present study was designed to investigate whether there is a multi-gene family in I. Indigotic and, if so, to characterize their properties. We conducted a comprehensive survey on the transcription profiling database by using tBLASTn analysis. Several bioinformatics methods were employed to perform the prediction of composition and physicochemical characters...
November 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27667518/pharmacokinetic-profiles-of-falcarindiol-and-oplopandiol-in-rats-after-oral-administration-of-polyynes-extract-of-oplopanax-elatus
#10
Wei Sun, Yi-Sheng He, Ling-Hui Xu, Bi-Ying Zhang, Lian-Wen Qi, Jie Yang, Ping Li, Xiao-Dong Wen
Polyynes, such as facarindiol (FAD) and oplopandiol (OPD), are responsible for anticancer activities of Oplopanax elatus (O. elatus). A novel approach to pharmacokinetics determination of the two natural polyynes in rats was developed and validated using a liquid chromatography-electrospray ionization-mass spectrometry (LC-MS) method. Biosamples were prepared by liquid-liquid extraction using ethyl acetate/n-hexane (V : V = 9 : 1) and the analytes were eluted on an Agilent ZORBAX Eclipse Plus C18 threaded column (4...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27667517/nano-lc-esi-ms-ms-analysis-of-proteins-in-dried-sea-dragon-solenognathus-hardwickii-and-bioinformatic-analysis-of-its-protein-expression-profiling
#11
Dong-Mei Zhang, Li-Xing Feng, Lu Li, Miao Liu, Bao-Hong Jiang, Min Yang, Guo-Qiang Li, Wan-Ying Wu, De-An Guo, Xuan Liu
The sea dragon Solenognathus hardwickii has long been used as a traditional Chinese medicine for the treatment of various diseases, such as male impotency. To gain a comprehensive insight into the protein components of the sea dragon, shotgun proteomic analysis of its protein expression profiling was conducted in the present study. Proteins were extracted from dried sea dragon using a trichloroacetic acid/acetone precipitation method and then separated by SDS-PAGE. The protein bands were cut from the gel and digested by trypsin to generate peptide mixture...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27667516/establishment-and-reliability-evaluation-of-the-design-space-for-hplc-analysis-of-six-alkaloids-in-coptis-chinensis-huanglian-using-bayesian-approach
#12
Sheng-Yun Dai, Bing Xu, Yi Zhang, Jian-Yu Li, Fei Sun, Xin-Yuan Shi, Yan-Jiang Qiao
Coptis chinensis (Huanglian) is a commonly used traditional Chinese medicine (TCM) herb and alkaloids are the most important chemical constituents in it. In the present study, an isocratic reverse phase high performance liquid chromatography (RP-HPLC) method allowing the separation of six alkaloids in Huanglian was for the first time developed under the quality by design (QbD) principles. First, five chromatographic parameters were identified to construct a Plackett-Burman experimental design. The critical resolution, analysis time, and peak width were responses modeled by multivariate linear regression...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27667515/two-new-limonoids-isolated-from-the-fuits-of-melia-toosendan
#13
Qiong Zhang, Qing-Hong Zheng, Jing-Yu Liang, Qing-Shan Li, Zhi-Da Min
In the present study, two new limonoids, 1α, 7α-dihydroxyl-3α-acetoxyl-12α-ethoxylnimbolinin (1) and 1α-tigloyloxy-3α-acetoxyl-7α-hydroxyl-12β-ethoxylnimbolinin (2), together with other four known limonoids (3-6), were isolated from the fruits of Melia toosendan. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and ESI-MS) and comparisons with the data reported in the literature. The isolated compounds were evaluated for their antibacterial activities. Compound 4 exhibited significant antibacterial activity against an oral pathogen, Porphyromonas gingivalis ATCC 33277, with an MIC value of 15...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27667514/a-new-biocompatible-microemulsion-increases-extraction-yield-and-bioavailability-of-andrographis-paniculata
#14
Xiao-Yan Liu, Xin Niu, Qian-Jin Feng, Xue-Zhi Yang, Dan-Wei Wang, Tong Zhao, Lei Li, Hong DU
The purpose of this study was to design and prepare a biocompatible microemulsion of Andrographis paniculata (BMAP) containing both fat-soluble and water-soluble constituents. We determined the contents of active constituents of BMAP and evaluated its bioavailability. The biocompatible microemulsion (BM), containing lecithin and bile salts, was optimized in the present study, showing a good physical stability. The mean droplet size was 19.12 nm, and the average polydispersity index (PDI) was 0.153. The contents of andrographolide and dehydroandrographolide in BMAP, as determined by high performance liquid chromatography (HPLC), were higher than that in ethanol extraction...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27667513/identification-and-characterization-of-a-novel-neuropeptide-neuropeptide-y-hs-from-leech-salivary-gland-of-haemadipsa-sylvestris
#15
Wei-Hui Liu, Yan Chen, Xue-Wei Bai, Hui-Min Yao, Xu-Guang Zhang, Xiu-Wen Yan, Ren Lai
The present study was designed to identify immunomodulatory components from the leech salivary gland of Haemadipsa sylvestris. The Sephadex G-50, Resource(TM) S column chromatography and reverse-phase high performance liquid chromatography (RP-HPLC) were used to isolate and purify the salivary gland extracts (SGE). Structural analysis of isolated compounds was based on Edman degradation and matrix assisted laser desorption ionization time-of-flight mass spectrometer (MALDI-TOF-MS). The cDNA encoding the precursor of the compound was cloned from the cDNA library of the salivary gland of H...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27667512/epimedium-koreanum-nakai-and-its-main-constituent-icariin-suppress-lipid-accumulation-during-adipocyte-differentiation-of-3t3-l1-preadipocytes
#16
Yunk-Yung Han, Mi-Young Song, Min-Sub Hwang, Ji-Hye Hwang, Yong-Ki Park, Hyo-Won Jung
Obesity is associated with a number of metabolic abnormalities such as type 2 diabetes and has become a major health problem worldwide. In the present study, we investigated the effects of Epimedium koreanum Nakai (Herba Epimedii, HE) and its main constituent icariin on the adipocyte differentiation in 3T3-L1 preadipocytes. HE extract and icariin significantly reduced lipid accumulation and suppressed the expressions of PPARγ, C/EBPα, and SREBP-1c in 3T3-L1 adipocytes. They also inhibited fatty acid synthase (FAS), acyl-Co A synthase (ACS1), and perilipin...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27667511/phenolic-acids-isolated-from-the-fungus-schizophyllum-commune-exert-analgesic-activity-by-inhibiting-voltage-gated-sodium-channels
#17
Hui-Min Yao, Gan Wang, Ya-Ping Liu, Ming-Qiang Rong, Chuan-Bin Shen, Xiu-Wen Yan, Xiao-Dong Luo, Ren Lai
The present study was designed to search for compounds with analgesic activity from the Schizophyllum commune (SC), which is widely consumed as edible and medicinal mushroom world. Thin layer chromatography (TLC), tosilica gel column chromatography, sephadex LH 20, and reverse-phase high performance liquid chromatography (RP-HPLC) were used to isolate and purify compounds from SC. Structural analysis of the isolated compounds was based on nuclear magnetic resonance (NMR). The effects of these compounds on voltage-gated sodium (NaV) channels were evaluated using patch clamp...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27667510/pharmacodynamic-study-on-insomnia-curing-effects-of-shuangxia-decoction-in-drosophila-melanogaster
#18
Zhi-Qian Zhang, Degejin, Di Geng, Qi Zhang, Yan Tian, Yuan Xi, Wen-Qi Wang, Hua-Qi Tang, Bing Xu, Hong-Ying Lin, Yi-Kun Sun
The present study aimed to establish a pharmacodynamic method using the pySolo software to explore the influence of freeze-dried powders of Shuangxia Decoction (SXD) on the sleep of normal Drosophila melanogaster and the Drosophila melanogaster whose sleep was divested by light. The dose-effect and the time-effect relationships of SXD on sleep were examined. The effect-onset concentration of SXD was 0.25%, the plateau appeared at the concentration of 2.5% and the total sleep time showed a downtrend when the concentration was greater than 2...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27667509/effects-of-angelica-dahurica-on-obesity-and-fatty-liver-in-mice
#19
Xi Lu, Zhi-Yi Yuan, Xiao-Jin Yan, Fan Lei, Jing-Fei Jiang, Xuan Yu, Xiu-Wei Yang, Dong-Ming Xing, Li-Jun DU
Angelica dahurica (A. dahurica) is a traditional Chinese medicinal plant being used in clinical practice. The present study demonstrated that A. dahurica could reduce white-fat weight in high-fat-diet hyperlipidemic mice, decrease total cholesterol and triglyceride concentrations in the livers of both high-fat-diet and Triton WR1339 induced hyperlipidemic mice, and enhance the total hepatic lipase activities of them. These findings were further supported by the results derived from the experiments with HepG2 cells in vitro...
September 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27608953/analysis-of-aristolochic-acids-aristololactams-and-their-analogues-using-liquid-chromatography-tandem-mass-spectrometry
#20
Jie Yu, Chao-Mei Ma, Xuan Wang, Ming-Ying Shang, Masao Hattori, Feng Xu, Yu Jing, Shi-Wen Dong, Yu-Qiong Xu, Cui-Ying Zhang, Shao-Qing Cai
More than 80 aristolochic acids (AAs) and aristololactams (ALs) have been found in plants of the Aristolochiaceae family, but relatively few have been fully studied. The present study aimed at developing and validating a liquid chromatography tandem mass spectrometry (LC/MS(n)) for the analysis of these compounds. We characterized the fragmentation behaviors of 31 AAs, ALs, and their analogues via high performance liquid chromatography coupled with electrospray ionization mass spectrometry. We summarized their fragmentation rules and used these rules to identify the constituents contained in Aristolochia contorta, Ar...
August 2016: Chinese Journal of Natural Medicines
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