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Journal of Endodontics

Cosimo Nardi, Linda Calistri, Silvia Pradella, Isacco Desideri, Chiara Lorini, Stefano Colagrande
INTRODUCTION: This study aimed to evaluate the diagnostic accuracy of orthopantomography (OPT) for the detection of clinically/surgically confirmed apical periodontitis (AP) without endodontic treatment using cone-beam computed tomographic (CBCT) imaging as the reference standard. METHODS: One hundred twenty patients without endodontically treated AP (diseased group) were detected via CBCT imaging using the periapical index system. They were divided into groups of 10 each according to the size of the lesion (2-4...
August 11, 2017: Journal of Endodontics
S Linu, M S Lekshmi, V S Varunkumar, V G Sam Joseph
INTRODUCTION: The aim of this study was to investigate the sequelae of direct pulp capping (DPC) using mineral trioxide aggregate (MTA) and Biodentine in mature permanent teeth with carious exposure. METHODS: Clinical records of 30 patients (15 each with MTA and Biodentine) treated with DPC technique from January 2015 to June 2015 were retrieved. Success rates (based on symptoms, sensibility tests, and radiographic analysis) and adverse events were analyzed. RESULTS: The patients were reviewed at 1, 3, 6, 12, and 18 months after treatment...
August 11, 2017: Journal of Endodontics
Athina M Mavridou, Lars Bergmans, Dick Barendregt, Paul Lambrechts
INTRODUCTION: The aim of this study was to perform a descriptive analysis of the occurrence of external cervical resorption (ECR) in relation to the patients' characteristics (sex, age, and tooth type) and the potentially involved predisposing factors. METHODS: This study includes data on 284 patients (337 teeth with evidence of ECR) referred to the University Hospital Leuven (Leuven, Belgium) and Endo Rotterdam (Rotterdam, the Netherlands) for diagnosis and treatment from 2010 to 2015...
August 11, 2017: Journal of Endodontics
Suman Arya, Jigyasa Duhan, Sanjay Tewari, Pankaj Sangwan, Veena Ghalaut, Sameer Aggarwal
INTRODUCTION: The purpose of this prospective study was to compare the success of primary root canal treatment between type 2 diabetic and nondiabetic patients and to investigate the effect of periapical healing on glycated hemoglobin (HbA1c) in type 2 diabetic patients with apical periodontitis. METHODS: Sixty mandibular molars with necrotic pulps and apical radiolucency (size ≥ 2 mm × 2 mm) were included in the study. Based on the HbA1c levels, patients were divided into 2 groups: type 2 diabetic (HbA1c ≥6...
August 10, 2017: Journal of Endodontics
Nobuyuki Kawashima, Sonoko Noda, Mioko Yamamoto, Takashi Okiji
Dental pulp mesenchymal stem cells (DPMSCs) highly express mesenchymal stem cell markers and possess the potential to differentiate into neural cells, osteoblasts, adipocytes, and chondrocytes. Thus, DPMSCs are considered suitable for tissue regeneration. The colony isolation method has commonly been used to collect relatively large amounts of heterogeneous DPMSCs. Homogenous DPMSCs can be isolated by fluorescence-activated cell sorting using antibodies against mesenchymal stem cell markers, although this method yields a limited number of cells...
August 3, 2017: Journal of Endodontics
Ivo Lambrichts, Ronald B Driesen, Yörg Dillen, Pascal Gervois, Jessica Ratajczak, Tim Vangansewinkel, Esther Wolfs, Annelies Bronckaers, Petra Hilkens
Dental pulp is a highly vascularized and innervated tissue containing a heterogeneous stem cell population with multilineage differentiation potential. Current endodontic treatments focus on the preservation of the pulp tissue and the regeneration of dental pulp after pathological insults. Human dental pulp stem cells (hDPSCs) are currently investigated as stem cell-based therapy for pulp regeneration and for peripheral nerve injury in which neurons and Schwann cells display limited regenerative capacity. We have developed a neuronal differentiation protocol for hDPSCs that requires neurosphere formation before neuronal maturation...
August 3, 2017: Journal of Endodontics
Anthony J Smith, Paul R Cooper
Pulp regeneration and its clinical translation into regenerative endodontic procedures are receiving increasing research attention, leading to significant growth of the published scientific and clinical literature within these areas. Development of research strategies, which consider patient-, clinician-, and scientist-based outcomes, will allow greater focus on key research questions driving more rapid clinical translation. Three key areas of focus for these research questions should include cells, signaling, and infection/inflammation...
August 1, 2017: Journal of Endodontics
Misako Nakashima, Koichiro Iohara
Based on a preclinical bench study in dogs, a pilot clinical study was completed. Dental pulp stem cell (DPSC) subsets were isolated by mobilization by granulocyte colony-stimulating factor and expanded in good manufacturing practice conditions. The safety and efficacy of their autologous transplantation for total pulp regeneration was assessed in 5 patients with irreversible pulpitis. The quality control of the DPSC subsets was ensured by the absence of contamination and karyotype aberrations, and positive expression of stem cell markers...
August 1, 2017: Journal of Endodontics
Mitsuhiro Tsukiboshi, Domenico Ricucci, José F Siqueira
This is a case series of 3 immature permanent teeth with dens evaginatus, partial pulp necrosis, and apical periodontitis that were treated by calcium hydroxide pulpotomy. In all cases, follow-up examinations revealed that the radicular pulp vitality was preserved, periapical lesions were healed, and the root canal walls were narrowed by hard tissue deposition. Repair of the apical root differed from case to case; further apical root development occurred in 2 cases, but apical closure was apparent in all of them...
August 1, 2017: Journal of Endodontics
Charlotte Jeanneau, Fionnuala T Lundy, Ikhlas A El Karim, Imad About
Fibroblasts represent the most abundant population within the dental pulp. Although other cell types such as odontoblasts and stem cells have been extensively investigated, very little attention was given to the fibroblasts, which have major roles in regulating the pulp biology and function under normal and pathologic conditions. Indeed, although pulp fibroblasts control the pulp vascularization and innervation under physiological conditions, these cells synthesize growth factors that enhance dentin-pulp regeneration, vascularization, and innervation...
August 1, 2017: Journal of Endodontics
Masaki Honda, Momoko Sato, Taku Toriumi
Dental pulp has garnered much attention as an easily accessible postnatal tissue source of high-quality mesenchymal stem cells (MSCs). Since the discovery of dental pulp stem cells (DPSCs) in permanent third molars, stem cells from human exfoliated deciduous teeth and from supernumerary teeth (mesiodentes) have been identified as a population distinct from DPSCs. Dental pulp is divided into 2 parts based on the developing stage: the coronal pulp and the radicular pulp. Root formation begins after the crown part is completed...
August 1, 2017: Journal of Endodontics
Gleyce O Silva, Zhaocheng Zhang, Carolina Cucco, Min Oh, Carlos H R Camargo, Jacques E Nör
AIM: The aim of this study was to evaluate the effects of Wnt signaling through lipoprotein receptor-related protein 6 (LRP6) and Frizzled6 on the endothelial differentiation of dental pulp stem cells (DPSCs). METHODS: DPSCs were stably transduced with enhanced green fluorescent protein (EGFP)-tagged lentiviral vectors (short hairpin RNA-LRP6, short hairpin RNA-Frizzled6, or empty vector controls). We evaluated the effects of LRP6 and Frizzled6 on expression of endothelial markers and on capillary tube formation mediated by DPSCs induced with recombinant human Wnt1 (rhWnt1) and/or recombinant human vascular endothelial growth factor165 (rhVEGF165)...
August 1, 2017: Journal of Endodontics
Maria T P Albuquerque, Juliana Nagata, Marco C Bottino
INTRODUCTION: The elimination of microbial flora in cases of immature permanent teeth with necrotic pulp is both key and a challenging goal for the long-term success of regenerative therapy. Recent research has focused on the development of cell-friendly intracanal drug delivery systems. This in vitro study aimed to investigate the antimicrobial action of 3-dimensional (3D) tubular-shaped triple antibiotic-eluting nanofibrous constructs against a multispecies biofilm on human dentin...
August 1, 2017: Journal of Endodontics
Kerstin M Galler, Matthias Widbiller
Sufficient proof is available today to demonstrate that dental pulp tissue engineering is possible. The body of evidence was generated mainly on cell transplantation; however, because of several severe problems afflicted with this approach, it might not be feasible for a clinical setting in the near future. More recently, cell homing has been proposed as a viable alternative. We suggest a modification of the tissue engineering paradigm, where resident cells are attracted by endogenous, dentin-derived growth factors that further induce cell proliferation and differentiation and a bioactive scaffold material laden with these growth factors that serves as a template for tissue formation...
August 1, 2017: Journal of Endodontics
Ashraf F Fouad
Dental pulp regeneration after pulp necrosis in immature teeth represents a major departure from traditional endodontic therapy of these conditions. Preliminary clinical attempts have shown the feasibility of developing mineralized repair tissue, which may provide a clinically acceptable outcome. However, this outcome may not provide sufficient host response and root strength to ensure the longevity of the involved teeth. It is not clear if these preliminary suboptimal results are caused by the inability to fully disinfect the pulp space or the absence of a suitable progenitor cell/scaffold template together with adequate vascularity...
August 1, 2017: Journal of Endodontics
Brunno Santos de Freitas Silva, Fernanda Paula Yamamoto-Silva, Marcondes Sena-Filho, Simone Sousa Silva Sant'Ana, Wilson José Mariano-Júnior, Oslei Paes de Almeida, Carlos Estrela
Periapical lesions usually are caused by root canal infection; nevertheless, other pathologies may eventually involve the tooth apex, making the correct diagnosis more difficult. Glandular odontogenic cysts (GOCs) are uncommon and, despite their cystic nature, may present an aggressive behavior and a high recurrence rate. This report describes a recurrent GOC mimicking a periapical lesion that was followed up for 20 years. A 45-year-old woman described tooth discomfort for several years in the anterior region of the mandible that was not exacerbated during eating or occlusion...
July 29, 2017: Journal of Endodontics
Navid Khalighinejad, Anita Aminoshariae, James C Kulild, Andre Mickel
INTRODUCTION: Preeclampsia (PE) is characterized by hypertension and proteinuria after the 20th week of gestation. There is an association between systemic inflammation and adverse pregnancy outcomes such as PE. Therefore, for the first time, the present study aimed to investigate the possible association between maternal apical periodontitis (AP) and PE. METHODS: In this case-control study, 50 mothers who were diagnosed with PE during pregnancy were included in the experimental group...
July 29, 2017: Journal of Endodontics
H Melike Bayram, Emre Bayram, Mert Ocak, M Bora Uzuner, Ferhat Geneci, Hakan Hamdi Celik
INTRODUCTION: The aim of the present study was to evaluate the frequency of dentinal microcracks observed after root canal preparation with HyFlex CM (Coltène/Whaledent, Altstätten, Switzerland), HyFlex EDM (Coltène/Whaledent), Vortex Blue (Dentsply Tulsa Dental Specialties, Tulsa, OK), and TRUShape (Dentsply Tulsa Dental Specialties) systems using micro-computed tomographic (micro-CT) analysis. METHODS: Forty human mandibular incisors with 1 and straight root canals were randomly assigned to 4 experimental groups (n = 10) and 1 control group for root canal preparation: group 1, HyFlex CM; group 2, HyFlex EDM; group 3, Vortex Blue; and group 4, TRUShape...
July 27, 2017: Journal of Endodontics
Tuba Gok, Ismail Davut Capar, Ilgin Akcay, Ali Keles
INTRODUCTION: The purpose of this study was to compare the ability of different root canal filling methods on the C1 root canal anatomy using 3-dimensional (3D) printer technology. METHODS: Mandibular molars were scanned with cone-beam computed tomographic (CBCT) imaging. A mandibular molar tooth with a C1 root canal configuration was selected according to images obtained from CBCT technology. The root canals were shaped with ProTaper Universal rotary instruments (Dentsply Maillefer, Ballaigues, Switzerland) and hand files...
July 27, 2017: Journal of Endodontics
Barbara Skrlj Golob, Giovanni Olivi, Mirijam Vrabec, Rita El Feghali, Steven Parker, Stefano Benedicenti
INTRODUCTION: The purpose of this study was to determine the effectiveness of laser-activated irrigation by photon-induced photoacoustic streaming (PIPS) in the reduction of Enterococcus faecalis in root canal disinfection, varying laser energy output, and sodium hypochlorite (NaOCl) concentration. For effective removal of the smear layer, the sequence and resting time of the final irrigation steps were modified compared with the standard PIPS protocol. METHODS: Eighty-six extracted single-rooted teeth were mechanically prepared, sterilized, and inoculated with E...
July 27, 2017: Journal of Endodontics
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