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Clinical Ophthalmology

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https://www.readbyqxmd.com/read/29225460/intravitreal-bevacizumab-injections-versus-dexamethasone-implant-for-treatment-na%C3%A3-ve-retinal-vein-occlusion-related-macular-edema
#1
Ilkka Laine, Juha-Matti Lindholm, Petteri Ylinen, Raimo Tuuminen
Purpose: To compare the short-term effects of three monthly intravitreal bevacizumab (IVB) injections to single dexamethasone (DEX) implantation in treatment-naïve patients with cystoid macular edema (CME) secondary to branch (BRVO) and central retinal vein occlusion (CRVO). Design: A retrospective single-center study. Subjects: A total of 135 eyes of 135 patients with BRVO (n=83) and CRVO (n=52). Methods: Changes in clinical parameters were recorded before treatment and at the first and third month after commencement of IVB (n=121) and DEX (n=14)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29213204/in-vitro-release-of-two-anti-muscarinic-drugs-from-soft-contact-lenses
#2
Alex Hui, Magdalena Bajgrowicz-Cieslak, Chau-Minh Phan, Lyndon Jones
The purpose of this study was to investigate the release of the anti-myopia drugs atropine sulfate and pirenzepine dihydrochloride from commercially available soft contact lenses. Standard ultraviolet (UV) absorbance-concentration curves were generated for atropine and pirenzepine. Ten commercially available contact lenses, including four multifocal lenses, were loaded by soaking in atropine or pirenzepine solutions at two different concentrations (10 mg/mL and 1 mg/mL). The release of the drugs into phosphate-buffered saline was determined over the course of 24 hours at 34°C using UV absorbance...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29200823/six-month-postoperative-outcomes-of-intraoperative-oct-guided-surgical-cystotomy-for-refractory-cystoid-macular-edema-in-diabetic-eyes
#3
Yuichi Asahina, Naoko Tachi, Yumi Asahina, Kayoko Yoshimura, Yoshiki Ueta, Yoshihiro Hashimoto
Purpose: This study evaluated the outcomes of surgical cystotomy for recurrent diabetic cystoid macular edema (CME). Patients and methods: We analyzed 20 eyes with a clinical diagnosis of diabetic retinopathy and refractory CME. Release of vitreoretinal adhesion, epiretinal membrane (ERM) and internal limiting membrane (ILM) peeling and cystotomy guided by intraoperative optical coherence tomography (iOCT) were performed in every patient. Pars plana vitrectomy was also performed in 17 patients, 11 of whom also underwent lensectomy and intraocular lens implantation...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29200822/intraocular-pressure-1-year-after-vitrectomy-in-eyes-without-a-history-of-glaucoma-or-ocular-hypertension
#4
Yuan Fang, Qingqing Long, Xiaoqian Wang, Rui Jiang, Xinghuai Sun
Objective: The aim of this study was to investigate the incidence, risk factors, and treatment of elevated intraocular pressure (IOP) 1 year after vitrectomy in eyes without a history of glaucoma or ocular hypertension. Patients and methods: This retrospective study comprised 256 eyes from 256 consecutive patients without a history of glaucoma or ocular hypertension who underwent vitrectomy and were followed up for 1 year. The incidence of elevated IOP at 1 year after vitrectomy was calculated...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29200821/spectropathology-corroborated-multimodal-quantitative-imaging-biomarkers-for-neuroretinal-degeneration-in-diabetic-retinopathy
#5
Arpan Guha Mazumder, Swarnadip Chatterjee, Saunak Chatterjee, Juan Jose Gonzalez, Swarnendu Bag, Sambuddha Ghosh, Anirban Mukherjee, Jyotirmoy Chatterjee
Introduction: Image-based early detection for diabetic retinopathy (DR) needs value addition due to lack of well-defined disease-specific quantitative imaging biomarkers (QIBs) for neuroretinal degeneration and spectropathological information at the systemic level. Retinal neurodegeneration is an early event in the pathogenesis of DR. Therefore, development of an integrated assessment method for detecting neuroretinal degeneration using spectropathology and QIBs is necessary for the early diagnosis of DR...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29200820/the-effect-of-flap-thickness-on-corneal-biomechanics-after-myopic-laser-in-situ-keratomileusis-using-the-m-2-microkeratome
#6
Iyad A Goussous, Mohamed-Sameh El-Agha, Ahmed Awadein, Mohamed H Hosny, Alaa A Ghaith, Ahmed L Khattab
Purpose: The purpose of this study was to determine the effect of flap thickness on corneal biomechanics after myopic laser in situ keratomileusis (LASIK). Methods: This is a prospective controlled non-randomized, institutional study. Patients underwent either epi-LASIK with mitomycin (advanced surface ablation [ASA]), thin-flap LASIK (90 µm head), or thick-flap LASIK (130 µm head). In ASA, the Moria Epi-K hydroseparator was used. LASIK flaps were created using the Moria M-2 mechanical microkeratome...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29200819/the-efficacy-of-preoperative-posterior-subtenon-injection-of-triamcinolone-acetonide-in-noninfectious-uveitic-patients-with-secondary-glaucoma-undergoing-trabeculectomy
#7
Narumon Keorochana, Sutheera Kunasuntiwarakul, Isaraporn Treesit, Raveewan Choontanom
Objective: The aim of this study was to evaluate the efficacy and safety of preoperative posterior subtenon injection of triamcinolone acetonide (PSTA) in noninfectious uveitic patients with secondary glaucoma undergoing primary trabeculectomy with mitomycin C. Design: This was a retrospective study. Patients and methods: We reviewed the medical records of 10 noninfectious uveitic patients, who had received a single preoperative PSTA 40 mg/1 mL, with secondary glaucoma undergoing primary trabeculectomy with mitomycin C...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29200818/photodynamic-therapy-combined-with-antivascular-endothelial-growth-factor-treatment-for-recalcitrant-chronic-central-serous-chorioretinopathy
#8
Masumi G Asahi, Andrew T Chon, Esmeralda Gallemore, Ron P Gallemore
Purpose: To determine whether combination photodynamic therapy (PDT) and antivascular endothelial growth factor (VEGF) therapy is effective in the management of chronic central serous chorioretinopathy (CSC) recalcitrant to conventional therapy. Methods: This was a retrospective analysis of eight patients with chronic CSC unresponsive to topical nonsteroidal anti-inflammatory drugs, focal photocoagulation, anti-VEGF alone, or PDT alone. All patients were evaluated with a full ophthalmic examination, spectral-domain optical coherence tomography (OCT), fluorescein angiography (FA), and most with indocyanine green angiography (ICGA) followed by treatment with half-fluence PDT and intravitreal anti-VEGF injection (seven bevacizumab, one aflibercept)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29200817/evaluation-of-corneal-symmetry-after-uv-corneal-crosslinking-for-keratoconus
#9
Hanan Mofty, Khaled Alzahrani, Fiona Carley, Sophie Harper, Arun Brahma, Leon Au, Debbie Morley, M Chantal Hillarby
Purpose: The purpose of this study was to assess UV corneal crosslinking (CXL) treatment outcomes for keratoconus by evaluating the corneal regularity in patients through follow-up using the Oculus Pentacam. Patients and methods: A total of 18 eyes from CXL patients with keratoconus were studied before and after CXL treatment, and six eyes from six patients who were not treated with CXL served as controls. Treated patients had Pentacam images taken before CXL treatment and regularly 3 months post treatment up to the 12th month...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29200816/multivariable-prediction-model-for-suspected-giant-cell-arteritis-development-and-validation
#10
Edsel B Ing, Gabriela Lahaie Luna, Andrew Toren, Royce Ing, John J Chen, Nitika Arora, Nurhan Torun, Otana A Jakpor, J Alexander Fraser, Felix J Tyndel, Arun Ne Sundaram, Xinyang Liu, Cindy Ty Lam, Vivek Patel, Ezekiel Weis, David Jordan, Steven Gilberg, Christian Pagnoux, Martin Ten Hove
Purpose: To develop and validate a diagnostic prediction model for patients with suspected giant cell arteritis (GCA). Methods: A retrospective review of records of consecutive adult patients undergoing temporal artery biopsy (TABx) for suspected GCA was conducted at seven university centers. The pathologic diagnosis was considered the final diagnosis. The predictor variables were age, gender, new onset headache, clinical temporal artery abnormality, jaw claudication, ischemic vision loss (VL), diplopia, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and platelet level...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29184388/anxiety-in-patients-undergoing-cataract-surgery-a-pre-and-postoperative-comparison
#11
David A Ramirez, Frank L Brodie, Jennifer Rose-Nussbaumer, Saraswathy Ramanathan
Purpose: Reducing surgery-related patient anxiety without under-emphasizing surgical risk is challenging for even the most experienced surgeon. The purpose of this study is to identify specific anxieties faced by patients in hopes of better informing the preoperative surgeon-patient dialogue. Setting: Comprehensive and specialty ophthalmology clinics at the University of California, San Francisco. Design: A prospective, survey-based study in which a pre- and postoperative questionnaire was administered to patients undergoing routine phacoemulsification...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29184387/lacrimal-drainage-anomalies-in-congenital-rubella-syndrome
#12
Shweta Gupta, Mohammad Javed Ali, Milind N Naik
Purpose: The objective of this study was to ascertain the lacrimal drainage anomalies in a cohort of patients suffering from congenital rubella syndrome (CRS). Methods: This was a retrospective case series performed in patients with CRS presenting with associated lacrimal drainage anomalies (LDA) over 6 years from 2011 to 2016. All the patients were confirmed as having CRS after clinical and laboratory testing. Data collected include demographics; associated lacrimal, ocular, and systemic anomalies; interventions performed for lacrimal anomalies; and their anatomical and functional outcomes...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29184386/novel-grid-combined-with-peripheral-distortion-correction-for-ultra-widefield-image-grading-of-age-related-macular-degeneration
#13
Patrick Oellers, Inês Laíns, Steven Mach, Shady Garas, Ivana K Kim, Demetrios G Vvvas, Joan W Miller, Deeba Husain, John B Miller
Purpose: Eyes with age-related macular degeneration (AMD) often harbor pathological changes in the retinal periphery and perimacular region. These extramacular changes have not been well classified, but may be phenotypically and functionally relevant. The purpose of this study was to demonstrate a novel grid to systematically study peripheral retinal abnormalities in AMD using geometric distortion-corrected ultra-widefield (UWF) imaging. Methods: This is a cross-sectional observational case series...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29184385/aflibercept-treatment-for-neovascular-amd-beyond-the-first-year-consensus-recommendations-by-a-uk-expert-roundtable-panel-2017-update
#14
EDITORIAL
Praveen J Patel, Helen Devonport, Sobha Sivaprasad, Adam H Ross, Gavin Walters, Richard P Gale, Andrew J Lotery, Sajjad Mahmood, James S Talks, Jackie Napier
National recommendations on continued administration of aflibercept solution for injection after the first year of treatment for neovascular age-related macular degeneration (nAMD) have been developed by an expert panel of UK retina specialists, based on clinician experience and treatment outcomes seen in year 2. The 2017 update reiterates that the treatment goal is to maintain or improve the macular structural and functional gains achieved in year 1 while attempting to reduce or minimize the treatment burden, recognizing the need for ongoing treatment...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29184384/treatment-of-refractory-uveitic-macular-edema-results-of-a-first-and-second-implant-of-long-acting-intravitreal-dexamethasone
#15
Marta Zola, Cristina Briamonte, Umberto Lorenzi, Federica Machetta, Federico M Grignolo, Antonio M Fea
Purpose: The purpose of this study was to report the functional and anatomical outcomes of a prospective study resulting from repeated dexamethasone intravitreal implants in patients with uveitic refractory macular edema. Methods: Twelve eyes of 9 patients with intermediate and posterior noninfectious inflammatory uveitis complicated with refractory macular edema were regularly reviewed after a dexamethasone intravitreal implant. Patients were examined at baseline, 30, 90, 135, and 180 days with best-corrected visual acuity (BCVA), complete slit-lamp examination, intraocular pressure (IOP), optical coherence tomography, and fluorescein angiography...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29184383/prevalence-and-factors-associated-with-childhood-visual-impairment-in-ethiopia
#16
Lidiya Bezabih, Tilaye Workneh Abebe, Robera Olana Fite
Background: Visual impairment is a significant loss of vision. It has an impact on the prosperity of different countries. It has been difficult to plan preventive measures against visual impairment due to the scarcity of data about the extent of the problem. Objectives: The study was aimed at assessing the prevalence and identifying factors associated with visual impairment among school-age children in Ethiopia. Materials and methods: A cross-sectional study design was used in four randomly selected schools found in Addis Ababa from May 15 to June 14, 2016...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29184382/phaco-capsulotomy-a-technique-to-prevent-the-argentinean-flag-sign
#17
Christopher C Teng
The Argentinean Flag Sign is a complication that occurs during capsulorhexis construction, in which the capsulorhexis extends to the periphery due to lens intumescence. Phaco capsulotomy is a technique in which the phacoemulsification tip is used to simultaneously create the initial tear in the anterior capsule and remove a portion of the intumescent lens, thereby debulking and relieving pressure from the lens and capsule, and preventing the Argentinean Flag Sign. A detailed description of the phaco capsulotomy technique is provided, including applications and potential complications...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29180847/optic-disc-segmentation-for-glaucoma-screening-system-using-fundus-images
#18
Ahmed Almazroa, Weiwei Sun, Sami Alodhayb, Kaamran Raahemifar, Vasudevan Lakshminarayanan
Segmenting the optic disc (OD) is an important and essential step in creating a frame of reference for diagnosing optic nerve head pathologies such as glaucoma. Therefore, a reliable OD segmentation technique is necessary for automatic screening of optic nerve head abnormalities. The main contribution of this paper is in presenting a novel OD segmentation algorithm based on applying a level set method on a localized OD image. To prevent the blood vessels from interfering with the level set process, an inpainting technique was applied...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29180846/different-fixation-targets-affect-retinal-sensitivity-obtained-by-microperimetry-in-normal-individuals
#19
Tomohiro Nizawa, Takayuki Baba, Masayasu Kitahashi, Toshiyuki Oshitari, Shuichi Yamamoto
Purpose: To determine the differences in the retinal sensitivities obtained by microperimetry with a single cross or a circular fixation target in normal individuals. Methods: Thirty-two eyes of 16 healthy volunteers (mean age 28.9±1.4 years, range 24-44 years) were studied. The retinal sensitivity of the central 0 degrees and of the mean central 2 degrees consisting of 8 points were determined independently using the two different fixation targets with Microperimeter 3...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29180845/clinical-outcomes-of-endoscope-assisted-vitrectomy-for-treatment-of-rhegmatogenous-retinal-detachment
#20
Sho Yokoyama, Takashi Kojima, Toshio Mori, Taisuke Matsuda, Hiroyuki Sato, Norihiko Yoshida, Tatsushi Kaga, R Theodore Smith, Kazuo Ichikawa
Summary: We evaluated the clinical outcomes for ophthalmic endoscope-assisted vitrectomy in consecutive patients with uncomplicated rhegmatogenous retinal detachment (RRD). The primary success rate was 98.4% (125/127) without performing a posterior drainage retinotomy or using perfluorocarbon liquids (PFCL) for subretinal fluid drainage. Purpose: To investigate the clinical outcomes of endoscope-assisted vitrectomy in patients with uncomplicated RRD. Methods: We examined 127 eyes from consecutive patients who underwent repair of RRD by 23- or 25-gauge endoscope-assisted vitrectomy, with a minimum follow-up of 3 months...
2017: Clinical Ophthalmology
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