journal
MENU ▼
Read by QxMD icon Read
search

Open Forum Infectious Diseases

journal
https://www.readbyqxmd.com/read/27844028/how-to-pitch-an-antibiotic-stewardship-program-to-the-hospital-c-suite
#1
REVIEW
Brad Spellberg, John G Bartlett, David N Gilbert
Hospitals will soon require antibiotic stewardship programs. Infectious diseases specialists must craft business plans to engage hospital leadership to fund such programs. In this article, we review key cost and revenue elements that should be covered in such plans. Society is placing increasing emphasis on the importance of antimicrobial stewardship programs (ASPs). New regulatory standards require hospitals to implement ASPs. Infectious Diseases (ID) specialists will need to help design and implement such programs at hospitals...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27844027/prosthetic-valve-endocarditis-caused-by-bartonella-henselae-a-case-report-of-molecular-diagnostics-informing-nonsurgical-management
#2
Patricia Bartley, Emmanouil Angelakis, Didier Raoult, Rangarajan Sampath, Robert A Bonomo, Robin L P Jump
Identifying the pathogen responsible for culture-negative valve endocarditis often depends on molecular studies performed on surgical specimens. A patient with Ehlers-Danlos syndrome who had an aortic graft, a mechanical aortic valve, and a mitral anulloplasty ring presented with culture-negative prosthetic valve endocarditis and aortic graft infection. Research-based polymerase chain reaction (PCR)/electrospray ionization mass spectrometry on peripheral blood samples identified Bartonella henselae. Quantitative PCR targeting the16S-23S ribonucleic acid intergenic region and Western immunoblotting confirmed this result...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27844026/severe-human-illness-caused-by-rift-valley-fever-virus-in-mauritania-2015
#3
Boushab Mohamed Boushab, Fatima Zahra Fall-Malick, Sidi El Wafi Ould Baba, Mohamed Lemine Ould Salem, Marie Roseline Darnycka Belizaire, Hamade Ledib, Mohamed Mahmoud Ould Baba Ahmed, Leonardo Kishi Basco, Hampaté Ba
BACKGROUND: Rift Valley Fever epizootics are characterized by numerous abortions and mortality among young animals. In humans, the illness is usually characterized by a mild self-limited febrile illness, which could progress to more serious complications.Objectives. The aim of the present prospective study was to describe severe clinical signs and symptoms of Rift Valley Fever in southern Mauritania. PATIENTS AND METHODS: Suspected cases were enrolled in Kiffa (Assaba) and Aleg (Brakna) Hospital Centers from September 1 to November 7, 2015, based on the presence of fever, hemorrhagic or meningoencephalitic syndromes, and probable contact with sick animals...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27833930/prognostic-value-of-transient-elastography-in-human-immunodeficiency-virus-infected-patients-with-chronic-hepatitis-c
#4
Leire Pérez-Latorre, Antonio Rivero-Juárez, Víctor Hontañón, Cristina Díez, Francisca Cuenca, Maria Luz Martín-Carbonero, María L Montes, José M Bellón, Teresa Aldámiz-Echevarría, Ana Carrero, Antonio Rivero, Juan González-García, Juan Berenguer
BACKGROUND: Our objective was to study the prognostic value of liver stiffness (LS) in HIV-infected patients with chronic hepatitis C (CHC). METHODS: We analyzed HIV-infected patients with compensated CHC and at least 1 determination of LS. The primary outcome was the occurrence of liver-related events (LRE), namely, decompensation or hepatocellular carcinoma, whichever occurred first. We selected patients without sustained viral response (SVR) or end-of-treatment response (ETR) during follow-up and allocated them to an estimation cohort (EC) and a validation cohort (VC)...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27833929/clinical-reasoning-of-infectious-diseases-physicians-behind-the-use-or-nonuse-of-transesophageal-echocardiography-in-staphylococcus-aureus-bacteremia
#5
Heather Young, Bryan C Knepper, Connie S Price, Susan Heard, Timothy C Jenkins
In this prospective cohort with Staphylococcus aureus bacteremia, transesophageal echocardiography (TEE) was performed in 24% of cases. Consulting Infectious Diseases physicians most frequently cited low suspicion for endocarditis due to rapid clearance of blood cultures and the presence of a secondary focus requiring an extended treatment duration as reasons for foregoing TEE.
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27807591/value-and-clinical-impact-of-an-infectious-disease-supervised-outpatient-parenteral-antibiotic-therapy-program
#6
Russell M Petrak, Nathan C Skorodin, Robert M Fliegelman, David W Hines, Vishnu V Chundi, Brian P Harting
Background.  Outpatient parenteral antibiotic therapy (OPAT) is a safe and effective modality for treating serious infections. This study was undertaken to define the value of OPAT in a multicentered infectious disease (ID) private practice setting. Methods.  Over a period of 32 months, 6120 patients were treated using 19 outpatient ID offices in 6 states. Analysis included patient demographics, indications of OPAT, diagnoses, therapeutic agent, duration of therapy, and site of therapy initiation. Outcomes were stratified by therapeutic success, clinical relapse, therapeutic complications, and hospitalizations after initiating therapy...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27807590/mitochondrial-haplogroups-as-a-risk-factor-for-herpes-zoster
#7
Rebecca T Levinson, Todd Hulgan, Spyros A Kalams, Joshua P Fessel, David C Samuels
Background.  Herpes zoster, or shingles, is a common, painful reactivation of latent varicella zoster virus infection. Understanding host factors that predispose to herpes zoster may permit development of more effective prevention strategies. Our objective was to examine mitochondrial haplogroups as a potential host factor related to herpes zoster incidence. Methods.  Study participants were drawn from BioVU, a deoxyribonucleic acid (DNA) biobank connected to deidentified electronic medical records (EMRs) from Vanderbilt University Medical Center...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27807589/rotavirus-and-norovirus-in-pediatric-healthcare-associated-gastroenteritis
#8
Jumi Yi, Bethany K Sederdahl, Kelly Wahl, Robert R Jerris, Colleen S Kraft, Courtney McCracken, Scott Gillespie, Amy E Kirby, Andi L Shane, Christine L Moe, Evan J Anderson
Rotavirus and norovirus are important etiologies of gastroenteritis among hospitalized children. During 2012-2013, we tested 207 residual stool specimens from children with healthcare-associated vomiting and/or diarrhea for rotavirus and norovirus. Twenty (10%) were rotavirus positive, and 3 (3%) were norovirus positive, stressing the importance of these pathogens in hospitalized children.
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27757411/ongoing-clinical-trials-of-human-immunodeficiency-virus-latency-reversing-and-immunomodulatory-agents
#9
Héloïse M Delagrèverie, Constance Delaugerre, Sharon R Lewin, Steven G Deeks, Jonathan Z Li
In chronic human immunodeficiency virus (HIV)-1 infection, long-lived latently infected cells are the major barrier to virus eradication and functional cure. Several therapeutic strategies to perturb, eliminate, and/or control this reservoir are now being pursued in the clinic. These strategies include latency reversal agents (LRAs) designed to reactivate HIV-1 ribonucleic acid transcription and virus production and a variety of immune-modifying drugs designed to reverse latency, block homeostatic proliferation, and replenish the viral reservoir, eliminate virus-producing cells, and/or control HIV replication after cessation of antiretroviral therapy...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27757410/fusarium-osteomyelitis-in-a-patient-with-pearson-syndrome-case-report-and-review-of-the-literature
#10
Rachael M Hiebert, Robert C Welliver, Zhongxin Yu
Fusarium species are ubiquitous fungi causing a wide array of infections, including invasive disease in the immunosuppressed. We present a fusarium bone infection in a child with Pearson syndrome and review the literature. Ten cases of fusarium osteomyelitis were reported in the past 40 years, and we review the treatments.
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27757409/predictors-of-latent-tuberculosis-infection-treatment-after-introduction-of-a-new-regimen-a-retrospective-cohort-study-at-an-inner-city-clinic
#11
Aliya Yamin, Ethan Bornstein, Rachel Hensel, Omar Mohamed, Russell R Kempker
Background.  Despite the low and decreasing prevalence of tuberculosis (TB) in the United States, there remain certain high-risk groups with high incidence rates. The targeted screening and treatment of latent TB infection (LTBI) among these high-risk groups are needed to achieve TB elimination; however, by most accounts, LTBI treatment completion rates remain low. Methods.  We retrospectively studied all patients accepting treatment for LTBI at the Fulton County Health Department TB clinic over 2 years...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27747255/influenza-virus-detection-following-administration-of-live-attenuated-intranasal-influenza-vaccine-in-children-with-cystic-fibrosis-and-their-healthy-siblings
#12
Constantina Boikos, Lawrence Joseph, Christine Martineau, Jesse Papenburg, David Scheifele, Larry C Lands, Gaston De Serres, Mark Chilvers, Caroline Quach
Background.  We aimed to explore the detection profile of influenza viruses following live-attenuated intranasal influenza vaccination (LAIV) in children aged 2-19 years with and without cystic fibrosis (CF). Methods.  Before the 2013-2014 influenza season, flocked nasal swabs were obtained before vaccination and 4 times in the week of follow-up from 76 participants (nCF: 57; nhealthy: 19). Influenza was detected by reverse transcription polymerase chain reaction (RT-PCR) assays. A Bayesian hierarchical logistic regression model was used to estimate the effect of CF status and age on influenza detection...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27747254/effects-of-a-syndrome-specific-antibiotic-stewardship-intervention-for-inpatient-community-acquired-pneumonia
#13
Michelle K Haas, Kristen Dalton, Bryan C Knepper, Sarah A Stella, Lilia Cervantes, Connie S Price, William J Burman, Philip S Mehler, Timothy C Jenkins
Background.  Syndrome-specific interventions are a recommended approach to antibiotic stewardship, but additional data are needed to understand their potential impact. We implemented an intervention to improve the management of inpatient community-acquired pneumonia (CAP) and evaluated its effects on antibiotic and resource utilization. Methods.  A stakeholder group developed and implemented a clinical practice guideline and order set for inpatient, non-intensive care unit CAP recommending a short course (5 days) of a fluoroquinolone-sparing antibiotic regimen in uncomplicated cases...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27747253/duration-of-colonization-with-klebsiella-pneumoniae-carbapenemase-producing-bacteria-at-long-term-acute-care-hospitals-in-chicago-illinois
#14
Manon R Haverkate, Shayna Weiner, Karen Lolans, Nicholas M Moore, Robert A Weinstein, Marc J M Bonten, Mary K Hayden, Martin C J Bootsma
Background.  High prevalence of Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae has been reported in long-term acute care hospitals (LTACHs), in part because of frequent readmissions of colonized patients. Knowledge of the duration of colonization with KPC is essential to identify patients at risk of KPC colonization upon readmission and to make predictions on the effects of transmission control measures. Methods.  We analyzed data on surveillance isolates that were collected at 4 LTACHs in the Chicago region during a period of bundled interventions, to simultaneously estimate the duration of colonization during an LTACH admission and between LTACH (re)admissions...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27747252/role-of-suppressive-oral-antibiotics-in-orthopedic-hardware-infections-for-those-not-undergoing-two-stage-replacement-surgery
#15
Sara C Keller, Sara E Cosgrove, Yvonne Higgins, Damani A Piggott, Greg Osgood, Paul G Auwaerter
Background.  The use of suppressive antibiotics in treatment of orthopedic hardware infections (OHIs), including spinal hardware infections, prosthetic joint infections, and infections of internal fixation devices, is controversial. Methods.  Over a 4-year period at 2 academic medical centers, patients with OHI who were treated with debridement and retention of hardware components, with single-stage exchange, or without surgery were studied to determine whether use of oral antibiotics for at least 6 months after diagnosis impacts successful treatment of the infection at 1 year after diagnosis...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27747251/adenosine-analog-nitd008-is-a-potent-inhibitor-of-zika-virus
#16
Yong-Qiang Deng, Na-Na Zhang, Chun-Feng Li, Min Tian, Jia-Nan Hao, Xu-Ping Xie, Pei-Yong Shi, Cheng-Feng Qin
The ongoing Zika virus (ZIKV) outbreaks have raised global concerns due to its unexpected clinical manifestations. Antiviral development is of high priority in response to the ZIKV emergency. In this study, we report that an adenosine analog NITD008 has potent in vitro and in vivo antiviral activity against ZIKV. The compound can effectively inhibit the historical and contemporary ZIKV strains in cultures as well as significantly reduce viremia and prevent mortality in A129 mice. Our results have demonstrated that NITD008 is potent inhibitor of ZIKV and can be used as reference inhibitor for future ZIKV antiviral drug screen and discovery...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27747250/probiotics-in-human-immunodeficiency-virus-infection-a-systematic-review-and-evidence-synthesis-of-benefits-and-risks
#17
George M Carter, Aryan Esmaeili, Hardikkumar Shah, Debbie Indyk, Matthew Johnson, Michael Andreae, Henry S Sacks
People living with human immunodeficiency virus frequently use dietary supplements, including probiotics, but concern exists about ingesting live organisms. We performed a systematic review of the benefits of probiotics and a meta-analysis of sepsis risk. We undertook a protocol-driven, comprehensive review to identify all relevant studies, assess their quality, and summarize the evidence. Of 2068 references, 27 were analyzed. The data suggest possible benefits for CD4 count, recurrence or management of bacterial vaginosis, and diarrhea management...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27747249/picasso-s-science-and-charity-paternalism-versus-humanism-in-medical-practice
#18
Joel T Katz, Shahram Khoshbin
No abstract text is available yet for this article.
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27699183/gram-positive-diplococci-in-a-cerebrospinal-fluid-gram-stain
#19
Jennifer P Collins, Lars F Westblade, Evan J Anderson
No abstract text is available yet for this article.
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/27800530/commentary-human-immunodeficiency-virus-and-allergic-bronchopulmonary-aspergillosis
#20
Emanuele Delfino, Antonio Di Biagio, Daniele Roberto Giacobbe, Claudio Viscoli
No abstract text is available yet for this article.
September 2016: Open Forum Infectious Diseases
journal
journal
49474
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"