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Computers in Biology and Medicine

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https://www.readbyqxmd.com/read/28528232/a-mathematical-and-biological-plausible-model-of-decision-execution-regulation-in-go-no-go-tasks-focusing-on-the-fronto-striatal-thalamic-pathway
#1
Golnaz Baghdadi, Farzad Towhidkhah, Reza Rostami
Discovering factors influencing the speed and accuracy of responses in tasks such as "Go/No-Go" is one of issues which have been raised in neurocognitive studies. Mathematical models are considered as tools to identify and to study decision making procedure from different aspects. In this paper, a mathematical model has been presented to show several factors can alter the output of decision making procedure before execution in a "Go/No-Go" task. The dynamic of this model has two stable fixed points, each of them corresponds to the "Press" and "Not-press" responses...
May 13, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28527352/a-cbr-framework-with-gradient-boosting-based-feature-selection-for-lung-cancer-subtype-classification
#2
Juan Ramos-González, Daniel López-Sánchez, Jose A Castellanos-Garzón, Juan F de Paz, Juan M Corchado
Molecular subtype classification represents a challenging field in lung cancer diagnosis. Although different methods have been proposed for biomarker selection, efficient discrimination between adenocarcinoma and squamous cell carcinoma in clinical practice presents several difficulties, especially when the latter is poorly differentiated. This is an area of growing importance, since certain treatments and other medical decisions are based on molecular and histological features. An urgent need exists for a system and a set of biomarkers that provide an accurate diagnosis...
May 13, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28527350/bi-dimensional-variational-mode-decomposition-of-laser-speckle-contrast-imaging-data-a-clinical-approach-to-critical-limb-ischemia
#3
Anne Humeau-Heurtier, Pierre Abraham, Samir Henni
The number of patients suffering from peripheral arterial occlusive disease (PAOD) is growing worldwide. PAOD corresponds to an impairment of perfusion in the distal portion of some arteries that can generate critical limb ischemia. For some patients, the pathology leads to the necessity of amputation. PAOD may be diagnosed and studied with transcutaneous oxygen (tcpO2) measurements. However, the tcpO2 technique is a contact technique: probes have to be positioned on the limb, which may be impossible in case of ulcers and can lead to infection risks...
May 13, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28511122/robotic-assessment-of-neuromuscular-characteristics-using-musculoskeletal-models-a-pilot-study
#4
V R Jayaneththi, J Viloria, L G Wiedemann, C Jarrett, A J McDaid
OBJECTIVE: Non-invasive neuromuscular characterization aims to provide greater insight into the effectiveness of existing and emerging rehabilitation therapies by quantifying neuromuscular characteristics relating to force production, muscle viscoelasticity and voluntary neural activation. In this paper, we propose a novel approach to evaluate neuromuscular characteristics, such as muscle fiber stiffness and viscosity, by combining robotic and HD-sEMG measurements with computational musculoskeletal modeling...
May 10, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28511121/influence-of-different-frequencies-of-axial-cyclic-loading-on-time-domain-vibration-response-of-the-lumbar-spine-a-finite-element-study
#5
Wei Fan, Li-Xin Guo
Very few studies have quantitatively analyzed influence of the loading frequency on time-domain vibration response of the whole lumbar spine in the presence of a physiologic compressive preload. In this study, a three-dimensional non-linear finite element model of ligamentous L1-S1 segment was developed to predict time-domain dynamic response of the whole lumbar spine to axial cyclic loading with different frequencies. A compressive follower preload of 400 N was applied to the model to simulate the physiologic compressive load...
May 10, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28527351/permutation-entropy-analysis-of-heart-rate-variability-for-the-assessment-of-cardiovascular-autonomic-neuropathy-in-type-1-diabetes-mellitus
#6
Claudia Carricarte Naranjo, Lazaro M Sanchez-Rodriguez, Marta Brown Martínez, Mario Estévez Báez, Andrés Machado García
Heart rate variability (HRV) analysis is a relevant tool for the diagnosis of cardiovascular autonomic neuropathy (CAN). To our knowledge, no previous investigation on CAN has assessed the complexity of HRV from an ordinal perspective. Therefore, the aim of this work is to explore the potential of permutation entropy (PE) analysis of HRV complexity for the assessment of CAN. For this purpose, we performed a short-term PE analysis of HRV in healthy subjects and type 1 diabetes mellitus patients, including patients with CAN...
May 8, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28511120/stokes-flow-patterns-induced-by-a-single-cardiac-cell
#7
Yasser Aboelkassem
Stokes flow motions induced by a beating single cardiac cell (cardiomyocyte) are obtained numerically using the method of fundamental solutions (MFS). A two-dimensional meshfree-Stokeslets computational framework is used to solve the Stokes governing equations around an isolated cardiomyocyte. An approximate beating kinematical model is derived and used to approximate the cell-length shortening over a complete cardiac cycle. The induced flow patterns have been found to be characterized by the presence of counter-rotating vortices at both cell's edges...
May 4, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28505552/probabilistic-pharmacokinetic-models-of-decompression-sickness-in-humans-part-1-coupled-perfusion-limited-compartments
#8
F Gregory Murphy, Ethan A Hada, David J Doolette, Laurens E Howle
Decompression sickness (DCS) is a disease caused by gas bubbles forming in body tissues following a reduction in ambient pressure, such as occurs in scuba diving. Probabilistic models for quantifying the risk of DCS are typically composed of a collection of independent, perfusion-limited theoretical tissue compartments which describe gas content or bubble volume within these compartments. It has been previously shown that 'pharmacokinetic' gas content models, with compartments coupled in series, show promise as predictors of the incidence of DCS...
May 4, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28500959/biomechanical-evaluation-of-implant-supported-prosthesis-with-various-tilting-implant-angles-and-bone-types-in-atrophic-maxilla-a-finite-element-study
#9
Zeynep Gümrükçü, Yavuz Tolga Korkmaz, Fatih Mehmet Korkmaz
BACKGROUND AND OBJECTIVE: The purpose of this study is to evaluate and compare bone stress that occurs as a result of using vertical implants with simultaneous sinus augmentation with bone stress generated from oblique implants without sinus augmentation in atrophic maxilla. METHODS: Six, three-dimensional (3D) finite element (FE) models of atrophic maxilla were generated with SolidWorks software. The maxilla models were varied for two different bone types. Models 2a, 2b and 2c represent maxilla models with D2 bone type...
May 4, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28499216/biobrick-chain-recommendations-for-genetic-circuit-design
#10
Jiaoyun Yang, Song Yu, Bowen Gong, Ning An, Gil Alterovitz
Synthetic biology databases have collected numerous biobricks to accelerate genetic circuit design. However, selecting biobricks is a tough task. Here, we leverage the fact that these manually designed circuits can provide underlying knowledge to support biobrick selection. We propose to design a recommendation system based on the analysis of available genetic circuits, which can narrow down the biobrick selection range and provide candidate biobricks for users to choose. A recommendation strategy based on a Markov model is established to tackle this issue...
May 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28494382/a-computer-supported-management-of-photographic-documentation-in-plastic-surgery-system-development-and-its-clinical-application
#11
Karol Korczak, Anna Kasielska-Trojan, Marian Niedźwiedziński, Bogusław Antoszewski
Photographic documentation is very important for plastic, reconstructive, and especially aesthetic surgery procedures. It can be used to improve patient care as well as to carry out scientific research. The results of our previous studies confirmed a strong demand for Information Technology (IT) systems dedicated to plastic surgery. Unfortunately, most of the solutions of this type are not suited to the actual needs. For this reason we decided to develop a reliable system for photographic documentation storage...
May 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28499215/numerical-study-on-the-air-conditioning-characteristics-of-the-human-nasal-cavity
#12
Da-Woon Kim, Seung-Kyu Chung, Yang Na
The air-conditioning characteristics of the human nasal cavity were investigated using computational fluid dynamics. The wall layer was modeled as a heat conducting layer consisting of water with constant thickness placed on top of epithelial cells. By assuming constant tissue temperature, prescribed to be 36 (°)C, which is close to the alveolar condition, the proposed wall model yielded a spatially varying surface temperature distribution that is in reasonable agreement with the measurement studies in the literature...
April 30, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28494383/a-robust-construction-algorithm-of-the-centerline-skeleton-for-complex-aortic-vascular-structure-using-computational-fluid-dynamics
#13
Julien Touati, Marco Bologna, Adeline Schwein, Francesco Migliavacca, Marc Garbey
Centerlines of blood vessels are useful tools to make important anatomical measurements (length, diameter, area), which cannot be accurately obtained using 2D images. In this paper a brand new method for centerline extraction of vascular trees is presented. By using computational fluid dynamics (CFD) we are able to obtain a robust and purely functional centerline allowing us to support better measurements than classic purely geometrical-based centerlines. We show that the CFD-based centerline is within a few pixels from the geometrical centerline where the latter is defined (far away from inlet/outlets and from the branches)...
April 29, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28479109/fuzzy-spectral-clustering-for-automated-delineation-of-chronic-wound-region-using-digital-images
#14
Dhiraj Manohar Dhane, Maitreya Maiti, Tushar Mungle, Chittaranjan Bar, Arun Achar, Maheshkumar Kolekar, Chandan Chakraborty
Chronic wound is an abnormal disease condition of localized injury to the skin and its underlying tissues having physiological impaired healing response. Assessment and management of such wound is a significant burden on the healthcare system. Currently, precise wound bed estimation depends on the clinical judgment and remains a difficult task. The paper introduces a novel method for ulcer boundary demarcation and estimation, using optical images captured by a hand-held digital camera. The proposed approach involves gray based fuzzy similarity measure using spatial knowledge of an image...
April 23, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28477446/two-phase-deep-convolutional-neural-network-for-reducing-class-skewness-in-histopathological-images-based-breast-cancer-detection
#15
Noorul Wahab, Asifullah Khan, Yeon Soo Lee
Different types of breast cancer are affecting lives of women across the world. Common types include Ductal carcinoma in situ (DCIS), Invasive ductal carcinoma (IDC), Tubular carcinoma, Medullary carcinoma, and Invasive lobular carcinoma (ILC). While detecting cancer, one important factor is mitotic count - showing how rapidly the cells are dividing. But the class imbalance problem, due to the small number of mitotic nuclei in comparison to the overwhelming number of non-mitotic nuclei, affects the performance of classification models...
April 18, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28433870/automated-detection-of-premature-delivery-using-empirical-mode-and-wavelet-packet-decomposition-techniques-with-uterine-electromyogram-signals
#16
U Rajendra Acharya, Vidya K Sudarshan, Soon Qing Rong, Zechariah Tan, Choo Min Lim, Joel Ew Koh, Sujatha Nayak, Sulatha V Bhandary
An accurate detection of preterm labor and the risk of preterm delivery before 37 weeks of gestational age is crucial to increase the chance of survival rate for both mother and the infant. Thus, the uterine contractions measured using uterine electromyogram (EMG) or electro hysterogram (EHG) need to have high sensitivity in the detection of true preterm labor signs. However, visual observation and manual interpretation of EHG signals at the time of emergency situation may lead to errors. Therefore, the employment of computer-based approaches can assist in fast and accurate detection during the emergency situation...
April 18, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28499136/a-novel-tool-for-the-identification-of-correlations-in-medical-data-by-faceted-search
#17
Danilo Schmidt, Klemens Budde, Daniel Sonntag, Hans-Jürgen Profitlich, Matthias Ihle, Oliver Staeck
This work focuses on the integration of multifaceted extensive data sets (e.g. laboratory values, vital data, medications) and partly unstructured medical data such as discharge letters, diagnostic reports, clinical notes etc. in a research database. Our main application is an integrated faceted search in nephrology based on information extraction results. We describe the details of the application of transplant medicine and the resulting technical architecture of the faceted search application.
April 14, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28460257/dynamics-of-a-three-species-ratio-dependent-food-chain-model-with-intra-specific-competition-within-the-top-predator
#18
Nijamuddin Ali, Mainul Haque, Ezio Venturino, Santabrata Chakravarty
In this paper, a ratio-dependent food chain model has been considered. The total population has been divided into three classes, namely prey, predator and top-predator population. We have also incorporated intra-specific competition of predators in the model. We have studied the boundedness, dissipativeness and permanence of the solutions of the system and analyzed the existence of various equilibrium points and stability of the system at those equilibrium points. The system exhibits Bogdanov-Takens bifurcation, saddle-node bifurcation, Hopf bifurcation for suitable choice of the relevant parameters...
April 14, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28433871/automatic-cumulative-sums-contour-detection-of-fbp-reconstructed-multi-object-nuclear-medicine-images
#19
Nicholas E Protonotarios, George M Spyrou, George A Kastis
The problem of determining the contours of objects in nuclear medicine images has been studied extensively in the past, however most of the analysis has focused on a single object as opposed to multiple objects. The aim of this work is to develop an automated method for determining the contour of multiple objects in positron emission tomography (PET) and single photon emission computed tomography (SPECT) filtered backprojection (FBP) reconstructed images. These contours can be used for computing body edges for attenuation correction in PET and SPECT, as well as for eliminating streak artifacts outside the objects, which could be useful in compressive sensing reconstruction...
April 14, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28431303/circular-shape-constrained-fuzzy-clustering-ciscfc-for-nucleus-segmentation-in-pap-smear-images
#20
Ratna Saha, Mariusz Bajger, Gobert Lee
Accurate detection and segmentation of cell nucleus is the precursor step towards computer aided analysis of Pap smear images. This is a challenging and complex task due to degree of overlap, inconsistent staining and poor contrast. In this paper, a novel nucleus segmentation method is proposed by incorporating a circular shape function in fuzzy clustering. The proposed method was evaluated quantitatively and qualitatively using the Overlapping Cervical Cytology Image Segmentation Challenge - ISBI 2014 challenge dataset comprised of 945 overlapping Pap smear images...
April 14, 2017: Computers in Biology and Medicine
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