Features of cardiovascular magnetic resonance native T1 mapping in maintenance hemodialysis patients and their related factors.

PURPOSE: Increased myocardial T1 values on cardiovascular MRI (CMRI) have been shown to be a surrogate marker for myocardial fibrosis. The use of CMRI in patients on hemodialysis (HD) remains limited. This research aimed to explore the characteristics of native T1 values in HD patients and identify factors related to T1 values.

METHODS: A total of thirty-two patients on HD and fourteen healthy controls were included in this study. All participants underwent CMRI. Using modified Look-Locker inversion recovery (MOLLI) sequence, native T1 mapping was achieved. Native CMRI T1 values were compared between the two groups. In order to analyze the relationship between T1 values and clinical parameters, correlation analysis was performed in patients on HD.

RESULTS: Patients on HD exhibited elevated global native T1 values compared to control subjects. In the HD group, the global native T1 value correlated positively with intact parathyroid hormone (iPTH) ( r  = 0.418, p  = 0.017) and negatively with triglycerides ( r = -0.366, p  = 0.039). Moreover, the global native T1 value exhibited a positive correlation with the left ventricular end-diastolic volume indexed to body surface area (BSA; r  = 0.528, p  = 0.014), left ventricular end-systolic volume indexed to BSA ( r  = 0.506, p  = 0.019), and left ventricular mass indexed to BSA ( r  = 0.600, p  = 0.005). A negative correlation was observed between the global native T1 value and ejection fraction ( r  = 0.-0.551, p  = 0.010).

CONCLUSION: The global native T1 value was prolonged in HD patients compared with controls. In the HD group, the global T1 value correlated strongly with iPTH, triglycerides, and cardiac structural and functional parameters.