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Cell Stem Cell

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https://www.readbyqxmd.com/read/28602620/integrin-%C3%AE-7-is-a-functional-marker-and-potential-therapeutic-target-in-glioblastoma
#1
Tobias L Haas, Maria Rita Sciuto, Lidia Brunetto, Cecilia Valvo, Michele Signore, Micol E Fiori, Simona di Martino, Stefano Giannetti, Liliana Morgante, Alessandra Boe, Michele Patrizii, Uwe Warnken, Martina Schnölzer, Andrea Ciolfi, Chiara Di Stefano, Mauro Biffoni, Lucia Ricci-Vitiani, Roberto Pallini, Ruggero De Maria
Functionally relevant markers of glioblastoma stem-like cells (GSCs) have potential for therapeutic targeting to treat this aggressive disease. Here we used generation and screening of thousands of monoclonal antibodies to search for receptors and signaling pathways preferentially enriched in GSCs. We identified integrin α7 (ITGA7) as a major laminin receptor in GSCs and in primary high-grade glioma specimens. Analyses of mRNA profiles in comprehensive datasets revealed that high ITGA7 expression negatively correlated with survival of patients with both low- and high-grade glioma...
June 5, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28506464/recruited-monocytes-and-type-2-immunity-promote-lung-regeneration-following-pneumonectomy
#2
Andrew J Lechner, Ian H Driver, Jinwoo Lee, Carmen M Conroy, Abigail Nagle, Richard M Locksley, Jason R Rock
To investigate the role of immune cells in lung regeneration, we used a unilateral pneumonectomy model that promotes the formation of new alveoli in the remaining lobes. Immunofluorescence and single-cell RNA sequencing found CD115+ and CCR2+ monocytes and M2-like macrophages accumulating in the lung during the peak of type 2 alveolar epithelial stem cell (AEC2) proliferation. Genetic loss of function in mice and adoptive transfer studies revealed that bone marrow-derived macrophages (BMDMs) traffic to the lung through a CCL2-CCR2 chemokine axis and are required for optimal lung regeneration, along with Il4ra-expressing leukocytes...
May 3, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28457749/an-fak-yap-mtor-signaling-axis-regulates-stem-cell-based-tissue-renewal-in-mice
#3
Jimmy Kuang-Hsien Hu, Wei Du, Samuel J Shelton, Michael C Oldham, C Michael DiPersio, Ophir D Klein
Tissue homeostasis requires the production of newly differentiated cells from resident adult stem cells. Central to this process is the expansion of undifferentiated intermediates known as transit-amplifying (TA) cells, but how stem cells are triggered to enter this proliferative TA state remains an important open question. Using the continuously growing mouse incisor as a model of stem cell-based tissue renewal, we found that the transcriptional cofactors YAP and TAZ are required both to maintain TA cell proliferation and to inhibit differentiation...
April 18, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575695/single-cell-rna-seq-analysis-maps-development-of-human-germline-cells-and-gonadal-niche-interactions
#4
Li Li, Ji Dong, Liying Yan, Jun Yong, Xixi Liu, Yuqiong Hu, Xiaoying Fan, Xinglong Wu, Hongshan Guo, Xiaoye Wang, Xiaohui Zhu, Rong Li, Jie Yan, Yuan Wei, Yangyu Zhao, Wei Wang, Yixin Ren, Peng Yuan, Zhiqiang Yan, Boqiang Hu, Fan Guo, Lu Wen, Fuchou Tang, Jie Qiao
No abstract text is available yet for this article.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575694/looking-back-single-cell-analysis
#5
(no author information available yet)
Over the past few years, burgeoning single-cell analyses platforms have unlocked access to previously unobtainable biological information about stem cell populations. For our tenth anniversary, we asked authors that cited a selection of our most popular papers in this area about how these studies influenced their work and the field.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575693/looking-back-aging-and-regeneration
#6
(no author information available yet)
Developing our understanding of how stem cell decline contributes to aging and its associated diseases promotes promising approaches to enhance stem cell regenerative capacity. For our tenth anniversary, we asked authors who cited a selection of our most popular papers in this area about the broad influences these studies have had.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575692/looking-back-disease-modeling
#7
(no author information available yet)
Over the past decade, the growth of stem cell-based models of human disorders has contributed to novel drug discovery and precision medicine possibilities. For our tenth anniversary, we asked authors who cited a selection of our most popular papers in this area about how these studies influenced them.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575691/looking-back-epigenomics
#8
(no author information available yet)
Our understanding of how changes in epigenomics facilitate reprogramming and lineage specification has grown extensively over the last decade. For our tenth anniversary, we asked authors who cited a selection of our most popular papers in this area about how these studies influenced their work and the field.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575690/looking-back-cancer-stem-cells
#9
(no author information available yet)
Over the past decade, our growing understanding of cancer stem cell characteristics and function continues to guide innovative new treatments to eradicate cancer. For our tenth anniversary, we asked authors who cited a selection of our most popular papers in this area about the broad influences these studies have had.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575689/racing-to-uncover-the-link-between-zika-virus-and-microcephaly
#10
Guo-Li Ming, Hongjun Song, Hengli Tang
In this Backstory, Ming, Song, and Tang give a behind-the-scenes account of the collaboration leading to their 2016 paper on Zika virus infection of neural progenitor cells. It was one of the first clues into how ZIKV could be causing birth defects in babies from infected mothers.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575688/the-dynamic-identity-of-intestinal-cancer-stem-cells
#11
Piero Dalerba
Elimination of self-renewing cancer stem cells (CSCs) is necessary to permanently eradicate malignant tissues. In a recent article in Nature, de Sousa e Melo et al. (2017) reveal that intestinal tumors can contain dynamic pools of functionally distinct CSC populations, which seem to interconvert depending on the host tissue microenvironment.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575687/mitotic-bookmarking-maintaining-the-stem-cell-identity-during-mitosis
#12
Xin Huang, Jianlong Wang
In Cell Reports, Liu et al. (2017) investigate mechanisms for how pluripotent stem cells maintain their identity during cell division. They show that the histone mark H3K27ac and pluripotency transcription factors remain associated with mitotic chromatin in ESCs and during iPSC reprogramming, demonstrating the importance of mitotic bookmarking in pluripotency.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575686/adipocytes-at-the-core-of-bone-function
#13
Gerald Grandl, Christian Wolfrum
Marrow adipose tissue (MAT) is a specialized adipose tissue with endocrine function found in bone marrow. In this issue of Cell Stem Cell, Ambrosi et al. (2017) identify a stem cell population in the bone marrow that can give rise to both osteogenic and adipogenic MAT precursors and is regulated by diet and aging and affects bone functionality.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575685/surface-markers-guide-the-journey-toward-naive-pluripotency
#14
Peter Karagiannis, Yasuhiro Takashima
Several protocols have managed to reset human primed PSCs to the naive state. In this issue of Cell Stem Cell, Collier et al. (2017) report a set of surface markers that identify which cells are susceptible to resetting and suggest a potential roadmap for the acquisition of naive pluripotency.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575684/gli-fully-halting-the-progression-of-fibrosis
#15
Christian F Guerrero-Juarez, Maksim V Plikus
Activating triggers, selective markers, and the residual regenerative potential of scar-forming myofibroblasts are largely determined by their origin. In this issue of Cell Stem Cell, Schneider et al. report that bone marrow myofibroblasts derive from Gli1(+) mesenchymal stromal cells and that a Gli inhibitor targets them for elimination in mice and humans, ameliorating fibrosis.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28575683/lineage-tracing-across-10-years
#16
EDITORIAL
Sheila Chari, Anh Nguyen, Jonathan Saxe, Deborah J Sweet
No abstract text is available yet for this article.
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28526555/modeling-psychomotor-retardation-using-ipscs-from-mct8-deficient-patients-indicates-a-prominent-role-for-the-blood-brain-barrier
#17
Gad D Vatine, Abraham Al-Ahmad, Bianca K Barriga, Soshana Svendsen, Ariel Salim, Leslie Garcia, Veronica J Garcia, Ritchie Ho, Nur Yucer, Tongcheng Qian, Ryan G Lim, Jie Wu, Leslie M Thompson, Weston R Spivia, Zhaohui Chen, Jennifer Van Eyk, Sean P Palecek, Samuel Refetoff, Eric V Shusta, Clive N Svendsen
Inactivating mutations in the thyroid hormone (TH) transporter Monocarboxylate transporter 8 (MCT8) cause severe psychomotor retardation in children. Animal models do not reflect the biology of the human disease. Using patient-specific induced pluripotent stem cells (iPSCs), we generated MCT8-deficient neural cells that showed normal TH-dependent neuronal properties and maturation. However, the blood-brain barrier (BBB) controls TH entry into the brain, and reduced TH availability to neural cells could instead underlie the diseased phenotype...
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28506465/deconstructing-olfactory-stem-cell-trajectories-at-single-cell-resolution
#18
Russell B Fletcher, Diya Das, Levi Gadye, Kelly N Street, Ariane Baudhuin, Allon Wagner, Michael B Cole, Quetzal Flores, Yoon Gi Choi, Nir Yosef, Elizabeth Purdom, Sandrine Dudoit, Davide Risso, John Ngai
A detailed understanding of the paths that stem cells traverse to generate mature progeny is vital for elucidating the mechanisms governing cell fate decisions and tissue homeostasis. Adult stem cells maintain and regenerate multiple mature cell lineages in the olfactory epithelium. Here we integrate single-cell RNA sequencing and robust statistical analyses with in vivo lineage tracing to define a detailed map of the postnatal olfactory epithelium, revealing cell fate potentials and branchpoints in olfactory stem cell lineage trajectories...
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28457750/single-cell-rna-seq-analysis-maps-development-of-human-germline-cells-and-gonadal-niche-interactions
#19
Li Li, Ji Dong, Liying Yan, Jun Yong, Xixi Liu, Yuqiong Hu, Xiaoying Fan, Xinglong Wu, Hongshan Guo, Xiaoye Wang, Xiaohui Zhu, Rong Li, Jie Yan, Yuan Wei, Yangyu Zhao, Wei Wang, Yixin Ren, Peng Yuan, Zhiqiang Yan, Boqiang Hu, Fan Guo, Lu Wen, Fuchou Tang, Jie Qiao
Human fetal germ cells (FGCs) are precursors to sperm and eggs and are crucial for maintenance of the species. However, the developmental trajectories and heterogeneity of human FGCs remain largely unknown. Here we performed single-cell RNA-seq analysis of over 2,000 FGCs and their gonadal niche cells in female and male human embryos spanning several developmental stages. We found that female FGCs undergo four distinct sequential phases characterized by mitosis, retinoic acid signaling, meiotic prophase, and oogenesis...
June 1, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/28457748/gli1-mesenchymal-stromal-cells-are-a-key-driver-of-bone-marrow-fibrosis-and-an-important-cellular-therapeutic-target
#20
Rebekka K Schneider, Ann Mullally, Aurelien Dugourd, Fabian Peisker, Remco Hoogenboezem, Paulina M H Van Strien, Eric M Bindels, Dirk Heckl, Guntram Büsche, David Fleck, Gerhard Müller-Newen, Janewit Wongboonsin, Monica Ventura Ferreira, Victor G Puelles, Julio Saez-Rodriguez, Benjamin L Ebert, Benjamin D Humphreys, Rafael Kramann
Bone marrow fibrosis (BMF) develops in various hematological and non-hematological conditions and is a central pathological feature of myelofibrosis. Effective cell-targeted therapeutics are needed, but the cellular origin of BMF remains elusive. Here, we show using genetic fate tracing in two murine models of BMF that Gli1(+) mesenchymal stromal cells (MSCs) are recruited from the endosteal and perivascular niche to become fibrosis-driving myofibroblasts in the bone marrow. Genetic ablation of Gli1(+) cells abolished BMF and rescued bone marrow failure...
June 1, 2017: Cell Stem Cell
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