Principles and Developments in Cancer Immunotherapy and Approaches for Combination with Tumour Irradiation.

Different immunotherapy concepts developed over recent decades include immune checkpoint inhibition, vaccination, and T cell-engaging therapies, as well as effectors on the immunosuppressive tumour microenvironment. For all these immunotherapy approaches, combination studies with tumour irradiation have been performed in vivo and in the clinic. The results point towards possible opportunities for combination therapies to improve patient outcome.