Revolutionizing Endodontics: Innovative Approaches for Treating Mature Teeth with Closed Apices and Apical Lesions: A Report of Two Cases.

Modern tissue engineering strategies have elucidated the potential of regenerative endodontic treatment (RET) as an alternative for treating mature teeth. Here, we report two cases in which cell-based RET (CB-RET) using encapsulated allogeneic umbilical cord mesenchymal stem cells (UC-MSCs) in a platelet-poor plasma (PPP)-based scaffold was used in two mature teeth with pulp necrosis and apical periodontitis. After 5 years of follow-up, the healing response was satisfactory in both cases, with evidence of pulp revitalization. This is the first study to report the success of an extended, 5-year follow-up for allogeneic CB-RET. This report presents an innovative and sustainable solution to challenging endodontic scenarios.