CLINICAL PREDICTIVE VALUE OF RENALASE IN POST-ERCP PANCREATITIS.

BACKGROUND & AIMS: Plasma levels of renalase decrease in acute experimental pancreatitis. We aimed to determine if decreases in plasma renalase levels after ERCP predict the occurrence of post-ERCP pancreatitis (PEP).

METHODS: In this prospective cohort study at a tertiary hospital, plasma renalase was determined before ERCP (baseline), at 30 and 60 min after ERCP. Native renalase levels, acidified renalase, and native/acidified renalase proportions were analyzed over time using a longitudinal regression model.

RESULTS: Among 273 subjects, 31 developed PEP. Only one PEP patient had baseline native renalase >6.0μg/ml, while 38 of 242 without PEP had native renalase >6.0μg/ml, indicating sensitivity of 97% (30/31) and specificity of 16% (38/242) in predicting PEP. Longitudinal models did not show differences over-time between the groups.

CONCLUSION: Baseline native renalase levels are very sensitive for predicting PEP. Further studies are needed to determine the potential clinical role of renalase in predicting and preventing PEP.