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Journal of Affective Disorders

Sun Jae Jung, So Mi J Cho, Hyeon Chang Kim
INTRODUCTION: The association of suicide with the use of oral contraceptives (OC) is unknown in the Asian population. We aimed to evaluate the association of OC use and suicidal behavior in a nationally representative population of Korean women. METHOD: Of the 44,501 women who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) (2007-2016), 27,067 women aged 20 years or older who had completed information on OC use and suicidal behavior were included...
September 7, 2018: Journal of Affective Disorders
Jonathan T Heinzman, Karin F Hoth, Michael H Cho, Phuwanat Sakornsakolpat, Elizabeth A Regan, Barry J Make, Gregory L Kinney, Frederick S Wamboldt, Kristen E Holm, Nicholas Bormann, Julian Robles, Victor Kim, Anand S Iyer, Edwin K Silverman, James D Crapo, Shizhong Han, James B Potash, Gen Shinozaki
BACKGROUND: Large sample GWAS is needed to identify genetic factors associated with depression. This study used genome-wide genotypic and phenotypic data from the COPDGene study to identify genetic risk factors for depression. METHODS: Data were from 9716 COPDGene subjects with ≥10 pack-year history. Depression was defined as antidepressant use and/or a HADS depression subscale score ≥8. Non-Hispanic White (6576) and African-American (3140) subsets were analyzed...
September 7, 2018: Journal of Affective Disorders
Nasser M Aldossary, Mamdouh Ali Kotb, Ahmed M Kamal
BACKGROUND: Traumatic brain injury (TBI) is the major public health problem worldwide, particularly in the Middle East. Diffuse axonal injury (DAI) is commonly found in TBI. Although DAI can lead to physical and psychosocial disabilities, its prognostic value is still a matter of debate. Magnetic Resonance (MR) is more sensitive for detecting DAI lesions. OBJECTIVE: To identify the radiological and clinical factors associated with the functional capacity one year after the traumatic brain injury...
September 5, 2018: Journal of Affective Disorders
Rodrigo Machado-Vieira
No abstract text is available yet for this article.
September 1, 2018: Journal of Affective Disorders
M Flores-Ramos, S Alcauter, M López-Titla, N Bernal-Santamaría, Edgar Calva-Coraza, R A E Edden
BACKGROUND: The role of testosterone (T) in the pathophysiology of affective disorders and anxiety is broadly supported. Evidence suggests that T has anxiolytic and antidepressant properties. One proposed route for the central effects of T is its interaction with the gamma-aminobutyric acid (GABA) system. We explored the relationship between T levels and GABA+ levels in anterior-cingulate (ACC) and the posterior-cingulate (PCC) regions in depressed women, using magnetic resonance spectroscopy (1 H-MRS)...
August 25, 2018: Journal of Affective Disorders
Mikko Nyman, Olli Eskola, Jaana Kajander, Riitta Jokinen, Jukka Penttinen, Tomi Karjalainen, Lauri Nummenmaa, Jussi Hirvonen, Donald Burns, Richard Hargreaves, Olof Solin, Jarmo Hietala
BACKGROUND: Neurotransmitter substance P (SP) and its preferred neurokinin-1 receptor (NK1R) have been implicated in the treatment of affective and addiction disorders. Despite promising preclinical data on antidepressant action, the clinical trials of NK1R antagonists in major depression have been disappointing. There are no direct in vivo imaging studies on NK1R characteristics in patients with a major depressive disorder (MDD). METHODS: In this cross-sectional case-control study, we recruited nine never-medicated patients with moderate to severe MDD and nine matched healthy controls...
August 25, 2018: Journal of Affective Disorders
Jeffrey R Vittengl, Lee Anna Clark, Jasper A J Smits, Michael E Thase, Robin B Jarrett
BACKGROUND: Cognitive therapy (CT) improves symptoms in adults with major depressive disorder (MDD) plus comorbid anxiety disorder, but the specific type of anxiety may influence outcomes. This study compared CT outcomes among adults with MDD plus social, other, or no comorbid anxiety disorders. METHODS: Outpatients with recurrent MDD (N = 523, including 87 with social and 110 with other comorbid anxiety disorders) received acute-phase CT. Higher risk responders (n = 241 with partial or unstable response) were randomized to 8 months of continuation treatment (CT or clinical management plus fluoxetine or pill placebo), followed by 24 months of assessment...
August 25, 2018: Journal of Affective Disorders
Ying-Yeh Chen, Yi-Lung Chen, Susan Shur-Fen Gau
OBJECTIVE: To explore the association between Attention-Deficit Hyperactivity Disorder ("ADHD") and suicidality in children. Mediating effects of family function and psychiatric co-morbidities were also explored. METHODS: This is a national representative cross-sectional survey of school-based sample of 4739 children aged 7-15. Logistic regression was used to assess the excess risks of suicidality (i.e., suicidal ideation, suicide plan, and suicide attempts) in 412 children with ADHD...
August 24, 2018: Journal of Affective Disorders
Yun Wang, Jing Ni, Lingyan Zhai, Ce Gao, Liming Xie, Lu Zhao, Xiaoxing Yin
BACKGROUND: Numerous studies indicate that inflammation plays important roles in the development of depression. Astrocytes are crucial regulators of immune response in the central nervous system, and strongly activated by pro-inflammatory cytokines. We hypothesized that inhibition of activated astrocytes contributed to ameliorate depressive-like symptoms. METHODS: This study evaluated the antidepressant-like effect of inhibition of activated astrocytes, by a well-established astrocyte inactivator fluorocitrate (FC), on a lipopolysaccharide (LPS)-induced model of depression...
August 24, 2018: Journal of Affective Disorders
Filipi Leles da Costa Dias, Antônio Lúcio Teixeira, Henrique Cerqueira Guimarães, Ana Paula Borges Santos, Simone Rios Fonseca Ritter, João Carlos Barbosa Machado, Maira Tonidandel Barbosa, Paulo Caramelli
BACKGROUND: The number of individuals with advanced age is growing worldwide, especially in developing countries. Depression is the most common mental disorder in the elderly. The aim of this study was to evaluate the prevalence rates and the correlates of late-life depression (LLD) and clinically significant depressive symptoms (CSDS) in a population aged 75+ years. METHODS: We evaluated 639 community-dwelling individuals aged 75+ years in Caeté (MG), Brazil, and used the MINI to diagnose LLD according to DSM-IV criteria and the GDS-15 to identify CSDS...
August 23, 2018: Journal of Affective Disorders
L Plans, C Barrot, E Nieto, J Rios, T G Schulze, S Papiol, M Mitjans, E Vieta, A Benabarre
BACKGROUND: Completed suicide is a major cause of death in bipolar disorder (BD) patients. OBJECTIVE: The aim of this paper is to provide an overall review of the existing literature of completed suicide in BD patients, including clinical and genetic data DATA SOURCES: We performed a systematic review of English and non-English articles published on MEDLINE/PubMed, PsycInfo and Cochrane database (1970-2017). Additional studies were identified by contacting clinical experts, searching bibliographies, major textbooks and website of World Health Organization...
August 23, 2018: Journal of Affective Disorders
Mark S Allen, Emma E Walter, Christian Swann
OBJECTIVE: This research synthesis sought to determine the magnitude of the association between sedentary behaviour (sitting time) and anxiety. EVIDENCE ACQUISITION: A comprehensive literature search of eight electronic databases (and a manual search) identified 13 observational studies that met inclusion criteria (22 effect sizes; total n = 70,425). Pooled mean effects were computed using inverse-variance weighted random effects meta-analysis and moderation by study and population characteristics were tested using random effects meta-regression...
August 23, 2018: Journal of Affective Disorders
S J M Druiven, S E Knapen, B W J H Penninx, N Antypa, R A Schoevers, H Riese, Y Meesters
BACKGROUND: The role of chronotype, the individual timing of sleep/activity, has been studied in relation to depressive and anxiety disorders. A cross-sectional association between a depressive episode and evening-type has been identified. However, until now the predicting capacity of chronotype concerning persistence of psychiatric disorders remains unclear. Our aim is to examine whether a later chronotype in patients with a depressive and/or anxiety disorder can serve as a predictor of a persistent course...
August 22, 2018: Journal of Affective Disorders
Philip Baiden, Cecilia Mengo, Godfred O Boateng, Eusebius Small
BACKGROUND: Although various studies have investigated and found a significant link between age at first alcohol use and health risk behaviors, few studies have investigated the effect of age at first alcohol use on suicidal ideation among adolescents. The objective of this study was to investigate the effect of age at first alcohol use on suicidal ideation. METHODS: Data for this study were obtained from the 2015 Youth Risk Behavior Surveillance system. A sample of 10,745 adolescents aged 14-18 years (50...
August 22, 2018: Journal of Affective Disorders
Rosanne Cawley, Eleanor E Pontin, Jade Touhey, Kate Sheehy, Peter James Taylor
BACKGROUND: Rejection is an adverse experience that may help explain the heightened risk of self-harm and suicide amongst many societal groups. The aim of this systematic review was to determine the relationship between rejection experiences and self-harm and suicidal ideation. METHOD: The databases PsychINFO, CINAHL, Medline and Web of Science were searched from inception until May 2017 using key search terms. Quantitative studies were included if they were; (i) mean sample age over 18; (ii) in the English language; (iii) and had a measure of self-harm or suicidal behaviour and a measure of rejection...
August 19, 2018: Journal of Affective Disorders
Ashleigh M Tickell, Elizabeth M Scott, Tracey Davenport, Frank Iorfino, Laura Ospina-Pinillos, Kate Harel, Lisa Parker, Ian B Hickie, Daniel F Hermens
BACKGROUND: There is growing evidence to support the need for personalised intervention in the early stages of a major psychiatric illness, as well as the clear delineation of subgroups in psychiatric disorders based on cognitive impairment. Affective disorders are often accompanied by neurocognitive deficits; however a lack of research among young adult inpatients highlights the need to assess the utility of cognitive testing in this population. METHODS: A computerised cognitive battery was administered to 50 current inpatient young adults (16-30 years; 75% female) with an affective disorder...
August 19, 2018: Journal of Affective Disorders
M Scheffers, M A J van Duijn, M Beldman, R J Bosscher, J T van Busschbach, R A Schoevers
BACKGROUND: Apart from changes in mood and cognition, depressive disorders are also characterized by changes in body experience, changes that largely influence daily functioning and aggravate distress. In order to gain more insight into this important issue, three domains of body experience - body attitude, body satisfaction and body awareness - and their associations with symptom severity of depression were studied pre- and post-treatment in a clinical sample of depressed patients in a multidisciplinary setting...
August 19, 2018: Journal of Affective Disorders
María Ribeiro-Fernández, Azucena Díez-Suárez, César Soutullo
BACKGROUND: Paediatric bipolar disorder (BD) has gained validity, and substantial research in the last 20 years has dissipated the controversy surrounding it. However, data on the prevalence, prodromes, phenomenology, and longitudinal stability of paediatric BD are still required. METHODS: We reviewed the medical records of all patients (n = 72) with DSM-IV BD evaluated over a 15-year period. We assessed the most frequently present symptoms prior to and at the time of diagnosis, the diagnostic stability of the disorder and its subtypes (I, II and NOS)...
August 18, 2018: Journal of Affective Disorders
Katherine S Young, Richard T LeBeau, Andrea N Niles, Kean J Hsu, Lisa J Burklund, Bita Mesri, Darby Saxbe, Matthew D Lieberman, Michelle G Craske
BACKGROUND: Although psychological treatments for social anxiety disorder (SAD) can be highly effective, many individuals do not respond to treatment. Identifying factors associated with improved outcomes can facilitate individualized treatment choices. We investigated whether patterns of neural connectivity predicted treatment responses and whether treatment type, cognitive behavioral therapy (CBT) or acceptance and commitment therapy (ACT), moderated this effect. METHODS: Participants with SAD (n = 34) underwent fMRI prior to treatment and completed implicit and explicit emotion regulation tasks...
August 18, 2018: Journal of Affective Disorders
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