Analysis of Scheimpflug Tomography Parameters for Detecting Subclinical Keratoconus in the Fellow Eyes of Patients with Unilateral Keratoconus in the Eastern Province of Saudi Arabia.

PURPOSE: We compared the characteristics of subtle morphological changes in subclinical keratoconus (KC) and normal corneas using Scheimpflug tomography (Pentacam® ) and assessed the efficacy of these parameters for distinguishing KC or subclinical KC from normal eyes.

PATIENTS AND METHODS: In this multicenter comparative study at Dhahran Eye Specialist Hospital and Al Kahhal Medical Complex in the Eastern Province of Saudi Arabia, we analyzed the Scheimpflug tomography charts of patients with topographically normal eyes and those with unilateral KC. Patients were divided into the normal (NL: patients considered for refractive surgery and with normal topographic/tomographic features, 129 eyes), KC (30 patients with manifest KC in one eye based on biomicroscopy and topographical findings), and forme fruste KC (FFKC: fellow eyes of patients in the KC group that met the NL group criteria) groups. Corneal morphological parameters were analyzed using the area under the receiver operating characteristic (ROC) curves (AUCs).

RESULTS: For distinguishing NL and KC groups, all measured corneal morphological parameters, except for flat keratometry, maximum Ambrósio relational thickness index, and minimum sagittal curvature, had AUCs >0.75. The surface variance index yielded the largest AUC (0.999). For distinguishing NL and FFKC groups, all corneal morphological parameters had AUCs <0.8. Total higher-order aberrations (RMS HOA) yielded the highest AUC, followed by Belin/Ambrỏsio Enhanced Ectasia total deviation (BAD-D), back elevation at the thinnest location, average pachymetric progression index (PPIave), and deviation of Ambrỏsio relational thickness (Da) (AUC 0.74-0.78).

CONCLUSION: The diagnostic performance of all tested topographic and tomographic parameters measured using Scheimpflug tomography for discriminating subclinical KC was fair at best, with the top parameters being RMS HOA, BAD-D, back elevation at the thinnest location, PPIave, and Da. Distinguishing between subclinical KC and healthy eyes remains challenging. Multimodal imaging techniques may be required for optimal early detection of subtle morphological changes.