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Clinical Ophthalmology

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https://www.readbyqxmd.com/read/28203056/safety-of-bilateral-same-day-intravitreal-injections-of-anti-vascular-endothelial-growth-factor-agents
#1
Miguel Ruão, María Andreu-Fenoll, Rosa Dolz-Marco, Roberto Gallego-Pinazo
PURPOSE: The aim was to evaluate the safety of bilateral same-day injections with intravitreal antiangiogenic drugs for macular diseases. METHODS: Cross-sectional retrospective review of unilateral and bilateral same-day antiangiogenic injections was conducted between January 2011 and March 2016 in the Unit of Macula, University and Polytechnic Hospital La Fe (Valencia, Spain). A total of 8,172 injections were administered, among which 6,560 were unilateral and 1,612 were bilateral injections...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28203055/resident-surgeon-efficiency-in-femtosecond-laser-assisted-cataract-surgery
#2
Andrew C Pittner, Brian R Sullivan
PURPOSE: Comparison of resident surgeon performance efficiencies in femtosecond laser-assisted cataract surgery (FLACS) versus conventional phacoemulsification. PATIENTS AND METHODS: A retrospective cohort study was conducted on consecutive patients undergoing phacoemulsification cataract surgery performed by senior ophthalmology residents under the supervision of 1 attending physician during a 9-month period in a large Veterans Affairs medical center. Medical records were reviewed for demographic information, preoperative nucleus grade, femtosecond laser pretreatment, operative procedure times, total operating room times, and surgical complications...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28203054/uveal-melanoma-epidemiology-etiology-and-treatment-of-primary-disease
#3
REVIEW
Benjamin A Krantz, Nikita Dave, Kimberly M Komatsubara, Brian P Marr, Richard D Carvajal
Uveal melanoma (UM) is the most common intraocular malignancy and arises from melanocytes in the iris, ciliary body, or choroid. Early diagnosis and local treatment is crucial, as survival correlates with primary tumor size. However, approximately 50% of patients will develop metastatic disease with 6-12 months' survival from metastatic diagnosis. Genomic analyses have led to the development of gene-expression profiles that effectively predict metastatic progression; unfortunately, no adjuvant therapy has been shown to prolong survival to date...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28203053/refractive-outcomes-and-safety-of-the-implantable-collamer-lens-in-young-low-to-moderate-myopes
#4
Paul J Dougherty, Taylor Priver
PURPOSE: To evaluate visual and refractive outcomes and safety of implantable collamer lens (ICL) implantation in low-to-moderate myopia. SETTING: Private Practice - Dougherty Laser Vision, Westlake Village, CA, USA. METHODS: A chart review was performed in 56 (104 eyes) consecutive patients who underwent implantation of the Visian ICL V4 model. Inclusion criteria were age between 21 and 40 years, spherical equivalent between -3.00 D and -10...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28203052/early-experiences-of-planning-stereotactic-radiosurgery-using-3d-printed-models-of-eyes-with-uveal-melanomas
#5
Alena Furdová, Miron Sramka, Andrej Thurzo, Adriana Furdová
OBJECTIVE: The objective of this study was to determine the use of 3D printed model of an eye with intraocular tumor for linear accelerator-based stereotactic radiosurgery. METHODS: The software for segmentation (3D Slicer) created virtual 3D model of eye globe with tumorous mass based on tissue density from computed tomography and magnetic resonance imaging data. A virtual model was then processed in the slicing software (Simplify3D(®)) and printed on 3D printer using fused deposition modeling technology...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28203051/a-review-and-update-on-orphan-drugs-for-the-treatment-of-noninfectious-uveitis
#6
REVIEW
Caiyun You, Haitham F Sahawneh, Lina Ma, Buraa Kubaisi, Alexander Schmidt, C Stephen Foster
INTRODUCTION: Uveitis, a leading cause of preventable blindness around the world, is a critically underserved disease in regard to the medications approved for use. Multiple immunomodulatory therapy (IMT) drugs are appropriate for uveitis therapy but are still off-label. These IMT agents, including antimetabolites, calcineurin inhibitors, alkylating agents, and biologic agents, have been designated as "orphan drugs" and are widely used for systemic autoimmune diseases or organ transplantation...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28203050/normal-flora-of-conjunctiva-and-lid-margin-as-well-as-its-antibiotic-sensitivity-in-patients-undergoing-cataract-surgery-at-phramongkutklao-hospital
#7
Ravee Ratnumnoi, Narumon Keorochana, Chavalit Sontisombat
OBJECTIVE: This study aimed to evaluate the normal flora of conjunctiva and lid margin, as well as its antibiotic sensitivity. DESIGN: This was a prospective cross-sectional study. PATIENTS AND METHODS: A prospective study was conducted on 120 patients who underwent cataract surgery at the Phramongkutklao Hospital from September 2014 to October 2014. Conjunctival and lid margin swabs were obtained from patients before they underwent cataract surgery...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28184151/wound-and-surface-temperatures-in-vivo-in-torsional-and-longitudinal-modalities-of-ultrasound-in-coaxial-microincisional-cataract-surgery
#8
Swapna Nair, Ramachandran Unnikrishnan Nair
BACKGROUND: To study phacoemulsification probe shaft/wound and corneal surface/tip temperatures in vivo during longitudinal, torsional and combined phacoemulsification modes and their relationship to machine parameters. DESIGN: This was a prospective study at Chaithanya Eye Hospital and Research Institute, Trivandrum, India (tertiary). PARTICIPANTS: Twenty-two eyes of 22 patients were randomized into six groups depending on the grade of nuclear sclerosis (NS) and the type of ultrasound used: Group 1, torsional in NS2; Group 2, torsional in NS3; Group 3, torsional with intermittent longitudinal in NS2; Group 4, torsional with intermittent longitudinal in NS3; Group 5, longitudinal in NS2; Group 6, longitudinal in NS3...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28184150/randomized-masked-in-vitro-comparison-of-three-commercially-available-tear-film-osmometers
#9
Guillermo Rocha, Eric Gulliver, Armand Borovik, Clara C Chan
PURPOSE: The purpose of this study was to compare the precision and accuracy of commercially available tear film osmometers. METHODS: Contrived tear solution target values representing the physiological range of tear osmolarity (normal eyes 297 mOsm/L, moderately dry eyes 342 mOsm/L, and severe dry eyes 383 mOsm/L) were constructed using a mix of mono- and divalent electrolytes, metabolites, serum albumin, and pH balanced to 7.4. Solution values were randomized and masked from the investigators during testing...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28182161/combination-verteporfin-photodynamic-therapy-ranibizumab-dexamethasone-in-choroidal-neovascularization-due-to-age-related-macular-degeneration-results-of-a-phase-ii-randomized-trial
#10
Ron P Gallemore, Josh Wallsh, Henry L Hudson, Allen C Ho, Richard Chace, Joel Pearlman
PURPOSE: To assess whether combination therapy (CT) reduces retreatments when compared to ranibizumab monotherapy (RM), while safely maintaining similar vision outcomes. METHODS: In this 24-month trial, patients with age-related macular degeneration (AMD) were randomized to 1) quarter-fluence or 2) half-fluence triple therapy (verteporfin photodynamic therapy [vPDT] + ranibizumab + dexamethasone), 3) half-fluence double therapy (vPDT + ranibizumab), or 4) RM. The primary outcomes were number of retreatment visits and change from baseline in visual acuity (VA) at 12 months...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28182152/trypan-blue-assisted-posterior-capsulorhexis-in-pediatric-cataract-surgery
#11
Ayman Lotfy, Ayman Abdelrahman
PURPOSE: To evaluate the safety and efficacy of staining the posterior capsule with trypan blue during capsulorhexis in pediatric cataract surgery. PATIENTS AND METHODS: This was a prospective randomized comparative study carried out at Alpha Vision Center, Zagazig, Egypt. This study included 2 groups of children with pediatric cataract randomly allocated to undergo irrigation and aspiration. In the trypan group, which included 11 eyes, trypan blue was used to stain the posterior capsule during posterior capsulorhexis...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28182145/stereoacuity-after-small-aperture-corneal-inlay-implantation
#12
Steven H Linn, David F Skanchy, Tyler S Quist, Jordan D Desautels, Majid Moshirfar
PURPOSE: The aim of this study was to compare stereoacuity before and after KAMRA corneal inlay implantation for the correction of presbyopia. PATIENTS AND METHODS: This is a prospective study of 60 patients who underwent KAMRA inlay implantation. Patients were examined before and 6 months after surgery for stereoacuity, uncorrected distance visual acuity (UDVA), and uncorrected near visual acuity (UNVA). RESULTS: The mean stereoacuity before surgery was 29...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28176965/re-perg-a-new-procedure-for-electrophysiologic-diagnosis-of-glaucoma-that-may-improve-perg-specificity
#13
Alberto Mavilio, Dario Sisto, Paolo Ferreri, Nicola Cardascia, Giovanni Alessio
PURPOSE: A significant variability of the second harmonic (2ndH) phase of steady-state pattern electroretinogram (SS-PERG) in intrasession retest has been recently described in glaucoma patients (GP), which has not been found in healthy subjects. To evaluate the reliability of phase variability in retest (a procedure called RE-PERG or REPERG) in the presence of cataract, which is known to affect standard PERG, we tested this procedure in GP, normal controls (NC), and cataract patients (CP)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28176960/pseudophakic-astigmatism-reduction-with-femtosecond-laser-assisted-corneal-arcuate-incisions-a-pilot-study
#14
Clayton Blehm, Richard Potvin
PURPOSE: The aim of this study was to assess the effectiveness of the Verion-LenSx guided arcuate incision technique to reduce refractive astigmatism in a pseudophakic population. PATIENTS AND METHODS: A prospective single-arm study was conducted in which one or both eyes of subjects required reduction of 1.0-2.0 D of refractive astigmatism after previous cataract surgery or refractive lens exchange. The surgeon used the refractive cylinder in the eye and the Woodcock astigmatism nomogram for preoperative planning, while the LenSx femtosecond laser with the Verion Image Guided System was used to create all arcuate incisions...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28176950/circulating-monocytes-and-b-lymphocytes-in-neovascular-age-related-macular-degeneration
#15
Sven Magnus Hector, Torben Lykke Sørensen
BACKGROUND: Individuals with neovascular age-related macular degeneration (AMD) have altered number and distribution of retinal macrophages and show changes in circulating antibodies. We wanted to investigate the corresponding precursors, with subpopulations. We therefore measured monocyte and B-lymphocyte populations in individuals with neovascular AMD. DESIGN: This was an observational case-control study. PARTICIPANTS OR SAMPLES: A total of 31 individuals with neovascular AMD and 30 healthy age-matched controls were included...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28176934/retinal-reperfusion-in-diabetic-retinopathy-following-treatment-with-anti-vegf-intravitreal-injections
#16
Ariana M Levin, Irene Rusu, Anton Orlin, Mrinali P Gupta, Peter Coombs, Donald J D'Amico, Szilárd Kiss
PURPOSE: The aim of this study is to report peripheral reperfusion of ischemic areas of the retina on ultra-widefield fluorescein angiography (UWFA) following anti-vascular endothelial growth factor (VEGF) intravitreal injections in patients treated for diabetic retinopathy. METHODS: This study is a retrospective review of 16 eyes of 15 patients with diabetic retinopathy, who received anti-VEGF intravitreal injections and underwent pre- and postinjection UWFA. The main outcome measured was the presence of reperfusion in postinjection UWFA images in areas of the retina that demonstrated nonperfusion in preinjection images...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28176902/herpes-simplex-keratitis-challenges-in-diagnosis-and-clinical-management
#17
REVIEW
Tayaba N Azher, Xiao-Tang Yin, Deena Tajfirouz, Andrew Jw Huang, Patrick M Stuart
Herpes simplex virus is responsible for numerous ocular diseases, the most common of which is herpetic stromal keratitis. This is a recurrent infection of the cornea that typically begins with a subclinical infection of the cornea that establishes a latent infection of sensory ganglia, most often the trigeminal ganglia. Recurring infections occur when the virus is reactivated from latency and travels back to the cornea, where it restimulates an inflammatory response. This inflammatory response can lead to decreased corneal sensation, scarring, and blindness...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28123287/switching-to-aflibercept-among-patients-with-treatment-resistant-neovascular-age-related-macular-degeneration-a-systematic-review-with-meta-analysis
#18
REVIEW
Kimberly Spooner, Thomas Hong, Wijeyanthy Wijeyakumar, Andrew A Chang
PURPOSE: To systematically review anatomical and functional outcomes subsequent to switching from bevacizumab/ranibizumab to aflibercept monotherapy in patients with treatment-resistant neovascular age-related macular degeneration (nAMD). DESIGN: Systematic review and meta-analysis. METHODS: Medline, PubMed, Embase, and Cochrane databases were searched up to July 2016 for available scientific literature which met inclusion criteria. Eligible studies reported visual and anatomical outcomes with at least 6 months of follow-up among patients with nAMD and persistent or resistant exudative fluid despite previous anti-vascular endothelial growth factor (VEGF) therapy (bevacizumab and/or ranibizumab) and were switched to aflibercept monotherapy...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28115829/ocular-melanoma-when-you-have-seen-one-you-have-not-seen-them-all-a-clinical-outcome-study-from-the-surveillance-epidemiology-and-end-results-seer-database-1973-2012
#19
Krishnaraj Mahendraraj, Sneha Shrestha, Christine Sm Lau, Ronald S Chamberlain
BACKGROUND: Ocular melanoma (OM) comprises <5% of all melanomas. Uveal melanoma (UM) is the most common subtype of OM, while conjunctival melanoma (CM) is rare and differs significantly from UM. The purpose of this study is to evaluate a large cohort of OM patients to differentiate demographic, pathologic, and clinical factors between these two neoplasms, which may affect treatment and outcomes. METHODS: The Surveillance, Epidemiology, and End Results database (1973-2012) was used to extract demographic and clinical data on 8,165 OM patients (92...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28115828/sometimes-new-does-not-mean-safer
#20
COMMENT
Constantin-Dan Bordeianu
No abstract text is available yet for this article.
2017: Clinical Ophthalmology
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