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Gastrointestinal Endoscopy

John M DeWitt, Kumar Sandrasegaran, Bert O'Neil, Michael G House, Nicholas J Zyromski, Amikar Sehdev, Susan M Perkins, Janet Flynn, Lynne McCranor, Safi Shahda
BACKGROUND AND AIMS: Locally advanced pancreatic cancer (LAPC) has a poor prognosis. There are limited data describing the use of photodynamic therapy (PDT) for pancreatic cancer in humans. We hypothesized that EUS-guided PDT for LAPC is safe, technically feasible and produces a dose- and time-dependent increasing degree of image-defined tumor necrosis. METHODS: In a single center, prospective, dose escalation phase I study, patients with treatment-naïve LAPC received intravenous (IV) porfimer sodium (Concordia Laboratories Inc; St Michael, Barbados) followed 2 days later by EUS-PDT...
September 14, 2018: Gastrointestinal Endoscopy
Madhav Desai, Mohammad Bilal, Nour Hamade, Venkata Subhash Gorrepati, Viveksandeep Thogulva Chandrasekar, Ramprasad Jegadeesan, Neil Gupta, Pradeep Bhandari, Alessandro Repici, Cesare Hassan, Prateek Sharma
BACKGROUND AND AIMS: Right-sided lesions are often missed during standard colonoscopy (SC). A second forward view examination or retroflexion in the right side of the colon, have both been proposed as techniques to improve ADR in the right side of the colon. Comparative data of examining the right side of the colon with a second forward view or retroflexion is not known in a pooled analysis. We performed a systematic review of the literature to assess the yield of a second forward view compared with retroflexion examination for the detection of right-sided adenomas...
September 14, 2018: Gastrointestinal Endoscopy
Yun Wang, Zu-Qiang Liu, Mei-Dong Xu, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Wei-Feng Chen, Wen-Zheng Qin, Jian-Wei Hu, Ming-Yan Cai, Li-Qing Yao, Ping-Hong Zhou, Quan-Lin Li
BACKGROUND & AIMS: Mucosal injury (MI) is one of the most common perioperative adverse events of per-oral endoscopic myotomy (POEM). Severe undertreated MI may lead to contamination of the tunnel and even mediastinitis. This study explored the characteristics, predictors and management approaches of intraoperative MI. METHODS: A retrospective review of the prospectively collected database at a large tertiary referral endoscopy unit was conducted for all patients undergoing POEM between August 2010 and March 2016...
September 12, 2018: Gastrointestinal Endoscopy
Zachary L Smith, Daniel K Mullady, Gabriel D Lang, Koushik K Das, Robert M Hovis, Riddhi S Patel, Thomas G Hollander, Jeffery Elsner, Catherine Ifune, Vladimir M Kushnir
BACKGROUND AND AIMS: ERCP is a complex procedure and often performed in patients at high risk for sedation-related adverse events (SRAE). However, there is no current standard of care with regard to mode of sedation and airway management during ERCP. The aim of this study was to assess the safety of general endotracheal anesthesia (GEA) versus propofol-based monitored anesthesia care without endotracheal intubation (MAC) in patients undergoing ERCP at high risk for SRAE. METHODS: Consecutive patients undergoing ERCP at high risk for SRAE at a single center were invited to participate in this randomized-controlled trial (NCT02850887) comparing GEA and MAC...
September 11, 2018: Gastrointestinal Endoscopy
Dongwook Oh, Tae Jun Song, Dong Hui Cho, Do Hyun Park, Dong-Wan Seo, Sung Koo Lee, Myung-Hwan Kim, Sang Soo Lee
BACKGROUND AND AIMS: Endoscopic gallbladder drainage (GBD) has been performed as an alternative to percutaneous drainage for acute cholecystitis. To date, there has been no comparative study between endoscopic ultrasound-guided cholecystostomy (EUSC) and endoscopic transpapillary cholecystostomy (ETC). The aim of this study was to compare the outcomes of EUSC and ETC. METHODS: Retrospective review of an endoscopic GBD database prospectively collected at the Asan Medical Center (between July 2010 and December 2014) was performed to identify consecutive patients with acute cholecystitis who underwent attempted endoscopic GBD...
September 10, 2018: Gastrointestinal Endoscopy
Shusei Fukunaga, Yasuaki Nagami, Masatsugu Shiba, Taishi Sakai, Hirotsugu Maruyama, Masaki Ominami, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Koichi Taira, Tetsuya Tanigawa, Hirokazu Yamagami, Toshio Watanabe, Yasuhiro Fujiwara
BACKGROUND AND AIMS: It is thought that preoperative biopsy for superficial-type colorectal tumors should be avoided because submucosal fibrosis caused by biopsy makes endoscopic mucosal resection impossible. However, few studies have reported the influence of biopsy on colorectal endoscopic submucosal dissection (ESD). This study aimed to examine the effect of biopsy on submucosal fibrosis and treatment outcomes of ESD for laterally spreading tumors (LSTs). METHODS: Between April 2005 and September 2015, 441 consecutive patients underwent colorectal ESD in Osaka City University Hospital...
September 7, 2018: Gastrointestinal Endoscopy
Saeed Ali, Robert H Hawes, Kambiz Kadkhodayan, Ehsan Rafiq, Udayakumar Navaneethan, Ji Y Bang, Shyam Varadarajulu, Muhammad K Hasan
BACKGROUND AND AIMS: Rapid on-site evaluation of touch imprint cytology (ROSE-TIC) is a simple and rapid method used for the diagnosis of benign and malignant lesions. We evaluated the diagnostic accuracy of ROSE-TIC for advanced intestinal luminal and indeterminate pancreatobiliary lesions during endoscopy. METHODS: This is a retrospective descriptive study of patients who underwent endoscopy or ERCP between January 1, 2014, and December 31, 2016. It included patients who were referred for the treatment of intestinal luminal lesions or evaluation of indeterminate pancreatobiliary lesions...
September 4, 2018: Gastrointestinal Endoscopy
Andrea Anderloni, Alessandro Fugazza, Edoardo Troncone, Francesco Auriemma, Silvia Carrara, Rossella Semeraro, Roberta Maselli, Milena di Leo, Ferdinando D'Amico, Amrita Sethi, Alessandro Repici
BACKGROUND AND AIMS: EUS-guided choledochoduodenostomy(EUS-CD) using a lumen-apposing metal stent (LAMS) has been recently reported as an alternative treatment approach for patients with malignant obstructive jaundice and failed endoscopic retrograde cholangiopancreatography (ERCP). We analyzed the safety, technical and clinical efficacy of EUS-CD using LAMS in patients with malignant obstructive jaundice. METHODS: Retrospective study of consecutive patients with inoperable malignant distal bile duct obstruction who underwent EUS-CD using an electrocautery enhanced(EC)- LAMS over a 3-year (2015-2018) period...
September 3, 2018: Gastrointestinal Endoscopy
Osamu Dohi, Nobuaki Yagi, Yuji Naito, Akifumi Fukui, Yasuyuki Gen, Naoto Iwai, Tomohiro Ueda, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiko Uchiyama, Tomohisa Takagi, Hideyuki Konishi, Akio Yanagisawa, Yoshito Itoh
BACKGROUND AND AIMS: Blue laser imaging (BLI)-bright (BLI-bright) has shown promise as a more useful tool for detection of early gastric cancer (EGC) than white-light imaging (WLI). However, the diagnostic performance of BLI-bright in the detection of EGC has not been investigated. We aimed to compare real-time detection rates of WLI with that of BLI-bright for EGC. METHODS: This was a prospective, randomized, controlled study in 2 Japanese academic centers. We investigated 629 patients undergoing follow-up endoscopy for atrophic gastritis with intestinal metaplasia or surveillance after endoscopic resection of EGC...
September 3, 2018: Gastrointestinal Endoscopy
Christian Jürgensen, Marius Distler, Alexander Arlt, Stefan Brückner, Mark Ellrichmann, Katja Matthes, Marleen Ludwig, Stephan Sulk, Laura Romberg, Sebastian Zeissig, Clemens Schafmayer, Sebastian Hinz, Thilo Welsch, Marcus Bahra, Heiko Aselmann, Jürgen Weitz, Fritz Klein, Thomas Becker, Jochen Hampe
BACKGROUND AND AIMS: Postoperative pancreatic leakage and fistulae (jointly referred as POPF) are a leading adverse event after partial pancreatic resection. Treatment algorithms are currently not standardized. Evidence regarding the role of endoscopy is scarce. METHODS: One hundred ninety-six POPF patients with (N=132) and without (N=64) concomitant pancreatic fluid collections (PFC) from centers in Berlin, Kiel, and Dresden were analyzed retrospectively. Clinical resolution was used as the primary endpoint of analysis...
September 1, 2018: Gastrointestinal Endoscopy
Masaya Iwamuro, Hiroyuki Sakae, Takehiro Tanaka, Hiroyuki Okada
No abstract text is available yet for this article.
August 31, 2018: Gastrointestinal Endoscopy
Andreas Probst, Tina Schaller, Helmut Messmann
No abstract text is available yet for this article.
August 31, 2018: Gastrointestinal Endoscopy
Takahiro Utsumi, Yukiko Hiramatsu, Shin'ichi Miyamoto
No abstract text is available yet for this article.
August 31, 2018: Gastrointestinal Endoscopy
Jesús Gotor Delso, Santiago Frago Larramona, Javier Fuentes Olmo, Rafael Uribarrena Amezaga
No abstract text is available yet for this article.
August 31, 2018: Gastrointestinal Endoscopy
Saurabh Chandan, Annie Braseth, Lokesh K Jha, Alexander T Hewlett, Renee L Young
No abstract text is available yet for this article.
August 31, 2018: Gastrointestinal Endoscopy
Chetan Mittal, Raj J Shah
BACKGROUND AND AIMS: Per-oral pancreatoscopy (POP) permits direct evaluation of the pancreatic duct for the visualization and sampling of neoplastic lesions, and treatment of pancreatic duct stones using intraductal lithotripsy techniques. Pancreatic laser endotherapy of mucosa has been described in animal models for tumor ablation but human experience is lacking. We describe 3 unique and challenging clinical situations that benefited from pancreatic laser dissection and ablation. METHODS: This was a retrospective case series...
August 31, 2018: Gastrointestinal Endoscopy
Rui Gaspar, Patricia Andrade, Guilherme Macedo
No abstract text is available yet for this article.
August 30, 2018: Gastrointestinal Endoscopy
Ahmet Tarık Eminler, Erkan Parlak, Aydın Seref Koksal, Bilal Toka, Mustafa Ihsan Uslan
BACKGROUND AND AIMS: Cannulation of the major papilla can be problematic and selective biliary cannulation may fail in up to 18% of cases. Various techniques, such as double-guidewire technique (DGWT), wire-guided cannulation over a pancreatic stent (WGC-PS), the precut endoscopic sphincterotomy (needle-knife precutting technique: NKP), and transpancreatic septotomy, have been used to improve the success rate of biliary cannulation. We conducted a prospective, randomized study in order to compare the biliary cannulation success rates of DGWT and WGC-PS techniques in patients with inadvertent passage of guidewire to pancreatic duct...
August 24, 2018: Gastrointestinal Endoscopy
Phillip S Ge, Christopher C Thompson, Pichamol Jirapinyo, Hiroyuki Aihara
BACKGROUND AND AIMS: The lack of reliable countertraction in endoscopic submucosal dissection (ESD) contributes to its technical demand and increased procedure time. We aimed to prospectively evaluate the efficacy of the suture pulley countertraction method in endoscopists new to both suturing and ESD. METHODS: Two 30 mm circular lesions were created in an ex vivo porcine stomach model. Endoscopists considered novices for both endoscopic suturing and ESD were randomized to either traditional or suture pulley ESD first and performed ESD using each technique...
August 24, 2018: Gastrointestinal Endoscopy
Monique T Barakat, Robert J Huang, Subhas Banerjee
BACKGROUND: Residual fluid within endoscope working channels after reprocessing may promote growth of pathogens. Current reprocessing guidelines therefore recommend endoscope drying with administration of forced filtered air; however, the duration and modality of administered air are not specified. The new DriScope Aid device enables automated administration of filtered air at controlled pressure through all internal endoscope channels. We systematically compared, for the first time, the impact of manual drying and automated drying on retained working channel fluid and bioburden after reprocessing...
August 24, 2018: Gastrointestinal Endoscopy
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