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Journal Article
Randomized Controlled Trial
Sham surgery for the trialing of cell-based therapies to the CNS may not be necessary.
Cell Stem Cell 2024 Februrary 2
Sham surgery is often required for cell therapies adopting a randomized placebo-controlled double-blinded trial design. Using the case of dopamine neuron therapy for Parkinson's disease, we argue that alternative trial designs should be considered instead, for several reasons relating to ethics, patient burden, ease of unblinding, and cost.
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