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Clinical Ophthalmology

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https://www.readbyqxmd.com/read/27895460/preoperative-optical-coherence-tomography-visualization-of-epiretinal-membranes-enhances-surgical-strategies
#1
Norihiro Suzuki, Yoshio Hirano, Miyu Ichida, Taneto Tomiyasu, Yuya Esaki, Tsutomu Yasukawa, Yuichiro Ogura
PURPOSE: The aim of this study was to evaluate the usefulness of preoperative optical coherence tomography (OCT) findings in patients with macular epiretinal membrane (ERM) for the planning of surgical strategy. PATIENTS AND METHODS: One hundred twenty-three eyes of 121 patients (49 men, 72 women; mean age, 66 years) with an idiopathic ERM were enrolled. All patients underwent an ophthalmic examination including indirect ophthalmoscopy and OCT (Cirrus HD-OCT 4000 and/or 5000)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27895459/amaurosis-fugax-delay-between-symptoms-and-surgery-by-specialty
#2
Pia Kvickström, Bertil Lindblom, Göran Bergström, Madeleine Zetterberg
PURPOSE: To describe the time course of management of patients with amaurosis fugax and analyze differences in management by different specialties. METHODS: Patients diagnosed with amaurosis fugax and subjected to carotid ultrasound in 2004-2010 at the Sahlgrenska University Hospital, Gothenburg, Sweden (n=302) were included in this retrospective cohort study, and data were collected from medical records. RESULTS: The prevalence of significant carotid stenosis was 18...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27895458/clinical-and-imaging-evaluation-of-the-response-to-intravenous-steroids-in-patients-with-graves-orbitopathy-and-analysis-on-who-requires-additional-therapy
#3
Theodora Tsirouki, Alexandra Bargiota, Stelios Tigas, Agathi Vasileiou, Eftichia Kapsalaki, Zoe Giotaki, Ioannis Asproudis, Agathokles Tsatsoulis, Georgios Koukoulis, Evangelia E Tsironi
OBJECTIVE: The aim of this study was to evaluate the safety and efficacy of an individualized steroid regimen in patients with moderate-to-severe Graves' orbitopathy (GO) by monitoring clinical and imaging parameters. METHODS: In total, 47 patients with active, moderate-to-severe GO were enrolled in this study. All the patients received the proposed treatment regimen by European Group on GO of 4.5 g of intravenous (IV) methylprednisolone for 12 weeks. At the end of the IV treatment, patients with persistent active GO (Group 1) who were assessed by clinical examination and orbital imaging with short tau inversion recovery-sequence magnetic resonance imaging (STIR MRI) received additional treatment with oral prednisolone, and those with inactive GO (Group 2) received no further treatment...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27881909/comparison-of-choroidal-thickness-measurements-between-spectral-domain-oct-and-swept-source-oct-in-normal-and-diseased-eyes
#4
Sidra Zafar, Ma Rehman Siddiqui, Rida Shahzad
PURPOSE: Sub-foveal choroidal thickness (SFCT) is affected in many ocular diseases. The aim of this study was to compare SFCT measurements between Topcon 3D 2000 spectral-domain optical coherence tomography (SD-OCT) and Topcon swept-source OCT (SS-OCT), with different laser wavelengths, in normal and diseased populations. MATERIALS AND METHODS: This was a prospective, cross-sectional, noninterventional study including 27 normal volunteers and 27 participants with retinal disease...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27877016/clinical-utility-of-antimicrobial-susceptibility-measurement-plate-covering-formulated-concentrations-of-various-ophthalmic-antimicrobial-drugs
#5
Norihiko Tou, Ryohei Nejima, Yoshifumi Ikeda, Yuichi Hori, Kaoru Araki-Sasaki, Kazunori Miyata, Yoshitsugu Inoue, Akihiko Tawara
PURPOSE: The purpose of this study was to evaluate the clinical utility of SG17, an ophthalmic antimicrobial susceptibility measurement plate. DESIGN: This was a multicenter, retrospective, observational study. PATIENTS AND METHODS: Using clinical isolates from patients with ocular infections, drug susceptibility testing using the Clinical Laboratory and Standards Institute standards was routinely conducted at five facilities. The minimum inhibitory concentrations of the isolated strains were determined using SG17 at the Research Foundation for Microbial Diseases of Osaka University...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27877015/rainbow-glare-after-laser-assisted-in-situ-keratomileusis-a-review-of-literature
#6
REVIEW
Majid Moshirfar, Jordan D Desautels, Tyler S Quist, David F Skanchy, Mark T Williams, Ryan T Wallace
This article reviews the current literature pertaining to rainbow glare (RG), including incidence rate, clinical presentation, etiology, prognosis, and management. RG is a rare optical complication of femtosecond laser-assisted in situ keratomileusis that results in patients seeing an array of spectral bands surrounding point sources of light under mesopic and scotopic conditions. The mechanism is thought to be a consequence of the formation of a transmissive diffraction grating on the posterior surface of the corneal flap created by the FS laser...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27853352/tear-lipid-layer-thickness-with-eye-drops-in-meibomian-gland-dysfunction
#7
Jennifer S Fogt, Matthew J Kowalski, P Ewen King-Smith, Alice T Epitropolous, Andrew J Hendershot, Carrie Lembach, John Paul Maszczak, Lisa A Jones-Jordan, Joseph T Barr
PURPOSE: The aim of this study was to evaluate the efficacy of a lipid containing emollient eye drop, Soothe XP, which was reformulated in 2014 with a more stable preservative and buffer system, compared to a control, non-emollient, eye drop (Systane Ultra) in improving lipid layer thickness (LLT) in subjects with dry eye due to meibomian gland dysfunction (MGD). PATIENTS AND METHODS: This prospective single-center, open-label, cross-over, examiner masked-study enrolled subjects aged 30-75 years with lipid-deficient dry eye and a clinical diagnosis of MGD as determined by a slit lamp examination, an evaluation of meibomian gland drop out with meibography, and a standard patient evaluation of eye dryness questionnaire of >5...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27853351/the-effect-of-humidity-and-temperature-on-visual-outcomes-after-myopic-corneal-laser-refractive-surgery
#8
Christopher T Hood, Roni M Shtein, Daniel Veldheer, Munira Hussain, Leslie M Niziol, David C Musch, Shahzad I Mian
OBJECTIVE: To determine whether procedure room environmental conditions are associated with outcomes after myopic laser in situ keratomileusis (LASIK) or laser-assisted keratomileusis (LASEK). DESIGN: Retrospective chart review. PARTICIPANTS: Eight hundred sixty-three eyes of 458 consecutive patients at a university-based academic practice. METHODS: We reviewed the medical records of consecutive patients who underwent LASIK or LASEK over a 3-year period...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27853350/intravitreal-aflibercept-for-the-treatment-of-choroidal-neovascularization-associated-with-pathologic-myopia-a-pilot-study
#9
Andrii R Korol, Oleg S Zadorozhnyy, Volodymyr O Naumenko, Taras B Kustryn, Nataliya V Pasyechnikova
PURPOSE: To determine the efficacy of intravitreal aflibercept injections for the treatment of patients with choroidal neovascularization (CNV) associated with pathologic myopia. METHODS: In this uncontrolled, prospective cohort study, 31 eyes of 30 consecutive patients affected by CNV associated with pathologic myopia were treated with intravitreal aflibercept (2 mg) as needed following two initial monthly doses and observed over a 12-month follow-up period. The primary endpoint was change in best-corrected visual acuity (BCVA) at month 12, while central retinal thickness (CRT) on optical coherence tomography (OCT), neovascularization activity on fluorescein angiography, the number of aflibercept injections administered, and safety were examined as secondary endpoints...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27843292/topography-modified-refraction-tmr-adjustment-of-treated-cylinder-amount-and-axis-to-the-topography-versus-standard-clinical-refraction-in-myopic-topography-guided-lasik
#10
Anastasios John Kanellopoulos
PURPOSE: To evaluate the safety, efficacy, and contralateral eye comparison of topography-guided myopic LASIK with two different refraction treatment strategies. SETTING: Private clinical ophthalmology practice. PATIENTS AND METHODS: A total of 100 eyes (50 patients) in consecutive cases of myopic topography-guided LASIK procedures with the same refractive platform (FS200 femtosecond and EX500 excimer lasers) were randomized for treatment as follows: one eye with the standard clinical refraction (group A) and the contralateral eye with the topographic astigmatic power and axis (topography-modified treatment refraction; group B)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27843291/a-new-endocapsular-open-ring-for-prevention-of-anterior-and-posterior-capsule-opacification
#11
Ioannis G Pallikaris, Nela R Stojanovic, Harilaos S Ginis
PURPOSE: The aim of this study is to demonstrate the functionality of a new design of a thick endocapsular open ring for prevention of anterior capsule opacification (ACO) and posterior capsule opacification (PCO). SETTING: The Institute of Vision and Optics, University of Crete and University Hospital of Heraklion, Crete, Greece. DESIGN: Prospective, interventional pilot study. METHODS: Fifteen patients (17 eyes) underwent cataract surgery with phacoemulsification...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27843290/vector-analysis-investigation-of-toric-intraocular-lens-with-no-deviation-from-the-intended-axis
#12
Atsushi Kawahara, Yoshinori Takayanagi
AIM: The aim of this research was to evaluate vector analysis after implantation of toric intraocular lenses (IOLs) without deviation from the intended axis. METHODS: The study included 18 eyes of 16 patients who underwent cataract surgery with the insertion of a toric implant (AcrySof IQ Toric). The postoperative IOL meridian placement completely corresponded to that planned. Using vector analysis, surgically induced astigmatism (SIA) was derived from the refractive outcome versus the predicted postoperative keratometric astigmatism and was compared with targeted induced astigmatism (TIA)...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27843289/six-month-visual-outcomes-for-the-correction-of-presbyopia-using-a-small-aperture-corneal-inlay-single-site-experience
#13
Majid Moshirfar, Tyler S Quist, David F Skanchy, Ryan T Wallace, Steven H Linn, Phillip C Hoopes
OBJECTIVE: The objective of this study was to describe 6-month postoperative efficacy and safety outcomes after monocular KAMRA corneal inlay implantation in emmetropic presbyopic patients. STUDY DESIGN: This study followed a retrospective chart analysis. SETTING: This study was performed at Hoopes Vision in Draper, UT, USA. SUBJECTS AND METHODS: Fifty-seven patients met the inclusion criteria of this study and underwent KAMRA corneal inlay implantation following the approval of the United States Food and Drug Association between May 2015 and April 2016 at a single site...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27843288/leber-s-hereditary-optic-neuropathy-is-multiorgan-not-mono-organ
#14
REVIEW
Josef Finsterer, Sinda Zarrouk-Mahjoub
Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder with bilateral loss of central vision primarily due to mitochondrial DNA (mtDNA) mutations in subunits of complex I in the respiratory chain (primary LHON mutations), while other mtDNA mutations can also be causative. Since the first description, it is known that LHON is not restricted to the eyes but is a multisystem disorder additionally involving the central nervous system, ears, endocrinological organs, heart, bone marrow, arteries, kidneys, or the peripheral nervous system...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27843287/incidence-of-and-risk-factors-for-chloroquine-and-hydroxychloroquine-retinopathy-in-thai-rheumatologic-patients
#15
Nuanpan Tangtavorn, Yosanan Yospaiboon, Tanapat Ratanapakorn, Suthasinee Sinawat, Thuss Sanguansak, Chavakij Bhoomibunchoo, Wipada Laovirojjanakul
OBJECTIVE: To study the incidences of and risk factors for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy in Thai rheumatologic patients. METHODS: A retrospective cohort study of 234 rheumatologic patients receiving either CQ or HCQ was conducted. Patients were divided based on whether or not they developed retinopathy as retinopathy-positive or negative groups. Medical records giving details regarding age, gender, body weight, underlying diseases, daily doses, and cumulative doses of CQ or HCQ were reviewed...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27843286/effect-of-cataract-surgery-on-subfoveal-choroidal-and-ganglion-cell-complex-thicknesses-measured-by-enhanced-depth-imaging-optical-coherence-tomography
#16
Erkan Celik, Burcin Cakır, Elif Betul Turkoglu, Emine Doğan, Gursoy Alagoz
PURPOSE: We aimed to evaluate the effect of cataract surgery on subfoveal choroidal thickness (CT) and ganglion cell complex (GCC) thickness, as measured by enhanced depth imaging-optical coherence tomography (OCT). METHODS: This prospective study included 30 eyes of 30 patients who had undergone uneventful phacoemulsification surgery for senile cataract but had no previous ocular surgery or other ocular abnormality. Best-corrected visual acuity, slit-lamp biomicroscopy, intraocular pressure, axial length, and central corneal thickness were measured preoperatively...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27843285/clinical-outcomes-with-toric-intraocular-lenses-planned-using-an-optical-low-coherence-reflectometry-ocular-biometer-with-a-new-toric-calculator
#17
Kjell G Gundersen, Richard Potvin
PURPOSE: To prospectively evaluate postoperative clinical outcomes with implantation of toric intraocular lenses (IOLs) using preoperative keratometry from an optical low coherence reflectometry (OLCR) ocular biometer (Lenstar(®) LS900) and the built-in Barrett toric calculator. PATIENTS AND METHODS: A prospective observational study recruited one or both eyes of subjects who underwent uncomplicated cataract surgery with toric IOL implantation using OLCR biometery data and the Barrett toric IOL calculator for toric IOL planning...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27826182/amaurosis-fugax-risk-factors-and-prevalence-of-significant-carotid-stenosis
#18
Pia Kvickström, Bertil Lindblom, Göran Bergström, Madeleine Zetterberg
PURPOSE: The purpose of this study was to describe clinical characteristics and prevalence of carotid stenosis in patients with amaurosis fugax (AF). METHOD: Patients diagnosed with AF and subjected to carotid ultrasound in 2004-2010 in Sahlgrenska University Hospital, Gothenburg (n=302), were included, and data were retrospectively collected from medical records. RESULTS: The prevalence of significant carotid stenosis was 18.9%, and 14.2% of the subjects were subjected to carotid endarterectomy...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27826181/analysis-of-the-association-between-the-lum-rs3759223-variant-and-high-myopia-in-a-japanese-population
#19
Shintaro Okui, Akira Meguro, Masaki Takeuchi, Takahiro Yamane, Eiichi Okada, Yasuhito Iijima, Nobuhisa Mizuki
PURPOSE: Many studies have investigated the relationship of the lumican gene (LUM) rs3759223 variant with the risk of high myopia, but the results have been inconsistent and inconclusive. In this study, we investigated whether LUM rs3759223 is associated with high myopia in a Japanese population. METHODS: We recruited 1,585 Japanese patients with high myopia (spherical equivalent [SE] <-9.00 diopters [D]) and 1,011 Japanese healthy controls (SE ≥-1.00 D). The rs3759223 variant was genotyped using the TaqMan assay, and the allelic and genotypic diversity among cases and controls was analyzed according to the SE level...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27826180/preliminary-analysis-of-the-relationship-between-serum-lutein-and-zeaxanthin-levels-and-macular-pigment-optical-density
#20
Shigeto Fujimura, Kohei Ueda, Yoko Nomura, Yasuo Yanagi
PURPOSE: To assess the relationship between combined serum lutein and zeaxanthin (L+Z) concentration and macular pigment optical density (MPOD), and to investigate the effect of L+Z+docosahexaenoic acid (DHA) dietary supplementation on the spatial distribution of MPOD. METHODS: Twenty healthy fellow eyes with unilateral wet age-related macular degeneration or chronic central serous chorioretinopathy were included. All participants received a dietary supplement for 6 months that contained 20 mg L, 1 mg Z, and 200 mg DHA...
2016: Clinical Ophthalmology
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