Search for Influence Factors in Lactobacilli with Probiotic Properties Isolated from Traditional Kazakh Foods.

The aim of this study was to investigate the factors influencing the probiotic potential of lactobacilli isolated from traditional Kazakh foods, focusing on the identification and characterisation of multifunctional proteins. The basis of the methodological approach in this scientific study is an empirical, experimental study of the factors of influence produced by lactobacilli, which were obtained from traditional Kazakh foods and have pronounced probiotic properties. In this scientific work, results were obtained indicating that the expressed factors of probiotic action can perform adhesive and signalling functions by analogy with homologous proteins of pathogenic and commensal/probiotic bacteria. This largely determines the usefulness of these factors for studying the mechanisms of their probiotic action. In addition, it was found that potential probiotic strains of lactobacilli, which were isolated from food products traditional for Kazakhstan, contain adhesion proteins to the components of the mammalian organism, namely human plasminogen and porcine mucin. It is going about ENO, GAPDH, and p66/DnaK, which, along with P40 and P75 muramidases, are classified as probiotic factors. They are also called multifunctional proteins and are designated as factors of probiotic action. The practical significance of the results obtained during the implementation of this study lies in the possibility of their application in the planning and implementation of activities in the field of ensuring food security in Kazakhstan.