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Cryptococcus neoformans Infections Differ Among Human Immunodeficiency Virus (HIV)-Seropositive and HIV-Seronegative Individuals: Results From a Nationwide Surveillance Program in France.

Olivier Paccoud, Marie Desnos-Ollivier, Sophie Cassaing, Karine Boukris-Sitbon, Alexandre Alanio, Anne-Pauline Bellanger, Christine Bonnal, Julie Bonhomme, Françoise Botterel, Marie-Elisabeth Bougnoux, Sophie Brun, Taieb Chouaki, Muriel Cornet, Eric Dannaoui, Magalie Demar, Nicole Desbois-Nogard, Marie-Fleur Durieux, Loïc Favennec, Arnaud Fekkar, Frederic Gabriel, Jean-Pierre Gangneux, Juliette Guitard, Lilia Hasseine, Antoine Huguenin, Solène Le Gal, Valérie Letscher-Bru, Caroline Mahinc, Florent Morio, Muriel Nicolas, Célia Rouges, Estelle Cateau, Florence Persat, Philippe Poirier, Stéphane Ranque, Gabrielle Roosen, Anne-Laure Roux, Milène Sasso, Olivier Lortholary, Fanny Lanternier
Open Forum Infectious Diseases 2024 Februrary
Among 1107 cryptococcosis cases from the French surveillance network (2005-2020), the proportion of HIV-seronegative individuals has recently surpassed that of HIV-seropositive individuals. We observed marked differences in patient characteristics, disease presentations, cryptococcal antigen results, infecting species, and mortality according to HIV serostatus.

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