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Clinical Ophthalmology

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[This corrects the article on p. 1819 in vol. 10, PMID: 27698551.].
2018: Clinical Ophthalmology
Béatrice Cochener
Purpose: The purpose of this study was to evaluate the influence of different levels of monovision on the clinical outcomes achieved with an extended range of vision (ERV) intraocular lens (IOL). Patients and methods: Subanalysis of 411 patients from the multicenter CONCERTO study aimed at evaluating the outcomes after bilateral implantation of the Tecnis Symfony IOL. Visual acuity, spectacle independence, photic phenomena incidence, and patient satisfaction outcomes were evaluated in six groups defined according to the level of monovision: 0...
2018: Clinical Ophthalmology
John A Hovanesian
Purpose: The purpose of this study was to determine the satisfaction levels of patients at least 2 years after cataract surgery implantation with bilateral accommodating or bilateral multifocal intraocular lenses (IOLs) and to determine the relative rate of spectacle independence and adverse symptoms in that same time frame. Design: Patient questionnaire administered in a single-center private practice at least 2 years after cataract surgery with presbyopia-correcting IOL implantation...
2018: Clinical Ophthalmology
Grace M Richter, Beau Sylvester, Zhongdi Chu, Bruce Burkemper, Ingy Madi, Ryuna Chang, Alena Reznik, Rohit Varma, Ruikang K Wang
Purpose: To quantify peripapillary microvasculature within the retinal nerve fiber layer (RNFL) in primary open-angle glaucoma (POAG) and normal eyes, determine association of perfusion parameters with structural and functional measures, and report diagnostic accuracy of perfusion parameters. Patients and methods: POAG and normal patients underwent 6×6 mm2 optic nerve head scans (Angioplex optical coherence tomography angiography [OCTA]; Cirrus HD-OCT 5000) and Humphrey Field Analyzer II-i 24-2 visual field (VF) testing...
2018: Clinical Ophthalmology
John P Fezza
Purpose: A new cross-linked hyaluronic acid (xlHA) gel occlusive device was assessed for safety and efficacy in the treatment of dry eyes. Methods: This was an institutional review board-approved, single-site, open-label, prospective study to assess the efficacy and safety of placing the xlHA gel in the lower canaliculus. Seventy-four participants aged 25-95 years with dry eyes, who failed treatment with artificial tears, were included. Patients were assessed with corneal slit lamp examination with fluorescein staining and with Schirmer's test, breakup time (TBUT), and tear meniscus height (TMH) at baseline, 1 month, and 3 months...
2018: Clinical Ophthalmology
Danial Mohabati, Elon Hc van Dijk, Thomas J van Rijssen, Eiko K de Jong, Myrte B Breukink, Jose P Martinez-Ciriano, Greet Dijkman, Carel B Hoyng, Sascha Fauser, Suzanne Yzer, Camiel Jf Boon
Purpose: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT). Patients and methods: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures...
2018: Clinical Ophthalmology
Ashish Sharma, Prahalad Reddy, Baruch D Kuppermann, Francesco Bandello, Anat Lowenstein
Retinal disease management has witnessed remarkable advances in posterior segment pharmacotherapy with the development of anti-VEGF molecules such as Lucentis® (ranibizumab), Eylea® (aflibercept), and off-label bevacizumab (Avastin). The US patents for ranibizumab and aflibercept will expire in 2020 (though Regeneron has indicated that it might attempt to extend its US patent to June 2023 with additional patent claims), and their European patents will expire in 2022 and 2025. Aflibercept comes off patent in 2022 in People's Republic of China and Japan...
2018: Clinical Ophthalmology
Darin Sakiyalak, Yuwared Chattagoon
Purpose: The aim of this study was to investigate the incidence of and risk factors for secondary ocular hypertension (OHT) in patients with moderate to severe infectious ulcerative keratitis and to evaluate the long-term outcome of patients with secondary OHT. Patients and methods: A retrospective chart review of 346 patients with moderate to severe infectious keratitis admitted to Siriraj Hospital during the period from 1 January 2005 to 31 May 2008 was conducted...
2018: Clinical Ophthalmology
Yukinori Sugano, Tetsuju Sekiryu, Minoru Furuta, Ryutaro Tomita, Hiroaki Shintake, Hiroki Maehara, Akira Ojima
Purpose: To assess the reproducibility of quantitative morphometrical evaluation of the choriocapillaris imaged with swept-source optical coherence tomography angiography (SS-OCTA). Subjects and methods: This observational, cross-sectional case series included 35 eyes of healthy individuals and 32 eyes of 32 patients. Two images of the fovea were taken using SS-OCTA with 3×3 mm squares. Images of the choriocapillaris within 800×800 pixel squares centered at the fovea were analyzed morphometrically using open-source software "AngioTool" that applies a Gaussian recursive filter and multiscale Hessian enhancement...
2018: Clinical Ophthalmology
Stephan Y Chiu, Jeremy W Shaw, Tiffany Q Luong, Donald S Fong, Bobeck S Modjtahedi
Purpose: The aim of this study was to characterize International Classification of Diseases (ICD-9) coding patterns used by ophthalmologists in clinical practice for hydroxychloroquine (HCQ) retinal toxicity. Design: This is a retrospective cohort study. Subjects: Patients enrolled in the Kaiser Permanente Southern California health plan who were dispensed HCQ between 2001 and 2014 were included in this study. Methods: Patients' medical records were electronically searched for the following ICD-9 codes that can be used to characterize retinopathy or maculopathy: toxic maculopathy, non-exudative age-related macular degeneration (AMD), drusen (degenerative), and/or (other) background retinopathy...
2018: Clinical Ophthalmology
Hsin-Yu Yang, Yu-Fan Chang, Chih-Chien Hsu, Yu-Chieh Ko, Catherine Jui-Ling Liu, Mei-Ju Chen
Purpose: We evaluated macular ganglion cell asymmetry as a tool for diagnosing paracentral scotoma (PCS) in early glaucoma. Patients and methods: This prospective study compared 58 patients with early glaucoma and PCS to 58 age-matched control individuals. All glaucomatous eyes had scotoma within the central 12 degrees of fixation and confined to one hemifield. We measured circumpapillary retinal nerve fiber layer (cpRNFL) thickness, macular ganglion cell-inner plexiform layer (GCIPL) thickness, and optic nerve head (ONH) parameters with Cirrus spectral domain optical coherence tomography...
2018: Clinical Ophthalmology
Samuel F Passi, Atalie C Thompson, Preeya K Gupta
Purpose: To compare the agreement and efficiency of a swept source-optical coherence tomography biometer, IOLMaster 700 (IOLM700), and a low-coherence optical reflectometry biometer, LENSTAR LS 900 (LS900), when acquiring biometry measurements during cataract evaluation. Methods: A retrospective chart review of biometry measurements that were performed in 64 eyes of 32 patients on the same day using the LS900 and the IOLM700. The total image acquisition time per subject was compared between the two machines using a Wilcoxon rank-sum test...
2018: Clinical Ophthalmology
Tomofusa Yamauchi, Hitoshi Tabuchi, Kosuke Takase, Zaigen Ohara, Hitoshi Imamura, Yoshiaki Kiuchi
Aim: We compared the visual performance of toric intraocular lenses (IOLs) and non-toric IOLs made of the same material. Patients and materials: The subjects included patients implanted with either Acrysof IQ® toric IOLs (SN6AT3-9) or Acrysof IQ® IOLs (SN60WF) bilaterally. The toric group included 103 patients who were implanted with Acrysof IQ toric IOLs bilaterally. The non-toric group was a corneal astigmatism-matched control group and included 103 patients who were implanted with Acrysof IQ IOLs bilaterally...
2018: Clinical Ophthalmology
Tirth J Shah, Mandi D Conway, Gholam A Peyman
Cataract surgery is one of the most commonly performed surgeries worldwide, with nearly 20 million cases annually. Appropriate prophylaxis after cataract surgery can contribute to a safe and quick visual recovery with high patient satisfaction. Despite being the current standard of care, the use of multiple postoperative eye drops can create a significant burden on these patients, contributing to documented and significant non-adherence to the postoperative regimen. Over the past 25 years, there have been a few studies analyzing the use of intracameral dexamethasone (DXM) in controlling inflammation following cataract surgery...
2018: Clinical Ophthalmology
Izumi Yoshida, Tomoaki Shiba, Yuichi Hori, Takatoshi Maeno
Purpose: Detecting primary breaks and confirming detachment preoperatively are important. Lincoff stated that retinal detachments progress according to gravity; his law has become popular. We evaluated Lincoff's law with a slight modification to determine whether it remains suitable for present cases independent of refractive error and previous cataract surgery. Patients and methods: Group 1 included superior region detachments not exceeding the 12 o'clock midline; the original break was within 1 1/2 clock hours of the highest detachment border...
2018: Clinical Ophthalmology
Matthew V Fry, James J Augsburger, June Hall, Zélia M Corrêa
Recognizing that <1% of all uveal melanomas occur in young persons, and that very few clinicians encounter more than a few such cases over an extended career, we felt that a retrospective review of literature and sharing of our clinical experience would be appropriate to remind readers about this age subgroup of patients with posterior uveal melanoma. This interest stems from the increase in reported cases of uveal melanoma in younger individuals and recent advances in the field.
2018: Clinical Ophthalmology
Taraprasad Das, Sabyasachi Pattanayak
Purpose: To describe the program planning of Sunetra (Healthy Eyes), the universal eye health coverage in the Indian state Odisha. Methods: The Indian state of Odisha launched the universal eye health coverage in October 2017. This is the first Indian state to officially respond to the World Health Organization's Global Action Plan. Results: The Government of Odisha pledged INR 6,820 million (US$ 100 million approximately) spread over 5 years...
2018: Clinical Ophthalmology
Shwu-Jiuan Sheu, Cheng-Kuo Cheng, Hsi-Kung Kuo, Ching-Yao Tsai, Tai-Chi Lin, Jonathan Tan, Hitesh Chandwani, Michael Adena, Shih-Jen Chen
Objectives: To characterize diabetic macular edema (DME) treatment patterns in Taiwan and examine their impact on health care resource utilization and visual and anatomic outcomes. Methods: Retrospective, observational cohort study of longitudinal data from medical records of five hospital ophthalmology clinics. Patients with type 2 diabetes and DME who received ≥1 laser treatment or pharmacotherapy (intravitreal/subtenon corticosteroids and/or intravitreal anti-vascular endothelial growth factor [VEGF] agents) between January 2012 and December 2013 (index period) and attended ≥1 follow-up visit after the first treatment during that period were identified (prevalent population, N=431)...
2018: Clinical Ophthalmology
Hakika Erdogan, Ziya Akingol, Ozlem Cam, Sadik Sencan
Purpose: The aim of the study was to statistically compare intraocular pressure (IOP) values measured using noncontact tonometer (NCT), Goldmann applanation tonometry (GAT) with fluorescein (fGAT), and GAT without fluorescein (nGAT). The study was also performed to test whether the values obtained using each technique change in accordance with the central corneal thickness (CCT) and refractive and keratometric values. Study design: This study was a prospective study of 188 eyes of 94 healthy volunteers...
2018: Clinical Ophthalmology
Mansing Ratanasukon, Patama Bhurayanontachai, Pichai Jirarattanasopa
Purpose: The purpose of this article was to study the real-life treatment results of polypoidal choroidal vasculopathy (PCV). Design: This was a retrospective study. Methods: Patients with presumed age-related macular degeneration were reviewed, and PCV diagnosis was made using the EVEREST study criteria. Outcomes were changes in visual acuity (VA) and central retinal thickness, time between treatments, follow-up time, and number of treatments...
2018: Clinical Ophthalmology
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