A new cytotoxic disaccharide glycoside from the tubers of Arisaema franchetianum .

A new disaccharide glycoside, franchoside A ( 1 ), and 17 known compounds were isolated from the tubers of Arisaema franchetianum Engler. The chemical structure of the previously undescribed compound 1 was elucidated on the basis of detailed spectroscopic analyses. Compounds 1 , 2 , 6 , 10 , 14 and 18 showed significant cytotoxic activities at varying IC50 values in the range of 4.0-10.6  μ M against five cancer cell lines. Compounds 8 , 10 , 13 and 17 (10  μ M) exhibited moderate anti-inflammatory activities by inhibiting the NF- κ B signaling pathway and the release of NO from RAW264.7 macrophages induced by lipopolysaccharide (LPS), while compounds 1 , 9 , 14 , 15 and 16 showed weak anti-inflammatory activities.