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Journal of Affective Disorders

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https://www.readbyqxmd.com/read/29161673/reduced-resting-state-thalamostriatal-functional-connectivity-is-associated-with-excessive-daytime-sleepiness-in-persons-with-and-without-depressive-disorders
#1
David T Plante, Rasmus M Birn, Erin C Walsh, Roxanne M Hoks, M Daniela Cornejo, Heather C Abercrombie
BACKGROUND: Excessive daytime sleepiness (EDS) is a common and significant problem encountered in affective illness, however, the biological underpinnings of EDS in persons with psychiatric disorders are not clear. This study evaluated the associations between thalamic connectivity with cortical and subcortical brain regions with EDS in persons with and without depressive disorders (DD). METHODS: Resting-state functional connectivity magnetic resonance imaging scans from 67 unmedicated young to middle-aged women with current DD (n = 30), remitted DD (n = 13), and healthy controls (n = 24) were utilized to examine the associations between thalamic connectivity with cortical/subcortical structures and EDS...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29161672/interpersonal-trauma-and-hoarding-the-mediating-role-of-aggression
#2
Brittany M Mathes, Amberly K Portero, Brittany A Gibby, Savannah L King, Amanda M Raines, Norman B Schmidt
BACKGROUND: A growing body of literature indicates that exposure to interpersonal trauma contributes to the onset or exacerbation of hoarding symptoms. However, little research has explored psychosocial factors that may help to explain the relationship between interpersonal trauma and hoarding symptoms. One outcome of trauma exposure that may be associated with hoarding symptoms is aggression, defined as the tendency to experience and express hostility and anger, and to engage in aggressive behavior...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29156363/quality-of-life-is-associated-with-chronic-inflammation-in-depression-a-cross-sectional-study
#3
M Faugere, J-A Micoulaud-Franchi, C Faget-Agius, C Lançon, M Cermolacce, R Richieri
BACKGROUND: Inflammation may play a crucial role in the pathophysiology of depression. However, the association between chronic inflammation and health outcomes in depression remains unclear, particularly for patient-reported outcomes. METHODS: The aim of this study was to investigate the relationship between quality of life (QoL) (physical and mental health, assessed by the SF-36) and chronic inflammation assessed using C-reactive protein (CRP) in patients with current major depressive disorder...
November 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29156365/antidepressant-polypharmacy-and-the-potential-of-pharmacokinetic-interactions-doxepin-but-not-mirtazapine-causes-clinically-relevant-changes-in-venlafaxine-metabolism
#4
Michael Paulzen, Ekkehard Haen, Christoph Hiemke, Bianca Fay, Sandra Unholzer, Gerhard Gründer, Georgios Schoretsanitis
BACKGROUND: To uncover pharmacokinetic interactions between venlafaxine and doxepin or mirtazapine in a naturalistic sample. METHODS: A therapeutic drug monitoring database containing plasma concentrations of venlafaxine (VEN) and its active metabolite O-desmethylvenlafaxine (ODVEN) was analyzed. We included 1067 of 1594 patients in the analysis. Three study groups were considered; a group of patients under venlafaxine without confounding medications, V0 (n = 905), a group of patients co-medicated with doxepin, VDOX (n = 25) and a second group, co-medicated with mirtazapine, VMIR, n = 137...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29156364/pattern-recognition-of-magnetic-resonance-imaging-based-gray-matter-volume-measurements-classifies-bipolar-disorder-and-major-depressive-disorder
#5
Harry Rubin-Falcone, Francesca Zanderigo, Binod Thapa-Chhetry, Martin Lan, Jeffrey M Miller, M Elizabeth Sublette, Maria A Oquendo, David J Hellerstein, Patrick J McGrath, Johnathan W Stewart, J John Mann
BACKGROUND: Bipolar Disorder (BD) cannot be reliably distinguished from Major Depressive Disorder (MDD) until the first manic or hypomanic episode. Consequently, many patients with BD are treated with antidepressants without mood stabilizers, a strategy that is often ineffective and carries a risk of inducing a manic episode. We previously reported reduced cortical thickness in right precuneus, right caudal middle-frontal cortex and left inferior parietal cortex in BD compared with MDD...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29156362/test-anxiety-effects-predictors-and-correlates-a-30-year-meta-analytic-review
#6
REVIEW
Nathaniel von der Embse, Dane Jester, Devlina Roy, James Post
BACKGROUND AND OBJECTIVES: Since the 1988 publication of Hembree's seminal meta-analysis on test anxiety, much has changed in the theoretical conceptualization of test anxiety, as well as the influences on test performance. The present study examined the influence of test anxiety on a variety of educational outcomes, in addition to demographic and intrapersonal correlates. DESIGN AND METHODS: Results of 238 studies from 1988 to the present, were synthesized via a meta-analytic framework to explicate predictors, correlates, and relationships with the test anxiety construct...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29156361/non-suicidal-self-injury-in-referred-adolescents-with-mood-disorders-and-its-association-with-cyclothymic-hypersensitive-temperament
#7
Gabriele Masi, Annarita Milone, Anna Rita Montesanto, Elena Valente, Simone Pisano
BACKGROUND: Non suicidal self-injuries (NSSIs) are deliberate self-harm behaviors without suicidal intent, usually starting in adolescence, with increasing rates of occurrence both in epidemiological and clinical samples. Several studies associated cyclothymic-hypersensitive temperament (CHT) with self-harm behaviors and suicidal risk. Aim of this study is to explore the association between NSSIs and CHT in a clinical sample of adolescents. We hypothesized that CHT may differentiate NSSI from non-NSSI adolescents with mood disorders, when other psychopathological features are controlled for...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29156360/does-the-15-item-geriatric-depression-scale-function-differently-in-old-people-with-different-levels-of-cognitive-functioning
#8
Francesca Chiesi, Caterina Primi, Martina Pigliautile, Marta Baroni, Sara Ercolani, Lucia Paolacci, Virginia Boccardi, Patrizia Mecocci
BACKGROUND: The 15-item version of the Geriatric Depression Scale (GDS-15) is widely employed to screen depression among elderly but little is known about the scale functioning in cognitively impaired individuals when compared to normal ones. The aim of the current study is to investigate Differential Item Functioning (DIF) across groups of older people that differ in terms of cognitive functioning applying Item Response Theory (IRT)-based analyses. METHODS: Data from an Italian multi-centric clinical-based study on cognitive impairment and dementia in old people were employed (N = 1903; Age: M = 77...
November 13, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29154166/sickness-absence-indicating-depressive-symptoms-of-working-population-in-south-korea
#9
Cheolmin Shin, Young-Hoon Ko, Seoyoung Yoon, Sang Won Jeon, Chi-Un Pae, Yong-Ku Kim, Ashwin A Patkar, Changsu Han
BACKGROUND: Sickness absence has been regarded as an important indicator of workers' health and work productivity. This study is aimed to evaluate the association between depressive symptoms and sickness absence in workers of South Korea. METHODS: We used nationwide cross-sectional survey data from 2889 individuals in the working population aged over 19 years in South Korea. Depressive symptoms were measured using Patient Health Questionnaire-9 (PHQ-9). Those respondents who scored above 10 on PHQ-9 were regarded as having depressive symptoms...
November 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29154159/turning-wounds-into-wisdom-posttraumatic-growth-over-the-course-of-two-types-of-trauma-focused-psychotherapy-in-patients-with-ptsd
#10
Mirjam J Nijdam, Christianne A I van der Meer, Mirjam van Zuiden, Pasha Dashtgard, Daniël Medema, Yulan Qing, Paul Zhutovsky, Anne Bakker, Miranda Olff
BACKGROUND: Treatment studies in PTSD patients have mostly focused on adverse psychopathological outcomes whereas positive outcomes have received less attention. Objectives of this study were to investigate posttraumatic growth in response to two different psychotherapies, to examine the relationship between symptom improvement and growth, and to determine if posttraumatic growth predicted treatment response. METHODS: Outpatients diagnosed with PTSD after various types of trauma (n = 116) participated in a randomized controlled trial that compared Brief Eclectic Psychotherapy for PTSD (BEP) and Eye Movement Desensitization and Reprocessing therapy (EMDR)...
November 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29156359/emotion-regulation-deficits-in-persons-with-body-focused-repetitive-behavior-disorders
#11
Jennifer R Alexander, David C Houghton, Christopher C Bauer, Heather C Lench, Douglas W Woods
BACKGROUND: Conceptualizations of emotion dysregulation (ED) and body-focused repetitive behavior disorders (BFRBDs) imply that ED may be a central component of BFRBDs as well as a factor that distinguishes BFRBDs from non-impairing, subclinical body-focused repetitive behaviors (BFRBs). The current study empirically tested these observations. METHODS: One hundred thirty-eight undergraduates (of 1900 who completed a screening survey) completed self-report measures assessing four emotion regulation (ER) deficits hypothesized to underlie ED (alexithymia, maladaptive emotional reactivity, experiential avoidance, and response inhibition when distressed); 34 of these participants had BFRBDs, 64 had subclinical BFRBs, and 42 were unaffected by BFRBs...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29154168/evaluating-an-e-mental-health-program-deprexis-as-adjunctive-treatment-tool-in-psychotherapy-for-depression-results-of-a-pragmatic-randomized-controlled-trial
#12
Thomas Berger, Tobias Krieger, Kerstin Sude, Björn Meyer, Andreas Maercker
BACKGROUND: Depressive disorders place a significant disease burden on individuals as well as on societies. Several web-based interventions for depression have shown to be effective in reducing depressive symptoms. However, it is not known whether web-based interventions, when used as adjunctive treatment tools to regular psychotherapy, have an additional effect compared to regular psychotherapy for depression. METHODS: Adults (N = 98) with a unipolar affective disorder were recruited in routine outpatient psychotherapy practices in Germany from therapists over the course of their initial sessions and randomized within therapists to one of two active treatment conditions: regular psychotherapy or psychotherapy plus a web-based depression program ("deprexis")...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29154167/genetic-clustering-of-depressed-patients-and-normal-controls-based-on-single-nucleotide-variant-proportion
#13
Chenglong Yu, Bernhard T Baune, Ke-Ang Fu, Ma-Li Wong, Julio Licinio
BACKGROUND: Genetic components play important roles in the susceptibility to major depressive disorder (MDD). The rapid development of sequencing technologies is allowing scientists to contribute new ideas for personalized medicine; thus, it is essential to design non-invasive genetic tests on sequencing data, which can help physicians diagnose and differentiate depressed patients and healthy individuals. METHODS: We have recently proposed a genetic concept involving single-nucleotide variant proportion (SNVP) in genes to study MDD...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29154158/the-prevalence-reporting-and-treatment-of-anxiety-among-older-adults-in-nursing-homes-and-other-residential-aged-care-facilities
#14
Alexandra S Creighton, Tanya E Davison, David W Kissane
BACKGROUND: Little is known about anxiety in aged care populations, despite its increase in this frail population. This study investigated the prevalence, recording, and treatment rate of anxiety disorders among aged care residents. METHODS: A cross-sectional, observational design was used to assess 180 elderly residents from 12 aged care facilities in Melbourne, Australia. Participants were assessed for threshold and subthreshold anxiety disorders and comorbid depression using the MINI for DSM-5...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29154156/delta-beta-correlation-as-a-candidate-endophenotype-of-social-anxiety-a-two-generation-family-study
#15
Anita Harrewijn, Melle J W van der Molen, Irene M van Vliet, Jeanine J Houwing-Duistermaat, P Michiel Westenberg
BACKGROUND: Social anxiety disorder (SAD) is characterized by an extreme and intense fear and avoidance of social situations. In this two-generation family study we examined delta-beta correlation during a social performance task as candidate endophenotype of SAD. METHODS: Nine families with a target participant (diagnosed with SAD), their spouse and children, as well as target's siblings with spouse and children performed a social performance task in which they gave a speech in front of a camera...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29149755/a-randomized-clinical-trial-of-adjunctive-ketamine-anesthesia-in-electro-convulsive-therapy-for-depression
#16
Minling Zhang, Robert Rosenheck, Xiaoming Lin, Qirong Li, Yanling Zhou, Yunshan Xiao, Xiong Huang, Ni Fan, Hongbo He
BACKGROUND: Electroconvulsive therapy (ECT) is a rapid acting and effective treatment for both major depressive disorder (MDD) and bipolar disorder (BP). Both propofol and ketamine are commonly used anesthetic agents but recent clinical studies suggest that ketamine has rapid-acting antidepressant properties, itself, at sub-anesthetic doses. METHODS: A total of 77 inpatients (41 MDD and 36 BP) were randomly assigned to receive ECT with propofol (1mg/kg) anesthesia or with ketamine (0...
November 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29154165/engagement-in-mobile-phone-app-for-self-monitoring-of-emotional-wellbeing-predicts-changes-in-mental-health-moodprism
#17
David Bakker, Nikki Rickard
BACKGROUND: Mobile apps are being used increasingly for mental health purposes, but evidence of their efficacy remains limited. The mechanisms underlying any effects of such apps are also unclear. This study examined the effectiveness of a self-monitoring mobile phone app by investigating the relationships between app engagement and mental health outcomes. METHOD: Participants downloaded the MoodPrism app from the iOS and Android app stores, completing in-app assessments at start of use and again 30days later...
November 9, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29161674/deep-brain-stimulation-of-the-subcallosal-cingulate-gyrus-in-patients-with-treatment-resistant-depression-a-double-blinded-randomized-controlled-study-and-long-term-follow-up-in-eight-patients
#18
Angela Merkl, Sabine Aust, Gerd-Helge Schneider, Veerle Visser-Vandewalle, Andreas Horn, Andrea A Kühn, Jens Kuhn, Malek Bajbouj
BACKGROUND: Deep brain stimulation (DBS) of the subcallosal cingulate gyrus (SCG) is an experimental approach in treatment-resistant depression (TRD). Short-term results of efficacy in DBS are incongruent and studies investigating long-term effects are warranted. METHODS: We assessed efficacy of SCG-DBS in eight patients randomized into a delayed-onset group (sham-DBS four weeks) and a non-delayed-onset group. The primary outcome measure was improvement on the Hamilton Depression Rating-Scale (HAMD-24-item-version)...
November 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29154155/the-dynamic-characteristics-of-the-anterior-cingulate-cortex-in-resting-state-fmri-of-patients-with-depression
#19
Hongna Zheng, Feng Li, Qijing Bo, Xianbin Li, Li Yao, Zhijun Yao, Chuanyue Wang, Xia Wu
BACKGROUND: The anterior cingulate cortex (ACC) is part of the limbic system of the brain. It is a bridge between attentional and emotional processing, which is responsible for the integration of visceral, attentional, and affective information. Lesioning of the ACC, which produces striking changes, is used to treat major depression disorder (MDD). Moreover, the brain dynamically integrates and coordinates functions of its different subparts to realize its cognitive capability. Hence, the spatio-temporal community distribution of the ACC is necessary to completely understand MDD...
November 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29149756/residual-anxiety-may-be-associated-with-depressive-relapse-during-continuation-therapy-of-bipolar-ii-depression
#20
Lorenzo Lorenzo-Luaces, Jay D Amsterdam, Robert J DeRubeis
BACKGROUND: Anxiety symptoms are common in bipolar disorder. We explored the effect of anxiety on the outcome of acute and continuation pharmacotherapy of bipolar II depression. METHODS: Data were derived from a randomized double-blind 12-week acute (N = 129) and 6-month continuation (N = 55) comparison of venlafaxine versus lithium monotherapy in bipolar II depression in adults. We distinguished between the items of the Hamilton Rating Scale for Depression (HRSD) that capture depression vs...
November 8, 2017: Journal of Affective Disorders
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