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Gastrointestinal Endoscopy

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https://www.readbyqxmd.com/read/29329992/eus-elastography-strain-ratio-and-fractal-based-quantitative-analysis-for-the-diagnosis-of-solid-pancreatic-lesions
#1
Silvia Carrara, Milena Di Leo, Fabio Grizzi, Loredana Correale, Rahal Daoud, Andrea Anderloni, Francesco Auriemma, Alessandro Fugazza, Paoletta Preatoni, Roberta Maselli, Cesare Hassan, Elena Finati, Benedetto Mangiavillano, Alessandro Repici
BACKGROUND AND AIMS: EUS elastography is useful in characterizing solid pancreatic lesions (SPLs), and fractal analysis-based technology has been used to evaluate geometric complexity in oncology. The aim of this study was to evaluate EUS elastography (strain ratio) and fractal analysis for the characterization of SPLs. METHODS: Consecutive patients with SPLs were prospectively enrolled between December 2015 and February 2017. Elastographic evaluation included parenchymal strain ratio (pSR) and wall strain ratio (wSR) and was performed with the EU-ME2 processor (Olympus)...
January 9, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29329991/dynamic-contrast-enhanced-eus-for-quantification-of-tumor-perfusion-in-colonic-cancer-a-prospective-cohort-study
#2
Marie Louise Malmstrøm, Adrian Săftoiu, Lene B Riis, Hazem Hassan, Tobias W Klausen, Mikkel S Rahbek, Ismail Gögenur, Peter Vilmann
BACKGROUND AND AIMS: Dynamic contrast enhanced endoscopic ultrasound (CE-EUS) for quantification of perfusion in colonic tumors has not previously been reported in the literature. The aim of the study was to investigate correlations between perfusion parameters and vessel density assessed by immunohistochemical staining with antibodies toward CD31 and CD105. METHODS: We conducted a prospective clinical study. In total, 28 patients with left-sided colonic adenocarcinoma, underwent CE-EUS and left-sided hemicolectomy within 2 weeks...
January 9, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29325707/successful-creation-of-pancreatic-cancer-organoids-by-means-of-eus-guided-fine-needle-biopsy-for-personalized-cancer-treatment
#3
Herve Tiriac, Juan Carlos Bucobo, Demetrios Tzimas, Suman Grewel, Joseph F Lacomb, Leahana M Rowehl, Satish Nagula, Maoxin Wu, Joseph Kim, Aaron Sasson, Shivakumar Vignesh, Laura Martello, Maria Munoz-Sagastibelza, Jonathan Somma, David A Tuveson, Ellen Li, Jonathan M Buscaglia
BACKGROUND AND AIMS: Pancreatic cancer organoids are tumor models of individualized human pancreatic ductal adenocarcinoma (PDA), created from surgical specimens and used for personalized treatment strategies. Unfortunately the vast majority of patients with PDA are not operative candidates. Creation of human PDA organoids at the time of initial tumor diagnosis is therefore critical. Our aim was to assess the feasibility of creating human PDA organoids by EUS fine-needle biopsy (EUS-FNB) in patients with PDA...
January 8, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29325706/contrast-harmonic-eus-for-the-prediction-of-pancreatic-neuroendocrine-tumor-aggressiveness-with-videos
#4
Maxime Palazzo, Bertrand Napoléon, Rodica Gincul, Mathieu Pioche, Bertrand Pujol, Christine Lefort, Fabien Fumex, Vincent Hautefeuille, Monique Fabre, Jérome Cros, Michèle Felce, Anne Couvelard, Alain Sauvanet, Philippe Lévy, Philippe Ruszniewski, Laurent Palazzo
BACKGROUND AND AIM: Contrast-harmonic EUS (CH-EUS) has the ability to depict a tumor microvasculature. Decreased microvascular density has been identified as a factor associated with tumor aggressiveness. We aimed to study the accuracy of CH-EUS for the prediction of pancreatic neuroendocrine tumor (PNET) aggressiveness. METHODS: Between June 2009 and March 2015, all consecutive patients with histology-proven PNETs and CH-EUS examination were included. Nine endosonographers analyzed blindly all the videos...
January 8, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29317271/temporal-trends-in-postcolonoscopy-colorectal-cancer-rates-in-screen-eligible-persons-a-population-based-study
#5
Sanjay K Murthy, Eric I Benchimol, Jill Tinmouth, Paul D James, Robin Ducharme, Alaa Rostom, Catherine Dubé
BACKGROUND AND AIMS: Colorectal cancers (CRCs) diagnosed between 6 and 36 months after colonoscopy, termed postcolonoscopy CRCs (PCCRCs), arise primarily due to missed or inadequately treated neoplasms during colonoscopy. Quality indicators and technological advances have been introduced to colonoscopy practice that should have reduced the PCCRC rate over time. We assessed temporal trends in the population rate of PCCRC as a measure of changing colonoscopy quality. METHODS: We conducted a population-based retrospective cohort study of 50- to 74-year-old people without major risk factors for CRC who underwent complete colonoscopy in Ontario, Canada between 1996 and 2010...
January 6, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29317270/clinical-outcome-of-endoscopic-mucosal-resection-of-sporadic-nonampullary-duodenal-adenoma-a-10-year-retrospective
#6
Yutaka Tomizawa, Gregory G Ginsberg
BACKGROUND AND AIMS: Sporadic non-ampullary duodenal adenomas (SNADAs), although uncommon, pose clinical challenges. Because SNADAs have malignant potential, endoscopic or surgical resection is generally recommended. Endoscopic mucosal resection (EMR) is increasingly used for resection of SNADAs, but large-scale data on natural history after EMR are scarce. In this study, we aimed to evaluate the clinical outcome of EMR for SNADAs and the natural history after EMR from a large single-operator experience with dedicated follow-up...
January 6, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29317269/the-impact-of-wire-caliber-on-ercp-outcomes-a-multicenter-randomized-controlled-trial-of-0-025-inch-and-0-035-inch-guidewires
#7
Milan S Bassan, Praka Sundaralingam, Scott B Fanning, James Lau, Jayaram Menon, Evan Ong, Rungsun Rerknimitr, Dong-Wan Seo, Eng Kiong Teo, Hsiu-Po Wang, D Nageshwar Reddy, Khean Lee Goh, Michael J Bourke
BACKGROUND AND AIMS: Wire-guided biliary cannulation has been demonstrated to improve cannulation rates and reduce post-ERCP pancreatitis (PEP), but the impact of wire caliber has not been studied. This study compares successful cannulation rates and ERCP adverse events using a 0.025-inch and 0.035-inch guidewire. METHODS: A randomized, single blinded, prospective multi-center trial at 9 high volume tertiary referral centers in the Asia Pacific region was performed...
January 6, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29317268/combination-of-albumin-bilrubin-grade-and-platelet-to-predict-compensated-patient-with-hepatocellular-carcinoma-who-do-not-require-endoscopic-screening-for-esophageal-varices
#8
Ping-Hsien Chen, Wei-Yao Hsieh, Chien-Wei Su, Ming-Chih Hou, Yen-Po Wang, I-Fang Hsin, Tsung-Chieh Yang, Wei-Chih Liao, Han-Chieh Lin, Fa-Yauh Lee, Jaw-Ching Wu
BACKGROUND: s & Aims: There is no consensus for screening high-risk esophageal varices (HRV) in patients with hepatocellular carcinoma (HCC). Here, we aimed to investigate the prevalence and risk factors of HRV in HCC patients and to assess the combination of albumin-bilirubin grade and platelet count (ALBI-PLT score) for predicting compensated patients who do not need unnecessary endoscopic screening for HRV. METHODS: The ALBI-PLT score was calculated by adding ALBI grade and point of platelet count (1 point if platelet count >150,000 /mm3 and 2 points if ≦150,000 /mm3)...
January 6, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29317267/spiral-enteroscopy-assisted-ercp-in-bariatric-length-roux-en-y-anatomy-a-large-single-center-series-and-review-of-the-literature-with-video
#9
Mohammad F Ali, Rani Modayil, Krishna C Gurram, Collin Brathwaite, David Friedel, Stavros Stavropoulos
BACKGROUND: Deep enteroscopy-assisted ERCP (DEA-ERCP) in post-bariatric Roux-en-Y (RY) anatomy is challenging. Laparoscopy-assisted ERCP (LA-ERCP) or EUS-directed transgastric ERCP (EDGE) are technically easier and faster, but are more invasive and morbid procedures. Therefore, we have used DEA-ERCP as our first-line approach, reserving EDGE and LA-ERCP for cases in which adjunctive techniques that cannot be performed through an enteroscope are required (eg, EUS-FNA, SO manometry), or DEA-ERCP failures...
January 6, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29309782/effectiveness-of-cap-assisted-device-in-the-endoscopic-removal-of-food-bolus-obstruction-from-the-esophagus
#10
Marie Ooi, Edward John Young, Nam Q Nguyen
BACKGROUND AND AIM: The use of a transparent cap has been found to be effective in retrieval of esophageal foreign body. However, data on the use of a cap in food bolus obstruction (FBO) are limited. This study aims to assess the effectiveness of a cap-assisted technique compared with conventional techniques in removal of FBO. METHODS: All patients who underwent an endoscopy for boneless FBO between 2011-2016 were prospectively recruited. The measured outcomes were procedure time, success rate of food bolus (FB) extraction, rate of en bloc removal, procedure-related adverse events and length of hospital stay (LOS) between the 2 groups...
January 5, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29309781/technical-feasibility-diagnostic-yield-and-safety-of-micro-forceps-biopsies-during-eus-evaluation-of-pancreatic-cystic-lesions-with-video
#11
Chetan Mittal, Joshua C Obuch, Hazem Hammad, Steven A Edmundowicz, Sachin Wani, Raj J Shah, Brian C Brauer, Augustin R Attwell, Jeffrey B Kaplan, Mihir S Wagh
BACKGROUND AND AIMS: Through-the-needle micro forceps are a recent addition to the EUS armamentarium for evaluation of pancreatic cystic lesions (PCLs). The main aim of this study was to assess the technical feasibility, diagnostic yield and safety of EUS-guided micro forceps biopsy for PCLs. METHODS: Our electronic endoscopy database was queried to identify patients who underwent EUS-FNA of PCLs and micro forceps biopsies, during the same procedure. The wall of the cyst was biopsied with the micro forceps through the 19-gauge needle and cyst fluid was collected for cytology, and CEA levels...
January 5, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29309780/pancreatic-cancer-screening-in-high-risk-individuals-with-germline-genetic-mutations
#12
Tomas DaVee, Emmanuel Coronel, Charilaos Papafragkakis, Sayam Thaiudom, Gandhi Lanke, Raja C Chakinala, Graciela M Nogueras González, Manoop S Bhutani, William A Ross, Brian R Weston, Jeffrey H Lee
BACKGROUND AND AIMS: Pancreas cancer (PC) is a deadly disease, which is most commonly diagnosed at an incurable stage. Different high-risk genetic variants and cancer syndromes increase the lifetime risk of developing PC. This study aims to assess the yield of initial PC screening in patients with high-risk germline mutations. METHODS: Asymptomatic adults underwent PC screening by EUS, MRI or CT during a 10-year period, and were retrospectively identified. High-risk individuals were defined as carrying germline mutations in BRCA1, BRCA2, p53 (Li-Fraumeni), STK11 (Peutz-Jeghers), MSH2 (Lynch), ATM (ataxia-telangiectasia), or APC (familial adenomatous polyposis)...
January 5, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29309779/obtaining-adequate-lamina-propria-for-subepithelial-fibrosis-evaluation-in-pediatric-eosinophilic-esophagitis
#13
Jason Wang, Jason Y Park, Rong Huang, Rhonda F Souza, Stuart J Spechler, Edaire Cheng
BACKGROUND & AIMS: Subepithelial fibrosis in eosinophilic esophagitis (EoE) can be detected only in esophageal biopsies with adequate amounts of lamina propria (LP). We investigated how often pediatric esophageal biopsies contain adequate LP, and whether esophageal eosinophilia influences the acquisition rates. METHODS: We evaluated 284 esophageal biopsy specimens from 39 EoE patients, and 87 biopsy specimens from 32 patients without esophageal eosinophilia or other esophageal abnormalities for the presence of adequate LP and fibrosis...
January 5, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29309778/comparison-of-the-diagnostic-performance-between-magnifying-chromoendoscopy-and-magnifying-narrow-band-imaging-for-superficial-colorectal-neoplasm-an-online-survey
#14
Taku Sakamoto, Takeshi Nakajima, Takahisa Matsuda, Yoshitaka Murakami, Hideki Ishikawa, Kenshi Yao, Yutaka Saito
BACKGROUND AND AIMS: Magnifying narrow-band imaging (mag-NBI) and magnifying chromoendoscopy using crystal violet staining for pit pattern analysis (pit pattern) is highly accurate for invasion depth diagnosis for superficial colorectal neoplasm. However, NBI and pit pattern have not been compared. METHODS: We conducted an online survey of endoscopists interested in image-enhanced endoscopy. Still images using white light, mag-NBI, and pit pattern were collected from lesions diagnosed at the National Cancer Center Hospital, Tokyo, Japan (NCCH)...
January 5, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29309777/endoscopic-mucosal-resection-of-laterally-spreading-lesions-around-or-involving-the-appendiceal-orifice-technique-risk-factors-for-failure-and-outcomes-of-a-tertiary-referral-cohort-with-video
#15
David J Tate, Lobke Desomer, Halim Awadie, Kathleen Goodrick, Luke Hourigan, Rajvinder Singh, Stephen J Williams, Michael J Bourke
BACKGROUND AND AIMS: Endoscopic mucosal resection (EMR) of peri-appendiceal sessile laterally spreading lesions (PA-LSLs) is technically demanding due to poor endoscopic access to the appendiceal lumen and the thin colonic wall at the base of the cecum. We aimed to assess the feasibility and safety of EMR for PA-LSLs. METHODS: Consecutive LSLs ≥20 mm and PA-LSLs ≥10 mm detected at 3 academic endoscopy centers from September 2008 until January 2017 were eligible...
January 5, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29307474/predictors-of-clinical-outcome-of-colonic-stents-in-patients-with-malignant-large-bowel-obstruction-due-to-extracolonic-malignancy
#16
Shahdabul Faraz, Suhail B Salem, Mark Schattner, Robin Mendelsohn, Arnold Markowitz, Emmy Ludwig, Junting Zheng, Hans Gerdes, Pari Shah
BACKGROUND AND AIMS: Colonic stent placement in patients with large-bowel obstruction (LBO) secondary to extra colonic malignancy (ECM) has been evaluated in small series with heterogeneous results. Our aim is to better characterize the technical and clinical success of colonic stent placement and to identify factors that affect this success in ECM patients. METHODS: All patients at a single high-volume center who presented for colonic stent placement for LBO due to ECM between 2001 and 2012 were retrospectively identified...
January 4, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29307473/assessment-of-peri-polyp-biopsies-of-flat-mucosa-in-patients-with-inflammatory-bowel-disease
#17
Noa Krugliak Cleveland, Dezheng Huo, Farah Sadiq, M Anthony Sofia, Julia Marks, Russell D Cohen, Stephen B Hanauer, Jerrold Turner, John Hart, David T Rubin
BACKGROUND: When colon polyps are removed in the setting of inflammatory bowel disease (IBD) involving the large intestine, biopsies of the flat mucosa surrounding such polyps have been recommended, but there are no data to support this practice. METHODS: We reviewed endoscopic and pathologic findings in IBD patients who had dysplastic polyps removed as well as biopsies of the adjacent flat mucosa. We assessed risk for subsequent neoplasia based on the presence or absence of dysplasia in the peri-polyp flat mucosa, and based on number and grade of index polypoid lesions...
January 4, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29305893/randomized-trial-comparing-the-franseen-and-fork-tip-needles-for-eus-guided-fine-needle-biopsy-of-solid-pancreatic-mass-lesions
#18
Ji Young Bang, Shantel Hebert-Magee, Udayakumar Navaneethan, Muhammad K Hasan, Robert Hawes, Shyam Varadarajulu
BACKGROUND AND AIMS: Recently, 3-plane symmetric needle with Franseen geometry and Fork-tip biopsy needle have been developed for histological tissue procurement. We compared 22-gauge Franseen and 22-gauge Fork-tip needles in patients undergoing EUS-guided sampling of pancreatic masses. METHODS: Fifty patients underwent sampling using both 22-gauge Franseen and 22-gauge Fork-tip needles, with randomization of needle order. Two dedicated passes were performed using both needles for cell block...
January 3, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29306520/guidelines-for-sedation-and-anesthesia-in-gi-endoscopy
#19
Dayna S Early, Jenifer R Lightdale, John J Vargo, Ruben D Acosta, Vinay Chandrasekhara, Krishnavel V Chathadi, John A Evans, Deborah A Fisher, Lisa Fonkalsrud, Joo Ha Hwang, Mouen A Khashab, V Raman Muthusamy, Shabana F Pasha, John R Saltzman, Amandeep K Shergill, Brooks D Cash, John M DeWitt
No abstract text is available yet for this article.
December 23, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29242059/usefulness-of-underwater-endoscopic-submucosal-dissection-in-saline-solution-with-a-monopolar-knife-for-colorectal-tumors
#20
Mitsuru Nagata
BACKGROUND AND AIM: Generally, colorectal endoscopic submucosal dissection (ESD) is performed with a monopolar knife with CO2 supply from an endoscope. There are few case reports about underwater ESD (UESD) in saline solution with a bipolar knife. The usefulness and safety of UESD in saline solution with a monopolar knife are unclear. The present study aimed to investigate the usefulness and safety of UESD in saline solution with a monopolar knife for colorectal tumors. METHODS: This was a retrospective, observational study on UESD for colorectal tumors...
December 11, 2017: Gastrointestinal Endoscopy
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