We have located links that may give you full text access.
DRBpred: A sequence-based machine learning method to effectively predict DNA- and RNA-binding residues.
Computers in Biology and Medicine 2024 January 30
DNA-binding and RNA-binding proteins are essential to an organism's normal life cycle. These proteins have diverse functions in various biological processes. DNA-binding proteins are crucial for DNA replication, transcription, repair, packaging, and gene expression. Likewise, RNA-binding proteins are essential for the post-transcriptional control of RNAs and RNA metabolism. Identifying DNA- and RNA-binding residue is essential for biological research and understanding the pathogenesis of many diseases. However, most DNA-binding and RNA-binding proteins still need to be discovered. This research explored various properties of the protein sequences, such as amino acid composition type, Position-Specific Scoring Matrix (PSSM) values of amino acids, Hidden Markov model (HMM) profiles, physiochemical properties, structural properties, torsion angles, and disorder regions. We utilized a sliding window technique to extract more information from a target residue's neighbors. We proposed an optimized Light Gradient Boosting Machine (LightGBM) method, named DRBpred, to predict DNA-binding and RNA-binding residues from the protein sequence. DRBpred shows an improvement of 112.00 %, 33.33 %, and 6.49 % for the DNA-binding test set compared to the state-of-the-art method. It shows an improvement of 112.50 %, 16.67 %, and 7.46 % for the RNA-binding test set regarding Sensitivity, Mathews Correlation Coefficient (MCC), and AUC metric.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app