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Ionic liquid-mediated ethosome for transdermal delivery of insulin.
Chemical Communications : Chem Comm 2024 March 12
Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl- sn-glycero -3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability.
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