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Clinical Ophthalmology

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https://www.readbyqxmd.com/read/28533678/effect-of-thermal-pulsation-treatment-on-tear-film-parameters-in-dry-eye-disease-patients
#1
Michelle J Kim, Sandra S Stinnett, Preeya K Gupta
PURPOSE: The goal of this study was to evaluate the effect of thermal pulsation treatment on tear film parameters, specifically osmolarity and matrix metalloproteinase-9 (MMP-9), in patients with meibomian gland dysfunction (MGD) and dry eye disease (DED). METHODS: A single-center review of 189 eyes that underwent thermal pulsation treatment was performed. Data were collected on pre and posttreatment osmolarity, MMP-9, tear break-up time (TBUT), and ocular surface disease index (OSDI) score...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28515637/ultrasound-biomicroscopy-value-in-evaluation-of-restoration-of-ciliary-muscles-contractility-after-cataract-extraction
#2
Ayser Abd El-Hameed Fayed
PURPOSE: To assess the changes in the contractility of the ciliary muscle in eyes with presbyopia before and after phacoemulsification and intracapsular lens implantation using ultrasound biomicroscopy (UBM). PATIENTS AND METHODS: This prospective study included 50 eyes of 30 consecutive subjects operated at the Department of Ophthalmology. Patients with any ocular disorder affecting visual acuity, corneal surface irregularities, had posterior capsular perforation or intensive postoperative corneal edema, or were <35 years of age, were excluded...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28515636/optic-cup-segmentation-type-ii-fuzzy-thresholding-approach-and-blood-vessel-extraction
#3
Ahmed Almazroa, Sami Alodhayb, Kaamran Raahemifar, Vasudevan Lakshminarayanan
We introduce here a new technique for segmenting optic cup using two-dimensional fundus images. Cup segmentation is the most challenging part of image processing of the optic nerve head due to the complexity of its structure. Using the blood vessels to segment the cup is important. Here, we report on blood vessel extraction using first a top-hat transform and Otsu's segmentation function to detect the curves in the blood vessels (kinks) which indicate the cup boundary. This was followed by an interval type-II fuzzy entropy procedure...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28507427/the-sensimed-triggerfish-contact-lens-sensor-efficacy-safety-and-patient-perspectives
#4
REVIEW
Grace E Dunbar, Bailey Yuguan Shen, Ahmad A Aref
Intraocular pressure, a major modifiable risk factor for glaucoma, has been shown to fluctuate throughout the day in patients with glaucoma. The detection and measurement of this fluctuation may help guide the clinical management of glaucomatous individuals. The Sensimed Triggerfish contact lens sensor (CLS), which has recently gained approval for marketing in the USA, is designed to detect intraocular pressure-related changes in an eye over a 24-hour period. This review will provide an overview of the Triggerfish CLS, as well as summarize current clinical data pertaining to the device...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28503064/combined-intrastromal-injection-of-amphotericin-b-and-topical-fluconazole-in-the-treatment-of-resistant-cases-of-keratomycosis-a-retrospective-study
#5
Waled Mahdy Nada, Mahmoud A Al Aswad, Wael M El-Haig
PURPOSE: To evaluate the efficacy of combination therapy of a single intrastromal injection of amphotericin B and topical fluconazole in resistant cases of fungal keratitis, and also topical amphotericin B as monotherapy in terms of the duration of the recovery period and toxic drug effects. METHODS: This retrospective 2-year study reviewed 68 cases of unilateral fungal keratitis diagnosed by clinical features and positive laboratory culture results. Forty-one cases were resistant and did not respond to monotherapy with an antifungal agent...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28503063/severe-symptoms-of-short-tear-break-up-time-dry-eye-are-associated-with-accommodative-microfluctuations
#6
Minako Kaido, Motoko Kawashima, Reiko Ishida, Kazuo Tsubota
AIM: Validating the hypothesis that accommodative microfluctuations (AMFs) may be associated with severe symptoms in short tear break-up time (BUT) dry eye (DE). METHODS: This study included 12 subjects with short BUT DE (age: 49.6±18.3 years). Diagnoses were performed based on the presence of DE symptoms, BUT ≤5 s, Schirmer score >5 mm, and negative keratoconjunctival epithelial damage. Tear evaluation, AMF, and functional visual acuity (VA) examinations were conducted before and after DE treatment...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28496302/goldmann-tonometer-error-correcting-prism-clinical-evaluation
#7
Sean McCafferty, Garrett Lim, William Duncan, Eniko T Enikov, Jim Schwiegerling, Jason Levine, Corin Kew
PURPOSE: Clinically evaluate a modified applanating surface Goldmann tonometer prism designed to substantially negate errors due to patient variability in biomechanics. METHODS: A modified Goldmann prism with a correcting applanation tonometry surface (CATS) was mathematically optimized to minimize the intraocular pressure (IOP) measurement error due to patient variability in corneal thickness, stiffness, curvature, and tear film adhesion force. A comparative clinical study of 109 eyes measured IOP with CATS and Goldmann prisms...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28496301/short-term-outcomes-in-patients-with-branch-retinal-vein-occlusion-who-received-intravitreal-aflibercept-with-or-without-intravitreal-ranibizumab
#8
Yoshihito Sakanishi, Ayumi Usui-Ouchi, Kazunori Tamaki, Keitaro Mashimo, Rei Ito, Nobuyuki Ebihara
PURPOSE: The purpose of this study was to determine the short-term outcomes for patients who received intravitreal aflibercept (IVA) with or without intravitreal ranibizumab (IVR) for macular edema (ME) due to branch retinal vein occlusion (BRVO). PATIENTS AND METHODS: Patients received IVA for ME due to BRVO. Patients who initially received IVA were defined as the treatment-naïve group and those who were switched from IVR to IVA after ME recurrence were defined as the switching group...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28496300/prospective-evaluation-of-intense-pulsed-light-and-meibomian-gland-expression-efficacy-on-relieving-signs-and-symptoms-of-dry-eye-disease-due-to-meibomian-gland-dysfunction
#9
Steven J Dell, Ronald N Gaster, Sheila C Barbarino, Derek N Cunningham
PURPOSE: The aim of this study was to estimate the efficacy of intense pulsed light (IPL), followed by meibomian gland expression (MGX), for reducing the number and severity of signs and symptoms of dry eye disease (DED) secondary to meibomian gland dysfunction (MGD). PATIENTS AND METHODS: In a prospective study conducted in two sites, 40 subjects (80 eyes) with moderate to severe MGD were enrolled. Major inclusion criteria consisted of at least two of the following measures being compatible with DED in both eyes: tear breakup time (TBUT), meibomian gland score (MGS), corneal fluorescein staining (CFS), Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, and tear film osmolarity (TFO)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28496299/response-of-eyes-with-age-related-macular-degeneration-to-anti-vegf-drugs-and-implications-for-therapy-planning
#10
Noriko Miyamoto, Michiko Mandai, Hiroshi Kojima, Takanori Kameda, Masataka Shimozono, Akihiro Nishida, Yasuo Kurimoto
PURPOSE: To evaluate the response to and dependence on aflibercept or ranibizumab in patients with age-related macular degeneration (AMD). METHODS: We retrospectively reviewed AMD patients who received induction therapy with aflibercept or ranibizumab for the following parameters: whether complete resolution of the retinal fluid ("good response") was achieved and whether recurrence was observed within 3 months ("dependent") after the induction treatment. With aflibercept treatment, treatment-naïve eyes with a good response/non-dependence were recommended a pro re nata regimen, and other eyes were recommended a proactive bimonthly regimen, followed by monitoring of visual acuity (VA) for 12 months...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28490862/ultra-wide-field-fluorescein-angiography-in-diabetic-retinopathy-a-narrative-review
#11
REVIEW
Alessandro Rabiolo, Mariacristina Parravano, Lea Querques, Maria Vittoria Cicinelli, Adriano Carnevali, Riccardo Sacconi, Teresa Centoducati, Stela Vujosevic, Francesco Bandello, Giuseppe Querques
Fluorescein angiography (FA) is a useful examination in patients suffering from diabetic retinopathy (DR). Traditional angiograms explore 30°-50° of the retina at once; however, visualization of peripheral retina is fundamental in order to assess nonperfused areas, vascular leakage, microvascular abnormalities, and neovascularizations. In order to expand the field of view, wide-field and ultra-wide-field imaging has been developed allowing to image up to 200° of retinal surface in one single shot. The aim of this narrative review was to provide an overview of the role of the most recent technique of ultra-wide-field fluorescein angiography in DR...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28490861/efficacy-of-intravitreal-aflibercept-injections-for-japanese-patients-with-polypoidal-choroidal-vasculopathy
#12
Akira Arakawa, Maiko Inoue, Shimpei Sato, Shin Yamane, Kazuaki Kadonosono
PURPOSE: To evaluate the efficacy of intravitreal aflibercept therapy in treatment-naïve Japanese patients with polypoidal choroidal vasculopathy (PCV) using Early Treatment Diabetic Retinopathy Study (ETDRS) letter scores. SUBJECTS AND METHODS: This study was a prospective, nonrandomized, interventional exploratory clinical trial performed in an institutional setting. Patients with PCV were treated with intravitreal aflibercept 2 mg/0.05 mL every 2 months after 3 initial monthly doses, for 1 year...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28490860/choroidal-structure-determined-by-binarizing-optical-coherence-tomography-images-in-eyes-with-reticular-pseudodrusen
#13
Naonori Masuda, Masashi Kojima, Mariko Yamashita, Tomo Nishi, Nahoko Ogata
PURPOSE: To compare the choroidal structure beneath the macular area in eyes with reticular pseudodrusen (RPD) and age-matched controls. METHODS: This study was performed at Nara Medical University Hospital, Japan. Twenty eyes of 14 patients (82.3±4.2 years, mean ± standard deviation) with RPD and 35 eyes of 20 age-matched controls (81.5±6.0 years) were studied. The choroidal structure was determined by binarizing the images obtained by enhanced depth imaging optical coherence tomography in all patients and controls...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28479850/automated-measurements-of-human-cone-photoreceptor-density-in-healthy-and-degenerative-retina-by-region-based-segmentation
#14
Suguru Miyagawa, Hisashi Fukuyama, Masakazu Hirota, Tatsuo Yamaguchi, Kazuo Kitamura, Takao Endo, Hiroyuki Kanda, Takeshi Morimoto, Takashi Fujikado
PURPOSE: The purpose of this study was to develop an algorithm based on region-based segmentation for automated calculations of human cone photoreceptor density of en face images obtained by an adaptive optics scanning laser ophthalmoscope (AOSLO). SUBJECTS AND METHODS: Cone mosaics of 15 eyes of 15 healthy subjects were photographed by a custom-built AOSLO. The cone density was calculated at 0.5, 1.0, and 1.5 mm temporal from the fovea using a region-based segmentation method (RSM) developed in our laboratory...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28479849/impression-cytology-implicates-cell-autophagy-in-aqueous-deficiency-dry-eye
#15
Tony Lin, Richard Filek, Joy M Wang, Chong H Wu, Hong Liu, Cindy Ml Hutnik
PURPOSE: Impression cytology in combination with a cell autophagy marker was used to demonstrate the utility of a novel frozen section technique, to assess the health of the ocular surface, as well as to correlate autophagic cell death with the commonly used clinical tests for dry eye. METHODS: Female patients over the age of 18 years who attended an outpatient ophthalmology clinic were invited to participate. Schirmer's test, tear film break-up time and the ocular surface disease index questionnaire were used as objective and subjective clinical tests for dry eye...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28461739/efficacy-of-transepithelial-corneal-collagen-crosslinking-for-keratoconus-12-month-follow-up
#16
Mohamed A Heikal, Tarek Tawfik Soliman, Ayser Fayed, Abdelmonem M Hamed
PURPOSE: To evaluate the efficacy of transepithelial corneal collagen crosslinking (TE-CXL) in patients with progressive keratoconus. PATIENTS AND METHODS: This is a prospective interventional consecutive study carried out on 30 eyes of 18 patients with progressive keratoconus who underwent TE-CLX using both ParaCel™ (riboflavin 0.25%, hydroxy propyl methyl cellulose, NaCl, ethylenediaminetetraacetic acid [EDTA], Tris, and benzalkonium chloride) and vibeX-Xtra (riboflavin 0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28461738/the-effect-of-vitreomacular-and-cataract-surgery-on-oxygen-saturation-in-retinal-vessels
#17
Yuki Nakano, Koichiro Manabe, Rie Osaka, Yukari Takasago, Aoi Ono, Mamoru Kobayashi, Tomoyoshi Fujita, Chieko Shiragami, Kazuyuki Hirooka, Akitaka Tsujikawa
PURPOSE: To evaluate the effects of vitreomacular and cataract surgery on retinal oximetry in vitreomacular disease. PATIENTS AND METHODS: Thirty-eight eyes with epiretinal membrane (ERM) and 15 with idiopathic macular hole (MH) underwent 25 gauge pars plana vitrectomy combined with cataract surgery and intraocular lens implantation. Retinal oximetry was performed using the Oxymap T1 before, 1 month, and 6 months after surgery. Oxymap T1 simultaneously captures monochrome images of the fundus at two different wavelengths of light...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28461737/comparison-of-the-biometric-measurements-calculated-with-zeiss-iol-master-and-wavelight-ob-820
#18
Georgios Labiris, Panagiota Ntonti, Konstantinos Ntitsos, Andreas Katsanos, Haris Sideroudi, Vasilios Kozobolis
BACKGROUND: The primary objective of this study was to investigate the level of agreement between IOL-Master and OB-820 ocular biometers. MATERIALS AND METHODS: In this prospective randomized case series, we measured the anterior chamber depth (ACD), the axial length (AL), the corneal radii (R1, R2), the ratio of mean corneal radius and spherical equivalent and the corneal astigmatism (cylinder [Cyl]) before and after cataract extraction surgery. RESULTS: Significant differences between pre- and postoperative data were observed for ACD for both biometric devices (P<0...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28461736/intersession-test-retest-variability-of-10-2-maia-microperimetry-in-fixation-threatening-glaucoma
#19
Evan N Wong, William H Morgan, Fred K Chen
PURPOSE: To determine the intersession test-retest variability (TRV) of CenterVue Macular Integrity Assessment (MAIA) microperimeter in glaucoma patients with fixation-threatening field defects. METHODS: This is a prospective case-control study of 27 participants consisting of 13 patients with stable primary open-angle glaucoma and 14 control subjects including 5 healthy individuals and 9 retinal patients (5 with non-neovascular age-related macular degeneration and 4 with inherited retinal disease)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28458513/perioperative-changes-of-the-intraocular-pressure-during-the-treatment-of-epiretinal-membrane-by-using-25-or-27-gauge-sutureless-vitrectomy-without-gas-tamponade
#20
Hirotsugu Takashina, Akira Watanabe, Hiroshi Tsuneoka
PURPOSE: The purpose of this study was to compare perioperative intraocular pressures (IOPs) in 25- or 27-gauge microincision vitrectomy surgery (MIVS) and to evaluate the stability of postoperative sclerotomy closure. MATERIALS AND METHODS: This is a retrospective review of 147 eyes treated for epiretinal membrane by using 25- or 27-gauge MIVS as the initial vitrectomy (25-gauge phacovitrectomy [25-P group]: 73 eyes, 25-gauge vitrectomy alone [25-A group]: 15 eyes, 27-gauge phacovitrectomy [27-P group]: 47 eyes, and 27-gauge vitrectomy alone [27-A group]: 12 eyes)...
2017: Clinical Ophthalmology
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