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Redoxisome update:TRX and TXNIP/TBP2-dependent Regulation of NLRP-1/NLRP-3 Inflammasome.
Antioxidants & Redox Signaling 2024 Februrary 23
Recent studies by Ball et al (Ball et al., 2022) and Zhang et al (Zhang et al., 2023) have provided evidence for the direct binding of thioredoxin1 (TRX1) to a component of inflammasome complex NLRP-1. This interaction suggests a potential role for TRX1 in the regulation of the NLR family pyrin domain containing 1 (NLRP-1) inflammasome. Furthermore, the NLRP-3 inflammasome is known to bind TRX1 and its inhibitor, thioredoxin-binding protein-2/thioredoxin-interacting protein/vitamin D3 upregulated protein-1 (TBP2/TXNP1/VDUP-1). This binding forms a redox-sensitive complex, termed the "Redoxisome", as described previously. However, the specific functions of NLRP-1 within the redoxisome complex remain undefined.
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