We have located links that may give you full text access.
Association between serum uric acid levels and depressive symptoms according to menopausal status.
Journal of Affective Disorders 2024 January 13
INTRODUCTION: The menopause-specific relationship between serum uric acid (SUA) and depressive symptoms were not known. We aimed to explore the association between SUA and depressive symptoms stratified by menopausal status.
METHODS: This is a cross-sectional study, a total of 4845 females were enrolled from China health and retirement longitudinal study (CHARLS) in China. The Center for Epidemiologic Studies Depression Scale (CESD) were used to measure depressive symptoms. A cut-off score of CES-D ≥ 10 was defined as depression. Multiple regression models were used to assess the relationship between SUA and depression stratified by menopausal status.
RESULTS: Overall, SUA was significantly associated with depressive symptoms/depression in post-menopause women (β = -0.39, 95 % CI: -0.60, -0.17) after adjusted potential confounders. Compared with those whose SUA levels were in the first tertile, participants with their SUA in the second (β = -0.76, 95 % CI: -1.30, -0.22) and third tertile (β = -1.24, 95 % CI: -1.80, -0.68) had milder depressive symptoms. However, SUA was not associated with depressive in pre-menopause women (β = 0.1, 95 % CI: -0.25, 0.46). An interaction between menopausal status and SUA on depressive symptoms were found in this study (P = 0.02). Similar results were found for depression.
LIMITATIONS: Some potential covariates like diet that could affect SUA levels were not considered in this study.
CONCLUSIONS: Higher SUA was associated with depressive symptoms/depression in post-menopause women. An interaction between menopausal status and SUA on depressive symptoms were found. SUA was not associated with depressive symptoms/depression in pre-menopause women.
METHODS: This is a cross-sectional study, a total of 4845 females were enrolled from China health and retirement longitudinal study (CHARLS) in China. The Center for Epidemiologic Studies Depression Scale (CESD) were used to measure depressive symptoms. A cut-off score of CES-D ≥ 10 was defined as depression. Multiple regression models were used to assess the relationship between SUA and depression stratified by menopausal status.
RESULTS: Overall, SUA was significantly associated with depressive symptoms/depression in post-menopause women (β = -0.39, 95 % CI: -0.60, -0.17) after adjusted potential confounders. Compared with those whose SUA levels were in the first tertile, participants with their SUA in the second (β = -0.76, 95 % CI: -1.30, -0.22) and third tertile (β = -1.24, 95 % CI: -1.80, -0.68) had milder depressive symptoms. However, SUA was not associated with depressive in pre-menopause women (β = 0.1, 95 % CI: -0.25, 0.46). An interaction between menopausal status and SUA on depressive symptoms were found in this study (P = 0.02). Similar results were found for depression.
LIMITATIONS: Some potential covariates like diet that could affect SUA levels were not considered in this study.
CONCLUSIONS: Higher SUA was associated with depressive symptoms/depression in post-menopause women. An interaction between menopausal status and SUA on depressive symptoms were found. SUA was not associated with depressive symptoms/depression in pre-menopause women.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app